In vivo brain dialysis study of the somatodendritic release of serotonin in the Raphe nuclei of the rat: effects of 8-hydroxy-2-(di-n-propylamino)tetralin.

abstract：:Regulator of G protein signaling (RGS) proteins are GTPase-activating proteins that modulate neurotransmitter and G protein signaling. RGS7 and its binding partners Galpha and Gbeta5 are enriched in brain, but biochemical mechanisms governing RGS7/Galpha/Gbeta5 interactions and membrane association are poorly defined....

journal_title：Journal of neurochemistry

authors： Rose JJ,Taylor JB,Shi J,Cockett MI,Jones PG,Hepler JR

更新日期：2000-11-01 00:00:00

abstract：:Our previous work demonstrated that immunoproteasome is up-regulated in the retina and brain in response to injury that does not involve an inflammatory response (J. Neurochem. 2008; 106:158). These results suggest additional non-immune functions for the immunoproteasome in the cellular stress response pathway. The pr...

journal_title：Journal of neurochemistry

authors： Hussong SA,Kapphahn RJ,Phillips SL,Maldonado M,Ferrington DA

更新日期：2010-06-01 00:00:00

abstract：:Alcohol abuse leads to tolerance, dependence, and memory impairments that involve excitatory glutamatergic NMDA synaptic transmission. The NMDA receptor (NMDAR) is known to undergo activity-dependent adaptive functional changes. Since we observed that acute ethanol inhibition of the NMDAR was regulated by protein tyro...

journal_title：Journal of neurochemistry

authors： Wu PH,Coultrap S,Browning MD,Proctor WR

更新日期：2010-12-01 00:00:00

abstract：:Within the cell membrane there exist various microdomains (lipid rafts) in which specific lipids and proteins are assembled and these microdomains are recovered in the detergent-resistant low-density membrane fraction (DRM). Septin is a novel GTP-binding, cytoskeletal protein having various isoforms that assemble into...

journal_title：Journal of neurochemistry

authors： Maimaitiyiming M,Kumanogoh H,Nakamura S,Nagata K,Suzaki T,Maekawa S

更新日期：2008-08-01 00:00:00

abstract：:Previous studies examining age differences in membrane fluidity and cholesterol content have reported on the average or total change in membrane structure, respectively. However, a membrane consists of an exofacial leaflet and a cytofacial leaflet that differ in fluidity and cholesterol distribution. The purpose of th...

journal_title：Journal of neurochemistry

authors： Igbavboa U,Avdulov NA,Schroeder F,Wood WG

更新日期：1996-04-01 00:00:00

abstract：:Tomosyn is a cytoplasmic protein that was shown to bind to Syntaxin1 and SNAP-25 through an R-SNARE domain, forming a complex that is almost identical in structure to the neuronal SNARE complex. Tomosyn inhibits exocytosis in various cell types and these effects were attributed to direct competition between tomosyn's ...

journal_title：Journal of neurochemistry

authors： Yizhar O,Lipstein N,Gladycheva SE,Matti U,Ernst SA,Rettig J,Stuenkel EL,Ashery U

更新日期：2007-10-01 00:00:00

abstract：:Accumulating evidence indicates that increased intracellular Na(+) concentration ([Na(+) ]i ) in astroglial cells is associated with the development of brain edema under ischemic conditions, but the underlying mechanisms are still elusive. Here, we report that in primary cultured rat cortical astrocytes, elevations of...

journal_title：Journal of neurochemistry

authors： Minieri L,Pivonkova H,Harantova L,Anderova M,Ferroni S

更新日期：2015-02-01 00:00:00

abstract：:Autoimmune optic neuritis (AON), a model of multiple sclerosis-associated optic neuritis, is accompanied by degeneration of retinal ganglion cells (RGCs) and optic nerve demyelination and axonal loss. In order to investigate the role of N-methyl-d-aspartate (NMDA) receptors in mediating RGC degeneration, upstream chan...

journal_title：Journal of neurochemistry

authors： Bojcevski J,Stojic A,Hoffmann DB,Williams SK,Müller A,Diem R,Fairless R

更新日期：2020-06-01 00:00:00

abstract：:Several mechanisms are thought to be involved in the progressive decline in neurons of the substantia nigra pars compacta (SNpc) that leads to Parkinson's disease (PD). Neurotoxin 6-hydroxydopamine (6-OHDA), which induces parkinsonian symptoms in experimental animals, is thought to be formed endogenously in patients w...

journal_title：Journal of neurochemistry

authors： Barkats M,Millecamps S,Bilang-Bleuel A,Mallet J

更新日期：2002-07-01 00:00:00

abstract：:PRMT1, a major arginine methyltransferase, plays critical roles in transcription, DNA damage response, and cell proliferation. Although we have previously discovered the crucial roles of PRMT1 for oligodendrocyte lineage progression in the central nervous system of neural stem cell-specific PRMT1 conditional knockout ...

journal_title：Journal of neurochemistry

authors： Hashimoto M,Kumabe A,Kim JD,Murata K,Sekizar S,Williams A,Lu W,Ishida J,Nakagawa T,Endo M,Minami Y,Fukamizu A

