Neurofilament-light increases the cell surface expression of the N-methyl-D-aspartate receptor and prevents its ubiquitination.

abstract：:The distribution of basal and of H2O2-stimulated cyclooxygenase activity in the primary fractions of rat brain homogenates and in the subfractions of crude mitochondrial fraction was studied. For comparison, the localization of H2O2-generating monoamine oxidase (MAO) as well as that of the mitochondrial marker succina...

journal_title：Journal of neurochemistry

authors： Seregi A,Serfözö P,Mergl Z

更新日期：1983-02-01 00:00:00

abstract：:Although transient receptor potential (TRP) channels expressed in the spinal substantia gelatinosa play a role in modulating nociceptive transmission, their properties have not been fully examined yet. In order to address this issue, the effects of 1,8-cineole and its stereoisomer 1,4-cineole on excitatory transmissio...

journal_title：Journal of neurochemistry

authors： Jiang CY,Wang C,Xu NX,Fujita T,Murata Y,Kumamoto E

更新日期：2016-02-01 00:00:00

abstract：:We have previously shown that Regulator of Calcineurin 1 (RCAN1) regulates multiple stages of vesicle exocytosis. However, the mechanisms by which RCAN1 affects secretory vesicle exocytosis and quantal release kinetics remain unknown. Here, we use carbon fibre amperometry to detect exocytosis from chromaffin cells and...

journal_title：Journal of neurochemistry

authors： Zanin MP,Mackenzie KD,Peiris H,Pritchard MA,Keating DJ

更新日期：2013-02-01 00:00:00

abstract：:Ammonia, amino acids (AA), and middle molecules (MM) have been implicated in the pathogenesis of experimentally induced acute hepatic coma in the pig. Hemodialysis (HD) using either a low- (Cuprophan = CU) or a high-permeability (polyacrylonitrile = AN 69) membrane has demonstrated the role of MM. Selective hemodialys...

journal_title：Journal of neurochemistry

authors： Denis J,Delorme ML,Boschat M,Nordlinger B,Opolon P

更新日期：1983-01-01 00:00:00

abstract：:We have screened a human cDNA library using an expressed sequence tag related to the BM-40/secreted protein, acidic and rich in cysteine (SPARC)/osteonectin family of proteins and isolated a novel cDNA. It encodes a protein precursor of 424 amino acids that consists of a signal peptide, a follistatin-like domain, a Ca...

journal_title：Journal of neurochemistry

authors： Vannahme C,Schübel S,Herud M,Gösling S,Hülsmann H,Paulsson M,Hartmann U,Maurer P

更新日期：1999-07-01 00:00:00

abstract：:Polyamine synthesis is induced by various extracellular signals, and it is widely held that this biochemical response participates in cell growth and differentiation. Certain of the triggers for synthesis in brain tissues also increase the breakdown of high-molecular-weight structural proteins, apparently by activatin...

journal_title：Journal of neurochemistry

authors： Najm I,Vanderklish P,Etebari A,Lynch G,Baudry M

更新日期：1991-10-01 00:00:00

abstract：:The putative neuroprotective properties of various flavonoids have long been reported. Among this class of chemicals, quercetin, a major flavone/flavonol naturally occurring in plants, deserves focused attention because of the myriad of beneficial effects observed in various in vitro and in vivo models of central nerv...

journal_title：Journal of neurochemistry

authors： Lee YJ,Bernstock JD,Nagaraja N,Ko B,Hallenbeck JM

更新日期：2016-07-01 00:00:00

abstract：:The effect of the glutamine synthetase (GS) inhibitor, methionine sulfoximine (MSO), on glutamate levels in, and glutamate release from, rat striatal tissue was examined. Tissue levels of glutamate were unchanged 24 h after an intraventricular injection of MSO, but tissue glutamine levels were decreased 50%. Calcium-d...

journal_title：Journal of neurochemistry

authors： Rothstein JD,Tabakoff B

更新日期：1984-11-01 00:00:00

abstract：:Poly A(+) messenger RNA (mRNA) was isolated from the brains of 3-week-old mice and translated in a cell-free system derived from wheat germ. Maximal stimulation of the system by brain mRNA was observed at a relatively low K+ concentration (45 mM) and low mRNA concentration (1-10 microgram/ml). The translational system...

journal_title：Journal of neurochemistry

authors： Matthees J,Campagnoni AT

更新日期：1980-10-01 00:00:00

abstract：:Cocaine- and amphetamine-regulated transcript (CART) is a peptide neurotransmitter that has been implicated in drug reward and reinforcement. CART mRNA and peptide expression are highly concentrated in several compartments of the mesolimbic reward pathway. Several lines of evidence suggest that CART peptides may contr...

