High-affinity, sodium-dependent gamma-aminobutyric acid uptake by slices of rat ovary.

abstract：:Microglial activation is common in several neurodegenerative disorders. In the present study, we used the murine BV-2 microglial cell line stimulated with gamma-interferon and lipopolysaccharide to gain new insights into the effects of endogenously produced NO on mitochondrial respiratory capacity, iron regulatory pro...

journal_title：Journal of neurochemistry

authors： Chénais B,Morjani H,Drapier JC

更新日期：2002-05-01 00:00:00

abstract：:Nerve growth factor (NGF) is a trophic and survival factor for cholinergic neurons, and it induces the expression of several genes that are essential for synthesis and storage of acetylcholine (ACh), specifically choline acetyltransferase, vesicular ACh transporter (VAChT), and choline transporter. We have found previ...

journal_title：Journal of neurochemistry

authors： Madziar B,Shah S,Brock M,Burke R,Lopez-Coviella I,Nickel AC,Cakal EB,Blusztajn JK,Berse B

更新日期：2008-12-01 00:00:00

abstract：:In the present study we have used perfused hippocampal slices to examine the hypothesis that nitric oxide (NO) can evoke the release of adenosine from nervous tissue. ATP stores were labeled by incubation with [3H]adenine. Electrical field stimulation at 5 Hz for 5 min evoked the release of 3H-purines, and this was en...

journal_title：Journal of neurochemistry

authors： Fallahi N,Broad RM,Jin S,Fredholm BB

更新日期：1996-07-01 00:00:00

abstract：:Unilateral ligation of the left common carotid artery in anesthetized Mongolian gerbils resulted in a steep rise in extracellular dopamine in the ipsilateral striatum in 9 out of 19 animals. Extracellular dopamine was measured by cerebral dialysis in vivo and reached a peak of 0.19 mM at 40 min. At the same time, the ...

journal_title：Journal of neurochemistry

authors： Slivka A,Brannan TS,Weinberger J,Knott PJ,Cohen G

更新日期：1988-06-01 00:00:00

abstract：:In the last 40 years, especially with the application of new neurochemical and molecular biological techniques, there has been explosive progress in understanding how certain ligands and drugs are transported across the blood-brain barrier and choroid plexus out of brain and CSF. In the CNS, there are several separate...

journal_title：Journal of neurochemistry

authors： Spector R

更新日期：2010-01-01 00:00:00

abstract：:Synapsin I, a prominent phosphoprotein in nerve terminals, is proposed to modulate exocytosis by interaction with the cytoplasmic surface of small synaptic vesicles and cytoskeletal elements in a phosphorylation-dependent manner. Tetanus toxin (TeTx), a potent inhibitor of neurotransmitter release, attenuated the depo...

journal_title：Journal of neurochemistry

authors： Presek P,Jessen S,Dreyer F,Jarvie PE,Findik D,Dunkley PR

更新日期：1992-10-01 00:00:00

abstract：:Excitotoxicity and defects in neuronal energy metabolism have both been implicated in the pathogenesis of neurodegenerative disease. These two mechanisms may be linked through the NMDA receptor, activation of which is dependent on neuronal membrane potential. Because the ability to maintain membrane potential is depen...

journal_title：Journal of neurochemistry

authors： Greene JG,Porter RH,Eller RV,Greenamyre JT

更新日期：1993-09-01 00:00:00

abstract：:Integrin-mediated interactions of cells with components of the extracellular matrix (ECM) regulate cell survival, cell proliferation, cell differentiation and cell migration through activation of multiple intracellular signal transduction pathways. In this study, we have demonstrated that integrin-matrix interactions ...

journal_title：Journal of neurochemistry

authors： Li BS,Daniels MP,Pant HC

更新日期：2001-02-01 00:00:00

abstract：:A mass fragmentographic method for the determination of trace amounts of amino acid neurotransmitter candidates from brain perfusates is described. The analytical procedure includes the measurements of glycine, beta-alanine, gamma-aminobutyric acid, proline, aspartic acid, and glutamic acid; alpha-alanine, leucine, an...

journal_title：Journal of neurochemistry

authors： Wolfensberger M,Amsler U

更新日期：1982-02-01 00:00:00

abstract：:The cellular prion protein (PrP(c)) is a glycosylphosphatidylinositol (GPI)-anchored plasma membrane protein whose conformational altered forms (PrP(sc)) are known to cause neurodegenerative diseases in mammals. In order to investigate the intracellular traffic of mammalian PrP(c) in living cells, we have generated a ...

journal_title：Journal of neurochemistry

authors： Lee KS,Magalhães AC,Zanata SM,Brentani RR,Martins VR,Prado MA

更新日期：2001-10-01 00:00:00

abstract：:The physiological function of the cellular prion protein (PrP(c)) is unclear. PrP(c) associates with lipid rafts, highly glycolipid-rich membrane domains containing a large variety of signaling molecules, e.g., sphingolipids (SL). In this study, we investigated possible connections between PrP(c) and sphingolipid-asso...

