Dopamine D2 receptor signaling modulates mutant ataxin-1 S776 phosphorylation and aggregation.

abstract：:Free radicals have been implicated in the etiology of many neurodegenerative conditions. Yet, because these species are highly reactive and thus short-lived it has been difficult to test these hypotheses. We adapted a method in which hydroxyl radicals are trapped by salicylate in vivo, resulting in the stable and quan...

journal_title：Journal of neurochemistry

authors： Giovanni A,Liang LP,Hastings TG,Zigmond MJ

更新日期：1995-04-01 00:00:00

abstract：:The delta-opioid receptor is known to regulate multiple effectors in various tissues. When expressed in human embryonic kidney 293 cells, the cloned delta-opioid receptor inhibited cyclic AMP (cAMP) accumulation in response to the delta-selective agonist [D-Pen2,D-Pen5]-enkephalin. The inhibitory response of [D-Pen2,D...

journal_title：Journal of neurochemistry

authors： Tsu RC,Chan JS,Wong YH

更新日期：1995-06-01 00:00:00

abstract：:Although transient receptor potential (TRP) channels expressed in the spinal substantia gelatinosa play a role in modulating nociceptive transmission, their properties have not been fully examined yet. In order to address this issue, the effects of 1,8-cineole and its stereoisomer 1,4-cineole on excitatory transmissio...

journal_title：Journal of neurochemistry

authors： Jiang CY,Wang C,Xu NX,Fujita T,Murata Y,Kumamoto E

更新日期：2016-02-01 00:00:00

abstract：:CYP46A1 is a neuron-specific cytochrome P450 that plays a pivotal role in maintaining cholesterol homeostasis in the CNS. However, the molecular mechanisms underlying human CYP46A1 expression are still poorly understood, partly because of the lack of a cellular model that expresses high levels of CYP46A1. Our previous...

journal_title：Journal of neurochemistry

authors： Milagre I,Nunes MJ,Castro-Caldas M,Moutinho M,Gama MJ,Rodrigues E

更新日期：2012-01-01 00:00:00

abstract：:Choline acetyltransferase (acetyl-CoA: choline O-acetyltransferase, I.U.B. 2.3.1.6) activity and total protein content in visual and extra-visual areas were compared in normal Long-Evans rats and in rats subjected to complete light-deprivation for 21 days from birth. The enzyme activity and the protein content in the ...

journal_title：Journal of neurochemistry

authors： Maletta GJ,Timiras PS

更新日期：1968-08-01 00:00:00

abstract：:This paper proposes a tentative amino acid sequence of guinea pig myelin basic protein obtained by comparison of peptide fragments of the guinea pig and bovine proteins. Analyses of the tryptic peptides confirmed the known sequence differences in the NH2-terminal half of the molecule and showed that in the COOH-termin...

journal_title：Journal of neurochemistry

authors： Deibler GE,Martenson RE,Krutzsch HC,Kies MW

更新日期：1984-07-01 00:00:00

abstract：:Several epidemiological and preclinical studies suggest that non-steroidal anti-inflammatory drugs (NSAIDs), which inhibit cyclooxygenase (COX), reduce the risk of Alzheimer's disease (AD) and can lower β-amyloid (Aβ) production and inhibit neuroinflammation. However, follow-up clinical trials, mostly using selective ...

journal_title：Journal of neurochemistry

authors： Choi SH,Aid S,Caracciolo L,Minami SS,Niikura T,Matsuoka Y,Turner RS,Mattson MP,Bosetti F

更新日期：2013-01-01 00:00:00

abstract：:Aging was associated with an increase in the density of specific binding sites for [3H]imipramine in postmortem specimens of human hypothalamus, frontal cortex, and parietal cortex. In general, [3H]imipramine binding was not affected by factors considered difficult to control in postmortem studies, i.e., time from dea...

journal_title：Journal of neurochemistry

authors： Severson JA,Marcusson JO,Osterburg HH,Finch CE,Winblad B

更新日期：1985-11-01 00:00:00

abstract：:Proper brain function in the nervous system relies on the accurate establishment of synaptic contacts during development. Countless synapses populate the adult brain in an orderly fashion. In each synapse, a presynaptic terminal loaded with neurotransmitters-containing synaptic vesicles is perfectly aligned to an arra...

journal_title：Journal of neurochemistry

authors： Pinto MJ,Almeida RD

更新日期：2016-12-01 00:00:00

abstract：:Spinocerebellar ataxia type 3 (SCA3) is one of at least nine inherited neurodegenerative diseases caused by an expansion of a polyglutamine tract within corresponding disease-specific proteins. In case of SCA3, mutation of Ataxin-3 results in aggregation of misfolded protein, formation of intranuclear as well as cytos...

journal_title：Journal of neurochemistry

authors： Liman J,Deeg S,Voigt A,Voßfeldt H,Dohm CP,Karch A,Weishaupt J,Schulz JB,Bähr M,Kermer P

