Multiple neurotrophic factors from skeletal muscle: demonstration of effects of basic fibroblast growth factor and comparisons with the 22-kilodalton choline acetyltransferase development factor.

abstract：:Oxidative stress has been implicated in mechanisms leading to neuronal cell injury in various pathological states of the brain. Here, we investigated the effect of peroxide exposure on the expression of genes coding for cytoplasmic and endoplasmic reticulum (ER) stress proteins. Primary neuronal cell cultures were exp...

journal_title：Journal of neurochemistry

authors： Paschen W,Mengesdorf T,Althausen S,Hotop S

更新日期：2001-03-01 00:00:00

abstract：:The glial-derived neurotrophic protein S100beta has been implicated in the development and maintenance of the nervous system. S100beta has also been postulated to play a role in mechanisms of neuropathology because of its specific localization and selective overexpression in Alzheimer's disease. However, the exact rel...

journal_title：Journal of neurochemistry

authors： Hu J,Ferreira A,Van Eldik LJ

更新日期：1997-12-01 00:00:00

abstract：:Hypoxia-inducible factor (HIF)-1 is the key transcriptional activator mediating both adaptive and pathological responses to hypoxia. The purpose of this study was to find the role of HIF-1 in regulating neprilysin (NEP) at the early stage of hypoxia and explore the underlying mechanism. In this study, we demonstrated ...

journal_title：Journal of neurochemistry

authors： Wang H,Sun M,Yang H,Tian X,Tong Y,Zhou T,Zhang T,Fu Y,Guo X,Fan D,Yu A,Fan M,Wu X,Xiao W,Chui D

更新日期：2014-10-01 00:00:00

abstract：:The ontogeny of muscarinic receptors was studied in human fetal striatum, brainstem, and cerebellum to investigate general principles of synaptogenesis as well as the physiological balance between various chemical synapses during development in a given region of the brain. [3H]Quinuclidinyl benzilate ([3H]QNB) binding...

journal_title：Journal of neurochemistry

authors： Ravikumar BV,Sastry PS

更新日期：1985-12-01 00:00:00

abstract：:Phosphatidylserine (PS), which is synthesized in mammalian tissues by the exchange between free serine and the nitrogen bases present in membrane glycerophospholipids, is strictly required for protein kinase C (PKC) activity. PKC, as other molecules involved in signal transduction, is present in lipid rafts, considere...

journal_title：Journal of neurochemistry

authors： Buratta S,Felicetti M,Mozzi R

更新日期：2007-11-01 00:00:00

abstract：:Ala and Gly substitutions for Pro 101 (P101) located in transmembrane domain 2 of the dopamine transporter (DAT) abolished transport activity but did not disrupt plasma membrane expression. Due to the high conservation of P101 in all neurotransmitter transporters and the capability of Pro to add flexibility to helices...

journal_title：Journal of neurochemistry

authors： Lin Z,Uhl GR

更新日期：2005-07-01 00:00:00

abstract：:In this report we demonstrate that a defective herpes simplex virus type one (HSV-1) vector can express enzymatically active tyrosine hydroxylase in cultured striatal cells that are thereby converted into L-DOPA-producing cells. A human tyrosine hydroxylase cDNA (form II) was inserted into an HSV-1 vector (pHSVth) and...

journal_title：Journal of neurochemistry

authors： Geller AI,During MJ,Oh YJ,Freese A,O'Malley K

更新日期：1995-02-01 00:00:00

abstract：:Glutamate receptors belonging to the subclass specifically activated by alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) were solubilized from rat forebrain membranes with Triton X-100 and partially purified through a series of three chromatographic steps. Specific [3H]AMPA binding increased 30-60-fold ...

journal_title：Journal of neurochemistry

authors： Bahr BA,Vodyanoy V,Hall RA,Suppiramaniam V,Kessler M,Sumikawa K,Lynch G

更新日期：1992-11-01 00:00:00

abstract：:In the human fetus, obtained postmortem at estimated gestational ages of 8-22 weeks, biochemical activities of cortical choline acetyltransferase (ChAT) and acetylcholinesterase (AChE) were comparable to those of adult brain tissue. In contrast cholinergic receptor binding, including muscarinic M1 and M2 subtypes (mea...

journal_title：Journal of neurochemistry

authors： Perry EK,Smith CJ,Atack JR,Candy JM,Johnson M,Perry RH

更新日期：1986-10-01 00:00:00

abstract：:A miniature swine model for diffuse brain injury has recently been developed that replicates the inertial loading conditions associated with rotational acceleration during automotive accidents. The swine model induces diffuse axonal pathology without macroscopic injury such as contusions and hematomas, thus affording ...

journal_title：Journal of neurochemistry

authors： Cecil KM,Lenkinski RE,Meaney DF,McIntosh TK,Smith DH

更新日期：1998-05-01 00:00:00

abstract：:A decline in the calcium-dependent release of neurotransmitters appears to underlie the decreased neuronal function that accompanies reduced oxygen tensions (hypoxia). To determine if alterations in calcium uptake are primary to these changes, synaptosomal calcium uptake was measured in the presence of 100%, 2.5%, or ...