journal_title：Journal of neurochemistry

authors： Schmalzbauer R,Eigenbrod S,Winoto-Morbach S,Xiang W,Schütze S,Bertsch U,Kretzschmar HA

更新日期：2008-08-01 00:00:00

abstract：:Spinocerebellar ataxia 1 (SCA1) is a dominantly inherited neurodegenerative disease associated with progressive ataxia resulting from the loss of cerebellar Purkinje cells (PCs) and neurons in the brainstem. In PCs of SCA1 transgenic mice, the disease causing ataxin-1 protein mediates the formation of S100B containing...

journal_title：Journal of neurochemistry

authors： Hearst SM,Lopez ME,Shao Q,Liu Y,Vig PJ

更新日期：2010-08-01 00:00:00

abstract：:Calmodulin (CaM)-dependent enzymes, such as CaM-dependent phosphodiesterase (CaM-PDE), CaM-dependent protein phosphatase (CN), and CaM-dependent protein kinase II (CaM kinase II), are found in high concentrations in differentiated mammalian neurons. In order to determine whether neuroblastoma cells express these CaM-d...

journal_title：Journal of neurochemistry

authors： Pennypacker KR,Kincaid RL,Polli JW,Billingsley ML

更新日期：1989-05-01 00:00:00

abstract：:Spatial solute concentration profiles resulting from in vivo microdialysis were measured in rat caudate-putamen by quantitative autoradiography. Radiolabeled sucrose was included in the dialysate, and the tissue concentration profile measured after infusions of 14 min and 61.5 min in an acute preparation. In addition,...

journal_title：Journal of neurochemistry

authors： Dykstra KH,Hsiao JK,Morrison PF,Bungay PM,Mefford IN,Scully MM,Dedrick RL

更新日期：1992-03-01 00:00:00

abstract：:In vivo microdialysis was used to determine whether the 3,4-methylenedioxymethamphetamine (MDMA)-induced release of serotonin (5-HT) in vivo involves a carrier-mediated process and to investigate further the state-dependent interaction between 5-HT and dopamine. MDMA produced a dose-dependent increase in the extracell...

journal_title：Journal of neurochemistry

authors： Gudelsky GA,Nash JF

更新日期：1996-01-01 00:00:00

abstract：:A rapid and simple procedure is presented to obtain nearly pure populations of human neuron-like cells from the SH-SY5Y neuroblastoma cell line. Sequential exposure of SH-SY5Y cells to retinoic acid and brain-derived neurotrophic factor in serum-free medium yields homogeneous populations of cells with neuronal morphol...

journal_title：Journal of neurochemistry

authors： Encinas M,Iglesias M,Liu Y,Wang H,Muhaisen A,Ceña V,Gallego C,Comella JX

更新日期：2000-09-01 00:00:00

abstract：:The uptake of radioactive biotin has been studied in glial cell cultures from dissociated cerebral hemispheres of newborn rats. We describe saturable kinetics for the biotin uptake at biotin concentrations of less than 60 nM and linear at greater than 60 nM. The uptake appeared temperature sensitive, Na+ independent, ...

journal_title：Journal of neurochemistry

authors： Rodriguez-Pombo P,Ugarte M

更新日期：1992-04-01 00:00:00

abstract：:Voltage-gated sodium channels (VGSC) are involved in the generation of action potentials in neurons. Brevetoxins (PbTx) are potent allosteric enhancers of VGSC function and are associated with the periodic 'red tide' blooms. Using PbTx-2 as a probe, we have characterized the effects of activation of VGSC on Ca(2+) dyn...

journal_title：Journal of neurochemistry

authors： Dravid SM,Baden DG,Murray TF

更新日期：2004-05-01 00:00:00

abstract：:To assess the postmortem stability of brain 3-methoxy-4-hydroxy-phenylethyleneglycol (MHPG) and 3,4-dihydroxyphenylethyleneglycol (DHPG) levels, groups of rats and mice were killed by cervical dislocation and left at either 21 degrees or 4 degrees C for intervals of up to 24 h until removal and freezing of whole brain...

journal_title：Journal of neurochemistry

authors： Warsh JJ,Godse DD,Li PP,Cheung SW

更新日期：1981-03-01 00:00:00

abstract：:Gap junctions serve as intercellular conduits that allow the exchange of small molecular weight molecules (up to 1 kDa) including ions, metabolic precursors and second messengers. Microglia are capable of recognizing peptidoglycan (PGN) derived from the outer cell wall of Staphylococcus aureus, a prevalent CNS pathoge...

