SLC6 transporter oligomerization.

abstract：:The presence of serine transhydroxymethylase (STHM; EC 2.1.2.1) in crude homogenates of rat, guinea pig and goat retina has been demonstrated. There was a variation in the levels of retinal STHM activity in the three species. Substantial STHM activity was found in all the three retinal preparations in the absence of p...

journal_title：Journal of neurochemistry

authors： Dasgupta P,Narayanaswami A

更新日期：1982-09-01 00:00:00

abstract：:The activity-dependent fusion, retrieval and recycling of synaptic vesicles is essential for the maintenance of neurotransmission. Until relatively recently it was believed that most mutations in genes that were essential for this process would be incompatible with life, because of this fundamental role. However, an e...

journal_title：Journal of neurochemistry

authors： Bonnycastle K,Davenport EC,Cousin MA

更新日期：2020-05-07 00:00:00

abstract：:The thalamic synapses relay peripheral sensory information to the cortex, and constitute an important part of the thalamocortical network that generates oscillatory activities responsible for different vigilance (sleep and wakefulness) states. However, the modulation of thalamic synaptic transmission by potential slee...

journal_title：Journal of neurochemistry

authors： Yang YC,Hu CC,Huang CS,Chou PY

更新日期：2014-03-01 00:00:00

abstract：:Apoptotic cell death has recently been implicated in diseases involving nonproliferating, terminally differentiated cells such as neurons. Previous experiments have documented that immunoglobulins from patients with amyotrophic lateral sclerosis (ALS) can kill motoneuron-neuroblastoma hybrid cells [ventral spinal cord...

journal_title：Journal of neurochemistry

authors： Alexianu ME,Mohamed AH,Smith RG,Colom LV,Appel SH

更新日期：1994-12-01 00:00:00

abstract：:Changes in the free fatty acid pool size and fatty acyl chain composition of mitochondrial membrane phospholipids and their relation to disruption of mitochondrial function were examined in rat brains after 30 min of cerebral ischemia (Pulsinelli-Brierley model) and 60 min of normoxic reoxygenation. During ischemia, s...

journal_title：Journal of neurochemistry

authors： Sun D,Gilboe DD

更新日期：1994-05-01 00:00:00

abstract：:Activity-dependent plasticity in nociceptive pathways has been implicated in pathomechanisms of chronic pain syndromes. Calcitonin gene-related peptide (CGRP), which is expressed by trigeminal nociceptors, has recently been identified as a key player in the mechanism of migraine headaches. Here we show that CGRP is co...

journal_title：Journal of neurochemistry

authors： Buldyrev I,Tanner NM,Hsieh HY,Dodd EG,Nguyen LT,Balkowiec A

更新日期：2006-12-01 00:00:00

abstract：:The decrease in receptor-stimulated cyclic AMP production after chronic ethanol exposure was suggested previously to be secondary to an ethanol-induced increase in extracellular adenosine. The present study was undertaken to ascertain whether a similar mechanism was responsible for the ethanol-induced desensitization ...

journal_title：Journal of neurochemistry

authors： Rabin RA,Fiorella D,Van Wylen DG

更新日期：1993-03-01 00:00:00

abstract：:From immunizations of mice with a glutathione S-transferase fusion protein containing residues 724-781 of the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor subunit GluR1-flop, two monoclonal antibodies (mAbs) were developed that differed widely in their ranges of specificity. In immunocytochemical ...

journal_title：Journal of neurochemistry

authors： Tönnes J,Stierli B,Cerletti C,Behrmann JT,Molnár E,Streit P

更新日期：1999-11-01 00:00:00

abstract：:This study evaluated the developmental gene and protein expression of proton-coupled oligopeptide transporters (POTs: peptide transporter, PepT1 and PepT2; peptide-histidine transporter, PhT1 and PhT2) in different regions of rodent brain, and the age-dependent uptake of a POT substrate, glycylsarcosine (GlySar), in b...

journal_title：Journal of neurochemistry

authors： Hu Y,Xie Y,Keep RF,Smith DE

更新日期：2014-06-01 00:00:00

abstract：:gamma-Aminobutyric acidB (GABAB) receptor recognition sites that inhibit cyclic AMP formation, open potassium channels, and close calcium channels are coupled to these effector systems by guanine nucleotide binding proteins (G proteins). These G proteins are ADP-ribosylated by islet-activating protein (IAP), also know...

journal_title：Journal of neurochemistry

authors： Wojcik WJ,Ulivi M,Paez X,Costa E

更新日期：1989-09-01 00:00:00

abstract：:By using a 125I-calmodulin overlay assay, three major high-affinity calmodulin-binding proteins, showing apparent molecular masses of 135, 60, and 50 kDa, have been detected in purified nuclear fractions isolated from rat neurons. It has been shown that after extraction of the nuclei with nucleases and high salt, all ...