journal_title：Journal of neurochemistry

authors： Peterson C,Gibson GE

更新日期：1984-01-01 00:00:00

abstract：:The contribution of neuromelanin (NM) to the pathogenesis of Parkinson's disease (PD) has long been suspected. In particular, a correlation has been reported between the estimated cell loss in the mesencephalic dopaminergic cell groups and the percentage of NM-pigmented neurons in these cell groups. To test whether th...

journal_title：Journal of neurochemistry

authors： Kastner A,Hirsch EC,Lejeune O,Javoy-Agid F,Rascol O,Agid Y

更新日期：1992-09-01 00:00:00

abstract：:Substantial amounts of phospholipase A2 activity were detected in bovine brain cytosol. The major phospholipase A2 activity was present in the precipitate at 40% saturation with solid ammonium sulfate. After the desaltate of the precipitate was loaded onto an Ultrogel AcA 54 gel filtration column, almost all the activ...

journal_title：Journal of neurochemistry

authors： Hirashima Y,Farooqui AA,Mills JS,Horrocks LA

更新日期：1992-08-01 00:00:00

abstract：:5-Hydroxytryptamine (5-HT) receptors contain seven putative transmembrane domains and couple via different guanine nucleotide binding proteins to specific effector enzymes. Studies with other receptors identify the second and third intracellular loops or the C-terminus of the receptor as important for selective effect...

journal_title：Journal of neurochemistry

authors： Oksenberg D,Havlik S,Peroutka SJ,Ashkenazi A

更新日期：1995-04-01 00:00:00

abstract：:The binding of [125I]beta h-endorphin to rat brain membranes was investigated in the presence of GTP and guanylyl-5'-imidodiphosphate. In contrast to the binding of the mu-selective opioid agonist, [3H][D-Ala2,MePhe4,Glyol5]enkephalin, and the delta-selective opioid agonist, [3H][D-penicillamine2, D-penicillamine5]enk...

journal_title：Journal of neurochemistry

authors： Selley DE,Tyler CB,Bidlack JM

更新日期：1988-06-01 00:00:00

abstract：:We applied our in vivo fatty acid method to examine concentrations, incorporation, and turnover rates of docosahexaenoic acid (22:6 n-3) in brains of rats subject to a dietary deficiency of alpha-linolenic acid (18:3 n-3) for three generations. Adult deficient and adequate rats of the F3 generation were infused intrav...

journal_title：Journal of neurochemistry

authors： Contreras MA,Greiner RS,Chang MC,Myers CS,Salem N Jr,Rapoport SI

更新日期：2000-12-01 00:00:00

abstract：:Calsenilin/DREAM/KChIP3 was identified as a calcium-binding protein that interacts with presenilins, serves as a transcription repressor, and binds to the A-type potassium channel. In this study, we hypothesized that calsenilin might be involved in the neurodegeneration of Alzheimer's disease and examined calsenilin e...

journal_title：Journal of neurochemistry

authors： Jo DG,Lee JY,Hong YM,Song S,Mook-Jung I,Koh JY,Jung YK

更新日期：2004-02-01 00:00:00

abstract：:Progressive supranuclear palsy (PSP) is a neurodegenerative movement disorder of unknown etiology. We hypothesized that mitochondrial DNA (mtDNA) aberration could occur in this disease and contribute to its pathogenesis. To address this we created transmitochondrial cytoplasmic hybrid (cybrid) cell lines expressing mi...

journal_title：Journal of neurochemistry

authors： Swerdlow RH,Golbe LI,Parks JK,Cassarino DS,Binder DR,Grawey AE,Litvan I,Bennett JP Jr,Wooten GF,Parker WD

更新日期：2000-10-01 00:00:00

abstract：:The mechanism(s) underlying neurodegeneration-associated activation of ERK1/2 remain poorly understood. We report that in cultured rat cortical neurons, whose basal ERK1/2 phosphorylation required NMDA receptors (NMDAR), the neurotoxic DNA intercalating drug cisplatin increased ERK1/2 phosphorylation via NMDAR despite...

journal_title：Journal of neurochemistry

authors： Gozdz A,Vashishta A,Kalita K,Szatmari E,Zheng JJ,Tamiya S,Delamere NA,Hetman M

更新日期：2008-09-01 00:00:00

abstract：:The myelin transcription factor 1 (Myt1) gene family is comprised of three zinc finger genes [Myt1, Myt1L (Myt1-Like) and NZF3] of the structurally unique CCHHC class that are expressed predominantly in the developing CNS. To understand the mechanism by which this family regulates neural differentiation, we searched f...

