Catecholamine-sensitive adenylate cyclase in the white perch (Roccus americanus) retina: evidence for beta-adrenergic and dopamine receptors linked to adenylate cyclase.

abstract：:Previous studies have demonstrated opposing roles for adenosine A1 and A2A receptors in the modulation of extracellular levels of glutamate and dopamine in the striatum. In the present study, acute systemic administration of motor-activating doses of the A2A receptor antagonist MSX-3 significantly decreased extracellu...

journal_title：Journal of neurochemistry

authors： Quarta D,Ferré S,Solinas M,You ZB,Hockemeyer J,Popoli P,Goldberg SR

更新日期：2004-03-01 00:00:00

abstract：:The behavior of a microdialysis probe in vivo is mathematically described. A diffusion-reaction model is developed that not only accounts for transport of substances through tissues and probe membranes but also accounts for transport across the microvasculature and metabolism. Time-dependent equations are presented bo...

journal_title：Journal of neurochemistry

authors： Morrison PF,Bungay PM,Hsiao JK,Ball BA,Mefford IN,Dedrick RL

更新日期：1991-07-01 00:00:00

abstract：:Increasing evidence suggests that proteasome inhibition plays a causal role in promoting the neurodegeneration and neuron death observed in multiple disorders, including Alzheimer's disease (AD) and Parkinson's disease (PD). The ability of severe and acute inhibition of proteasome function to induce neuron death and n...

journal_title：Journal of neurochemistry

authors： Ding Q,Dimayuga E,Martin S,Bruce-Keller AJ,Nukala V,Cuervo AM,Keller JN

更新日期：2003-07-01 00:00:00

abstract：:The effect of ascorbic acid on Ca2+ uptake in cultured rat astrocytes was examined in the presence of ouabain and monensin, which are considered to drive the Na(+)-Ca2+ exchanger in the reverse mode. Ascorbic acid at 0.1-1 mM inhibited Na(+)-dependent Ca2+ uptake significantly but not Na(+)-dependent glutamate uptake ...

journal_title：Journal of neurochemistry

authors： Takuma K,Matsuda T,Asano S,Baba A

更新日期：1995-04-01 00:00:00

abstract：:Presynaptic nicotinic acetylcholine receptors on striatal nerve terminals modulate the release of dopamine. We have compared the effects of a number of nicotinic agonists and antagonists on a perfused synaptosome preparation preloaded with [3H]dopamine. (-)-Nicotine, acetylcholine, and the nicotinic agonists cytisine ...

journal_title：Journal of neurochemistry

authors： Rapier C,Lunt GG,Wonnacott S

更新日期：1990-03-01 00:00:00

abstract：:Purkinje cell degeneration (pcd) was first identified in a spontaneous mouse mutant showing cerebellar ataxia. In addition to cerebellar Purkinje cells (PCs), retinal photoreceptors, mitral cells in the olfactory bulb, and a discrete subpopulation of thalamic neurons also degenerate in the mutant brains. The gene resp...

journal_title：Journal of neurochemistry

authors： Zhou L,Hossain MI,Yamazaki M,Abe M,Natsume R,Konno K,Kageyama S,Komatsu M,Watanabe M,Sakimura K,Takebayashi H

更新日期：2018-11-01 00:00:00

abstract：:It is well established that chronic nicotine treatment produces a dose-dependent increase in high-affinity L-[3H]nicotine binding. This increase may be due to chronic desensitization of the receptor. Sophisticated kinetic analyses of high-affinity nicotine binding to rat brain have demonstrated that the association ra...

journal_title：Journal of neurochemistry

authors： Bhat RV,Marks MJ,Collins AC

更新日期：1994-02-01 00:00:00

abstract：:The cellular prion protein (PrP(c)) is a glycosylphosphatidylinositol (GPI)-anchored plasma membrane protein whose conformational altered forms (PrP(sc)) are known to cause neurodegenerative diseases in mammals. In order to investigate the intracellular traffic of mammalian PrP(c) in living cells, we have generated a ...

journal_title：Journal of neurochemistry

authors： Lee KS,Magalhães AC,Zanata SM,Brentani RR,Martins VR,Prado MA

更新日期：2001-10-01 00:00:00

abstract：:In Alzheimer's disease, the neuritic or senile amyloid plaques in hippocampus and association cortex, the diffuse plaques in brain areas such as the cerebellum and sensorimotor cortex, and the amyloid deposits in the walls of pial and parenchymal blood vessels are mainly composed of amyloid beta-peptides. In the prese...

journal_title：Journal of neurochemistry

authors： Ghersi-Egea JF,Gorevic PD,Ghiso J,Frangione B,Patlak CS,Fenstermacher JD

更新日期：1996-08-01 00:00:00

abstract：:The lack of effective therapies for neurodegenerative disorders is one of the most relevant challenges of this century, considering that, as the global population ages, the incidence of these type of diseases is quickly on the rise. Among these disorders, synucleinopathies, which are characterized by the abnormal accu...

