PAL31 may play an important role as inflammatory modulator in the repair process of the spinal cord injury rat.


:Functional regeneration in a complete T8 transection model Cheng et al. (1996) and most recently, acidic fibroblast growth factor (aFGF; also known as FGF-1) involved in the repair process of the spinal cord injury (SCI) rat Tsai et al. (2008) have been reported. To further reveal the mechanism of the repair process of SCI, in additionally, we have identified a 30 kDa specific protein kinase A substrate induced at 6 days after SCI. However, the induction of the transducing signal was reduced in samples treated with aFGF. The 30 kDa protein was purified and identified by mass spectrometry as a novel protein, PAL31. The results of immunohistochemical study showed that PAL31 is abundantly expressed in the epicenter of the injured spinal cord and colocalizes with ED1-positive cells (macrophages) and CD8 T lymphocytes. Over-expression of PAL31 in RAW 264.7 cells resulted in the down-regulation of macrophage chemoattractant protein 1, inducible nitric oxide synthase, and signal transducer and activator of transcription-1. However, knockdown of PAL31 by small interfering RNA seems to lead to apoptosis when the cells were treated with inflammatory inducers. These experimental results suggest that PAL31 may involve in the modulation of the inflammatory response and, at the same time, prevent apoptosis process of macrophage after SCI.


J Neurochem


Shen LF,Cheng H,Tsai MC,Kuo HS,Chak KF




Has Abstract


2009-03-01 00:00:00














  • Release of adenosine from rat hippocampal slices by nitric oxide donors.

    abstract::In the present study we have used perfused hippocampal slices to examine the hypothesis that nitric oxide (NO) can evoke the release of adenosine from nervous tissue. ATP stores were labeled by incubation with [3H]adenine. Electrical field stimulation at 5 Hz for 5 min evoked the release of 3H-purines, and this was en...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章


    authors: Fallahi N,Broad RM,Jin S,Fredholm BB

    更新日期:1996-07-01 00:00:00

  • The discoidin domain receptor 1 gene has a functional A2RE sequence.

    abstract::Discoidin domain receptor 1 (DDR1) is expressed in myelin oligodendrocytes and co-localizes with myelin basic protein (MBP). Alternative splicing of DDR1 generates five isoforms designated DDR1a-e. The MBP mRNA contains an hnRNP A2 response element (A2RE) sequence that is recognized by heterogeneous nuclear ribonucleo...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章


    authors: Roig B,Moyano S,Martorell L,Costas J,Vilella E

    更新日期:2012-02-01 00:00:00

  • Sequence of guinea pig myelin basic protein.

    abstract::This paper proposes a tentative amino acid sequence of guinea pig myelin basic protein obtained by comparison of peptide fragments of the guinea pig and bovine proteins. Analyses of the tryptic peptides confirmed the known sequence differences in the NH2-terminal half of the molecule and showed that in the COOH-termin...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章


    authors: Deibler GE,Martenson RE,Krutzsch HC,Kies MW

    更新日期:1984-07-01 00:00:00

  • A nicotinic acetylcholine receptor transmembrane point mutation (G275E) associated with resistance to spinosad in Frankliniella occidentalis.

    abstract::High levels of resistance to spinosad, a macrocyclic lactone insecticide, have been reported previously in western flower thrips, Frankliniella occidentalis, an economically important insect pest of vegetables, fruit and ornamental crops. We have cloned the nicotinic acetylcholine receptor (nAChR) α6 subunit from F. o...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章


    authors: Puinean AM,Lansdell SJ,Collins T,Bielza P,Millar NS

    更新日期:2013-03-01 00:00:00

  • gamma-Aminobutyric acidA receptor heterogeneity is increased by alternative splicing of a novel beta-subunit gene transcript.

    abstract::DNA sequences encoding two variants of a novel gamma-aminobutyric acidA (GABAA) receptor beta subunit were isolated from an embryonic chicken whole-brain cDNA library and a chicken genomic library. The coding regions of these variants only differ from each other by the absence or presence of 12 bp in the region that e...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章


    authors: Bateson AN,Lasham A,Darlison MG

    更新日期:1991-04-01 00:00:00

  • Elevated density of [3H]imipramine binding in aged human brain.

