Some common properties between a brain protein that is modified by posttranslational arginylation and the microtubule-associated STOP protein.

abstract：:Both acidosis and oxidative stress contribute to ischemic brain injury. The present study examines interactions between acidosis and oxidative stress in murine cortical cultures. Acidosis (pH 6.2) was found to potentiate markedly neuronal death induced by H2O2 exposure. To determine if this effect was mediated by decr...

journal_title：Journal of neurochemistry

authors： Ying W,Han SK,Miller JW,Swanson RA

更新日期：1999-10-01 00:00:00

abstract：:Hairy/Enhancer of split (Hes) 6 is a basic helix-loop-helix protein that interacts with the transcriptional co-repressor, Groucho, and antagonizes the neural functions of the Notch pathway. More specifically, mouse Hes6 regulates cerebral corticogenesis by promoting neurogenesis and suppressing astrocyte differentiati...

journal_title：Journal of neurochemistry

authors： Belanger-Jasmin S,Llamosas E,Tang Y,Joachim K,Osiceanu AM,Jhas S,Stifani S

更新日期：2007-12-01 00:00:00

abstract：:Neuronal survival after ischemic injury is determined through the induction of several biological pathways. We examined whether lubeluzole, an agent efficacious in both clinical and experimental models of cerebral ischemia, modulated the signal transduction mechanisms of nitric oxide (NO), a downstream mediator of ano...

journal_title：Journal of neurochemistry

authors： Maiese K,TenBroeke M,Kue I

更新日期：1997-02-01 00:00:00

abstract：:The p75 neurotrophin receptor (p75NTR) is a low-affinity receptor that is capable of binding neurotrophins. Two different p75NTR knockout mouse lines are available either with a deletion in Exon III (p75NTRExIII-/- ) or in Exon IV (p75NTRExIV-/- ). In p75NTRExIII knockout mice, only the full-length p75NTR is deleted, ...

journal_title：Journal of neurochemistry

authors： Busch R,Baldus M,Vogt MA,Berger SM,Bartsch D,Gass P,von Bohlen Und Halbach O

更新日期：2017-05-01 00:00:00

abstract：:We examined the effects of wild-type and mutant atlastin-1 on vesicle transport in the endoplasmic reticulum (ER)-Golgi interface and vesicle budding from ER-derived microsomes using the temperature-sensitive reporter vesicular stomatitis virus glycoprotein (VSV-G), and the ability of purified atlastin-1 to form tubul...

journal_title：Journal of neurochemistry

authors： Muriel MP,Dauphin A,Namekawa M,Gervais A,Brice A,Ruberg M

更新日期：2009-09-01 00:00:00

abstract：:The accumulation of choline, homocholine, and 4-hydroxybutyltrimethylammonium by rat brain synaptosomes was measured; the choline uptake mechanism transported homocholine but not hydroxybutyltrimethylammonium, which, in addition, did not block choline accumulation. In cats' superior cervical ganglia, preganglionic ner...

journal_title：Journal of neurochemistry

authors： Collier B

更新日期：1981-03-01 00:00:00

abstract：:Pituitary adenylate cyclase-activating polypeptide (PACAP) gene expression was analyzed in PC12 cells. PC12 cells transfected with a PACAP promoter-luciferase reporter construct were utilized to investigate the effects of PACAP, either alone or in combination with nerve growth factor (NGF), on PACAP transcriptional re...

journal_title：Journal of neurochemistry

authors： Hashimoto H,Hagihara N,Koga K,Yamamoto K,Shintani N,Tomimoto S,Mori W,Koyama Y,Matsuda T,Baba A

更新日期：2000-02-01 00:00:00

abstract：:We have previously demonstrated hippocampal hyperglutamatergic signaling occurs prior to plaque accumulation in AβPP/PS1 mice. Here, we evaluate 2-Amino-6-(trifluoromethoxy) benzothiazole (riluzole) as an early intervention strategy for Alzheimer's disease (AD), aimed at restoring glutamate neurotransmission prior to ...

journal_title：Journal of neurochemistry

authors： Hascup KN,Findley CA,Britz J,Esperant-Hilaire N,Broderick SO,Delfino K,Tischkau S,Bartke A,Hascup ER

更新日期：2020-10-26 00:00:00

abstract：:Autoimmune optic neuritis (AON), a model of multiple sclerosis-associated optic neuritis, is accompanied by degeneration of retinal ganglion cells (RGCs) and optic nerve demyelination and axonal loss. In order to investigate the role of N-methyl-d-aspartate (NMDA) receptors in mediating RGC degeneration, upstream chan...

journal_title：Journal of neurochemistry

authors： Bojcevski J,Stojic A,Hoffmann DB,Williams SK,Müller A,Diem R,Fairless R

更新日期：2020-06-01 00:00:00

abstract：:Circulating microRNAs (miRNAs) have emerged as diagnostic and prognostic biomarkers for traumatic brain injury (TBI). However, a comprehensive characterization of the serum miRNA profile in patients with TBI and the roles of these potential markers in neuronal regulation have rarely been reported. In this study, the l...

