Glial pathology in a novel spontaneous mutant mouse of the Eif2b5 gene: a vanishing white matter disease model.

abstract：:Stabilized microtubules are required for neuronal morphogenesis and migration. However, the underlying mechanism is not fully understood. In this study, we demonstrate that myosin X (Myo10), which is composed of full-length myosin X (fMyo10) and headless myosin X (hMyo10), is important for axon development. fMyo10 is ...

journal_title：Journal of neurochemistry

authors： Yu H,Sun D,Wang N,Wang M,Lan Y,Fan W,Zhao Y,Guo W,Zhu X

更新日期：2015-10-01 00:00:00

abstract：:OPA1, a nuclear encoded mitochondrial protein causing autosomal dominant optic atrophy, is a key player in mitochondrial fusion and cristae morphology regulation. In the present study, we have compared the OPA1 transcription and translation products of different mouse tissues. Unlike in humans, we found only two exons...

journal_title：Journal of neurochemistry

authors： Akepati VR,Müller EC,Otto A,Strauss HM,Portwich M,Alexander C

更新日期：2008-07-01 00:00:00

abstract：:A specific and sensitive gas chromatographic-mass spectrometric assay for measurement of normetanephrine (NMN) in different rat brain regions is presented. The results show that hypothalamus contains the highest concentrations of the norepinephrine metabolite. An increase of NMN concentrations has been detected in ani...

journal_title：Journal of neurochemistry

authors： Mocchetti I,De Angelis L,Racagni G

更新日期：1981-12-01 00:00:00

abstract：:A monoclonal antibody (8-18C5) directed against myelin/oligodendrocyte glycoprotein (MOG) induced demyelination in aggregating brain cell cultures. With increasing doses of anti-MOG antibody in the presence of complement, myelin basic protein (MBP) concentration decreased in a dose-related manner. A similar, albeit le...

journal_title：Journal of neurochemistry

authors： Kerlero de Rosbo N,Honegger P,Lassmann H,Matthieu JM

更新日期：1990-08-01 00:00:00

abstract：:Dysregulation of the central noradrenergic system is a core feature of post-traumatic stress disorder (PTSD). Here, we examined molecular changes in locus coeruleus (LC) triggered by single-prolonged stress (SPS) PTSD model at a time when behavioral symptoms are manifested, and the effect of early intervention with in...

journal_title：Journal of neurochemistry

authors： Sabban EL,Laukova M,Alaluf LG,Olsson E,Serova LI

更新日期：2015-12-01 00:00:00

abstract：:Peroxynitrite, the product of the radical-radical reaction between nitric oxide and superoxide anion, is a potent oxidant involved in tissue damage in neurodegenerative disorders. We investigated the modifications induced by peroxynitrite in tyrosine residues of proteins from synaptosomes. Peroxynitrite treatment (> o...

journal_title：Journal of neurochemistry

authors： Di Stasi AM,Mallozzi C,Macchia G,Petrucci TC,Minetti M

更新日期：1999-08-01 00:00:00

abstract：:G-protein coupled receptors may mediate their effects on neuronal growth and differentiation through activation of extracellular signal-regulated kinases 1/2 (ERK1/2), often elicited by transactivation of growth factor receptor tyrosine kinases. This elaborate signaling process includes inducible formation and traffic...

journal_title：Journal of neurochemistry

authors： Asimaki O,Leondaritis G,Lois G,Sakellaridis N,Mangoura D

更新日期：2011-03-01 00:00:00

abstract：:We demonstrate that 1-methyl-4-phenylpyridinium (MPP+) is toxic to chick peripheral sympathetic neurons maintained in culture in the presence of nerve growth factor (NGF). When MPP+ was added to the culture medium at the time the neurons were plated, cell loss after 3 days in culture was evident at concentrations as l...

journal_title：Journal of neurochemistry

authors： Bhave SV,Johannessen JN,Lash LH,Wakade TD,Wakade AR

更新日期：1996-08-01 00:00:00

abstract：:Glycine and GABA are likely co-transmitters in the spinal cord. Their possible interactions in presynaptic terminals have, however, not been investigated. We studied the effects of glycine on GABA release using superfused mouse spinal cord synaptosomes. Glycine concentration dependently elicited [(3)H]GABA release whi...

journal_title：Journal of neurochemistry

authors： Raiteri L,Raiteri M,Bonanno G

更新日期：2001-03-01 00:00:00

abstract：:The neuronal nitric oxide (NO) synthase generates NO from arginine. NO mediates its physiological effects mainly by stimulating the synthesis of cyclic GMP. We have investigated the role of the arginine availability on the NMDA-induced cyclic GMP accumulation in immature rat brain slices. The effect of NMDA was blocke...

