Myelin basic protein gene and the function of antisense RNA in its repression in myelin-deficient mutant mouse.

abstract：:The 17-kDa endogenous brain protein glia maturation factor (GMF) was transfected into C6 rat glioma cells using a replication-defective human adenovirus vector. The cells overexpressed GMF but did not secrete the protein into the medium. Transfection with GMF led to the activation of the transcription factor nuclear f...

journal_title：Journal of neurochemistry

authors： Lim R,Zaheer A,Yorek MA,Darby CJ,Oberley LW

更新日期：2000-02-01 00:00:00

abstract：:Long term consumption of a high fat diet (HFD) contributes to increased morbidity and mortality. Yet the specific effects of HFD consumption on brain aging are poorly understood. In the present study 20-month old male C57Bl/6 mice were fed either 'western diet' (41% fat), very high fat lard diet (60% fat), or correspo...

journal_title：Journal of neurochemistry

authors： Morrison CD,Pistell PJ,Ingram DK,Johnson WD,Liu Y,Fernandez-Kim SO,White CL,Purpera MN,Uranga RM,Bruce-Keller AJ,Keller JN

更新日期：2010-09-01 00:00:00

abstract：:Ligand binding to the cannabinoid receptor of brain membranes has been characterized using [3H]CP 55,940 and the Multiscreen Filtration System. Binding of [3H]CP 55,940 is saturable and reaches equilibrium by 45 min at room temperature. At a concentration of 10 micrograms of membrane protein/well, the KD for [3H]CP 55...

journal_title：Journal of neurochemistry

authors： Hillard CJ,Edgemond WS,Campbell WB

更新日期：1995-02-01 00:00:00

abstract：:The effect of L-glutamate on the adrenergic-stimulated release of melatonin in the rat pineal gland was examined using an in vitro perfusion system. L-Glutamate by itself had no effect on melatonin secretion whereas L-glutamate administered prior to (-)-isoproterenol (beta-adrenergic agonist) and L-phenylephrine (alph...

journal_title：Journal of neurochemistry

authors： Kus L,Handa RJ,McNulty JA

更新日期：1994-06-01 00:00:00

abstract：:The prescribed drugs for treatment of cognitive deficits in Alzheimer's disease (AD) patients are regarded as symptomatic drugs. Effective disease modifying therapies are not yet prescribed in AD patients. Three major hallmarks of AD (e.g. cholinergic hypofunction, Aβ and tau neuropathologies) are closely linked raisi...

journal_title：Journal of neurochemistry

authors： Fisher A

更新日期：2012-01-01 00:00:00

abstract：:Administration of kainate or pentylenetetrazole increased c-fos, c-jun, junB, and junD mRNA levels in rat brain in a dose-dependent manner. Kainate increased these mRNA levels predominantly in the hippocampus, and pentylenetetrazole was more effective in the cortex. Adrenalectomy (3 days) was used to eliminate endogen...

journal_title：Journal of neurochemistry

authors： Li X,Song L,Kolasa K,Jope RS

更新日期：1992-06-01 00:00:00

abstract：:Haptoglobin (Hp) binds hemoglobin (Hb) with high affinity and provides the primary defense against its toxicity after intravascular hemolysis. Neurons are exposed to extracellular Hb after CNS hemorrhage, and a therapeutic effect of Hp via Hb sequestration has been hypothesized. In this study, we tested the hypothesis...

journal_title：Journal of neurochemistry

authors： Chen-Roetling J,Regan RF

更新日期：2016-11-01 00:00:00

abstract：:Alzheimer's disease (AD) is a neurodegenerative pathology characterized by aggregates of amyloid-β (Aβ) and phosphorylated tau protein, synaptic dysfunction, and spatial memory impairment. The Wnt signaling pathway has several key functions in the adult brain and has been associated with AD, mainly as a neuroprotectiv...

journal_title：Journal of neurochemistry

authors： Tapia-Rojas C,Inestrosa NC

更新日期：2018-02-01 00:00:00

abstract：:Functional activation of NMDA receptors requires co-activation of glutamate- and glycine-binding sites. D-serine is considered to be an endogenous ligand for the glycine site of NMDA receptors. Using a combination of a rat formalin-induced conditioned place avoidance (F-CPA) behavioral model and whole-cell patch-clamp...

journal_title：Journal of neurochemistry

authors： Ren WH,Guo JD,Cao H,Wang H,Wang PF,Sha H,Ji RR,Zhao ZQ,Zhang YQ

更新日期：2006-03-01 00:00:00

abstract：:A glutamate binding protein was purified from bovine brain to apparent homogeneity. The procedure used for the purification of this protein involved extraction of a crude synaptic membrane fraction with Na-cholate, followed by solubilization of the binding protein from the membranes by Triton X-100, and, finally, affi...

journal_title：Journal of neurochemistry

authors： Michaelis EK,Chittenden WL,Johnson BE,Galton N,Decedue C

更新日期：1984-02-01 00:00:00

abstract：:1-Benzyl-1,2,3,4-tetrahydroisoquinoline (1BnTIQ) was detected as a novel endogenous amine in mouse brain and parkinsonian CSF by using the gas chromatography-selected ion-monitoring method. The level of 1BnTIQ was very high in CSF of some parkinsonian patients compared with that of controls with other neurological dis...