更新日期：2014-06-01 00:00:00

abstract：:Glutamate or a related excitatory amino acid is thought to be the major excitatory neurotransmitter of hippocampal afferents, intrinsic neurons, and efferents. We have used an autoradiographic technique to investigate the status of excitatory amino acid receptors in the hippocampal formation of patients dying with dem...

journal_title：Journal of neurochemistry

authors： Greenamyre JT,Penney JB,D'Amato CJ,Young AB

更新日期：1987-02-01 00:00:00

abstract：:Head injury was induced in rats by a weight drop device, falling over the left hemisphere. The rats were killed at 15 min, 4 h, and 24 h after injury. Cortical slices were taken from the injured zone, from the corresponding region of the contralateral hemisphere, and from the frontal lobe of both hemispheres. These co...

journal_title：Journal of neurochemistry

authors： Shohami E,Shapira Y,Yadid G,Reisfeld N,Yedgar S

更新日期：1989-11-01 00:00:00

abstract：:In invertebrates, the phenolamines, tyramine and octopamine, mediate many functional roles usually associated with the catecholamines, noradrenaline and adrenaline, in vertebrates. The α- and β-adrenergic classes of insect octopamine receptor are better activated by octopamine than tyramine. Similarly, the Tyramine 1 ...

journal_title：Journal of neurochemistry

authors： Bayliss A,Roselli G,Evans PD

更新日期：2013-04-01 00:00:00

abstract：:Alzheimer's disease is characterized neuropathologically by the presence of neuritic and amyloid plaques, vascular amyloid, and neurofibrillary tangles in specific brain areas. The main constituent of amyloid deposits is amyloid beta protein, a 40-42 amino acid proteolytic product of the amyloid beta-precursor protein...

journal_title：Journal of neurochemistry

authors： Conn KJ,Pietropaolo M,Ju ST,Abraham CR

更新日期：1996-05-01 00:00:00

abstract：:K-252b is a kinase inhibitor structurally related to K-252a, which is known to abolish selectively the effects of nerve growth factor (NGF) on PC12 cells and PNS neurons. We tested whether K-252b, K-252a, and staurosporine, another related compound, are effective and selective inhibitors of NGF actions on CNS neurons....

journal_title：Journal of neurochemistry

authors： Knüsel B,Hefti F

更新日期：1991-09-01 00:00:00

abstract：:Capsaicin receptors are expressed in primary sensory neurons and excited by heat and protons. We examined the inflammation-induced changes of the level of VR1 capsaicin receptor mRNA in sensory neurons and the sensitivity of primary afferents to capsaicin. Carrageenan treatment induced axonal transport of VR1 mRNA, bu...

journal_title：Journal of neurochemistry

authors： Tohda C,Sasaki M,Konemura T,Sasamura T,Itoh M,Kuraishi Y

更新日期：2001-03-01 00:00:00

abstract：:Synaptosomes (vesicles of nerve endings) isolated from rabbit brain were studied as a model system for the uptake of inorganic phosphate. The phosphate uptake showed a sodium-dependent, saturable component with a Kt of 0.29 mM. The sodium-dependent component was larger at pH 6 than at pH 7.4 or 8. Application of potas...

journal_title：Journal of neurochemistry

authors： Salamin A,Deshusses J,Straub RW

更新日期：1981-12-01 00:00:00

abstract：:Transcriptional responses to growth factor and G protein-coupled receptors were compared in PC12 cells using retroviral luciferase reporters. In cells stably expressing alpha(1A)-adrenergic receptors, norepinephrine activated all five reporters [AP1 (activator protein-1), SRE (serum response element), CRE (cyclic AMP ...

journal_title：Journal of neurochemistry

authors： Minneman KP,Lee D,Zhong H,Berts A,Abbott KL,Murphy TJ

更新日期：2000-06-01 00:00:00

abstract：:We demonstrated that glutamate increased the cyclic AMP level in cultured neurons from rat spinal cord. A bath application of glutamate (300 microM) elicited a rapid increase of the cyclic AMP concentration reaching a level three times as high as the basal level in approximately 3 min, and its content then decreased t...

journal_title：Journal of neurochemistry

authors： Tsuji K,Nakamura Y,Ogata T,Shibata T,Kataoka K

更新日期：1995-10-01 00:00:00

abstract：:To identify the transductional mechanisms responsible for the neuroprotective effect of nitric oxide (NO) during ischemic preconditioning (IPC), we investigated the effects of this gaseous mediator on mitochondrial Mn-superoxide dismutase (Mn-SOD) expression and activity. In addition, the possible involvement of Ras/e...

journal_title：Journal of neurochemistry

authors： Scorziello A,Santillo M,Adornetto A,Dell'aversano C,Sirabella R,Damiano S,Canzoniero LM,Renzo GF,Annunziato L