更新日期：2020-08-16 00:00:00

abstract：:We studied the formation of early endosomes in differentiating oligodendrocytes and type-2 astrocytes, which are derived from common precursor cells in rat neonates, using fluorescent analogues of lactosylceramide (LacCer) and sulfatide labeled with 4,4-difluoro-5,7-dimethyl-4-bora-3a,4a-diaza-s-indacene++ +-3-pentano...

journal_title：Journal of neurochemistry

authors： Watanabe R,Asakura K,Rodriguez M,Pagano RE

更新日期：1999-10-01 00:00:00

abstract：:Prothymosin alpha (ProTα), a nuclear protein devoid of signal sequence, has been shown to possess a number of cellular functions including cell survival. Most recently, we demonstrated that ProTα is localized in the nuclei of neurons, while it is found in both nuclei and cytoplasm in the astrocytes and microglia of ad...

journal_title：Journal of neurochemistry

authors： Halder SK,Matsunaga H,Ueda H

更新日期：2012-10-01 00:00:00

abstract：:Despite considerable efforts to unravel the role of cellular prion protein (PrP(C)) in neuronal functions, the mechanisms by which PrP(C) takes part in the homeostasis of a defined neuronal phenotype remain poorly characterized. By taking advantage of a neuroectodermal cell line (1C11) endowed with the capacity to dif...

journal_title：Journal of neurochemistry

authors： Pradines E,Loubet D,Mouillet-Richard S,Manivet P,Launay JM,Kellermann O,Schneider B

更新日期：2009-08-01 00:00:00

abstract：:We have previously shown that in cell extracts from rat striatum, cyclic AMP response element (CRE) binding protein (CREB), rather than AP-1 proteins, preferentially interacts with the CRE-2 element of the proenkephalin second messenger-inducible enhancer, even under conditions in which AP-1 proteins are highly induce...

journal_title：Journal of neurochemistry

authors： Konradi C,Cole RL,Green D,Senatus P,Leveque JC,Pollack AE,Grossbard SJ,Hyman SE

更新日期：1995-09-01 00:00:00

abstract：:One-week treatment with the benzodiazepine (BZ) flurazepam (FZP), results in anticonvulsant tolerance, associated with reduced GABAA receptor (GABAR) subunit protein and miniature inhibitory post-synaptic current (mIPSC) amplitude in CA1 neurons of rat hippocampus. Because protein kinase A (PKA) has been shown to modu...

journal_title：Journal of neurochemistry

authors： Lilly SM,Zeng XJ,Tietz EI

更新日期：2003-05-01 00:00:00

abstract：:Tau is a microtubule-associated protein that loses microtubule binding activity and aggregates into paired helical filaments (PHFs) in Alzheimer's disease. Nonenzymic glycation is one of the posttranslational modifications detected in PHF-tau, but not in normal tau. PHF-tau has reduced ability to bind to microtubules....

journal_title：Journal of neurochemistry

authors： Nacharaju P,Ko L,Yen SH

更新日期：1997-10-01 00:00:00

abstract：:Female mice are more susceptible to apolipoprotein E (apoE4)-induced cognitive deficits than male mice. These deficits can be antagonized by stimulating androgen receptors (ARs). To determine the role of AR in the cognitive effects of apoE4, we backcrossed mutant mice with a naturally occurring defect in the AR [testi...

journal_title：Journal of neurochemistry

authors： Rizk-Jackson A,Robertson J,Raber J

更新日期：2008-04-01 00:00:00

abstract：:The high concentration of gamma-aminobutyric acid (GABA) recently demonstrated in rat ovary prompted us to examine the capacity of ovarian slices to take up [3H]GABA. Active uptake, dependent on temperature and sodium concentration, was observed and a kinetic constant (Km) of 1.0 microM found for the uptake process. O...

journal_title：Journal of neurochemistry

authors： Erdö SL

更新日期：1983-02-01 00:00:00

abstract：:Synaptotagmin-7 (Syt-7) is one of two major calcium sensors for exocytosis in adrenal chromaffin cells, the other being synaptotagmin-1 (Syt-1). Despite a broad appreciation for the importance of Syt-7, questions remain as to its localization, function in mediating discharge of dense core granule cargos, and role in t...

journal_title：Journal of neurochemistry

authors： Bendahmane M,Morales A,Kreutzberger AJB,Schenk NA,Mohan R,Bakshi S,Philippe JM,Zhang S,Kiessling V,Tamm LK,Giovannucci DR,Jenkins PM,Anantharam A

更新日期：2020-09-01 00:00:00

abstract：:Extracts of skeletal muscle contain chromatographically distinct molecules that enhance the cholinergic development of cultured embryonic rat spinal cord neurons. We have recently purified a 20-22 kilodalton anionic polypeptide choline acetyltransferase (ChAT) development factor (CDF) from rat skeletal muscle extracts...

