Regulation of multiple effectors by the cloned delta-opioid receptor: stimulation of phospholipase C and type II adenylyl cyclase.

abstract：:We have previously demonstrated hippocampal hyperglutamatergic signaling occurs prior to plaque accumulation in AβPP/PS1 mice. Here, we evaluate 2-Amino-6-(trifluoromethoxy) benzothiazole (riluzole) as an early intervention strategy for Alzheimer's disease (AD), aimed at restoring glutamate neurotransmission prior to ...

journal_title：Journal of neurochemistry

authors： Hascup KN,Findley CA,Britz J,Esperant-Hilaire N,Broderick SO,Delfino K,Tischkau S,Bartke A,Hascup ER

更新日期：2020-10-26 00:00:00

abstract：:Cathepsin D (CD) was purified to homogeneity from postmortem human cerebral cortex. Incubation of CD with human neurofilament proteins (NFPs) prepared by axonal flotation led to the rapid degradation of the 200,000, 160,000, and 70,000 NFP subunits (200K, 160K, and 70K) which had been separated by one- or two-dimensio...

journal_title：Journal of neurochemistry

authors： Nixon RA,Marotta CA

更新日期：1984-08-01 00:00:00

abstract：:The NMDA receptor/channel has been shown to be inhibited by ethanol in the clinically relevant range 25-100 mM. We studied heteromeric assemblies (NR1b/NR2) of the NMDA receptor, expressed in oocytes, to address three questions regarding this inhibition, and discovered the following: (1) The inhibition was nearly equi...

journal_title：Journal of neurochemistry

authors： Chu B,Anantharam V,Treistman SN

更新日期：1995-07-01 00:00:00

abstract：:The epitope for HNK-1 and patient's monoclonal autoantibodies in demyelinating polyneuropathy associated with immunoglobulin M gammopathy is borne by different types of N-linked oligosaccharide structures in human P0 and myelin-associated glycoprotein (MAG). Fourteen glycopeptide fractions bearing different oligosacch...

journal_title：Journal of neurochemistry

authors： Burger D,Perruisseau G,Simon M,Steck AJ

更新日期：1992-03-01 00:00:00

abstract：:Although transient receptor potential (TRP) channels expressed in the spinal substantia gelatinosa play a role in modulating nociceptive transmission, their properties have not been fully examined yet. In order to address this issue, the effects of 1,8-cineole and its stereoisomer 1,4-cineole on excitatory transmissio...

journal_title：Journal of neurochemistry

authors： Jiang CY,Wang C,Xu NX,Fujita T,Murata Y,Kumamoto E

更新日期：2016-02-01 00:00:00

abstract：:An early biochemical change in the Parkinsonian substantia nigra (SN) is reduction in total glutathione (GSH + GSSG) levels in affected dopaminergic neurons prior to depletion in mitochondrial complex I activity, dopamine loss, and cell death. We have demonstrated using dopaminergic PC12 cell lines genetically enginee...

journal_title：Journal of neurochemistry

authors： Hsu M,Srinivas B,Kumar J,Subramanian R,Andersen J

更新日期：2005-03-01 00:00:00

abstract：:Adenylate cyclase in homogenates of Drosophila melanogaster is heterogeneous with respect to its affinity toward MgATP and its subcellular distribution. Km values for MgATP range, under similar assay conditions, from approximately 10(-5) M to approximately 10(-3) M, depending on the body region and on the subcellular ...

journal_title：Journal of neurochemistry

authors： Dudai Y,Zvi S

更新日期：1985-08-01 00:00:00

abstract：:Benzodiazepines are commonly used as sedatives, sleeping aids, and anti-anxiety drugs. However, chronic treatment with benzodiazepines is known to induce dependence, which is considered related to neuroplastic changes in the mesolimbic system. This study investigated the involvement of K(+) -Cl(-) co-transporter 2 (KC...

journal_title：Journal of neurochemistry

authors： Shibasaki M,Masukawa D,Ishii K,Yamagishi Y,Mori T,Suzuki T

更新日期：2013-06-01 00:00:00

abstract：:The translocation of intravenously administered tritiated 3-O-methyl-D-glucopyranose (3-OMG) into brain has been studied in an intact nephrectomized rat preparation by infusing a series of hexoses into one internal carotid artery. 3-OMG rapidly penetrated into brain with peak concentrations, attained 5-8 min after inj...

journal_title：Journal of neurochemistry

authors： Bidder TG

更新日期：1968-08-01 00:00:00

abstract：:Calmodulin regulated spectrin-associated protein 1 (CAMSAP1) is a vertebrate microtubule-binding protein, and a representative of a family of cytoskeletal proteins that arose with animals. We reported previously that the central region of the protein, which contains no recognized functional domain, inhibited neurite o...

