Paradoxical effect of ethanol on potassium channel currents and cell survival in cerebellar granule neurons.

abstract：:Although transient receptor potential (TRP) channels expressed in the spinal substantia gelatinosa play a role in modulating nociceptive transmission, their properties have not been fully examined yet. In order to address this issue, the effects of 1,8-cineole and its stereoisomer 1,4-cineole on excitatory transmissio...

journal_title：Journal of neurochemistry

authors： Jiang CY,Wang C,Xu NX,Fujita T,Murata Y,Kumamoto E

更新日期：2016-02-01 00:00:00

abstract：:Cultures of myelinated SJL/J fetal mouse spinal cord were incubated with serum and lymphoid cells from syngeneic animals with experimental allergic encephalomyelitis (EAE) induced by syngeneic spinal cord homogenate (SSCH) in complete Freund's adjuvant or others injected with complete Freund's adjuvant alone. After 24...

journal_title：Journal of neurochemistry

authors： Roth GA,Bornstein MB,Röyttä M,Lyman WD,Raine CS

更新日期：1985-02-01 00:00:00

abstract：:Using tritium-labelled 4,5,6,7-tetrahydroisoxazolo[4,5-c]pyridin-3-ol (THPO) its tissue distribution and metabolism were investigated in adult mice and 4-day-old chicks after systemic administration of the drug. It was found not to be significantly metabolized in the brain since metabolites of THPO corresponding to on...

journal_title：Journal of neurochemistry

authors： Schousboe A,Hjeds H,Engler J,Krogsgaard-Larsen P,Wood JD

更新日期：1986-09-01 00:00:00

abstract：:The olfactory bulb (OB) contains the highest concentration of the insulin receptor (IR) kinase in the central nervous system; however, its functional role and modulation in this region remains poorly understood. IR kinase contains a number of proline-rich motifs, making it an excellent candidate for modulation by SH(3...

journal_title：Journal of neurochemistry

authors： Marks DR,Fadool DA

更新日期：2007-11-01 00:00:00

abstract：:At 0 degrees C, when Na+ was the only cation present in the incubation medium, increasing the Na+ concentration from 3 to 10 mM enhanced the affinity of [3H]1-[2-(++di-phenylmethoxy)ethyl]-4-(3-phenyl-2-propenyl)piperaz ine [( 3H]GBR 12783) for the specific binding site present in rat striatal membranes without affect...

journal_title：Journal of neurochemistry

authors： Bonnet JJ,Benmansour S,Vaugeois JM,Costentin J

更新日期：1988-03-01 00:00:00

abstract：:Taurine is the abundant sulfur-containing beta-amino acid in brain where it exerts a neuroprotective effect. Although it is known that the blood-brain barrier (BBB) mediates taurine transport, the regulation of taurine transport have not been clarified yet. A conditionally immortalized rat brain capillary endothelial ...

journal_title：Journal of neurochemistry

authors： Kang YS,Ohtsuki S,Takanaga H,Tomi M,Hosoya K,Terasaki T

更新日期：2002-12-01 00:00:00

abstract：:We have examined the binding of the adenosine agonist radioligands [3N]N6-cyclohexyladenosine ([3H]CHA) and [3H]5'-N-ethylcarboxamidoadenosine ([3H]NECA) to membranes prepared from postmortem human pineal glands. The results showed that the A-1-specific ligand CHA did not bind to membranes. By contrast, [3H]NECA, a no...

journal_title：Journal of neurochemistry

authors： Reynaud D,Gharib A,Lagarde M,Sarda N

更新日期：1990-10-01 00:00:00

abstract：:Glycerol phosphate dehydrogenase (GPDH), glucose-6-phosphate dehydrogenase (G6PDH), and lactate dehydrogenase (LDH) activities were determined in oligodendrocytes, neurons, and astrocytes isolated from the brains of developing rats. The activity of each enzyme was significantly lower in both neurons and astrocytes tha...

journal_title：Journal of neurochemistry

authors： Cammer W,Snyder DS,Zimmerman TR Jr,Farooq M,Norton WT

更新日期：1982-02-01 00:00:00

abstract：:Brain-derived neurotrophic factor (BDNF) which is primarily associated with neuronal survivability, differentiation and synaptic plasticity has been reported to mediate neurodegeneration in hypoxia through its p75 Neurotrophin receptors (p75NTR). The molecular events promoting BDNF-mediated pro-death signalling in hyp...

journal_title：Journal of neurochemistry

authors： Sharma D,Barhwal KK,Biswal SN,Srivastava AK,Bhardwaj P,Kumar A,Chaurasia OP,Hota SK

