Calcitonin gene-related peptide enhances release of native brain-derived neurotrophic factor from trigeminal ganglion neurons.

abstract：:Autism is a behaviorally defined neurodevelopmental disorder and among its symptoms are disturbances in face and emotional processing. Emerging evidence demonstrates abnormalities in the GABAergic (gamma-aminobutyric acid) system in autism, which likely contributes to these deficits. GABA(B) receptors play an importan...

journal_title：Journal of neurochemistry

authors： Oblak AL,Gibbs TT,Blatt GJ

更新日期：2010-09-01 00:00:00

abstract：:The Na(+)-glutamate cotransporters are believed to countertransport OH- and K+. Previous evidence that the velocity of glutamate uptake can exceed the acid extrusion capacity of astrocytes raised the question of whether intracellular pH can become rate limiting for glutamate uptake. Cytoplasmic buffering capacity and ...

journal_title：Journal of neurochemistry

authors： Judd MG,Nagaraja TN,Brookes N

更新日期：1996-01-01 00:00:00

abstract：:Endoplasmic reticulum (ER) stress occurs when protein folding or maturation is disrupted. A malfunction in the ER stress response can lead to cell death and has been observed in many neurological diseases. However, how the ER stress response is regulated in neuronal cells remains largely unclear. Here, we studied an E...

journal_title：Journal of neurochemistry

authors： Eagleman DE,Zhu J,Liu DC,Seimetz J,Kalsotra A,Tsai NP

更新日期：2020-10-16 00:00:00

abstract：:Protracted opiate withdrawal can extend for months of disrupted hormonal circadian rhythms. We examined rodent behaviors and these circadian disturbances in hormone and peptide levels as well as brain clock gene expression during 60 days of protracted withdrawal. Our behavioral tests included open field, elevated plus...

journal_title：Journal of neurochemistry

authors： Li SX,Liu LJ,Jiang WG,Sun LL,Zhou SJ,Le Foll B,Zhang XY,Kosten TR,Lu L

更新日期：2010-10-01 00:00:00

abstract：:Cerebral amyloid angiopathy (CAA) is a major pathological feature of Alzheimer's disease and related disorders. Human cerebrovascular smooth muscle (HCSM) cells, which are intimately associated with CAA, have been used as an in vitro model system to investigate pathologic interactions with amyloid beta protein (A beta...

journal_title：Journal of neurochemistry

authors： Jung SS,Zhang W,Van Nostrand WE

更新日期：2003-06-01 00:00:00

abstract：:Neurofilament (NF) proteins are distributed in a diminishing proximodistal gradient along rat sciatic nerve when compared with total noncollagen or other proteins in nerve. About a twofold decline of NF proteins can be detected by quantitating nerve proteins that have been separated by gel electrophoresis. A similar d...

journal_title：Journal of neurochemistry

authors： Schlaepfer WW,Bruce J

更新日期：1990-08-01 00:00:00

abstract：:Brain edema in hepatic encephalopathy has been associated with circulating ammonia that is metabolized to glutamine. We measured alterations in blood chemistry and brain regional specific gravity and ion and amino acid contents in models of simple hyperammonemia and liver failure induced by daily administrations of am...

journal_title：Journal of neurochemistry

authors： Hilgier W,Olson JE

更新日期：1994-01-01 00:00:00

abstract：:In the central nervous system, astrocytes extend endfoot processes to ensheath synapses and microvessels. However, the mechanisms underlying this astrocytic process extension remain unclear. A limitation of the use of 2D cultured astrocytes for such studies is that they display a flat, epithelioid morphology, with no ...

journal_title：Journal of neurochemistry

authors： Sato J,Horibe S,Kawauchi S,Sasaki N,Hirata KI,Rikitake Y

更新日期：2018-11-01 00:00:00

abstract：:Accumulating evidence indicates that increased intracellular Na(+) concentration ([Na(+) ]i ) in astroglial cells is associated with the development of brain edema under ischemic conditions, but the underlying mechanisms are still elusive. Here, we report that in primary cultured rat cortical astrocytes, elevations of...

journal_title：Journal of neurochemistry

authors： Minieri L,Pivonkova H,Harantova L,Anderova M,Ferroni S

更新日期：2015-02-01 00:00:00

abstract：:Gliosis is commonly observed in the CNS following tissue damage, and it also occurs in aging and in many neurodegenerative diseases. Glial fibrillary acidic protein (GFAP) accumulation is a prominent feature of astrocytic gliosis. An inhibition or delay in GFAP synthesis could mitigate scar formation and thus reduce t...