    abstract::Aging was associated with an increase in the density of specific binding sites for [3H]imipramine in postmortem specimens of human hypothalamus, frontal cortex, and parietal cortex. In general, [3H]imipramine binding was not affected by factors considered difficult to control in postmortem studies, i.e., time from dea...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章


    authors: Severson JA,Marcusson JO,Osterburg HH,Finch CE,Winblad B

    更新日期:1985-11-01 00:00:00

  • Ubiquitin/proteasome-dependent down-regulation following clathrin-mediated internalization of histamine H1-receptors in Chinese hamster ovary cells.

    abstract::We investigated the regulatory pathways responsible for agonist-induced internalization and down-regulation of G(q) protein-coupled histamine H(1)-receptors in Chinese hamster ovary cells. Histamine-induced internalization and down-regulation of H(1)-receptors were detected as the loss of [(3)H]mepyramine binding site...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章


    authors: Hishinuma S,Komazaki H,Fukui H,Shoji M

    更新日期:2010-05-01 00:00:00

  • Disruption of receptor-mediated activation of G protein by mutating a conserved arginine residue in the switch II region of the alpha subunit.

    abstract::A naturally occurring point mutation (R231H) within one of the major 3gamma-binding surface (switch II region) on the a subunit of Gs (alpha(s)) has previously been found to disrupt receptor-mediated activation of Gs. The disruption caused by mutating this conserved residue may be a general phenomenon for all a subuni...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章


    authors: Ho MK,Yung LY,Wong YH

    更新日期:1999-11-01 00:00:00

  • Mutations in the myelin proteolipid protein gene alter oligodendrocyte gene expression in jimpy and jimpymsd mice.

    abstract::The mouse myelin proteolipid protein (PLP) gene has been studied in normal and jimpymsd mice. Potential upstream regulatory regions of the normal gene have been cloned and mapped, but when these regions were studied in jimpymsd mice by Southern blots, no alterations were observed, relative to the normal gene. To asses...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章


    authors: Macklin WB,Gardinier MV,Obeso ZO,King KD,Wight PA

    更新日期:1991-01-01 00:00:00

  • Regulation of actin and its mRNA by thyroid hormones in cultures of fetal human brain during second trimester of gestation.

    abstract::The effect of thyroid hormones (THs) on the expression of actin gene during fetal human brain development and the period of sensitivity to the hormones have been investigated. Developmental profile of actin in the cytoskeletal (CSK) and noncytoskeletal (non-CSK) fractions in the fetal cerebra showed a pronounced rise ...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章


    authors: Pal U,Biswas SC,Sarkar PK

    更新日期:1997-09-01 00:00:00

  • Subcellular and perisynaptic distribution of rat brain aldehyde dehydrogenase activity.

    abstract::The nuclear mitochondrial and synaptosomal fractions of rat brain were each found to contain some 25-30% of the total aldehyde dehydrogenase activity. The cytoplasmic fraction had a very low total aldehyde dehydrogenase activity. There were differences in the distribution of the activity when different aldehydes were ...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章


    authors: Koivula T,Turner AJ,Huttunen M,Koivusalo M

    更新日期:1981-06-01 00:00:00

  • Modulation of cerebral vascular tone by activated glia: involvement of nitric oxide.

    abstract::The ability of activated glia to affect cerebral vascular tone has been evaluated using an in vitro experimental system in which basilar arteries were incubated with glial cultures activated by treatment with lipopolysaccharide (LPS). Vascular tone was measured with an isometric myograph. Contraction in response to hi...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章


    authors: Chisari M,Salomone S,Laureanti F,Copani A,Sortino MA

    更新日期:2004-12-01 00:00:00

  • Postnatal development of cholecystokinin-like immunoreactivity and its mRNA level in rat brain regions.

    abstract::Developmental changes of preprocholecystokinin mRNA (CCK mRNA) and cholecystokinin-like immunoreactivity (CCK-LI) were examined in rat brain regions (frontal cortex, colliculi, hippocampus, striatum, and cerebellum) using RNA dot blot assays with cholecystokinin (CCK) cDNA and radioimmunoassay, respectively. The CCK-L...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章


    authors: Takeda K,Koshimoto H,Uchiumi F,Haun RS,Dixon JE,Kato T

    更新日期:1989-09-01 00:00:00

  • Do axonal defects in tau and amyloid precursor protein transgenic animals model axonopathy in Alzheimer's disease?

    abstract::The subcellular localization of organelles, mRNAs and proteins is particularly challenging in neurons. Owing to their extended morphology, with axons in humans exceeding a meter in length, in addition to which they are not renewed but persist for the entire lifespan, it is no surprise that neurons are highly vulnerabl...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章,评审


    authors: Götz J,Ittner LM,Kins S

    更新日期:2006-08-01 00:00:00

  • Influence of monoclonal antibodies on microtubule assembly.