journal_title：Journal of neurochemistry

authors： Grima G,Cuénod M,Pfeiffer S,Mayer B,Do KQ

更新日期：1998-11-01 00:00:00

abstract：:Rat cerebral cortex synaptosomes were exposed in superfusion to various depolarizing stimuli and the release of somatostatin-like immunoreactivity (SRIF-LI) was measured by means of a radioimmunoassay procedure. High KCl (9-50 mM) concentration dependently evoked SRIF-LI release; the evoked overflow reached a plateau ...

journal_title：Journal of neurochemistry

authors： Bonanno G,Parodi B,Cafaggi S,Raiteri M

更新日期：1991-10-01 00:00:00

abstract：:Recent studies have shown that mast cells (MCs) are present in rat brain, that they have a predominantly thalamic localization, and that they contain histamine (HA). However, the degree to which these cells contribute to brain HA levels has remained unclear. Our recent studies of the precise distribution of rat brain ...

journal_title：Journal of neurochemistry

authors： Goldschmidt RC,Hough LB,Glick SD

更新日期：1985-06-01 00:00:00

abstract：:Epilepsy is a serious neurological condition exhibiting complex pathology and deserving of more serious attention. More than 30% of people with epilepsy are not responsive to more than 20 anti-epileptic drugs currently available, reflecting an unmet clinical need for novel therapeutic strategies. Not much is known abo...

journal_title：Journal of neurochemistry

authors： Paudel YN,Semple BD,Jones NC,Othman I,Shaikh MF

更新日期：2019-12-01 00:00:00

abstract：:Glycogen synthase kinase-3beta (GSK-3beta) is a multifunctional enzyme involved in a variety of biological events including development, glucose metabolism and cell death. Its activity is inhibited by phosphorylation of the Ser9 residue and up-regulated by Tyr216 phosphorylation. Activated GSK-3beta increases phosphor...

journal_title：Journal of neurochemistry

authors： Hawkes C,Jhamandas JH,Kar S

更新日期：2005-10-01 00:00:00

abstract：:3 alpha-Hydroxysteroid oxidoreductase (EC 1.1.1.50) was localized in the rat brain by cryostat sectioning, microassay, and neurochemical lesions. Single 16-microns sections were cut, homogenized, and assayed. In the olfactory tubercle 3 alpha-hydroxysteroid oxidoreductase activity is high in the piaglial layer at the ...

journal_title：Journal of neurochemistry

authors： Krieger NR,Scott RG

更新日期：1989-06-01 00:00:00

abstract：:Transporters of the solute carrier 6 (SLC6) family mediate the reuptake of neurotransmitters such as dopamine, norepinephrine, serotonin, GABA, and glycine. SLC6 family members are 12 transmembrane helix-spanning proteins that operate using the transmembrane sodium gradient for transport. These transporters assume var...

journal_title：Journal of neurochemistry

authors： Jayaraman K,Das AK,Luethi D,Szöllősi D,Schütz GJ,Reith MEA,Sitte HH,Stockner T

更新日期：2020-08-07 00:00:00

abstract：:A continuous enzyme-linked fluorometric assay was used for determining the characteristics for glutamate exocytosis from guinea-pig cerebrocortical synaptosomes. Ca2+-dependent release can be induced not only by K+, but also by the Na+ channel activator veratridine and the Ca2+ ionophore ionomycin. K+-induced release ...

journal_title：Journal of neurochemistry

authors： Sanchez-Prieto J,Sihra TS,Nicholls DG

更新日期：1987-07-01 00:00:00

abstract：:The cleavage-product of amyloid precursor protein (APP) constitutes the core component of plaques found in the brains of Alzheimer's disease (AD) patients. APP is ubiquitously expressed and its precise physiological functions remain unclear. This protein has been proposed to regulate synaptic function and processes un...

journal_title：Journal of neurochemistry

authors： Senechal Y,Kelly PH,Cryan JF,Natt F,Dev KK

更新日期：2007-09-01 00:00:00

abstract：:A ganglioside antigen was detected in infant human brains by the monoclonal antibody C-50. Structural analysis of the isolated ganglioside antigen showed it to be 3'-isoLM1, sialosyllactotetraosylceramide. The concentration of this ganglioside in human infant brain was 0.5 nmol/g. ...

journal_title：Journal of neurochemistry

authors： Molin K,Månsson JE,Fredman P,Svennerholm L

更新日期：1987-07-01 00:00:00

abstract：:Analysis of the initial rates of 45Ca2+ uptake by rat brain mitochondria in Ca2+-1,2-bis(o-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid buffers indicated that nontelencephalic mitochondria exhibited both a much less pronounced stimulatory effect of spermine and significantly more hyperbolic kinetics of Ca2+ uptake t...