journal_title：Journal of neurochemistry

authors： Kotake Y,Tasaki Y,Makino Y,Ohta S,Hirobe M

更新日期：1995-12-01 00:00:00

abstract：:beta-Amyloid peptides (Abeta40 and Abeta42) are the major constituents of amyloid plaques, which are one of the hallmarks of Alzheimer's disease (AD). The Abeta is derived from sequential cleavages of amyloid precursor protein (APP) by beta- and gamma-secretases. gamma-Secretase consists of at least four proteins wher...

journal_title：Journal of neurochemistry

authors： Lai MT,Crouthamel MC,DiMuzio J,Pietrak BL,Donoviel DB,Bernstein A,Gardell SJ,Li YM,Hazuda D

更新日期：2006-01-01 00:00:00

abstract：:The mechanisms by which chronic nicotine self-administration augments hypothalamo-pituitary-adrenal (HPA) responses to stress are only partially understood. Nicotine self-administration alters neuropeptide expression in corticotropin-releasing factor (CRF) neurons within paraventricular nucleus (PVN) and increases PVN...

journal_title：Journal of neurochemistry

authors： Yu G,Chen H,Wu X,Matta SG,Sharp BM

更新日期：2010-05-01 00:00:00

abstract：:The binding of the potent adenosine uptake inhibitor [3H]nitrobenzylthioinosine ([3H]NBI) to brain membrane fractions was investigated. Reversible, saturable, specific, high-affinity binding was demonstrated in both rat and human brain. The KD in both was 0.15 nM with Bmax values of 140-200 fmol/mg protein. Linear Sca...

journal_title：Journal of neurochemistry

authors： Marangos PJ,Patel J,Clark-Rosenberg R,Martino AM

更新日期：1982-07-01 00:00:00

abstract：:Specific D2 binding in rat striatum was characterized and then the effects of chronic disruption of dopaminergic activity on antagonist and agonist binding to these sites were studied. D2 receptors were defined as those sites capable of binding [3H]spiperone in the presence of cinanserin, a 5-HT2 antagonist, but not i...

journal_title：Journal of neurochemistry

authors： MacKenzie RG,Zigmond MJ

更新日期：1984-11-01 00:00:00

abstract：:Fingolimod, a sphingosine-1-phosphate receptor (S1PR) agonist, is clinically available to treat multiple sclerosis and is showing promise in treating stroke. We investigated if fingolimod provides long-term protection from experimental neonatal germinal matrix hemorrhage (GMH), aiming to support a potential mechanism ...

journal_title：Journal of neurochemistry

authors： Rolland WB,Krafft PR,Lekic T,Klebe D,LeGrand J,Weldon AJ,Xu L,Zhang JH

更新日期：2017-03-01 00:00:00

abstract：:Rat hippocampal glutamatergic terminals possess NMDA autoreceptors whose activation by low micromolar NMDA elicits glutamate exocytosis in the presence of physiological Mg(2+) (1.2 mM), the release of glutamate being significantly reduced when compared to that in Mg(2+)-free condition. Both glutamate and glycine were ...

journal_title：Journal of neurochemistry

authors： Musante V,Summa M,Cunha RA,Raiteri M,Pittaluga A

更新日期：2011-05-01 00:00:00

abstract：:Nucleocytoplasmic transport is a crucial process for cell function. We assessed the general effect of chronic alcohol exposure on this transport in growing astrocytes for the first time. Import and export of proteins to the nucleus were examined by pulse-chase experiments using (3)H-methionine, and we showed that etha...

journal_title：Journal of neurochemistry

authors： Marín MP,Tomas M,Esteban-Pretel G,Megías L,López-Iglesias C,Egea G,Renau-Piqueras J

更新日期：2008-08-01 00:00:00

abstract：:The effects of phenytoin, a potent antiepileptic drug, on the active transport of cations within membranes remain controversial. To assess the direct effects of phenytoin on the Na+,K+ pump, we studied the drug's influence on the phosphorylation of partially purified (Na+,K+)-ATPase from mouse brain. (Na+,K+)-ATPase s...

journal_title：Journal of neurochemistry

authors： Guillaume D,Grisar T,Delgado-Escueta AV

更新日期：1986-09-01 00:00:00

abstract：:The regulatory role of ascorbic acid in norepinephrine biosynthesis was studied using digitonin-permeabilized chromaffin cells. When permeabilized chromaffin cells were incubated with [3H]3,4-dihydroxyphenylethylamine ([3H]dopamine) in calcium-free medium, the amounts of radioactive dopamine and norepinephrine measure...

journal_title：Journal of neurochemistry

authors： Morita K,Levine M,Pollard HB

更新日期：1986-03-01 00:00:00

abstract：:Neurodegenerative diseases, such as Parkinson's disease, Alzheimer's disease, and Huntington's disease, are considered incurable and significantly reduce the quality of life of the patients. A variety of drugs that modulate neurotransmitter levels have been used for the treatment of the neurodegenerative diseases but ...