journal_title：Journal of neurochemistry

authors： Garg S,Md Syed M,Kielian T

更新日期：2005-10-01 00:00:00

abstract：:The binding of the potent adenosine uptake inhibitor [3H]nitrobenzylthioinosine ([3H]NBI) to brain membrane fractions was investigated. Reversible, saturable, specific, high-affinity binding was demonstrated in both rat and human brain. The KD in both was 0.15 nM with Bmax values of 140-200 fmol/mg protein. Linear Sca...

journal_title：Journal of neurochemistry

authors： Marangos PJ,Patel J,Clark-Rosenberg R,Martino AM

更新日期：1982-07-01 00:00:00

abstract：:Previous studies have indicated that the brains of DBA/2J (D2) mice have a more heavily myelinated CNS than those of C57BL/6J (B6) at postnatal days 17-21. However, the amount of myelin in the brains of F1 (B6 X D2) hybrids is even higher than in their parental strains. To investigate further factors involved in regul...

journal_title：Journal of neurochemistry

authors： Sato C,Yu RK

更新日期：1987-10-01 00:00:00

abstract：:Environment-induced relapse is a major concern in drug addiction because of the strong associations formed between drug reward and environment. Cocaine-conditioned place preference is an ideal experimental tool to examine adaptations in the molecular pathways that are activated upon re-exposure to an environment previ...

journal_title：Journal of neurochemistry

authors： Tropea TF,Kosofsky BE,Rajadhyaksha AM

更新日期：2008-08-01 00:00:00

abstract：:To explore the hypothesis that alterations in cellular membrane lipids are present at the stage of pre-clinical Alzheimer's disease (AD) (i.e., cognitively normal at death, but with AD neuropathology), we performed targeted shotgun lipidomics of lipid extracts from post-mortem brains of subjects with pre-clinical AD. ...

journal_title：Journal of neurochemistry

authors： Cheng H,Wang M,Li JL,Cairns NJ,Han X

更新日期：2013-12-01 00:00:00

abstract：:Modulation of [3H]muscimol binding by picrotoxin, pentobarbitone, and etomidate was investigated in rat cerebellar and cerebral cortical membranes. In cerebellum, at 37 degrees C in the presence of chloride ions (150 mM), picrotoxin and picrotoxinin decreased specific [3H]muscimol binding to 43 +/- 3% of control, with...

journal_title：Journal of neurochemistry

authors： Quast U,Brenner O

更新日期：1983-08-01 00:00:00

abstract：:Clinical and experimental data indicate that spinal cord injury (SCI) elicits pathological T-cell responses. Implicit in these data, but poorly understood, is that B lymphocytes (B cells) also contribute to the delayed pathophysiology of spinal trauma. Here, for the first time, we show that experimental spinal contusi...

journal_title：Journal of neurochemistry

authors： Ankeny DP,Lucin KM,Sanders VM,McGaughy VM,Popovich PG

更新日期：2006-11-01 00:00:00

abstract：:Late Infantile Neuronal Ceroid Lipofuscinosis (LINCL) is a rare neurodegenerative disease caused by mutations in the Cln2 gene that leads to deficiency or loss of function of the tripeptidyl peptidase 1 (TPP1) enzyme. TPP1 deficiency is known to cause the accumulation of autofluoroscent lipid-protein pigments in brain...

journal_title：Journal of neurochemistry

authors： Ghosh A,Rangasamy SB,Modi KK,Pahan K

更新日期：2017-05-01 00:00:00

abstract：:ATP-gated P2X3 receptors of sensory ganglion neurons are important transducers of painful stimuli and are modulated by extracellular algogenic substances, via changes in the receptor phosphorylation state. The present study investigated the role of calcium/calmodulin-dependent serine protein kinase (CASK) in interacti...

journal_title：Journal of neurochemistry

authors： Gnanasekaran A,Sundukova M,Hullugundi S,Birsa N,Bianchini G,Hsueh YP,Nistri A,Fabbretti E

更新日期：2013-07-01 00:00:00

abstract：:Astrocytic glutamate transporter-1 (GLT-1) is responsible for 90% of forebrain glutamate uptake in the adult CNS. Retinoic acid (RA) is a potent regulator of neural cell differentiation and neuronal maturation in the developing CNS through activation of RA receptors/retinoic X receptors (RXRs) or non-genomic mechanism...

journal_title：Journal of neurochemistry

authors： Chan TJ,Her LS,Liaw HJ,Chen MC,Tzeng SF

更新日期：2012-05-01 00:00:00

abstract：:Traumatic spinal cord injury has recently been shown to cause a rapid increase in free fatty acids (FFAs) and lipid degradation in cats. The present studies report a more delayed, time-dependent increase in FFAs and a concomitant decrease in phospholipids following traumatic spinal injury in rats. The largest percenta...

journal_title：Journal of neurochemistry

authors： Faden AI,Chan PH,Longar S

更新日期：1987-06-01 00:00:00