    abstract::The influence on microtubule assembly in vitro of monoclonal antibodies against microtubule-associated proteins (MAPs) was studied. Light scattering was used for measuring net polymer formation and electron microscopy for determining the influence of antibodies on microtubule morphology. Control experiments showed tha...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章


    authors: Matus A,Riederer B,Huber G

    更新日期:1987-09-01 00:00:00

  • Heterogeneity of the S-100 protein specific binding sites in synaptosomal particulate fractions and subfractions.

    abstract::The specific interaction of S-100 protein with synaptosomal particulate fractions (SYN) was further investigated with special reference to the number of binding components and their localization in synaptosomal subfractions. Binding studies were conducted on SYN from various CNS regions, on synaptosomal subfractions f...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章


    authors: Donato R

    更新日期:1982-07-01 00:00:00

  • Effects of denervation and simple disuse on rates of oxidation and on activities of four mitochondrial enzymes in type I muscle.

    abstract::To differentiate the effect of muscle contractile activity from that of motor nerve on oxidative processes in type I muscle, oxidative processes were studied in muscle after immobilization and after denervation. The two processes led to similar atrophy of muscle weight and of the mean diameter of muscle fibers. Disuse...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章


    authors: Nemeth PM,Meyer D,Kark RA

    更新日期:1980-12-01 00:00:00

  • Characterization of the P-type and V-type ATPases of cholinergic synaptic vesicles and coupling of nucleotide hydrolysis to acetylcholine transport.

    abstract::Both phosphointermediate- and vacuolar-type (P- and V-type, respectively) ATPase activities found in cholinergic synaptic vesicles isolated from electric organ are immunoprecipitated by a monoclonal antibody to the SV2 epitope characteristic of synaptic vesicles. The two activities can be distinguished by assay in the...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章


    authors: Hicks BW,Parsons SM

    更新日期:1992-04-01 00:00:00

  • Riluzole attenuates glutamatergic tone and cognitive decline in AβPP/PS1 mice.

    abstract::We have previously demonstrated hippocampal hyperglutamatergic signaling occurs prior to plaque accumulation in AβPP/PS1 mice. Here, we evaluate 2-Amino-6-(trifluoromethoxy) benzothiazole (riluzole) as an early intervention strategy for Alzheimer's disease (AD), aimed at restoring glutamate neurotransmission prior to ...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章


    authors: Hascup KN,Findley CA,Britz J,Esperant-Hilaire N,Broderick SO,Delfino K,Tischkau S,Bartke A,Hascup ER

    更新日期:2020-10-26 00:00:00

  • An endogenous aminoenkephalinase inhibitor: purification and characterization of Arg0-Met5-enkephalin from bovine striatum.

    abstract::Arg0-Met5-enkephalin (Arg0-MEK) was isolated from bovine striatum and purified to homogeneity. The peptide was extracted with trichloroacetic acid, followed by column chromatography successively on Bio-Sil C8, semipreparative HPLC Radial-Pak C18, fast protein liquid chromatography (FPLC) Mono S, HPLC Ultrasphere-ODS, ...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章


    authors: Hui KS,Lo ES,Hui MP

    更新日期:1994-11-01 00:00:00

  • Postmortem changes of normetanephrine determined by a mass-fragmentographic technique in different rat brain areas.

    abstract::A specific and sensitive gas chromatographic-mass spectrometric assay for measurement of normetanephrine (NMN) in different rat brain regions is presented. The results show that hypothalamus contains the highest concentrations of the norepinephrine metabolite. An increase of NMN concentrations has been detected in ani...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章


    authors: Mocchetti I,De Angelis L,Racagni G

    更新日期:1981-12-01 00:00:00

  • Resistance to disruption of multilamellar fragments of central nervous system myelin.

    abstract::Single-bilayer vesicles of myelin are desirable for studying myelin development and metabolism. Accordingly, our interest was drawn to a procedure for vesiculating myelin (Steck et al., Biochim, Biophys. Acta 509, 397-408, 1978). We used X-ray diffraction analysis to examine these putative vesicle preparations because...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章


    authors: Sedzik J,Toews AD,Blaurock AE,Morell P

    更新日期:1984-11-01 00:00:00

  • Cell-free synthesis of the myelin basic proteins in a wheat germ system programmed with brain messenger RNA.