journal_title：Journal of neurochemistry

authors： McManaman J,Crawford F,Clark R,Richker J,Fuller F

更新日期：1989-12-01 00:00:00

abstract：:A miniature swine model for diffuse brain injury has recently been developed that replicates the inertial loading conditions associated with rotational acceleration during automotive accidents. The swine model induces diffuse axonal pathology without macroscopic injury such as contusions and hematomas, thus affording ...

journal_title：Journal of neurochemistry

authors： Cecil KM,Lenkinski RE,Meaney DF,McIntosh TK,Smith DH

更新日期：1998-05-01 00:00:00

abstract：:Heterozygous CB1 receptor knockout mice were used to examine the effect of reduced CB1 receptor density on G-protein activation in membranes prepared from four brain regions: cerebellum, hippocampus, striatum/globus pallidus (striatum/GP) and cingulate cortex. Results showed that CB1 receptor levels were approximately...

journal_title：Journal of neurochemistry

authors： Selley DE,Rorrer WK,Breivogel CS,Zimmer AM,Zimmer A,Martin BR,Sim-Selley LJ

更新日期：2001-05-01 00:00:00

abstract：:The present experiments assessed the effects of SR 48692, a selective nonpeptide antagonist of neurotensin receptors, on mesolimbic dopaminergic neurotransmission. Dopamine release evoked by the electrical stimulation of the median forebrain bundle (20 Hz, 10 s) was measured in the nucleus accumbens of urethane-anesth...

journal_title：Journal of neurochemistry

authors： Brun P,Steinberg R,Le Fur G,Soubrié P

更新日期：1995-05-01 00:00:00

abstract：:Human immunodeficiency virus (HIV)-1-associated neurocognitive disorders (HAND) associated with infection and activation of mononuclear phagocytes (MP) in the brain, occur late in disease. Infected/activated MP initiate neuroinflammation activating glial cells and ultimately disrupting neuronal function. Astrocytes se...

journal_title：Journal of neurochemistry

authors： Fields J,Gardner-Mercer J,Borgmann K,Clark I,Ghorpade A

更新日期：2011-07-01 00:00:00

abstract：:In adult New Zealand white rabbits, the effects of food deprivation and of massive elevations of plasma uridine or thymidine concentrations on CSF and plasma nucleoside and oxypurine concentrations were studied. Nucleoside and oxypurine levels were determined by high performance liquid chromatography using unequivocal...

journal_title：Journal of neurochemistry

authors： Eells JT,Spector R,Huntoon S

更新日期：1984-06-01 00:00:00

abstract：:The biological activities of maitotoxin are strictly dependent on the extracellular calcium concentration and are always associated with an increase of the free cytosolic calcium level. We tested the effects of voltage-sensitive calcium channel blockers (nicardipine and omega-conotoxin) on maitotoxin-induced intracell...

journal_title：Journal of neurochemistry

authors： Meucci O,Grimaldi M,Scorziello A,Govoni S,Bergamaschi S,Yasumoto T,Schettini G

更新日期：1992-08-01 00:00:00

abstract：:The natural vitamin E tocotrienols possess properties not shared by tocopherols. Nanomolar alpha-tocotrienol, not alpha-tocopherol, is potently neuroprotective. On a concentration basis, this finding represents the most potent of all biological functions exhibited by any natural vitamin E molecule. We sought to dissec...

journal_title：Journal of neurochemistry

authors： Khanna S,Roy S,Parinandi NL,Maurer M,Sen CK

更新日期：2006-09-01 00:00:00

abstract：:PCR was used to isolate identical partial cDNA clones encoding a serotonin 5-HT3 receptor subunit from rat nodose and superior cervical ganglia. The amino acid sequence predicted from these clones, extending from the putative transmembrane domain I to the stop codon, demonstrated a 93% homology with the 5-HT3 receptor...

journal_title：Journal of neurochemistry

authors： Miquel MC,Emerit MB,Gingrich JA,Nosjean A,Hamon M,el Mestikawy S

更新日期：1995-08-01 00:00:00

abstract：:To identify genes induced by transient forebrain ischemia, we used the mRNA differential display technique in the four-vessel occlusion model in rats. Some genes were identified as candidates that encode ischemia-responsive protein, and one of them was cloned as ischemia-responsive protein 94 kDa (irp94) from the rat ...

journal_title：Journal of neurochemistry

authors： Yagita Y,Kitagawa K,Taguchi A,Ohtsuki T,Kuwabara K,Mabuchi T,Matsumoto M,Yanagihara T,Hori M

更新日期：1999-04-01 00:00:00

abstract：:Ketamine is an anesthetic that exhibits analgesic, psychotomimetic, and rapid antidepressant effects that are of particular neuropharmacological interest. Recent studies revealed astrocytic Ca(2+) signaling and regulated exocytosis as ketamine-targeted processes. Thus high-resolution cell-attached membrane capacitance...

journal_title：Journal of neurochemistry

authors： Lasič E,Rituper B,Jorgačevski J,Kreft M,Stenovec M,Zorec R

更新日期：2016-09-01 00:00:00