当前位置： SCI文献检索 > JOURNAL OF NEUROCHEMISTRY期刊下所有文献 > Ischemia-induced changes in cerebral mitochondrial free fatty acids, phospholipids, and respiration in the rat.

Ischemia-induced changes in cerebral mitochondrial free fatty acids, phospholipids, and respiration in the rat.

Abstract：

:Changes in the free fatty acid pool size and fatty acyl chain composition of mitochondrial membrane phospholipids and their relation to disruption of mitochondrial function were examined in rat brains after 30 min of cerebral ischemia (Pulsinelli-Brierley model) and 60 min of normoxic reoxygenation. During ischemia, significant hydrolysis of polyunsaturated molecular species from diacyl phosphatidylcholine, particularly fatty acyl 20:4 (arachidonic acid; 20% decrease) and 22:6 (docosahexaenoic acid; 15% decrease), was observed. Thirty minutes of ischemia caused a 16% loss of 18:2 (linoleic acid) from phosphatidylethanolamine. Recirculation for 60 min did not return the polyunsaturated fatty acid content of phospholipids to normal. Total content of free fatty acids increased during ischemia, particularly 18:2 and 22:6, which exhibited the most dramatic rise. The free fatty acid pool size continued to increase during 60 min of recirculation. The respiratory control ratio decreased significantly during 30 min of ischemia with no apparent recovery following 60 min of reoxygenation. The degree of free radical-mediated lipid peroxidation in mitochondria was significantly increased during ischemia and reperfusion. It was concluded that (a) 30 min of cerebral ischemia caused differential degradation in each of the phospholipid classes and preferential hydrolysis of the polyunsaturated molecular species and (b) 60 min of normoxic reperfusion failed to promote reacylation of the mitochondrial phospholipids and restoration of normal respiration.

journal_name

J Neurochem

journal_title

Journal of neurochemistry

authors

Sun D,Gilboe DD

doi

10.1046/j.1471-4159.1994.62051921.x

subject

Has Abstract

pub_date

1994-05-01 00:00:00

pages

1921-8

issue

5

eissn

0022-3042

issn

1471-4159

journal_volume

62

pub_type

杂志文章

相关文献

JOURNAL OF NEUROCHEMISTRY文献大全
  • The effect of chronic treatment with the GABA transaminase inhibitors gamma-vinyl-GABA and ethanolamine-O-sulphate on the in vivo release of GABA from rat hippocampus.

    abstract：:The effects of chronic treatment with the specific, mechanism-based, irreversible inhibitors of 4-aminobutyrate aminotransferase (EC 2.6.1.19; GABA transaminase), ethanolamine O-sulphate (EOS), and 4-aminohexenoate [vigabatrin; gamma-vinyl-GABA (GVG)] on the extracellular concentrations of GABA in the hippocampus have...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章

    doi：10.1046/j.1471-4159.1995.64052256.x

    authors： Qume M,Whitton PS,Fowler LJ

    更新日期：1995-05-01 00:00:00

  • Epigenetic control of early neurodegenerative events in diabetic retinopathy by the histone deacetylase SIRT6.

    abstract：:Diabetic retinopathy (DR) is one of the common complications associated with diabetes mellitus and the leading cause of blindness worldwide. Recent research has demonstrated that DR is not only a microvascular disease but may be a result of neurodegenerative processes. Moreover, glucose-induced neuron and glial cell d...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章

    doi：10.1111/jnc.14243

    authors： Zorrilla-Zubilete MA,Yeste A,Quintana FJ,Toiber D,Mostoslavsky R,Silberman DM

    更新日期：2018-01-01 00:00:00

  • Basement membrane proteins influence brain capillary endothelial barrier function in vitro.

    abstract：:The influence of basement membrane proteins on cellular barrier properties of primary cultures of porcine brain capillary endothelial cells grown on permeable filter inserts has been investigated. Measurements of transcellular electrical resistance (TER) by impedance spectroscopy were performed with cells cultured on ...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章

    doi：10.1046/j.1471-4159.1998.71031151.x

    authors： Tilling T,Korte D,Hoheisel D,Galla HJ

    更新日期：1998-09-01 00:00:00

  • SUMOylation of MeCP2 is essential for transcriptional repression and hippocampal synapse development.