journal_title：Journal of neurochemistry

authors： Li XM,Qi J,Juorio AV,Boulton AA

更新日期：1993-10-01 00:00:00

abstract：:Fragile X syndrome (FXS) is caused by the loss of functional fragile X mental retardation protein (FMRP). Loss of FMRP results in an elevated basal protein expression profile of FMRP targeted mRNAs, a loss of local metabotropic glutamate receptor (mGluR)-regulated protein synthesis, exaggerated long-term depression an...

journal_title：Journal of neurochemistry

authors： Schmit TL,Dowell JA,Maes ME,Wilhelm M

更新日期：2013-12-01 00:00:00

abstract：:Microelectrophoretic methods were used to study the effects on cat spinal neurones of a number of compounds structurally related to the gamma-aminobutyric acid (GABA) agonists muscimol, THIP, and isoguvacine. While N-methylmuscimol was an agonist at bicuculline methochloride-sensitive GABA receptors, somewhat weaker t...

journal_title：Journal of neurochemistry

authors： Krogsgaard-Larsen P,Hjeds H,Curtis DR,Leah JD,Peet MJ

更新日期：1982-11-01 00:00:00

abstract：:Spinocerebellar ataxia type 3 (SCA3) is one of at least nine inherited neurodegenerative diseases caused by an expansion of a polyglutamine tract within corresponding disease-specific proteins. In case of SCA3, mutation of Ataxin-3 results in aggregation of misfolded protein, formation of intranuclear as well as cytos...

journal_title：Journal of neurochemistry

authors： Liman J,Deeg S,Voigt A,Voßfeldt H,Dohm CP,Karch A,Weishaupt J,Schulz JB,Bähr M,Kermer P

更新日期：2014-06-01 00:00:00

abstract：:Neural stem cells (NSCs) are self-renewing multipotent cells that undergo symmetric and asymmetric cell division during development of the nervous system. The behavior of NSCs is tightly regulated by intrinsic processes such as transcriptional and post-transcriptional control, as well as the stem cell niche factors th...

journal_title：Journal of neurochemistry

authors： Gan HT,Tham M,Hariharan S,Ramasamy S,Yu YH,Ahmed S

更新日期：2011-05-01 00:00:00

abstract：:Transmitter release at high probability phasic synapses of crayfish neuromuscular junctions depresses by over 50% in 60 min when stimulated at 0.2 Hz. Inhibition of the protein phosphatase calcineurin by intracellular pre-synaptic injection of autoinhibitory peptide inhibited low-frequency depression (LFD) and resulte...

journal_title：Journal of neurochemistry

authors： Silverman-Gavrila LB,Charlton MP

更新日期：2009-05-01 00:00:00

abstract：:The modulation by adenosine analogues and endogenous adenosine of the electrically evoked release of [3H]acetylcholine ([3H]ACh) was compared in subslices of the three areas of the rat hippocampus (CA1, CA3, and dentate gyrus). The mixed A1/A2 agonist 2-chloroadenosine (CADO; 2-10 microM) inhibited, in a concentration...

journal_title：Journal of neurochemistry

authors： Cunha RA,Milusheva E,Vizi ES,Ribeiro JA,Sebastião AM

更新日期：1994-07-01 00:00:00

abstract：:Enzymes considered to be markers for neurons (angiotensin converting enzyme, thermolysin-like metalloendopeptidase, alanine aminopeptidase, and glutamate-oxaloacetate transaminase), glia (glutamine synthetase, pyruvate carboxylase, and beta-glucuronidase), and endothelial cells (alkaline phosphatase and plasminogen ac...

journal_title：Journal of neurochemistry

authors： Butterworth J

更新日期：1986-08-01 00:00:00

abstract：:Electrophorus electroplax microsomes were examined for Ca2+- and Mg2+-dependent ATPase activity. In addition to the previously reported low-affinity ATPase, a high-affinity (Ca2+,Mg2+)-ATPase was found. At low ATP and Mg2+ concentrations (200 microM or less), the high-affinity (Ca2+,Mg2+)-ATPase exhibits an activity o...

journal_title：Journal of neurochemistry

authors： Amende LM,Chock SP,Albers RW

更新日期：1983-04-01 00:00:00

abstract：:We examined the modulation of nitric oxide production in vivo by measuring levels of nitrite (NO2-) and nitrate (NO3-) in the dialysate of the cerebellum in conscious rats, by using an in vivo brain microdialysis technique. The levels of both NO2- and NO3- were decreased by the intraperitoneal injection of NG-nitro-L-...

journal_title：Journal of neurochemistry

authors： Yamada K,Nabeshima T

更新日期：1997-03-01 00:00:00

abstract：:Spinal muscular atrophy (SMA) is a motor neuron disease caused by loss of function mutations in the Survival Motor Neuron 1 (SMN1) gene and reduced expression of the SMN protein, leading to spinal motor neuron death, muscle weakness and atrophy. Although humans harbour the highly homologous SMN2 gene, its defective sp...