journal_title：Journal of neurochemistry

authors： Jensen JR,Lynch G,Baudry M

更新日期：1989-10-01 00:00:00

abstract：:We addressed the balance between thrombin and its serpin protease nexin I (PNI) after sciatic nerve injury in the mouse. Prothrombin levels increased twofold 24 h after nerve crush, as measured by a specific chromogenic assay, and peaked at day 3. Thrombin activity also increased 2-4 days after injury in distal sciati...

journal_title：Journal of neurochemistry

authors： Smirnova IV,Ma JY,Citron BA,Ratzlaff KT,Gregory EJ,Akaaboune M,Festoff BW

更新日期：1996-11-01 00:00:00

abstract：:GN11 and GT1-7 are immortalized gonadotropin-releasing hormone-positive murine cell lines exhibiting the features of immature olfactory neurons and differentiated hypothalamic neurons, respectively. Using electron microscopy and biochemical assays (RT-PCR and immunoblotting) we determined the presence of numerous cave...

journal_title：Journal of neurochemistry

authors： D'Orlando C,Guzzi F,Gravati M,Biella G,Toselli M,Meneveri R,Barisani D,Parenti M

更新日期：2008-03-01 00:00:00

abstract：:A diphtheria toxin-neurotrophin-4/5 (NT-4/5) chimera (DAB389-NT4), in which the native receptor binding domain of diphtheria toxin was replaced with a synthetic gene encoding rat NT-4/5, was expressed, refolded, and purified. This fusion toxin has a deduced molecular mass of 60,163 and is formed by joining the first 3...

journal_title：Journal of neurochemistry

authors： Negro A,Skaper SD

更新日期：1997-02-01 00:00:00

abstract：:Previous studies examining age differences in membrane fluidity and cholesterol content have reported on the average or total change in membrane structure, respectively. However, a membrane consists of an exofacial leaflet and a cytofacial leaflet that differ in fluidity and cholesterol distribution. The purpose of th...

journal_title：Journal of neurochemistry

authors： Igbavboa U,Avdulov NA,Schroeder F,Wood WG

更新日期：1996-04-01 00:00:00

abstract：:The release of preaccumulated gamma-amino[3H]butyric acid ([3H]GABA) from putative GABAergic amacrine cells was studied in neuronal monolayer cultures made from embryonic chick retina. Release was specifically stimulated by excitatory amino acid agonists. N-Methyl-D-aspartate (NMDA; EC50, 19.1 +/- 5.0 microM), kainic ...

journal_title：Journal of neurochemistry

authors： Hofmann HD,Möckel V

更新日期：1991-03-01 00:00:00

abstract：:The glial-derived neurotrophic protein S100beta has been implicated in the development and maintenance of the nervous system. S100beta has also been postulated to play a role in mechanisms of neuropathology because of its specific localization and selective overexpression in Alzheimer's disease. However, the exact rel...

journal_title：Journal of neurochemistry

authors： Hu J,Ferreira A,Van Eldik LJ

更新日期：1997-12-01 00:00:00

abstract：:In adult New Zealand white rabbits, the effects of food deprivation and of massive elevations of plasma uridine or thymidine concentrations on CSF and plasma nucleoside and oxypurine concentrations were studied. Nucleoside and oxypurine levels were determined by high performance liquid chromatography using unequivocal...

journal_title：Journal of neurochemistry

authors： Eells JT,Spector R,Huntoon S

更新日期：1984-06-01 00:00:00

abstract：:The turnover of acetylcholine (ACh) in rat brain synaptosomes and its compartmentation in the labile bound and stable bound pools were investigated. The P(2) fraction from rat brain was subjected to three sequential incubations, each terminated by centrifugation followed by determination of ACh concentrations by gas c...

journal_title：Journal of neurochemistry

authors： Jope RS

更新日期：1981-05-01 00:00:00

abstract：:125I-Porcine brain natriuretic peptide (125I-pBNP) bound to mouse astrocytes in primary culture in a time-dependent manner (t1/2 = 4.5 min), similar to 125I-human atrial natriuretic peptide (125I-hANP) (t1/2 = 5 min). Binding was saturable and reached equilibrium after 90 min at 22 degrees C for both radioligands. Sca...

journal_title：Journal of neurochemistry

authors： Yeung VT,Lai CK,Cockram CS,Young JD,Nicholls MG

更新日期：1991-05-01 00:00:00

abstract：:The glial glutamate transporter EAAT2 (excitatory amino acid transporter 2) is the major mediator of glutamate clearance that terminates glutamate-mediated neurotransmission. Loss of EAAT2 and associated glutamate uptake function has been reported in the brains of patients with Alzheimer's disease (AD). We previously ...

journal_title：Journal of neurochemistry

authors： Tian G,Kong Q,Lai L,Ray-Chaudhury A,Lin CL

更新日期：2010-05-01 00:00:00