    abstract：:Methyl CpG binding protein 2 (MeCP2) binds to methylated DNA and acts as a transcriptional repressor. Mutations of human MECP2 gene lead to Rett syndrome, a severe neural developmental disorder. Here, we report that the MeCP2 protein can be modified by covalent linkage to small ubiquitin-like modifier (SUMO) and SUMOy...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章

    doi：10.1111/jnc.12523

    authors： Cheng J,Huang M,Zhu Y,Xin YJ,Zhao YK,Huang J,Yu JX,Zhou WH,Qiu Z

    更新日期：2014-03-01 00:00:00

  • Disrupted-in-schizophrenia-1 as a broader link of glutamatergic transmission to schizophrenia impacts cerebral neurochemistry via the production of the 'gliotransmitter' d-serine, a NMDA receptor coagonist.

    abstract：:This Editorial highlights a study by Xia and coworkers in the current issue of the Journal of Neurochemistry, in which the authors reveal a possible mechanistic link between DISC1 (disrupted-in-schizophrenia-1), a genetic risk factor for schizophrenia, and N-methyl-d-aspartate receptor (NMDAR) that is also linked with...

    journal_title：Journal of neurochemistry

    pub_type： 社论

    doi：10.1111/jnc.13699

    authors： Wu S,Barger SW

    更新日期：2016-08-01 00:00:00

  • [3H]spiroxatrine: a 5-HT1A radioligand with agonist binding properties.

    abstract：:Spiroxatrine has been reported to be a 5-HT1A serotonin receptor antagonist. Therefore [3H]spiroxatrine was synthesized and its 5-HT1A receptor binding properties in homogenates of rat hippocampal membranes were characterized with the expectation that it would be the first 5-HT1A antagonist radioligand. [3H]8-Hydroxyd...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章

    doi：10.1111/j.1471-4159.1988.tb02943.x

    authors： Herrick-Davis K,Titeler M

    更新日期：1988-02-01 00:00:00

  • Clearing amyloid through the blood-brain barrier.

    abstract：:According to the amyloid hypothesis, accumulation of amyloid beta-peptide (A beta) in the brain is the primary pathogenic event in Alzheimer's disease (AD). Recent evidence indicates that A beta within the intravascular space is linked to A beta deposited in the brain suggesting that transport of A beta between the br...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章,评审

    doi：10.1111/j.1471-4159.2004.02385.x

    authors： Zlokovic BV

    更新日期：2004-05-01 00:00:00

  • The phosphorylation status of extracellular-regulated kinase 1/2 in astrocytes and neurons from rat hippocampus determines the thrombin-induced calcium release and ROS generation.

    abstract：:Challenge of protease-activated receptors induces cytosolic Ca(2+) concentration ([Ca(2+) ](c)) increase, mitogen-activated protein kinase activation and reactive oxygen species (ROS) formation with a bandwidth of responses in individual cells. We detected in this study in situ the thrombin-induced [Ca(2+) ](c) rise a...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章

    doi：10.1111/j.1471-4159.2011.07527.x

    authors： Zündorf G,Reiser G

    更新日期：2011-12-01 00:00:00

  • Synaptic and extrasynaptic GABA transporters as targets for anti-epileptic drugs.

    abstract：:Inhibition of the GABA transporter subtype GAT1 by the clinically available anti-epileptic drug tiagabine has proven to be an effective strategy for the treatment of some patients with partial seizures. In 2005, the investigational drug EF1502 was described as possessing activity at both GAT1 and BGT-1. When combined ...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章

    doi：10.1111/j.1471-4159.2009.05982.x

    authors： Madsen KK,Clausen RP,Larsson OM,Krogsgaard-Larsen P,Schousboe A,White HS

    更新日期：2009-05-01 00:00:00

  • Allelic variation of human serotonin transporter gene expression.

    abstract：:Mood, emotion, cognition, and motor functions as well as circadian and neuroendocrine rhythms, including food intake, sleep, and reproductive activity, are modulated by the midbrain raphe serotonin (5-HT) system. By directing the magnitude and duration of postsynaptic responses, carrier-facilitated 5-HT transport into...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章

    doi：10.1046/j.1471-4159.1996.66062621.x

    authors： Heils A,Teufel A,Petri S,Stöber G,Riederer P,Bengel D,Lesch KP

    更新日期：1996-06-01 00:00:00

  • The human brain endothelial cell line hCMEC/D3 as a human blood-brain barrier model for drug transport studies.