journal_title：Journal of neurochemistry

authors： Pagliarini V,Guerra M,Di Rosa V,Compagnucci C,Sette C

更新日期：2020-04-01 00:00:00

abstract：:In the PNS, ciliary neurotrophic factor (CNTF) is found in significant amounts in the adult sciatic nerve, localized to myelin-related Schwann cells (SCs). Levels are undetectable in newborn but high in adult animals. After crush injury, CNTF production is reduced, recovering only as the nerve regenerates; if regenera...

journal_title：Journal of neurochemistry

authors： Lee DA,Zurawel RH,Windebank AJ

更新日期：1995-08-01 00:00:00

abstract：:[3H]Spiroperidol binding to homogenates of rat striatum is saturable and shows either monophasic or biphasic saturation isotherms under specified conditions. In poorly washed membrane fragment preparations, saturation isotherms of [3H]spiroperidol binding are monophasic, revealing an apparently homogeneous set of site...

journal_title：Journal of neurochemistry

authors： Andorn AC,Maguire ME

更新日期：1980-11-01 00:00:00

abstract：:gamma-Aminobutyric acid (GABA) concentrations were measured in CSF specimens from two large groups of control subjects, one without neurological or psychiatric disease, and one with a variety of neurological disorders not known to involve altered GABAergic function in brain. CSF GABA was also measured in patients with...

journal_title：Journal of neurochemistry

authors： Perry TL,Hansen S,Wall RA,Gauthier SG

更新日期：1982-03-01 00:00:00

abstract：:We have examined the metabolism of phosphate and sulfate groups modifying the P0 protein, the major protein of peripheral nervous system myelin, using an in vitro incubation system. Incorporation of [3H]leucine into the P0 peptide backbone decreased approximately 25-fold between 10 and 90 days of age, a finding reflec...

journal_title：Journal of neurochemistry

authors： Toews AD,Fischer HR,Goodrum JF,Windes S,Morell P

更新日期：1987-03-01 00:00:00

abstract：:Chick pineal glands in organ culture showed a circadian rhythm in the rate of thymidine incorporation. Thymidine incorporation was very markedly inhibited when 3-isobutyl-l-methylxanthine (IBMX) was continuously present. When IBMX was added to cultures in control medium during the photoperiod of the second day in cult...

journal_title：Journal of neurochemistry

authors： Wainwright SD,Wainwright LK

更新日期：1991-05-01 00:00:00

abstract：:The effects of long-term treatment with imipramine or mirtazapine, two antidepressant drugs with different mechanisms of action, on the response of cortical dopaminergic neurons to foot-shock stress or to the anxiogenic drug FG7142 were evaluated in freely moving rats. As expected, foot shock induced a marked increase...

journal_title：Journal of neurochemistry

authors： Dazzi L,Spiga F,Pira L,Ladu S,Vacca G,Rivano A,Jentsch JD,Biggio G

更新日期：2001-02-01 00:00:00

abstract：:Deep hypothermia protects the brain from ischemic damage and is therefore used during major cardiovascular surgeries requiring cardiopulmonary bypass and a period of circulatory arrest. Here, we demonstrated that small ubiquitin-like modifier (SUMO1-3) conjugation is markedly activated in the brain during deep to mode...

journal_title：Journal of neurochemistry

authors： Wang L,Ma Q,Yang W,Mackensen GB,Paschen W

更新日期：2012-11-01 00:00:00

abstract：:Carboxypeptidase E (CPE) functions in the posttranslational processing of bioactive peptides. Like other peptide processing enzymes, CPE is initially produced as a precursor ("proCPE") that undergoes posttranslational processing at a site containing five adjacent Arg residues near the N-terminus and at other sites nea...

journal_title：Journal of neurochemistry

authors： Song L,Fricker L

更新日期：1995-07-01 00:00:00

abstract：:Myelin-deficient (mld) is a complex mutation affecting the myelin basic protein (MBP) locus of the mouse. It consists of duplication and partial inversion of the MBP gene and results in a dysfunctional MBP locus. The mutant phenotype is reversed, both in vivo and in vitro, in approximately 5% of mld oligodendrocytes. ...

journal_title：Journal of neurochemistry

authors： Sun Y,Xu J,Barbarese E,Carson JH

更新日期：1997-02-01 00:00:00

abstract：:Human brain aldose reductase and hexonate dehydrogenase are inhibited by alrestatin (AY 22,284) and sorbinil (CP 45,634). Inhibition by alrestatin is noncompetitive for both enzymes, and slightly stronger for hexonate dehydrogenase (KI values 52-250 microM) than for aldose reductase (KI values 170-320 microM). Sorbini...

journal_title：Journal of neurochemistry

authors： O'Brien MM,Schofield PJ,Edwards MR

更新日期：1982-09-01 00:00:00