更新日期：2019-01-01 00:00:00

abstract：:Agonist activation of the delta-opioid receptor leads to internalization via G betagamma recruitment of G protein coupled receptor kinase-2, which phosphorylates the receptor at several sites, including Ser363, allowing beta-arrestin binding and localization to clathrin coated pits. Using human embryonic kidney cells ...

journal_title：Journal of neurochemistry

authors： Bradbury FA,Zelnik JC,Traynor JR

更新日期：2009-06-01 00:00:00

abstract：:Highly purified human serum cholinesterase (EC 3.1.1.8, also known as pseudocholinesterase and butyrylcholinesterase) had peptidase activity toward substance P. Digestion of substance P was monitored by high performance liquid chromatography, which separated three product peptides. The cleavages occurred sequentially....

journal_title：Journal of neurochemistry

authors： Lockridge O

更新日期：1982-07-01 00:00:00

abstract：:rho(1) GABA(C) receptor antagonists inhibit myopia in chick but the site of this effect is not known. The sclera ultimately determines the shape and size of the globe and thus an untested possibility is that GABA agents have a scleral mechanism. Whether rho(1) GABA(C) receptors are expressed and located in chick scler...

journal_title：Journal of neurochemistry

authors： Cheng ZY,Chebib M,Schmid KL

更新日期：2011-07-01 00:00:00

abstract：:The circadian rhythm of methionine S-adenosyltransferase, which catalyzes the formation of S-adenosylmethionine, a cosubstrate for melatonin in the pineal gland, follows the pattern of hydroxyindole-O-methyltransferase. Around the middle of the dark period, methionine S-adenosyltransferase and hydroxyindole-O-methyltr...

journal_title：Journal of neurochemistry

authors： Guchhait RB,Monjan AA

更新日期：1981-06-01 00:00:00

abstract：:Traumatic spinal cord injury has recently been shown to cause a rapid increase in free fatty acids (FFAs) and lipid degradation in cats. The present studies report a more delayed, time-dependent increase in FFAs and a concomitant decrease in phospholipids following traumatic spinal injury in rats. The largest percenta...

journal_title：Journal of neurochemistry

authors： Faden AI,Chan PH,Longar S

更新日期：1987-06-01 00:00:00

abstract：:Autoimmune optic neuritis (AON), a model of multiple sclerosis-associated optic neuritis, is accompanied by degeneration of retinal ganglion cells (RGCs) and optic nerve demyelination and axonal loss. In order to investigate the role of N-methyl-d-aspartate (NMDA) receptors in mediating RGC degeneration, upstream chan...

journal_title：Journal of neurochemistry

authors： Bojcevski J,Stojic A,Hoffmann DB,Williams SK,Müller A,Diem R,Fairless R

更新日期：2020-06-01 00:00:00

abstract：:Real-time alterations in intracellular Ca2+ ([Ca2+]i) were monitored in fluo-3-loaded cerebellar granule neurons (CGNs) exposed to the brevetoxin PbTx-1. [Ca2+]i was measured using a fluorescent plate reader (FLIPR), which measures simultaneously the mean intracellular Ca2+ change in a population of cultured cells in ...

journal_title：Journal of neurochemistry

authors： Berman FW,Murray TF

更新日期：2000-04-01 00:00:00

abstract：:Recombinant baculoviral vectors efficiently transduce several types of cells in the brain. To characterize host responses to virus challenge, thus verifying the suitability of using baculovirus for the development of gene therapy strategies in the central nervous system, we used cDNA microarray technology to examine i...

journal_title：Journal of neurochemistry

authors： Boulaire J,Zhao Y,Wang S

更新日期：2009-06-01 00:00:00

abstract：:Extracellular adenosine in the brain, which modulates various physiological and pathological processes, fluctuates in a complicated manner that reflects the circadian cycle, neuronal activity, metabolism, and disease states. The dynamics of extracellular adenosine in the brain are not fully understood, largely because...

journal_title：Journal of neurochemistry

authors： Yamashiro K,Fujii Y,Maekawa S,Morita M

更新日期：2017-01-01 00:00:00

abstract：:Unilateral ligation of the left common carotid artery in anesthetized Mongolian gerbils resulted in a steep rise in extracellular dopamine in the ipsilateral striatum in 9 out of 19 animals. Extracellular dopamine was measured by cerebral dialysis in vivo and reached a peak of 0.19 mM at 40 min. At the same time, the ...

journal_title：Journal of neurochemistry

authors： Slivka A,Brannan TS,Weinberger J,Knott PJ,Cohen G

更新日期：1988-06-01 00:00:00

abstract：:Amino acid neurotransmitters in the nucleus tractus solitarius (NTS) are thought to play a key role in the mediation of visceral reflexes and glutamate has been proposed as the neurotransmitter of visceral afferent nerves projecting to this region. The present studies sought to characterize the use of in vivo microdia...