更新日期：2007-11-01 00:00:00

abstract：:P-glycoprotein (P-gp), an adenosine triphosphate (ATP)-binding cassette transporter which acts as a drug efflux pump, is highly expressed at the blood-brain barrier (BBB) where it plays an important role in brain protection. Recently, P-gp has been reported to be located in the caveolae of multidrug-resistant cells. I...

journal_title：Journal of neurochemistry

authors： Jodoin J,Demeule M,Fenart L,Cecchelli R,Farmer S,Linton KJ,Higgins CF,Béliveau R

更新日期：2003-11-01 00:00:00

abstract：:Caveolin-1 is the predominant structural protein of caveolae, a subset of (lipid) membrane rafts that compartmentalize cell signaling. Caveolin-1 binds most to G protein-coupled receptors and their signaling partners, thereby enhancing interactions among signaling cascade components and the relative activation of spec...

journal_title：Journal of neurochemistry

authors： Chakrabarti S,Chang A,Liu NJ,Gintzler AR

更新日期：2016-12-01 00:00:00

abstract：:We have demonstrated by indirect immunofluorescence the cellular localization of a monoclonal antibody (mAb 224-58), produced after immunization of a mouse with human central nervous system (CNS) myelin. Serologically, mAb 224-58 was found to be specific for 3'-sulfomonogalactosylglycolipids, namely 3'-sulfogalactosyl...

journal_title：Journal of neurochemistry

authors： Guerci A,Monge M,Baron-Van Evercooren A,Lubetzki C,Dancea S,Boutry JM,Goujet-Zalc C,Zalc B

更新日期：1986-02-01 00:00:00

abstract：:As a result of the identification, pharmacological characterization, and localization of the cannabinoid receptor in the CNS, the existence of an endogenous ligand for this receptor can be hypothesized. Following the premise that such a substance could have the properties of a neuromodulator being stored in intracellu...

journal_title：Journal of neurochemistry

authors： Evans DM,Johnson MR,Howlett AC

更新日期：1992-02-01 00:00:00

abstract：:Excessive N-methyl-D-aspartate (NMDA) signaling is thought to contribute to bipolar disorder symptoms. Lithium and carbamazepine, effective against bipolar mania, are reported in rats to reduce brain transcription of an arachidonic acid selective calcium-dependent cytosolic phospholipase A(2) (cPLA(2)), as well as exp...

journal_title：Journal of neurochemistry

authors： Rao JS,Ertley RN,Rapoport SI,Bazinet RP,Lee HJ

更新日期：2007-09-01 00:00:00

abstract：:Differential screening of a cDNA library prepared from mRNA of the hippocampus of estrogen-stimulated ovariectomized female rats led to the identification of a single estrogen-induced clone. Analysis of the sequence identified this cDNA as the gene coding for subunit III of the enzyme cytochrome c oxidase. Cytochrome ...

journal_title：Journal of neurochemistry

authors： Bettini E,Maggi A

更新日期：1992-05-01 00:00:00

abstract：:The modulation of 3,4-dihydroxyphenylethylamine (dopamine, DA) synthesis and release in rabbit retina in vitro by high K+; adenylate cyclase activators such as forskolin, 2-chloroadenosine, vasoactive intestinal polypeptide (VIP); and the putative DA autoreceptor agonist N-n-propyl-3-(3-hydroxyphenyl) piperidine (3-PP...

journal_title：Journal of neurochemistry

authors： Ofori S,Magistretti PJ,Schorderet M

更新日期：1986-10-01 00:00:00

abstract：:Glutamate receptor (GluR) δ1 is widely expressed in the developing forebrain, whereas GluRδ2 is selectively expressed in cerebellar Purkinje cells. Recently, we found that trans-synaptic interaction of postsynaptic GluRδ2 and pre-synaptic neurexins (NRXNs) through cerebellin precursor protein (Cbln) 1 mediates excitat...

journal_title：Journal of neurochemistry

authors： Yasumura M,Yoshida T,Lee SJ,Uemura T,Joo JY,Mishina M

更新日期：2012-06-01 00:00:00

abstract：:Alpha-synuclein (ASYN) is a major constituent of the typical protein aggregates observed in several neurodegenerative diseases that are collectively referred to as synucleinopathies. A causal involvement of ASYN in the initiation and progression of neurological diseases is suggested by observations indicating that sin...

journal_title：Journal of neurochemistry

authors： Schildknecht S,Gerding HR,Karreman C,Drescher M,Lashuel HA,Outeiro TF,Di Monte DA,Leist M

更新日期：2013-05-01 00:00:00

abstract：:The degradation pattern and rate of [Ile5]-Angiotensin (Ang) I, II, and III were studied in neuron-enriched and glia-enriched cells in primary cultures from rat brain. Metabolites were separated by HPLC, and their identities were evaluated by comparison of their retention times with those of synthetic Ang peptide frag...

journal_title：Journal of neurochemistry

authors： Hermann K,Phillips MI,Raizada MK

更新日期：1989-03-01 00:00:00