journal_title：Journal of neurochemistry

authors： Romm E,Nielsen JA,Kim JG,Hudson LD

更新日期：2005-06-01 00:00:00

abstract：:The relationships between presynaptic acetylcholinesterase (AChE) and high-affinity choline uptake (HACU) were investigated using a monolayer of rat cortex synaptosomes in superfusion conditions. The following sets of experiments were performed: determination of [3H]choline ([3H]Ch) uptake during superfusion with [3H]...

journal_title：Journal of neurochemistry

authors： Raiteri M,Marchi M,Caviglia AM

更新日期：1986-12-01 00:00:00

abstract：:The origin of afferent somatostatin-containing fibers terminating in medial and ventral parts of the striatum has been investigated by performing various neurochemical and surgical lesions in the rat. Lesions of the anterior hypothalamus, amygdala, and the hippocampal commissure as well as lesions with 6-hydroxydopami...

journal_title：Journal of neurochemistry

authors： Widmann R,Mensdorff-Pouilly N,Pfaller K,Sperk G

更新日期：1987-06-01 00:00:00

abstract：:Phosphodiesterase (PDE) 7B, a cAMP-specific PDE which is dominantly expressed in striatum, is expected to be involved in dopaminergic signaling in striatal neurons. Here we show, for the first time, the involvement of the dopaminergic signaling pathway in transcriptional activation of rat PDE7B in primary striatal cul...

journal_title：Journal of neurochemistry

authors： Sasaki T,Kotera J,Omori K

更新日期：2004-04-01 00:00:00

abstract：:GABA(A) receptors are the major inhibitory neurotransmitter receptors in the brain. Some of them are targets of benzodiazepines that are widely used in clinical practice for their sedative/hypnotic, anxiolytic, muscle relaxant and anticonvulsant effects. In order to rationally separate these different drug actions, we...

journal_title：Journal of neurochemistry

authors： Tan KR,Baur R,Charon S,Goeldner M,Sigel E

更新日期：2009-12-01 00:00:00

abstract：:Environment-induced relapse is a major concern in drug addiction because of the strong associations formed between drug reward and environment. Cocaine-conditioned place preference is an ideal experimental tool to examine adaptations in the molecular pathways that are activated upon re-exposure to an environment previ...

journal_title：Journal of neurochemistry

authors： Tropea TF,Kosofsky BE,Rajadhyaksha AM

更新日期：2008-08-01 00:00:00

abstract：:Oligodendroglial cell death in the myelin proteolipid protein (PLP) mutants can be partially rescued by the environment factor(s) supplied by the wild-type cells in vivo and in vitro. It is possible that the presence of PLP or DM-20 results in secretion of a factor or factors in the CNS influencing oligodendrocyte dev...

journal_title：Journal of neurochemistry

authors： Nakao J,Yamada M,Kagawa T,Kim SU,Miyao Y,Shimizu K,Mikoshiba K,Ikenaka K

更新日期：1995-06-01 00:00:00

abstract：:To investigate the role of the neuronal growth-associated protein GAP-43 (neuromodulin, B-50, F1, P-57) in neurotransmitter release, we transfected PC12 cells with a recombinant expression vector coding for antisense human GAP-43 cRNA. Two stable transfectants, designated AS1 and AS2, were selected that had integrated...

journal_title：Journal of neurochemistry

authors： Ivins KJ,Neve KA,Feller DJ,Fidel SA,Neve RL

更新日期：1993-02-01 00:00:00

abstract：:Mouse monoclonal B-50 antibodies (Mabs) were screened to select a Mab that may interfere with suggested functions of B-50 (GAP-43), such as involvement in neurotransmitter release. Because the Mab NM2 reacted with peptide fragments of rat B-50 containing the unique protein kinase C (PKC) phosphorylation site at serine...

journal_title：Journal of neurochemistry

authors： Oestreicher AB,Hens JJ,Marquart A,Mercken M,De Graan PN,Zwiers H,Gipsen WH

更新日期：1994-03-01 00:00:00

abstract：:In rats rendered hyperthyroid by chronic treatment with L-triiodothyronine (T3) hormone there was a 21 and 27% decrease, respectively, in the number of binding sites for [3H]flunitrazepam ([3H]FNZ) and [3H]ethyl-beta-carboline-3-carboxylate ([3H]beta-CCE) without changes in affinity for the two ligands. Two weeks afte...

journal_title：Journal of neurochemistry

authors： Medina JH,De Robertis E

更新日期：1985-05-01 00:00:00

abstract：:Transient exposure to ethanol (EtOH) results in a massive neurodegeneration in the developing brain leading to behavioral and cognitive deficits observed in fetal alcohol syndrome. There is now compelling evidence that K+ channels play an important role in the control of programmed cell death. The aim of the present w...

journal_title：Journal of neurochemistry

authors： Lefebvre T,Gonzalez BJ,Vaudry D,Desrues L,Falluel-Morel A,Aubert N,Fournier A,Tonon MC,Vaudry H,Castel H

更新日期：2009-08-01 00:00:00