Abstract:
:We examined the modulation of nitric oxide production in vivo by measuring levels of nitrite (NO2-) and nitrate (NO3-) in the dialysate of the cerebellum in conscious rats, by using an in vivo brain microdialysis technique. The levels of both NO2- and NO3- were decreased by the intraperitoneal injection of NG-nitro-L-arginine methyl ester, an inhibitor of nitric oxide synthase, whereas NG-nitro-D-arginine methyl ester had no effect. L-Arginine by itself increased NO2- and NO3- levels and diminished the reduction of their levels caused by NG-nitro-L-arginine methyl ester. Direct infusion of L-glutamate, N-methyl-D-aspartate, or KCl into the cerebellum through a dialysis probe resulted in an increase in NO2- and/or NO3- levels. The effects of N-methyl-D-aspartate and KCl were dependent on extracellular calcium. Furthermore, the stimulatory effects of L-glutamate and N-methyl-D-aspartate were inhibited by NG-nitro-L-arginine methyl ester and (+/-)-3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid (CPP), an N-methyl-D-aspartate receptor antagonist. These results suggest that NO2- and NO3- levels may be related to nitric oxide production in vivo.
journal_name
J Neurochemjournal_title
Journal of neurochemistryauthors
Yamada K,Nabeshima Tdoi
10.1046/j.1471-4159.1997.68031234.xsubject
Has Abstractpub_date
1997-03-01 00:00:00pages
1234-43issue
3eissn
0022-3042issn
1471-4159journal_volume
68pub_type
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journal_title:Journal of neurochemistry
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journal_title:Journal of neurochemistry
pub_type: 杂志文章
doi:10.1111/j.1471-4159.2007.04745.x
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journal_title:Journal of neurochemistry
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doi:10.1046/j.1471-4159.1995.65041816.x
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journal_title:Journal of neurochemistry
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更新日期:1987-12-01 00:00:00
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journal_title:Journal of neurochemistry
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更新日期:2000-09-01 00:00:00
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journal_title:Journal of neurochemistry
pub_type: 杂志文章
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更新日期:1986-08-01 00:00:00
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journal_title:Journal of neurochemistry
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abstract::IMP-GMP 5'-nucleotidase has been purified to homogeneity from total rat brain extracts. This preparation showed a unique band (Mr 54,000 +/- 1,509) in sodium dodecyl sulfate-polyacrylamide gel electrophoresis. The enzyme presented the following properties: optimal pH value, 6.5-6.8; relative velocity measured in the p...
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pub_type: 杂志文章
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