journal_title：Journal of neurochemistry

authors： Valera E,Masliah E

更新日期：2016-10-01 00:00:00

abstract：:The aggravating effect of hyperglycemia on ischemic brain injury can be mimicked in a model of in vitro ischemia (IVI) using murine hippocampal slice cultures. Using this model, we found that the damage in the CA1 region following IVI in the absence or presence of 40 mm glucose (hyperglycemia) is highly temperature de...

journal_title：Journal of neurochemistry

authors： Rytter A,Cardoso CM,Johansson P,Cronberg T,Hansson MJ,Mattiasson G,Elmér E,Wieloch T

更新日期：2005-11-01 00:00:00

abstract：:As a result of the identification, pharmacological characterization, and localization of the cannabinoid receptor in the CNS, the existence of an endogenous ligand for this receptor can be hypothesized. Following the premise that such a substance could have the properties of a neuromodulator being stored in intracellu...

journal_title：Journal of neurochemistry

authors： Evans DM,Johnson MR,Howlett AC

更新日期：1992-02-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) is a neurotrophic factor essential for maintenance of motor neurons. Loss of this factor produces a phenotype similar to amyotrophic lateral sclerosis (ALS). We recently showed that ALS-producing mutations of Cu/Zn-superoxide dismutase (SOD1) disrupt post-transcriptional regul...

journal_title：Journal of neurochemistry

authors： Li X,Lu L,Bush DJ,Zhang X,Zheng L,Suswam EA,King PH

更新日期：2009-02-01 00:00:00

abstract：:In the present study we have used perfused hippocampal slices to examine the hypothesis that nitric oxide (NO) can evoke the release of adenosine from nervous tissue. ATP stores were labeled by incubation with [3H]adenine. Electrical field stimulation at 5 Hz for 5 min evoked the release of 3H-purines, and this was en...

journal_title：Journal of neurochemistry

authors： Fallahi N,Broad RM,Jin S,Fredholm BB

更新日期：1996-07-01 00:00:00

abstract：:The inhibition of [3H]5-hydroxytryptamine [( 3H]5-HT) binding in rat brain by 1-[2-(3-bromoacetamidophenyl)ethyl]-4-(3-trifluoromethylphenyl) piperazine (BrAcTFMPP) and that by spiperone were compared. Spiperone inhibition of [3H]5-HT binding in cortex was consistent with displacement from two sites with dissociation ...

journal_title：Journal of neurochemistry

authors： Ransom RW,Asarch KB,Shih JC

更新日期：1985-03-01 00:00:00

abstract：:Brain inflammation includes microglial activation and enhanced production of diffusible chemical mediators, including prostaglandin E2. Prostaglandin E2 is generally considered a proinflammatory molecule, but it also promotes neuronal survival and down-regulates some aspects of microglial activation. It remains unknow...

journal_title：Journal of neurochemistry

authors： Caggiano AO,Kraig RP

更新日期：1998-06-01 00:00:00

abstract：:Expression of the neurotrophin-3 (NT-3) receptor (TrkC) and the effects of NT-3 on signal transduction were investigated in highly enriched populations of embryonic rat hippocampal pyramidal neurons grown in bilaminar cultures. PCR analysis revealed that the predominant trkC isoform is K1, which lacks an insert in the...

journal_title：Journal of neurochemistry

authors： Marsh HN,Palfrey HC

更新日期：1996-09-01 00:00:00

abstract：:Based on our initial finding that the nitric oxide (NO) sensitive fluorochrome diaminofluorescein (DAF) was localized to mitochondria in cultured primary neurons, we investigated whether brain mitochondria produce NO through a mitochondrial NO synthase (mtNOS) enzyme. Isolated brain mitochondria were loaded with DAF a...

journal_title：Journal of neurochemistry

authors： Lacza Z,Horn TF,Snipes JA,Zhang J,Roychowdhury S,Horváth EM,Figueroa JP,Kollai M,Szabó C,Busija DW

更新日期：2004-08-01 00:00:00

abstract：:The time course of changes in extracellular glutamic acid levels and their Ca2+ dependency were studied in the rat striatum during focal cerebral ischaemia, using microdialysis. Ischaemia-induced changes were compared with those produced by high K(+)-evoked local depolarization. To optimize time resolution, glutamate ...

journal_title：Journal of neurochemistry

authors： Wahl F,Obrenovitch TP,Hardy AM,Plotkine M,Boulu R,Symon L

更新日期：1994-09-01 00:00:00

abstract：:Adrenal chromaffin cells release neurotransmitters in response to stress and may be involved in conditions such as post-traumatic stress and anxiety disorders. Neurotransmitter release is triggered, in part, by activation of nicotinic acetylcholine receptors (nAChRs). However, despite decades of use as a model system ...

journal_title：Journal of neurochemistry

authors： Hone AJ,Rueda-Ruzafa L,Gordon TJ,Gajewiak J,Christensen S,Dyhring T,Albillos A,McIntosh JM