journal_title：Journal of neurochemistry

authors： King MD,Phillips GW,Bignone PA,Hayes NV,Pinder JC,Baines AJ

更新日期：2014-02-01 00:00:00

abstract：:beta-Amyloid peptides (Abeta40 and Abeta42) are the major constituents of amyloid plaques, which are one of the hallmarks of Alzheimer's disease (AD). The Abeta is derived from sequential cleavages of amyloid precursor protein (APP) by beta- and gamma-secretases. gamma-Secretase consists of at least four proteins wher...

journal_title：Journal of neurochemistry

authors： Lai MT,Crouthamel MC,DiMuzio J,Pietrak BL,Donoviel DB,Bernstein A,Gardell SJ,Li YM,Hazuda D

更新日期：2006-01-01 00:00:00

abstract：:Although alterations in mitochondrial dynamics are associated with cellular responses to injury, the functional role of these dynamic changes in ischemic neurons is underexplored. One of these dynamic responses to injury includes mitochondrial biogenesis. Various sublethal pre-conditioning stimuli that induce an ische...

journal_title：Journal of neurochemistry

authors： Stetler RA,Leak RK,Yin W,Zhang L,Wang S,Gao Y,Chen J

更新日期：2012-11-01 00:00:00

abstract：:The RGS proteins are a recently discovered family of G protein regulators that have been shown to act as GTPase-activating proteins (GAPs) on the G(alpha i) and G(alpha q) subfamilies of the heterotrimeric G proteins. Here, we demonstrate that RGS7 is a potent GAP in vitro on G(alpha i1), and G(alpha o) heterotrimeric...

journal_title：Journal of neurochemistry

authors： Shuey DJ,Betty M,Jones PG,Khawaja XZ,Cockett MI

更新日期：1998-05-01 00:00:00

abstract：:Gangliosides administered exogenously are well-known effectors of differentiation in many neuroblastoma lines and primary neuronal cultures. Previous studies suggested the phosphoinositide signaling mechanism could be a contributing factor. We have found that treatment of Neuro-2A cells with bovine brain ganglioside m...

journal_title：Journal of neurochemistry

authors： Vaswani KK,Wu GS,Ledeen RW

更新日期：1990-08-01 00:00:00

abstract：:A protein has been purified from human brain that appears to be the human equivalent of bovine 14-3-3 protein. On polyacrylamide gel electrophoresis the protein migrates as a faster major component, termed 14-3-3-2 protein, and a slower minor component, termed 14-3-3-1 protein, which consists of approximately 12% of t...

journal_title：Journal of neurochemistry

authors： Boston PF,Jackson P,Kynoch PA,Thompson RJ

更新日期：1982-05-01 00:00:00

abstract：:While transplanted neural stem cells (NSCs) have been shown to hold promise for cell replacement in models of a number of neurological disorders, these examples have typically been under conditions where the host cells become dysfunctional due to a cell autonomous etiology, i.e. a 'sick' cell within a relatively suppo...

journal_title：Journal of neurochemistry

authors： Taylor RM,Lee JP,Palacino JJ,Bower KA,Li J,Vanier MT,Wenger DA,Sidman RL,Snyder EY

更新日期：2006-06-01 00:00:00

abstract：:Spiroxatrine has been reported to be a 5-HT1A serotonin receptor antagonist. Therefore [3H]spiroxatrine was synthesized and its 5-HT1A receptor binding properties in homogenates of rat hippocampal membranes were characterized with the expectation that it would be the first 5-HT1A antagonist radioligand. [3H]8-Hydroxyd...

journal_title：Journal of neurochemistry

authors： Herrick-Davis K,Titeler M

更新日期：1988-02-01 00:00:00

abstract：:We have correlated myelin membrane structure with biochemical composition in the CNS and PNS of a phylogenetic series of animals, including elasmobranchs, teleosts, amphibians, and mammals. X-ray diffraction patterns were recorded from freshly dissected, unfixed tissue and used to determine the thicknesses of the liqu...

journal_title：Journal of neurochemistry

authors： Kirschner DA,Inouye H,Ganser AL,Mann V

更新日期：1989-11-01 00:00:00

abstract：:Machado-Joseph disease (MJD) is an autosomal dominant neurodegenerative disorder caused by an expansion of the polyglutamine tract near the C-terminus of the MJD-1 gene product, ataxin-3. Ataxin-3 is degraded by the proteasome. However, the precise mechanism of ataxin-3 degradation remains to be elucidated. In this st...

journal_title：Journal of neurochemistry

authors： Wang H,Jia N,Fei E,Wang Z,Liu C,Zhang T,Fan J,Wu M,Chen L,Nukina N,Zhou J,Wang G

更新日期：2007-06-01 00:00:00

abstract：:Changes in the activity of Na+,K+-ATPase and in the water, Na+, and K+ levels in the parietal cortex, hippocampus, and thalamus were investigated in rats 1, 3, 6, and 24 h following systemic kainic acid injection. An increase in Na+,K+-ATPase activity was observed in all three regions 3 h after the treatment, with a s...