journal_title：Journal of neurochemistry

authors： Salinas A,Wilde JD,Maldve RE

更新日期：2006-04-01 00:00:00

abstract：:Differential screening of a cDNA library prepared from mRNA of the hippocampus of estrogen-stimulated ovariectomized female rats led to the identification of a single estrogen-induced clone. Analysis of the sequence identified this cDNA as the gene coding for subunit III of the enzyme cytochrome c oxidase. Cytochrome ...

journal_title：Journal of neurochemistry

authors： Bettini E,Maggi A

更新日期：1992-05-01 00:00:00

abstract：:Despite considerable efforts to unravel the role of cellular prion protein (PrP(C)) in neuronal functions, the mechanisms by which PrP(C) takes part in the homeostasis of a defined neuronal phenotype remain poorly characterized. By taking advantage of a neuroectodermal cell line (1C11) endowed with the capacity to dif...

journal_title：Journal of neurochemistry

authors： Pradines E,Loubet D,Mouillet-Richard S,Manivet P,Launay JM,Kellermann O,Schneider B

更新日期：2009-08-01 00:00:00

abstract：:Leucine and beta-(+/-)-2-aminobicyclo[2.2.1]heptane-2-carboxylic acid (BCH) stimulated, in a dose-dependent manner, reductive amination of 2-oxoglutarate in rat brain synaptosomes treated with Triton X-100. The concentration dependence curves were sigmoid, with 10-15-fold stimulations at 15 mM leucine (or BCH); oxidat...

journal_title：Journal of neurochemistry

authors： Erecińska M,Nelson D

更新日期：1990-04-01 00:00:00

abstract：:OPA1, a nuclear encoded mitochondrial protein causing autosomal dominant optic atrophy, is a key player in mitochondrial fusion and cristae morphology regulation. In the present study, we have compared the OPA1 transcription and translation products of different mouse tissues. Unlike in humans, we found only two exons...

journal_title：Journal of neurochemistry

authors： Akepati VR,Müller EC,Otto A,Strauss HM,Portwich M,Alexander C

更新日期：2008-07-01 00:00:00

abstract：:The presence of the biologically uncommon D-aspartic acid (D-aspartate) in human brain white matter has been previously reported. The earlier study has now been expanded to include D/L-aspartate ratios from 67 normal brains. The data show that the D-aspartate content increases rapidly from 1 year to approximately 35 y...

journal_title：Journal of neurochemistry

authors： Man EH,Fisher GH,Payan IL,Cadilla-Perezrios R,Garcia NM,Chemburkar R,Arends G,Frey WH 2nd

更新日期：1987-02-01 00:00:00

abstract：:Nuclear factor (NF)-κB-mediated neuroinflammation is an important mechanism of intracerebral hemorrhage (ICH)-induced neurotoxicity. Silent information regulator 1 (SIRT1) plays a multi-protective effect in a variety of diseases by deacetylating and inhibiting NF-κB/p65. However, the role of SIRT1 in brain damage foll...

journal_title：Journal of neurochemistry

authors： Deng HJ,Zhou CH,Huang LT,Wen LB,Zhou ML,Wang CX

更新日期：2020-12-02 00:00:00

abstract：:Declining levels of estrogen in women result in increases in gonadotropins such as luteinizing hormone (LH) through loss of feedback inhibition. LH, like estrogen, is modulated by hormone replacement therapy. However, the role of post-menopausal gonadotropin increases on cognition has not been evaluated. Here, we demo...

journal_title：Journal of neurochemistry

authors： Bryan KJ,Mudd JC,Richardson SL,Chang J,Lee HG,Zhu X,Smith MA,Casadesus G

更新日期：2010-02-01 00:00:00

abstract：:Recent studies have suggested important roles for certain proteases and protease inhibitors in the growth and development of the CNS. In the present studies, inhibitors of urokinase or thrombin in cultured neural cells and serum-free medium from the cells were identified by screening for components that formed sodium ...

journal_title：Journal of neurochemistry

authors： Wagner SL,Lau AL,Nguyen A,Mimuro J,Loskutoff DJ,Isackson PJ,Cunningham DD

更新日期：1991-01-01 00:00:00

abstract：:Selective serotonin reuptake inhibitors (SSRIs) were designed to treat depression by increasing serotonin levels throughout the brain via inhibition of clearance from the extracellular space. Although increases in serotonin levels are observed after acute SSRI exposure, 3-6 weeks of continuous use is required for reli...

journal_title：Journal of neurochemistry

authors： Dankoski EC,Carroll S,Wightman RM

更新日期：2016-03-01 00:00:00

abstract：:Schwannoma-derived growth factor (SDGF) is a potent mitogen and neuronal differentiation factor. Because of its relationship to epidermal growth factor (EGF) and the heregulins, it was asked if SDGF interacts with the EGF receptor or HER2/neu. SDGF binds to and causes the phosphorylation on tyrosine of the EGF recepto...