journal_title：Journal of neurochemistry

authors： Pujol MJ,Bosser R,Vendrell M,Serratosa J,Bachs O

更新日期：1993-04-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) is a neurotrophic factor essential for maintenance of motor neurons. Loss of this factor produces a phenotype similar to amyotrophic lateral sclerosis (ALS). We recently showed that ALS-producing mutations of Cu/Zn-superoxide dismutase (SOD1) disrupt post-transcriptional regul...

journal_title：Journal of neurochemistry

authors： Li X,Lu L,Bush DJ,Zhang X,Zheng L,Suswam EA,King PH

更新日期：2009-02-01 00:00:00

abstract：:Rat hippocampal glutamatergic terminals possess NMDA autoreceptors whose activation by low micromolar NMDA elicits glutamate exocytosis in the presence of physiological Mg(2+) (1.2 mM), the release of glutamate being significantly reduced when compared to that in Mg(2+)-free condition. Both glutamate and glycine were ...

journal_title：Journal of neurochemistry

authors： Musante V,Summa M,Cunha RA,Raiteri M,Pittaluga A

更新日期：2011-05-01 00:00:00

abstract：:Obesity is a worldwide health problem that urgently needs to be solved. Leptin is an anti-obesity hormone that activates satiety signals to the brain. Evidence to suggest that leptin resistance is involved in the development of obesity is increasing; however, the molecular mechanisms involved remain unclear. We herein...

journal_title：Journal of neurochemistry

authors： Hosoi T,Matsuzaki S,Miyahara T,Shimizu K,Hasegawa Y,Ozawa K

更新日期：2015-05-01 00:00:00

abstract：:The sites of interaction of quinacrine with synaptic membranes were labeled with quinacrine mustard. Quinacrine mustard had an inhibitory effect on depolarization-induced calcium uptake by synaptosomes similar to that of quinacrine. The inhibition of depolarization-induced calcium uptake by quinacrine was reduced by 7...

journal_title：Journal of neurochemistry

authors： Ohta A,Baba A,Iwata H

更新日期：1985-08-01 00:00:00

abstract：:The role of the glutamate dehydrogenase reaction as a pathway of glutamate synthesis was studied by incubating synaptosomes with 5 mM 15NH4Cl and then utilizing gas chromatography-mass spectrometry to measure isotopic enrichment in glutamate and aspartate. The rate of formation of [15N]glutamate and [15N]aspartate fro...

journal_title：Journal of neurochemistry

authors： Yudkoff M,Nissim I,Nelson D,Lin ZP,Erecińska M

更新日期：1991-07-01 00:00:00

abstract：:The dopamine (DA) transporter (DAT) regulates DA neurotransmission by recycling DA back into neurons. Drugs that interfere with DAT function, e.g., cocaine and amphetamine, can have profound behavioral effects. The kinetics of DA transport by DAT in isolated synaptosomal or single cell preparations have been previousl...

journal_title：Journal of neurochemistry

authors： Jones SR,Joseph JD,Barak LS,Caron MG,Wightman RM

更新日期：1999-12-01 00:00:00

abstract：:Alzheimer's disease is characterized neuropathologically by the presence of neuritic and amyloid plaques, vascular amyloid, and neurofibrillary tangles in specific brain areas. The main constituent of amyloid deposits is amyloid beta protein, a 40-42 amino acid proteolytic product of the amyloid beta-precursor protein...

journal_title：Journal of neurochemistry

authors： Conn KJ,Pietropaolo M,Ju ST,Abraham CR

更新日期：1996-05-01 00:00:00

abstract：:Developmental changes of preprocholecystokinin mRNA (CCK mRNA) and cholecystokinin-like immunoreactivity (CCK-LI) were examined in rat brain regions (frontal cortex, colliculi, hippocampus, striatum, and cerebellum) using RNA dot blot assays with cholecystokinin (CCK) cDNA and radioimmunoassay, respectively. The CCK-L...

journal_title：Journal of neurochemistry

authors： Takeda K,Koshimoto H,Uchiumi F,Haun RS,Dixon JE,Kato T

更新日期：1989-09-01 00:00:00

abstract：:Incorporation of [1-14C]palmitic acid into neutral lipids and phospholipids of rat cerebral cortex was examined in vitro in normal Krebs--Ringer bicarbonate buffer containing 3% (wt/vol) albumin and 0.75 mM palmitic acid. Under standard assay conditions, radioactivity in the triacylglycerol fraction increased rapidly ...

journal_title：Journal of neurochemistry

authors： Mizobuchi M,Morisaki N,Matsuoka N,Saito Y,Kumagai A

更新日期：1982-05-01 00:00:00

abstract：:Caspase cleavage of amyloid precursor protein (APP) has been reported to be important in amyloid beta protein (Aβ)-mediated neurotoxicity. However, the underlying mechanisms are not clearly understood. In this study, we explored the effect of caspase cleavage of APP on tau phosphorylation in relation to Aβ. We found t...