journal_title：Journal of neurochemistry

authors： Sztriha L,Joó F,Dux L,Böti Z

更新日期：1987-07-01 00:00:00

abstract：:The Na(+)-glutamate cotransporters are believed to countertransport OH- and K+. Previous evidence that the velocity of glutamate uptake can exceed the acid extrusion capacity of astrocytes raised the question of whether intracellular pH can become rate limiting for glutamate uptake. Cytoplasmic buffering capacity and ...

journal_title：Journal of neurochemistry

authors： Judd MG,Nagaraja TN,Brookes N

更新日期：1996-01-01 00:00:00

abstract：:We have introduced a series of point mutations into the human opioid receptor-like (ORL1) receptor and characterized them for their ability to constitutively activate G protein-coupled receptor signalling pathways. Among the 12 mutants generated, mutation at Asn133 (N133W) gave increased basal signalling through three...

journal_title：Journal of neurochemistry

authors： Kam KW,New DC,Wong YH

更新日期：2002-12-01 00:00:00

abstract：:Neuronal differentiation requires exquisitely timed cell cycle arrest for progenitors to acquire an appropriate neuronal cell fate and is achieved by communication between soluble signals, such as growth factors and extracellular matrix molecules. Here we report that the expression of TIMP-2, a matrix metalloproteinas...

journal_title：Journal of neurochemistry

authors： Jaworski DM,Pérez-Martínez L

更新日期：2006-07-01 00:00:00

abstract：:The mechanism of attachment of acetylcholinesterase (AChE) to neuronal membranes in interneuronal synapses is poorly understood. We have isolated, sequenced, and cloned a hydrophobic protein that copurifies with AChE from human caudate nucleus and that we propose forms a part of a complex of membrane proteins attached...

journal_title：Journal of neurochemistry

authors： Navaratnam DS,Fernando FS,Priddle JD,Giles K,Clegg SM,Pappin DJ,Craig I,Smith AD

更新日期：2000-05-01 00:00:00

abstract：:A protein that binds vesamicol has been purified from a soluble fraction of the Torpedo electric organ homogenate that does not contain synaptic vesicles. The purified vesamicol-binding protein (VBP) has a molecular mass of 470 kDa composed of 30- and 24-kDa subunits. Chemical deglycosylation yielded a single, heterog...

journal_title：Journal of neurochemistry

authors： Hicks BW,Rogers GA,Parsons SM

更新日期：1991-08-01 00:00:00

abstract：:We have reported that the nuclear isoforms of Ca2+/calmodulin-dependent protein kinase II (CaM KII) are involved in the expression of the exon IV-containing brain-derived neurotrophic factor (BDNF) mRNA. We document here the cis-elements and transcription factors responsive to CaM KII in the activation of the promoter...

journal_title：Journal of neurochemistry

authors： Takeuchi Y,Miyamoto E,Fukunaga K

更新日期：2002-10-01 00:00:00

abstract：:Carboxymethylation and phosphorylation of protein phosphatase 2A (PP2A) catalytic C subunit are evolutionary conserved mechanisms that critically control PP2A holoenzyme assembly and substrate specificity. Down-regulation of PP2A methylation and PP2A enzymes containing the B alpha regulatory subunit occur in Alzheimer...

journal_title：Journal of neurochemistry

authors： Nunbhakdi-Craig V,Schuechner S,Sontag JM,Montgomery L,Pallas DC,Juno C,Mudrak I,Ogris E,Sontag E

更新日期：2007-05-01 00:00:00

abstract：:We have examined the catecholamine-sensitive adenylate cyclase in the retina of the white perch (Roccus americanus). Both dopamine and the beta-adrenergic agonist isoproterenol stimulate cyclic AMP accumulation in this retina, but serotonin, an indoleamine, and phenylephrine, an alpha-adrenergic agonist, had no effect...

journal_title：Journal of neurochemistry

authors： O'Connor P,Kropf RB,Dowling JE

更新日期：1989-09-01 00:00:00

abstract：:We previously showed that Nuclear Factor kappaB (NF-kappaB) inactivation in astrocytes leads to improved functional recovery following spinal cord injury (SCI). This correlated with reduced expression of pro-inflammatory mediators and chondroitin sulfate proteoglycans, and increased white matter preservation. Hence we...

journal_title：Journal of neurochemistry

authors： Brambilla R,Hurtado A,Persaud T,Esham K,Pearse DD,Oudega M,Bethea JR

更新日期：2009-07-01 00:00:00

abstract：:Repeated intermittent treatment with amphetamine (AMPH) induces both neurite outgrowth and enhanced AMPH-stimulated dopamine (DA) release in PC12 cells. We investigated the role of protein kinases in the induction of these AMPH-mediated events by using inhibitors of protein kinase C (PKC), mitogen activated protein ki...

journal_title：Journal of neurochemistry

authors： Park YH,Kantor L,Guptaroy B,Zhang M,Wang KK,Gnegy ME

更新日期：2003-12-01 00:00:00