    abstract：:The human brain endothelial capillary cell line hCMEC/D3 has been developed recently as a model for the human blood-brain barrier. In this study a further characterization of this model was performed with special emphasis on permeability properties and active drug transport. Para- or transcellular permeabilities (P(e)...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章

    doi：10.1111/j.1471-4159.2008.05730.x

    authors： Poller B,Gutmann H,Krähenbühl S,Weksler B,Romero I,Couraud PO,Tuffin G,Drewe J,Huwyler J

    更新日期：2008-12-01 00:00:00

  • P2X7 receptor-induced death of motor neurons by a peroxynitrite/FAS-dependent pathway.

    abstract：:The P2X7 receptor/channel responds to extracellular ATP and is associated with neuronal death and neuroinflammation in spinal cord injury and amyotrophic lateral sclerosis. Whether activation of P2X7 directly causes motor neuron death is unknown. We found that cultured motor neurons isolated from embryonic rat spinal ...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章

    doi：10.1111/jnc.12286

    authors： Gandelman M,Levy M,Cassina P,Barbeito L,Beckman JS

    更新日期：2013-08-01 00:00:00

  • Effects of wild-type and mutated copper/zinc superoxide dismutase on neuronal survival and L-DOPA-induced toxicity in postnatal midbrain culture.

    abstract：:Mutations in the free radical-scavenging enzyme copper/zinc superoxide dismutase (Cu/Zn-SOD) are associated with neuronal death in humans and mice. Here, we examine the effects of human wild-type (WT SOD) and mutant (Gly93 --> Ala; G93A) Cu/Zn-SOD enzyme on the fate of postnatal midbrain neurons. One-week-old cultures...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章

    doi：10.1046/j.1471-4159.1997.69010021.x

    authors： Mena MA,Khan U,Togasaki DM,Sulzer D,Epstein CJ,Przedborski S

    更新日期：1997-07-01 00:00:00

  • The non-peptidic δ-opioid receptor agonist Tan-67 mediates neuroprotection post-ischemically and is associated with altered amyloid precursor protein expression, maturation and processing in mice.

    abstract：:Tan-67 is a selective non-peptidic δ-opioid receptor (DOR) agonist that confers neuroprotection against cerebral ischemia/reperfusion (I/R)-caused neuronal injury in pre-treated animals. In this study, we examined whether post-ischemic administration of Tan-67 in stroke mice is also neuroprotective and whether the tre...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章

    doi：10.1111/jnc.14265

    authors： Min JW,Liu Y,Wang D,Qiao F,Wang H

    更新日期：2018-02-01 00:00:00

  • Transgenic murine dopaminergic neurons expressing human Cu/Zn superoxide dismutase exhibit increased density in culture, but no resistance to methylphenylpyridinium-induced degeneration.

    abstract：:Primary dopaminergic neuronal cultures with increased superoxide dismutase (SOD) activity were established for studying the role of superoxide anion (O2-) in 1-methyl-4-phenylpyridinium (MPP+)-induced degeneration of dopamine (DA) neurons. Mean SOD activity in cultures prepared from transgenic (human) Cu/Zn SOD (hSOD1...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章

    doi：10.1046/j.1471-4159.1997.68010058.x

    authors： Sanchez-Ramos JR,Song S,Facca A,Basit A,Epstein CJ

    更新日期：1997-01-01 00:00:00

  • Agonist and cyclic AMP-mediated regulation of beta 1-adrenergic receptor mRNA and gene transcription in rat C6 glioma cells.

    abstract：:Exposure of rat C6 glioma cells to either agonists or agents that increase cyclic AMP levels leads to down-regulation of beta 1-adrenergic receptors (beta 1 AR) as measured by loss of radioligand binding sites. The present study examines the influence of isoproterenol and forskolin treatment on levels of beta 1 AR mRN...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章

    doi：10.1046/j.1471-4159.1994.63051635.x

    authors： Hosoda K,Feussner GK,Rydelek-Fitzgerald L,Fishman PH,Duman RS

    更新日期：1994-11-01 00:00:00

  • Reggie/flotillin and the targeted delivery of cargo.

    abstract：:The two proteins reggie-1/flotillin-2 and reggie-2/flotillin-1 form microdomains at the plasma membrane and at intracellular compartments where src tyrosine kinases associate with them. Specific GPI-anchored proteins, in particular prion protein and Thy-1, co-cluster with reggie microdomains at the plasma membrane and...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章,评审

    doi：10.1111/j.1471-4159.2010.07007.x

    authors： Stuermer CA

    更新日期：2011-03-01 00:00:00

  • Binding of the repressor complex REST-mSIN3b by small molecules restores neuronal gene transcription in Huntington's disease models.