journal_title：Journal of neurochemistry

authors： Huang M,Rathore SS,Lindau M

更新日期：2019-10-01 00:00:00

abstract：:The Coffin-Lowry syndrome, a rare syndromic form of X-linked mental retardation, is caused by loss-of-function mutations in the hRSK2 (RPS6KA3) gene. To further investigate RSK2 (90-kDa ribosomal S6 kinase) implication in cognitive processes, a mrsk2_KO mouse has previously been generated as an animal model of Coffin-...

journal_title：Journal of neurochemistry

authors： Marques Pereira P,Gruss M,Braun K,Foos N,Pannetier S,Hanauer A

更新日期：2008-12-01 00:00:00

abstract：:The protein B-50 is dephosphorylated in rat cortical synaptic plasma membranes (SPM) by protein phosphatase type 1 and 2A (PP-1 and PP-2A)-like activities. The present studies further demonstrate that B-50 is dephosphorylated not only by a spontaneously active PP-1-like enzyme, but also by a latent form after pretreat...

journal_title：Journal of neurochemistry

authors： Han YF,Wang W,Schlender KK,Ganjeizadeh M,Dokas LA

更新日期：1992-07-01 00:00:00

abstract：:The F3 molecule is a member of the immunoglobulin superfamily anchored to plasma membranes by a glycosylphosphatidylinositol group. In adult mouse cerebellum, F3 is predominantly expressed on a subset of axons, the parallel fibers, and at their synapses. In vitro studies established that it is a plurifunctional molecu...

journal_title：Journal of neurochemistry

authors： Olive S,Dubois C,Schachner M,Rougon G

更新日期：1995-11-01 00:00:00

abstract：:Levels of dopamine (DA), 3,4-dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA), noradrenaline (NA), 3-methoxy-4-hydroxyphenylglycol (MHPG), and 5-hydroxyindoleacetic acid (5-HIAA) in the CSF of patients with Huntington's disease (HD) were measured by HPLC. CSF DA, DOPAC, and MHPG levels were found to be incr...

journal_title：Journal of neurochemistry

authors： Garrett MC,Soares-da-Silva P

更新日期：1992-01-01 00:00:00

abstract：:Manganese is an essential nutrient, integral to proper metabolism of amino acids, proteins and lipids. Excessive environmental exposure to manganese can produce extrapyramidal symptoms similar to those observed in Parkinson's disease (PD). We used in vivo and in vitro models to examine cellular and circuitry alteratio...

journal_title：Journal of neurochemistry

authors： Stanwood GD,Leitch DB,Savchenko V,Wu J,Fitsanakis VA,Anderson DJ,Stankowski JN,Aschner M,McLaughlin B

更新日期：2009-07-01 00:00:00

abstract：:To identify genes induced by transient forebrain ischemia, we used the mRNA differential display technique in the four-vessel occlusion model in rats. Some genes were identified as candidates that encode ischemia-responsive protein, and one of them was cloned as ischemia-responsive protein 94 kDa (irp94) from the rat ...

journal_title：Journal of neurochemistry

authors： Yagita Y,Kitagawa K,Taguchi A,Ohtsuki T,Kuwabara K,Mabuchi T,Matsumoto M,Yanagihara T,Hori M

更新日期：1999-04-01 00:00:00

abstract：:The effect of vigabatrin (gamma-vinyl-gamma-aminobutyric acid), a new anticonvulsant drug, on the transmitter amino acids in rat cisternal CSF was studied. CSF was collected through a permanently implanted polyethylene cannula from freely moving rats at 5, 24, 48, and 96 h after administration of 1,000 mg/kg of vigaba...

journal_title：Journal of neurochemistry

authors： Halonen T,Pitkänen A,Riekkinen PJ

更新日期：1990-12-01 00:00:00

abstract：:Astrocytic glutamate transporter-1 (GLT-1) is responsible for 90% of forebrain glutamate uptake in the adult CNS. Retinoic acid (RA) is a potent regulator of neural cell differentiation and neuronal maturation in the developing CNS through activation of RA receptors/retinoic X receptors (RXRs) or non-genomic mechanism...

journal_title：Journal of neurochemistry

authors： Chan TJ,Her LS,Liaw HJ,Chen MC,Tzeng SF

更新日期：2012-05-01 00:00:00

abstract：:Leucine-rich repeat kinase 2 (LRRK2) is a large multidomain scaffolding protein with kinase and GTPase activities involved in synaptic vesicle (SV) dynamics. While its role in Parkinson's disease has been largely investigated, little is known about LRRK2 physiological role and until now few proteins have been describe...

journal_title：Journal of neurochemistry

authors： Marte A,Russo I,Rebosio C,Valente P,Belluzzi E,Pischedda F,Montani C,Lavarello C,Petretto A,Fedele E,Baldelli P,Benfenati F,Piccoli G,Greggio E,Onofri F

更新日期：2019-08-01 00:00:00