journal_title：Journal of neurochemistry

authors： Park SS,Jung HJ,Kim YJ,Park TK,Kim C,Choi H,Mook-Jung IH,Koo EH,Park SA

更新日期：2012-12-01 00:00:00

abstract：:The myelin-deficient (mld) mouse is an autosomal recessive mutant characterized by hypomyelination of the CNS due to reduced expression of the myelin basic protein (MBP) gene. In the mld mutant, the MBP gene is duplicated in tandem. One gene is intact, but a large portion is inverted upstream of the other copy, and it...

journal_title：Journal of neurochemistry

authors： Okano H,Aruga J,Nakagawa T,Shiota C,Mikoshiba K

更新日期：1991-02-01 00:00:00

abstract：:Ethanol provides neuroprotection following ischemia/reperfusion. This study assessed ethanol's effect on hyperglycolysis and NADPH oxidase (NOX) activation. Adult, male Sprague-Dawley rats were subjected to middle cerebral artery occlusion (MCAO) for 2 h. Three sets of experiments were conducted to determine ethanol's...

journal_title：Journal of neurochemistry

authors： Kochanski R,Peng C,Higashida T,Geng X,Hüttemann M,Guthikonda M,Ding Y

更新日期：2013-07-01 00:00:00

abstract：:Studies on glial cultures have demonstrated that fetal bovine serum contains a factor that induces bipotential glial precursors known as oligodendrocyte-type 2 astrocyte (O-2A) progenitors to become type 2 astroglia rather than oligodendroglia. The goal of this research project was to characterize and purify this fact...

journal_title：Journal of neurochemistry

authors： Levison SW,McCarthy KD

更新日期：1991-09-01 00:00:00

abstract：:After traumatic brain injury, progesterone has important neuroprotective effects in the nervous system. There is better functional outcome and less oedema formation in pseudopregnant rat females (high levels of endogenous progesterone) than in males. In addition to intracellular progesterone receptors, membrane bindin...

journal_title：Journal of neurochemistry

authors： Meffre D,Delespierre B,Gouézou M,Leclerc P,Vinson GP,Schumacher M,Stein DG,Guennoun R

更新日期：2005-06-01 00:00:00

abstract：:Mutations in Parkin, an E3 ligase, which participates in the ubiquitin-proteasome system (UPS), cause juvenile onset Parkinson's disease (PD). Some mutants aggregate upon over-expression, but the effects of such aggregation on the UPS and neuronal survival have not been characterized. We show in this study that transi...

journal_title：Journal of neurochemistry

authors： Kyratzi E,Pavlaki M,Kontostavlaki D,Rideout HJ,Stefanis L

更新日期：2007-08-01 00:00:00

abstract：:The regional distribution of inositol 1,4,5-trisphosphate (InsP3), inositol 1,3,4,5-tetrakisphosphate (InsP4), and ryanodine binding sites has been characterised and compared in the rat brain using radioligand binding assays. Cortical [3H]InsP3 binding indicated similar positional and stereospecificity as observed in ...

journal_title：Journal of neurochemistry

authors： Smith SM,Nahorski SR

更新日期：1993-05-01 00:00:00

abstract：:The effect of the glutamine synthetase (GS) inhibitor, methionine sulfoximine (MSO), on glutamate levels in, and glutamate release from, rat striatal tissue was examined. Tissue levels of glutamate were unchanged 24 h after an intraventricular injection of MSO, but tissue glutamine levels were decreased 50%. Calcium-d...

journal_title：Journal of neurochemistry

authors： Rothstein JD,Tabakoff B

更新日期：1984-11-01 00:00:00

abstract：:We sought to investigate whether dexamethasone produces a coordinated, time-dependent effect on all enzymes in the catecholamine biosynthetic pathway in PC12 cells. The levels of mRNAs of tyrosine hydroxylase (TH), aromatic L-amino acid decarboxylase (AADC), and dopamine beta-hydroxylase (DBH) were examined at 0, 6, 1...

journal_title：Journal of neurochemistry

authors： Kim KT,Park DH,Joh TH

更新日期：1993-03-01 00:00:00

abstract：:The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor activated by dioxin and polyaromatic hydrocarbons. Recent studies have revealed that AhR activity in central neurons depends on the NMDA receptor. In this study, we investigated how the neuronal activity influence AhR-mediated dioxin-respon...

journal_title：Journal of neurochemistry

authors： Lin CH,Juan SH,Wang CY,Sun YY,Chou CM,Chang SF,Hu SY,Lee WS,Lee YH

更新日期：2008-03-01 00:00:00