更新日期：2020-07-01 00:00:00

abstract：:The protein kinase v-akt murine thymoma viral oncogene homolog (AKT) gene family comprises three human homologs that phosphorylate and inactivate glycogen synthase kinase 3beta (GSK3beta). Studies have reported the genetic association of AKT1 with schizophrenia. Additionally, decreased AKT1 protein expression and the ...

journal_title：Journal of neurochemistry

authors： Ide M,Ohnishi T,Murayama M,Matsumoto I,Yamada K,Iwayama Y,Dedova I,Toyota T,Asada T,Takashima A,Yoshikawa T

更新日期：2006-10-01 00:00:00

abstract：:The thermodynamic parameters associated with the interactions of agonists and antagonists with glycine receptors in rat spinal cord membranes were determined. The binding of the antagonist [3H]strychnine and the inhibition of strychnine binding by 11 different glycinergic ligands were examined at temperatures between ...

journal_title：Journal of neurochemistry

authors： Ruiz-Gómez A,García-Calvo M,Vázquez J,Marvizón JC,Valdivieso F,Mayor F Jr

更新日期：1989-06-01 00:00:00

abstract：:NMDA (N-methyl-D-aspartate) subtype of glutamate receptors are core components of dendritic spine postsynaptic densities (PSDs), in which they are anchored via their carboxy-terminal tails to cytoskeletal proteins. In this study, we examined the role of the neuronal intermediate filament protein, neurofilament-light (...

journal_title：Journal of neurochemistry

authors： Ratnam J,Teichberg VI

更新日期：2005-02-01 00:00:00

abstract：:In a study employing mouse brain synaptosomes and synaptosomal sonicates, the complete metabolic machinery was found to be present for transport of arginine into synaptosomes, its conversion to ornithine, and the formation from the latter of glutamic acid, gamma-aminobutyric acid, and proline. The results show that a ...

journal_title：Journal of neurochemistry

authors： Johnson JL,Roberts E

更新日期：1984-04-01 00:00:00

abstract：:The L1- and F11-like axonal glycoproteins, implicated in neurite outgrowth and fasciculation, are members of the Ig superfamily comprising multiple fibronectin type III-like domains. Their Ig-like and fibronectin type III-related domains are likely to be composed of seven beta-strands arranged in two opposing beta-she...

journal_title：Journal of neurochemistry

authors： Brümmendorf T,Rathjen FG

更新日期：1993-10-01 00:00:00

abstract：:This study investigates the implication of mitochondria- and caspase-dependent pathways in the death of retinal neurones exposed to the neurosteroid pregnenolone sulfate (PS) shown to evoke apoptosis and contribute to amplification and propagation of excitotoxicity. After a brief PS challenge of intact retinas, caspas...

journal_title：Journal of neurochemistry

authors： Cascio C,Guarneri R,Russo D,De Leo G,Guarneri M,Piccoli F,Guarneri P

更新日期：2002-12-01 00:00:00

abstract：:Glutamate is the major excitatory transmitter in the vertebrate brain and its extracellular levels are tightly regulated to prevent excitotoxic effects. The Na(+)-dependent glutamate/aspartate transporter GLAST/EAAT1 is regulated in the short and in the long term by glutamate. A receptors-independent change in its mem...

journal_title：Journal of neurochemistry

authors： Rosas S,Vargas MA,López-Bayghen E,Ortega A

更新日期：2007-05-01 00:00:00

abstract：:Null mutations in progranulin (GRN) are associated with frontotemporal lobar degeneration characterized by intraneuronal accumulation of TAR DNA-binding protein-43 (TDP-43). However, the mechanism by which GRN deficiency leads to neurodegeneration remains largely unknown. In primary cortical neurons derived from Grn k...

journal_title：Journal of neurochemistry

authors： Kleinberger G,Wils H,Ponsaerts P,Joris G,Timmermans JP,Van Broeckhoven C,Kumar-Singh S

更新日期：2010-11-01 00:00:00

abstract：:Primary neuronal cultures from 8-day-old rat cerebellum were incubated in the presence of exogenously added 16 nM [gamma-32P]ATP. Phosphorylation of a 45-kDa endogenous protein was detected within 1 min and increased linearly for approximately 20 min. Unlike what was seen with [gamma-32P]ATP, in the presence of [32P]o...

journal_title：Journal of neurochemistry

authors： Volonté C,Merlo D,Ciotti MT,Calissano P

更新日期：1994-12-01 00:00:00

abstract：:The activities of the three major catecholamine-synthesizing enzymes were determined in brain tissue pellets dissected from 500-micrometers thick horizontal sections of rat lower brainstem. The rostrocaudal distributions of the three enzymatic activities were generally not parallel, suggesting differences in the respe...

journal_title：Journal of neurochemistry

authors： Chamba G,Denoroy L,Renaud B

更新日期：1982-08-01 00:00:00