    abstract：:Transcriptional dysregulation is a hallmark of Huntington's disease (HD) and one cause of this dysregulation is enhanced activity of the REST-mSIN3a-mSIN3b-CoREST-HDAC repressor complex, which silences transcription through REST binding to the RE1/NRSE silencer. Normally, huntingtin (HTT) prevents this binding, allowi...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章

    doi：10.1111/jnc.12348

    authors： Conforti P,Zuccato C,Gaudenzi G,Ieraci A,Camnasio S,Buckley NJ,Mutti C,Cotelli F,Contini A,Cattaneo E

    更新日期：2013-10-01 00:00:00

  • Allele-specific silencing of mutant Huntington's disease gene.

    abstract：:Huntington's disease (HD) is an autosomal-dominant neurodegenerative disorder caused by a poly-glutamine expansion in huntingtin, the protein encoded by the HD gene. PolyQ-expanded huntingtin is toxic to neurons, especially the medium spiny neurons of the striatum. At the same time, wild-type huntingtin has important ...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章

    doi：10.1111/j.1471-4159.2008.05734.x

    authors： Zhang Y,Engelman J,Friedlander RM

    更新日期：2009-01-01 00:00:00

  • Ethanol inhibition of recombinant heteromeric NMDA channels in the presence and absence of modulators.

    abstract：:The NMDA receptor/channel has been shown to be inhibited by ethanol in the clinically relevant range 25-100 mM. We studied heteromeric assemblies (NR1b/NR2) of the NMDA receptor, expressed in oocytes, to address three questions regarding this inhibition, and discovered the following: (1) The inhibition was nearly equi...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章

    doi：10.1046/j.1471-4159.1995.65010140.x

    authors： Chu B,Anantharam V,Treistman SN

    更新日期：1995-07-01 00:00:00

  • Increased nuclear factor-erythroid 2 p45-related factor 2 activity protects SH-SY5Y cells against oxidative damage.

    abstract：:The ability of cells to control the balance between the generation and quenching of reactive oxygen species is important in combating potentially damaging effects of oxidative stress. One mechanism that cells use to maintain redox homeostasis is the antioxidant response pathway. Antioxidant response elements (AREs) ar...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章

    doi：10.1111/j.1471-4159.2005.03377.x

    authors： Cao TT,Ma L,Kandpal G,Warren L,Hess JF,Seabrook GR

    更新日期：2005-10-01 00:00:00

  • [3H]nitrobenzylthioinosine binding as a probe for the study of adenosine uptake sites in brain.

    abstract：:The binding of the potent adenosine uptake inhibitor [3H]nitrobenzylthioinosine ([3H]NBI) to brain membrane fractions was investigated. Reversible, saturable, specific, high-affinity binding was demonstrated in both rat and human brain. The KD in both was 0.15 nM with Bmax values of 140-200 fmol/mg protein. Linear Sca...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章

    doi：10.1111/j.1471-4159.1982.tb04717.x

    authors： Marangos PJ,Patel J,Clark-Rosenberg R,Martino AM

    更新日期：1982-07-01 00:00:00

  • Ontogenetic profile of the adenosine uptake sites in rat forebrain.

    abstract：:The ontogenesis of rat forebrain adenosine uptake sites labelled by [3H]nitrobenzylthioinosine ([3H]NBI) was determined and compared to that of rat forebrain adenosine receptors labelled by N6-cyclohexyl[3H]adenosine ([3H]-CHA). [3H]NBI binding is highly invariant with similar levels of [3H]NBI binding sites from embr...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章

    doi：10.1111/j.1471-4159.1987.tb00972.x

    authors： Morgan PF,Montgomery P,Marangos PJ

    更新日期：1987-09-01 00:00:00

  • Radiolabeling and in vitro /in vivo evaluation of N-(1-adamantyl)-8-methoxy-4-oxo-1-phenyl-1,4-dihydroquinoline-3-carboxamide as a PET probe for imaging cannabinoid type 2 receptor.