journal_title：Journal of neurochemistry

authors： Sved AF,Curtis JT

更新日期：1993-12-01 00:00:00

abstract：:The effectiveness of intranasal drug administration to stimulate central neuronal systems is well known from drug addiction and has also been considered as an alternative pharmacokinetic approach to treat brain disorders such as Parkinson's disease. In the present study, the possible neurochemical effects of intranasa...

journal_title：Journal of neurochemistry

authors： De Souza Silva MA,Mattern C,Häcker R,Nogueira PJ,Huston JP,Schwarting RK

更新日期：1997-01-01 00:00:00

abstract：:Choline acetyltransferase (ChAT), the enzyme synthesizing acetylcholine, is known to be activated by brain derived neurotrophic factor (BDNF). We found that the specific removal of the carbohydrate polysialic acid (PSA) significantly increased BDNF-induced ChAT-activity in embryonic septal neurons. Using a p75 neurotr...

journal_title：Journal of neurochemistry

authors： Burgess A,Aubert I

更新日期：2006-11-01 00:00:00

abstract：:The presence of gamma-hydroxybutyric acid (GHB) in synaptosome-enriched fractions of rat brain was ascertained using a GLC technique. The stability of GHB in synaptosomes was evaluated by addition of various gamma-aminobutyric acid (GABA) transaminase (GABA-T) inhibitors, GHB, or ethosuximide to the homogenizing mediu...

journal_title：Journal of neurochemistry

authors： Snead OC 3rd

更新日期：1987-01-01 00:00:00

abstract：:A rat kidney epithelial cell line expressing the rat neurokinin-1 receptor (NK-1 R) was used to investigate the relationship between receptor phosphorylation and desensitization. Substance P (SP) maximally stimulated cellular inositol 1,4,5-trisphosphate (IP3) production 14-fold within 3 s, after which cellular IP3 le...

journal_title：Journal of neurochemistry

authors： Vigna SR

更新日期：1999-11-01 00:00:00

abstract：:The polypeptide composition and glycosylation of soluble isoforms of neural cell adhesion molecule (NCAM) in developing rat brain, CSF, and plasma were characterized. Soluble NCAM in rat brain consisted of several glycosylated isoforms. The degree of glycosylation was developmentally regulated. After desialylation, fo...

journal_title：Journal of neurochemistry

authors： Krog L,Olsen M,Dalseg AM,Roth J,Bock E

更新日期：1992-09-01 00:00:00

abstract：:The subcellular distribution of peptide histidine isoleucine amide (PHI)-27-like peptides (PLP) was investigated in rat cerebral cortex and whole rat brain in comparison with the distribution of vasoactive intestinal peptide (VIP). The highest content of PLP was found in the crude mitochondrial fraction (P2) and was a...

journal_title：Journal of neurochemistry

authors： Korchak DM,Gysling K,Beinfeld MC

更新日期：1985-01-01 00:00:00

abstract：:Properties so far studied of the 125-kDa 14C-arginylated protein from rat brain show remarkable similarities with those of the STOP (stable tubule only polypeptide) protein. On sodium dodecyl sulfate-polyacrylamide gel electrophoresis the 125-kDa 14C-arginylated protein moves to the same position as the STOP protein. ...

journal_title：Journal of neurochemistry

authors： Bongiovanni G,Barra HS,Hallak ME

更新日期：1994-12-01 00:00:00

abstract：:The intracerebroventricular injection of pyridoxal phosphate (PLP, 0.125-1.25 mumol/rat) causes epileptic seizures (4 min leads to 1 min) that are preventable or reversible by GABA (1 mumol/rat), by muscimol (0.025 mumol/rat), or by diazepam (1.75 mumol/rat). At the peak of PLP-induced convulsions, the activities of G...

journal_title：Journal of neurochemistry

authors： Kouyoumdjian JC,Ebadi M

更新日期：1981-01-01 00:00:00

abstract：:Adenosine transport by rat and guinea pig synaptosomes was studied to establish the basis for the marked differences in the potency of some transport inhibitors in these species. An analysis of transport kinetics in the presence and absence of nitrobenzylthioinosine (NBTI) using synaptosomes derived from several areas...

journal_title：Journal of neurochemistry

authors： Shank RP,Baldy WJ

更新日期：1990-08-01 00:00:00

abstract：:The rat glial cell line B49 releases into its culture medium a potent neurotrophic factor that exhibits relative specificity for the dopaminergic neurons in dissociated cultures of rat embryonic midbrain. This factor is a heparin-binding, basic protein that is heterogeneously glycosylated and migrates on sodium dodecy...

journal_title：Journal of neurochemistry

authors： Lin LF,Zhang TJ,Collins F,Armes LG

更新日期：1994-08-01 00:00:00