    abstract::Poly A(+) messenger RNA (mRNA) was isolated from the brains of 3-week-old mice and translated in a cell-free system derived from wheat germ. Maximal stimulation of the system by brain mRNA was observed at a relatively low K+ concentration (45 mM) and low mRNA concentration (1-10 microgram/ml). The translational system...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章


    authors: Matthees J,Campagnoni AT

    更新日期:1980-10-01 00:00:00

  • SNARE proteins--why so many, why so few?

    abstract::Both trafficking and secretion critically depend on accurate and specific membrane recognition and fusion. A key step in these processes is the assembly of a complex consisting of a small number of proteins, i.e., the exocytic core complex. In nerve terminals, this set consists of VAMP and synaptotagmin, which reside ...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章,评审


    authors: Linial M

    更新日期:1997-11-01 00:00:00

  • Mutant presenilin 2 transgenic mouse: effect on an age-dependent increase of amyloid beta-protein 42 in the brain.

    abstract::The N141I missense mutation in presenilin (PS) 2 is tightly linked with a form of autosomal dominant familial Alzheimer's disease (AD) in the Volga German families. We have generated transgenic mouse lines overexpressing human wild-type or mutant PS2 under transcriptional control of the chicken beta-actin promoter. In...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章


    authors: Oyama F,Sawamura N,Kobayashi K,Morishima-Kawashima M,Kuramochi T,Ito M,Tomita T,Maruyama K,Saido TC,Iwatsubo T,Capell A,Walter J,Grünberg J,Ueyama Y,Haass C,Ihara Y

    更新日期:1998-07-01 00:00:00

  • The F3 neuronal glycosylphosphatidylinositol-linked molecule is localized to glycolipid-enriched membrane subdomains and interacts with L1 and fyn kinase in cerebellum.

    abstract::The F3 molecule is a member of the immunoglobulin superfamily anchored to plasma membranes by a glycosylphosphatidylinositol group. In adult mouse cerebellum, F3 is predominantly expressed on a subset of axons, the parallel fibers, and at their synapses. In vitro studies established that it is a plurifunctional molecu...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章


    authors: Olive S,Dubois C,Schachner M,Rougon G

    更新日期:1995-11-01 00:00:00

  • Accumulation of DNA damage in aging neurons occurs through a mechanism other than apoptosis.

    abstract::Two biochemical strategies using nick translation-type of incubation and terminal tranferase-catalyzed reaction were used to assess single-(SSB) and double-strand (DSB) breaks in DNA of permeabilized neurons isolated from young, adult, and old rat cerebral cortex. Both SSBs and DSBs accumulate with age. On prior treat...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章


    authors: Mandavilli BS,Rao KS

    更新日期:1996-10-01 00:00:00

  • L-3,4-dihydroxyphenylalanine-induced dopamine release in the striatum of intact and 6-hydroxydopamine-treated rats: differential effects of monoamine oxidase A and B inhibitors.

    abstract::Administration of L-DOPA (50 mg/kg) elicits a significant increase in extracellular dopamine in striata of rats treated with the catecholaminergic neurotoxin 6-hydroxydopamine but not in striata of intact rats. To assess the role of dopaminergic nerve terminals in determining the effects of exogenous L-DOPA on extrace...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章


    authors: Wachtel SR,Abercrombie ED

    更新日期:1994-07-01 00:00:00

  • Protective effects of extracellular acidosis and blockade of sodium/hydrogen ion exchange during recovery from metabolic inhibition in neuronal tissue culture.

    abstract::Acidosis is a universal response of tissue to ischemia. In the brain, severe acidosis has been linked to worsening of cerebral infarction. However, milder acidosis can have protective effects. As part of our investigations of the therapeutic window in our neuronal tissue culture model of ischemia, we investigated the ...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章


    authors: Vornov JJ,Thomas AG,Jo D

    更新日期:1996-12-01 00:00:00

  • Evidence for the involvement of carnitine-dependent long-chain acyltransferases in neuronal triglyceride and phospholipid fatty acid turnover.

    abstract::This study focuses on the potential involvement of carnitine palmitoyltransferase (CPT) on the phospholipid and triglyceride fatty acid turnover in neurons. This category of enzymes, which has been identified in several rat brain tissues, is well known for its role in modulating cellular fatty acid oxidation. Neuronal...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章


    authors: Arduini A,Denisova N,Virmani A,Avrova N,Federici G,Arrigoni-Martelli E

    更新日期:1994-04-01 00:00:00