Ethanol enhancement of cocaine- and amphetamine-regulated transcript mRNA and peptide expression in the nucleus accumbens.

abstract：:The possibility that the mechanism of lead neurotoxicity may be at the level of transcription was investigated in PC12 cells. In electrophoretic mobility gel shift assays Pb2+ was found to increase activator protein-1 complex (AP-1) DNA binding activity in PC12 cells; the increase was time- and concentration-dependent...

journal_title：Journal of neurochemistry

authors： Chakraborti T,Kim KA,Goldstein GG,Bressler JP

更新日期：1999-07-01 00:00:00

abstract：:A neurochemical evaluation of beagle dogs with naturally occurring spontaneous generalized convulsive seizures was performed. Amino acid profiles of serum, cerebrospinal fluid (CSF), and biopsied cerebral cortex from epileptic dogs were compared with those from seizure-free siblings. No differences in absolute levels ...

journal_title：Journal of neurochemistry

authors： van Gelder NM,Edmonds HL Jr,Hegreberg GA,Chatburn CC,Clemmons RM,Sylvester DM

更新日期：1980-11-01 00:00:00

abstract：:p-glycoprotein (p-gp) is an ATP-binding cassette transporter and its overexpression is responsible for the acquisition of the multidrug resistance phenotype in human tumors. p-gp is localized at the blood-brain barrier and is involved in brain cytoprotection. Our previous work used immunoprecipitation to show that cav...

journal_title：Journal of neurochemistry

authors： Barakat S,Demeule M,Pilorget A,Régina A,Gingras D,Baggetto LG,Béliveau R

更新日期：2007-04-01 00:00:00

abstract：:Calcitonin gene-related peptide-like immunoreactivity (CGRP-LI) was measured in selected regions of the cervical, thoracic, and lumbar spinal cord of untreated rabbits and, following intrathecal injection of the serotonergic neurotoxin 5,7-dihydroxytryptamine (5,7-DHT), in the thoracolumbar cord in rats using a sheep ...

journal_title：Journal of neurochemistry

authors： Fone KC

更新日期：1992-10-01 00:00:00

abstract：:Beta-carbolines have been suggested to be involved in the pathogenesis of Parkinson's disease as a result of their structural similarity to the neurotoxin N -methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). The chloral-derived beta-carboline derivative 1-trichloromethyl-1,2,3,4-tetrahydro-beta-carboline (TaClo) caus...

journal_title：Journal of neurochemistry

authors： Riederer F,Luborzewski A,God R,Bringmann G,Scholz J,Feineis D,Moser A

更新日期：2002-05-01 00:00:00

abstract：:The effect of thyroid hormones (THs) on the expression of actin gene during fetal human brain development and the period of sensitivity to the hormones have been investigated. Developmental profile of actin in the cytoskeletal (CSK) and noncytoskeletal (non-CSK) fractions in the fetal cerebra showed a pronounced rise ...

journal_title：Journal of neurochemistry

authors： Pal U,Biswas SC,Sarkar PK

更新日期：1997-09-01 00:00:00

abstract：:The cause of neuronal degeneration in Alzheimer's disease (AD) has not been completely clarified, but has been variously attributed to increases in cytosolic calcium and increased generation of reactive oxygen species (ROS). The beta-amyloid fragment (Abeta) of the amyloid precursor protein induces calcium influx, ROS...

journal_title：Journal of neurochemistry

authors： Ho PI,Collins SC,Dhitavat S,Ortiz D,Ashline D,Rogers E,Shea TB

更新日期：2001-07-01 00:00:00

abstract：:Neuronal nicotinic acetylcholine receptors are differentially sensitive to blockade by the competitive antagonist dihydro-beta-erythroidine. Both alpha and beta subunits participate in determining sensitivity to this antagonist. The alpha subunit contribution to dihydro-beta-erythroidine sensitivity is illustrated by ...

journal_title：Journal of neurochemistry

authors： Harvey SC,Maddox FN,Luetje CW

更新日期：1996-11-01 00:00:00

abstract：:The lipid compositions of 10 different brain regions from patients affected by Alzheimer's disease/senile dementia of Alzheimer's type were analyzed. The total phospholipid amount decreased somewhat in nucleus caudatus and in white matter. The cortical areas that are morphologically affected by Alzheimer's disease, i....

journal_title：Journal of neurochemistry

authors： Söderberg M,Edlund C,Alafuzoff I,Kristensson K,Dallner G

更新日期：1992-11-01 00:00:00

abstract：:Seven monoclonal antibodies (MAbs) directed to tetrasialoganglioside (GQ1b) were established, purified GQ1b being used for immunization and hybridoma screening. All of the MAbs reacted strongly with GQ1b, although they also reacted with other gangliosides, with different specificities and reactivities. Some MAbs (1H10...