journal_title：Journal of neurochemistry

authors： Maher PA,Schubert D

更新日期：1995-10-01 00:00:00

abstract：:45Ca2+ uptake measurements were performed on intact and osmotically lysed synaptosomes from rat brain to study the possible influence of prostaglandins (PGs) on Ca2+ movements into and within the nerve endings. The K+-induced 45Ca2+ uptake of intact synaptosomes was not influenced by several inhibitors of PG synthesis...

journal_title：Journal of neurochemistry

authors： Denzlinger C,Hertting G,Jackisch R

更新日期：1982-08-01 00:00:00

abstract：:A method for rapid, automated (less than 5 min), and sensitive (detection limit 50 fmol/10 microliter) determination of gamma-aminobutyric acid (GABA) is described. The method is based on precolumn derivatization with o-phthaldialdehyde/t-butylthiol reagent and separation by reverse-phase HPLC with electrochemical det...

journal_title：Journal of neurochemistry

authors： Kehr J,Ungerstedt U

更新日期：1988-10-01 00:00:00

abstract：:Neuronal differentiation requires exquisitely timed cell cycle arrest for progenitors to acquire an appropriate neuronal cell fate and is achieved by communication between soluble signals, such as growth factors and extracellular matrix molecules. Here we report that the expression of TIMP-2, a matrix metalloproteinas...

journal_title：Journal of neurochemistry

authors： Jaworski DM,Pérez-Martínez L

更新日期：2006-07-01 00:00:00

abstract：:The endocytotic uptake and intracellular decay of horseradish peroxidase isoenzymes C and A by cultured mouse neuroblastoma cells were analyzed quantitatively by a direct spectrophotometric assay. At concentrations below 1 mg/ml, the rate of uptake of the isoenzyme C was more than three times as much as the isoenzyme ...

journal_title：Journal of neurochemistry

authors： Chan KY,Haschke RH

更新日期：1981-01-01 00:00:00

abstract：:[3H]Ouabain binding was studied in sections of rabbit somatosensory cortex by quantitative autoradiography and in rabbit brain microsomal membranes using a conventional filtration assay. KD values of 8-12 nM for specific high-affinity binding of [3H]ouabain were found by both methods. High-affinity binding was not uni...

journal_title：Journal of neurochemistry

authors： Antonelli MC,Baskin DG,Garland M,Stahl WL

更新日期：1989-01-01 00:00:00

abstract：:The content, synthesis and transport of D-aspartate (D-Asp) in the CNS of Aplysia californica is investigated using capillary electrophoresis (CE) with both laser-induced fluorescence and radionuclide detection. Millimolar concentrations of D-Asp are found in various regions of the CNS. In the cerebral ganglion, three...

journal_title：Journal of neurochemistry

authors： Miao H,Rubakhin SS,Scanlan CR,Wang L,Sweedler JV

更新日期：2006-04-01 00:00:00

abstract：:Hippocampus mossy fibre terminals activate CA3 pyramidal neurons via two distinct mechanisms, both quantal and glutamatergic: (i) rapid excitatory transmission in response to afferent action potentials and (ii) delayed and prolonged release following nicotinic receptor activation. These processes were analysed here us...

journal_title：Journal of neurochemistry

authors： Bancila V,Cordeiro JM,Bloc A,Dunant Y

更新日期：2009-07-01 00:00:00

abstract：:The monoamines dopamine, norepinephrine, epinephrine, and serotonin and their major metabolites 3,4-dihydroxyphenylacetic acid, homovanillic acid, 3-methoxy-4-hydroxyphenylethylene glycol, and 5-hydroxyindoleacetic acid were measured in the CNS of the rat during development from fetal day 18 to young adult. The catech...

journal_title：Journal of neurochemistry

authors： Herregodts P,Velkeniers B,Ebinger G,Michotte Y,Vanhaelst L,Hooghe-Peters E

更新日期：1990-09-01 00:00:00

abstract：:Dopamine neurons have been suggested to use glutamate as a cotransmitter. To identify the basis of such a phenotype, we have examined the expression of the three recently identified vesicular glutamate transporters (VGLUT1-3) in postnatal rat dopamine neurons in culture. We found that the majority of isolated dopamine...

journal_title：Journal of neurochemistry

authors： Dal Bo G,St-Gelais F,Danik M,Williams S,Cotton M,Trudeau LE

更新日期：2004-03-01 00:00:00

abstract：:Fragile X syndrome (FXS) is a developmental disorder caused by the loss of Fragile X Mental Retardation 1 (FMR1) gene function because of a CGG repeat expansion (> 200 repeats) in the gene. The molecular mechanism(s) linking loss of FMR1 function to the molecular pathology and cognitive/behavioral disability remain un...

journal_title：Journal of neurochemistry

authors： Wang X,Snape M,Klann E,Stone JG,Singh A,Petersen RB,Castellani RJ,Casadesus G,Smith MA,Zhu X

更新日期：2012-05-01 00:00:00