    abstract：:The cannabinoid type 2 (CB2) receptor plays an important role in neuroinflammatory and neurodegenerative diseases such as multiple sclerosis, amyotrophic lateral sclerosis, and Alzheimer’s disease and is therefore a very promising target for therapeutic approaches as well as for imaging. Based on the literature, we id...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章

    doi：10.1111/jnc.12354

    authors： Mu L,Bieri D,Slavik R,Drandarov K,Müller A,Cermak S,Weber M,Schibli R,Krämer SD,Ametamey SM

    更新日期：2013-09-01 00:00:00

  • PAL31 may play an important role as inflammatory modulator in the repair process of the spinal cord injury rat.

    abstract：:Functional regeneration in a complete T8 transection model Cheng et al. (1996) and most recently, acidic fibroblast growth factor (aFGF; also known as FGF-1) involved in the repair process of the spinal cord injury (SCI) rat Tsai et al. (2008) have been reported. To further reveal the mechanism of the repair process o...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章

    doi：10.1111/j.1471-4159.2008.05865.x

    authors： Shen LF,Cheng H,Tsai MC,Kuo HS,Chak KF

    更新日期：2009-03-01 00:00:00

  • Subunit-dependent inhibition and potentiation of 5-HT3 receptor by the anticancer drug, topotecan.

    abstract：:The 5-hydroxytryptamine (serotonin, 5-HT) type 3 (5-HT3) receptor belongs to the superfamily of Cys-loop ligand-gated ion channels, and can be either homopentameric (5-HT3A) or heteropentameric (5-HT3AB) receptor. Several modulators are known, which either inhibit or potentiate this channel, but few have any appreciab...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章

    doi：10.1111/jnc.12146

    authors： Nakamura Y,Ishida Y,Yamada T,Kondo M,Shimada S

    更新日期：2013-04-01 00:00:00

  • Morphine and HIV-Tat increase microglial-free radical production and oxidative stress: possible role in cytokine regulation.

    abstract：:Opiate abuse alters the progression of human immunodeficiency virus and may increase the risk of neuroAIDS. As neuroAIDS is associated with altered microglial reactivity, the combined effects of human immunodeficiency virus-Tat and morphine were determined in cultured microglia. Specifically, experiments determined th...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章

    doi：10.1111/j.1471-4159.2008.05756.x

    authors： Turchan-Cholewo J,Dimayuga FO,Gupta S,Keller JN,Knapp PE,Hauser KF,Bruce-Keller AJ

    更新日期：2009-01-01 00:00:00

  • Effect of sound stimulation at several levels on concentrations of primary amines, including neurotransmitter candidates, in perilymph of the guinea pig inner ear.

    abstract：:Perilymph, which bathes the sensory cells of the cochlea, was collected from guinea pigs exposed to noise and analyzed via two cation-exchange HPLC procedures with fluorescence detection, resolving 51 and 81 primary-amine compounds, respectively, at a sensitivity limit of 0.1 pmol relative to leucine. During a first p...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章

    doi：10.1111/j.1471-4159.1983.tb04745.x

    authors： Drescher MJ,Drescher DG,Medina JE

    更新日期：1983-08-01 00:00:00

  • Purification and initial characterization of rat B49 glial cell line-derived neurotrophic factor.

    abstract：:The rat glial cell line B49 releases into its culture medium a potent neurotrophic factor that exhibits relative specificity for the dopaminergic neurons in dissociated cultures of rat embryonic midbrain. This factor is a heparin-binding, basic protein that is heterogeneously glycosylated and migrates on sodium dodecy...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章

    doi：10.1046/j.1471-4159.1994.63020758.x

    authors： Lin LF,Zhang TJ,Collins F,Armes LG

    更新日期：1994-08-01 00:00:00

  • Chromatographic separation of reaction products from the choline acetyltransferase and carnitine acetyltransferase assay: differential ChAT and CrAT activity in brain extracts from Alzheimer's disease versus controls.

    abstract：:Choline acetyltransferase (ChAT) catalyzes the reaction between choline and acetylcoenzyme A (AcCoA) to form acetylcholine (ACh) in nerve terminals. ACh metabolism has implications in numerous aspects of physiology and varied disease states, such as Alzheimer's disease. Therefore a specific, sensitive, and reliable me...

    journal_title：Journal of neurochemistry

    pub_type： 杂志文章

    doi：10.1111/j.1471-4159.2012.07793.x

    authors： Bailey JA,Lahiri DK

    更新日期：2012-08-01 00:00:00