journal_title：Journal of neurochemistry

authors： Yamamoto H,Tsuji S,Nagai Y

更新日期：1990-02-01 00:00:00

abstract：:Functional activation of NMDA receptors requires co-activation of glutamate- and glycine-binding sites. D-serine is considered to be an endogenous ligand for the glycine site of NMDA receptors. Using a combination of a rat formalin-induced conditioned place avoidance (F-CPA) behavioral model and whole-cell patch-clamp...

journal_title：Journal of neurochemistry

authors： Ren WH,Guo JD,Cao H,Wang H,Wang PF,Sha H,Ji RR,Zhao ZQ,Zhang YQ

更新日期：2006-03-01 00:00:00

abstract：:Oxidation of ketone bodies (KBs) generates acetyl coenzyme A (AcCoA), which can be further incorporated into fatty acid. We have determined the rates of lipogenesis from ketone bodies in developing rats and their relation to the activities of enzymes involved in the production of cytoplasmic AcCoA via different pathwa...

journal_title：Journal of neurochemistry

authors： Yeh YY,Ginsburg JR,Tso TB

更新日期：1983-01-01 00:00:00

abstract：:Spinocerebellar ataxia type-3, also known as Machado-Joseph Disease, is one of many inherited neurodegenerative disorders caused by polyglutamine-encoding CAG repeat expansions in otherwise unrelated disease genes. Polyglutamine disorders are characterized by disease protein misfolding and aggregation; often within th...

journal_title：Journal of neurochemistry

authors： Berke SJ,Schmied FA,Brunt ER,Ellerby LM,Paulson HL

更新日期：2004-05-01 00:00:00

abstract：:Hyperexcitability of the hippocampus is a commonly observed phenomenon in the years preceding a diagnosis of Alzheimer's disease (AD). Our previous work suggests a dysregulation in glutamate neurotransmission may mediate this hyperexcitability, and glutamate dysregulation correlates with cognitive deficits in the rTg(...

journal_title：Journal of neurochemistry

authors： Hunsberger HC,Weitzner DS,Rudy CC,Hickman JE,Libell EM,Speer RR,Gerhardt GA,Reed MN

更新日期：2015-10-01 00:00:00

abstract：:The time course of the reduction in brain protein synthesis following transient bilateral ischemia in the gerbil was characterized and compared with changes in a number of metabolites related to brain energy metabolism. The recovery of brain protein synthesis was similar following ischemic periods of 5, 10, or 20 min;...

journal_title：Journal of neurochemistry

authors： Nowak TS Jr,Fried RL,Lust WD,Passonneau JV

更新日期：1985-02-01 00:00:00

abstract：:Using nuclear reaction 6Li(n, alpha)3H and dielectric detectors, we have studied the distribution of Li in the brain of adult mice, following Li treatment of the animals. Two strains of animals were used in parallel: "quaking" dysmyelinating mutants and normally myelinated controls. The distribution appeared to be sha...

journal_title：Journal of neurochemistry

authors： Heurteaux C,Baumann N,Lachapelle F,Wissocq JC,Thellier M

更新日期：1986-04-01 00:00:00

abstract：:Urotensin-II (U-II), a peptide with multiple vascular effects, is detected in cholinergic neurons of the rat brainstem and spinal cord. Here, the effects of U-II on [Ca2+]i was examined in dissociated rat spinal cord neurons by fura 2 microfluorimetry. The neurons investigated were choline acetyltransferase-positive a...

journal_title：Journal of neurochemistry

authors： Filipeanu CM,Brailoiu E,Le Dun S,Dun NJ

更新日期：2002-11-01 00:00:00

abstract：:A new technology called in vivo spectrophotometry was applied to the quantitative determination of the variations in local acetylcholinesterase (AChE) activities. Repeated measurements of the enzyme activities in the same live animal allowed the study of the in vivo inhibition of AChE by amitriptyline. Interactions be...

journal_title：Journal of neurochemistry

authors： Chappey O,Testylier G,Gourmelon P,Galonnier M,Bourre JM,Fatome M,Scherrmann JM,Viret J

更新日期：1990-01-01 00:00:00

abstract：:In cerebellum, 75% of all GABAA receptors contain alpha1 subunits. Here, we investigated compensatory changes in GABAA receptor subunit expression and composition in alpha1 subunit-knockout mice. In these mice the total number of cerebellar GABAA receptors was reduced by 46%. Whereas the number of receptors containing...

journal_title：Journal of neurochemistry

authors： Ogris W,Lehner R,Fuchs K,Furtmüller B,Höger H,Homanics GE,Sieghart W

更新日期：2006-01-01 00:00:00

abstract：:A simple and rapid method for preparation of enriched neurofilament protein from mammalian peripheral nerve or spinal cord is described. Tissue extracts from guinea pig nerve or spinal cord are fractionated by ammonium sulfate fractionation, chromatography on Sepharofe 4B, and precipitation with ethanol. Molecular exc...

journal_title：Journal of neurochemistry

authors： Shecket G,Lasek RJ

更新日期：1980-12-01 00:00:00

abstract：:The kinetics of the reactions of nine opioid peptides with the neutral endopeptidase ("enkephalinase") activities of human kidney, rat kidney, and rat brain have been determined. These opioid peptides can be divided into two classes, those that are good inhibitors of Leu5-enkephalin hydrolysis (Ki less than 75 microM)...

journal_title：Journal of neurochemistry

authors： Hersh LB

更新日期：1984-08-01 00:00:00

abstract：:5-HT(3) (serotonin type 3) receptors are targets of antiemetics, antipsychotics, and antidepressants and are believed to play a role in cognition. Nevertheless, contrasting results have been obtained with respect to their functions in the CNS and in the control of transmitter release. We used rat hippocampal neurons i...

journal_title：Journal of neurochemistry

authors： Dorostkar MM,Boehm S

更新日期：2007-01-01 00:00:00

abstract：:Dopamine- and cAMP-regulated phosphoprotein (Mr 32 kDa, DARPP-32) is an integrator of multiple neuronal signals and plays a crucial role particularly in mediating the dopaminergic component of the systems involved in the evaluation of stimuli and the ensuing elaboration of complex behavioral responses (e.g., responses...

journal_title：Journal of neurochemistry

authors： Scheggi S,De Montis MG,Gambarana C

更新日期：2018-11-01 00:00:00

abstract：:Unilateral frontal cortex ablations were performed in rats so that the glutamate terminals in the ipsilateral rostral neostriatum were removed. At 1 or 7 days later, intraperitoneal injections of ammonium acetate induced different changes in amino acid concentrations in the intact and deafferentated neostriatum. After...

journal_title：Journal of neurochemistry

authors： Engelsen BA,Fosse VM,Fonnum F

更新日期：1987-03-01 00:00:00

abstract：:The characteristics of the serotonin (5-HT) output in the dorsal and median raphe nuclei of the rat were studies using in vivo microdialysis. The basal output of 5-HT increased after KCl was added to the perfusion fluid. In contrast, neither the omission of calcium ions nor the addition of 0.5 microM tetrodotoxin affe...

journal_title：Journal of neurochemistry

authors： Adell A,Carceller A,Artigas F

更新日期：1993-05-01 00:00:00

abstract：:Tau, a microtubule-associated protein, is encoded by a single gene, whose expression is primarily neuronal. In this work, we defined an 80-bp region of the tau promoter that confers tau protein with neuronal expression. This fragment works in conjunction with an endogenous initiation region to activate neuronal precur...

journal_title：Journal of neurochemistry

authors： Heicklen-Klein A,Ginzburg I

更新日期：2000-10-01 00:00:00

abstract：:Bradykinin, a mediator of inflammation, is produced in the brain during trauma and stroke. It is thought to open the blood-brain barrier, although the mechanism is unclear. We have investigated, therefore, the effect of bradykinin on the expression of interleukin-6 (IL-6), a putative modulator of the blood-brain barri...

journal_title：Journal of neurochemistry

authors： Schwaninger M,Sallmann S,Petersen N,Schneider A,Prinz S,Libermann TA,Spranger M

更新日期：1999-10-01 00:00:00

abstract：:Vesicular sequestration is important in the regulation of cytoplasmic concentrations of monoamines such as dopamine. Moreover, recent evidence suggests that increases in cytoplasmic dopamine levels, perhaps attributable to changes in vesicular monoamine transporter function, contribute to methamphetamine-induced dopam...

journal_title：Journal of neurochemistry

authors： Brown JM,Hanson GR,Fleckenstein AE

更新日期：2000-05-01 00:00:00

abstract：:Temporal carbohydrate expression patterns at cell surfaces are thought to be of crucial regulatory significance during developmental processes. Hitherto, however, data on individual membrane proteins undergoing development-associated changes in glycosylation are sparsely. Here, we show that the two natriuretic peptide...

journal_title：Journal of neurochemistry

authors： Müller D,Hildebrand M,Lübberstedt J,Kuhn M,Middendorff R

更新日期：2010-11-01 00:00:00

abstract：:The time course of Ca2+-dependent [3H]acetylcholine [( 3H]ACh) release and inactivation of 45Ca2+ entry were examined in rat brain synaptosomes depolarized by 45 mM [K+]0. Under conditions where the intrasynaptosomal stores of releasable [3H]ACh were neither exhausted nor replenished in the course of stimulation, the ...

journal_title：Journal of neurochemistry

authors： Suszkiw JB,O'Leary ME

更新日期：1983-09-01 00:00:00