journal_title：Journal of neurochemistry

authors： Yan J,Bu X,Li Z,Wu J,Wang C,Li D,Song J,Wang J

更新日期：2019-07-01 00:00:00

abstract：:High-affinity binding sites (apparent KD = 1.5 nM) for [3H]desipramine have been demonstrated and characterized in membranes prepared from rat brain. The binding of [3H]desipramine was found to be saturable, reversible, heat-sensitive, sodium-dependent, and regionally distributed among various regions of the brain. Hi...

journal_title：Journal of neurochemistry

authors： Rehavi M,Skolnick P,Brownstein MJ,Paul SM

更新日期：1982-04-01 00:00:00

abstract：:The natural vitamin E tocotrienols possess properties not shared by tocopherols. Nanomolar alpha-tocotrienol, not alpha-tocopherol, is potently neuroprotective. On a concentration basis, this finding represents the most potent of all biological functions exhibited by any natural vitamin E molecule. We sought to dissec...

journal_title：Journal of neurochemistry

authors： Khanna S,Roy S,Parinandi NL,Maurer M,Sen CK

更新日期：2006-09-01 00:00:00

abstract：:Protein aggregation is a common feature of several neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration. How protein aggregates are formed and contribute to neurodegeneration, however, is not clear. Mutation of Ubiquilin 2 (UBQLN2) has recently been linked to ...

journal_title：Journal of neurochemistry

authors： Xia Y,Yan LH,Huang B,Liu M,Liu X,Huang C

更新日期：2014-04-01 00:00:00

abstract：:Quinolinic acid is an excitatory, neurotoxic tryptophan metabolite proposed to play a role in the pathogenesis of hepatic encephalopathy. This involvement was investigated in rat and rabbit models of fulminant hepatic failure at different stages of hepatic encephalopathy. Although plasma and brain tryptophan levels we...

journal_title：Journal of neurochemistry

authors： Basile AS,Saito K,Li Y,Heyes MP

更新日期：1995-06-01 00:00:00

abstract：:Accumulation of misfolded proteins and alterations in the ubiquitin-proteasome pathway are associated with various neurodegenerative conditions of the CNS and PNS. Aggregates containing ubiquitin and peripheral myelin protein 22 (PMP22) have been observed in the Trembler J mouse model of Charcot-Marie-Tooth disease ty...

journal_title：Journal of neurochemistry

authors： Fortun J,Li J,Go J,Fenstermaker A,Fletcher BS,Notterpek L

更新日期：2005-03-01 00:00:00

abstract：:Trichloroethylene, a chlorinated solvent widely used as a degreasing agent, is a common environmental contaminant. Emerging evidence suggests that chronic exposure to trichloroethylene may contribute to the development of Parkinson's disease. The purpose of this study was to determine if selective loss of nigrostriata...

journal_title：Journal of neurochemistry

authors： Liu M,Choi DY,Hunter RL,Pandya JD,Cass WA,Sullivan PG,Kim HC,Gash DM,Bing G

更新日期：2010-02-01 00:00:00

abstract：:The in vitro and ex vivo effects of lithium on muscarinic cholinergic inositol phospholipid hydrolysis and muscarinic cholinergic inhibition of dopamine D1-receptor-stimulated cyclic AMP formation were examined in rat brain slices. Following chronic lithium feeding, carbachol-stimulated inositol phosphate accumulation...

journal_title：Journal of neurochemistry

authors： Whitworth P,Kendall DA

更新日期：1989-08-01 00:00:00

abstract：:Frontotemporal lobar degeneration (FTLD) is the second leading cause of dementia in individuals under age 65. In many patients, the predominant pathology includes neuronal cytoplasmic or intranuclear inclusions of ubiquitinated TAR DNA binding protein 43 (FTLD-TDP). Recently, a genome-wide association study identified...

journal_title：Journal of neurochemistry

authors： Nicholson AM,Finch NA,Wojtas A,Baker MC,Perkerson RB 3rd,Castanedes-Casey M,Rousseau L,Benussi L,Binetti G,Ghidoni R,Hsiung GY,Mackenzie IR,Finger E,Boeve BF,Ertekin-Taner N,Graff-Radford NR,Dickson DW,Rademakers R

更新日期：2013-09-01 00:00:00

abstract：:Recently, we described estrogen and agonists of the G-protein coupled estrogen receptor GPR30 to induce protein kinase C (PKC)ε-dependent pain sensitization. PKCε phosphorylates the ion channel transient receptor potential, vanilloid subclass I (TRPV1) close to a novel microtubule-TRPV1 binding site. We now modeled th...

journal_title：Journal of neurochemistry

authors： Goswami C,Kuhn J,Dina OA,Fernández-Ballester G,Levine JD,Ferrer-Montiel A,Hucho T

更新日期：2011-06-01 00:00:00

abstract：:Intracerebroventricular injection of lipopolysaccharide (LPS) induces a marked increase in circulating interleukin (IL)-6 levels and in IL-6 mRNA expression in brain and peripheral organs. Recently, it was reported that intraperitoneal administration of alpha-adrenoceptor antagonists inhibits centrally injected LPS-in...

journal_title：Journal of neurochemistry

authors： Song DK,Im YB,Jung JS,Suh HW,Huh SO,Park SW,Wie MB,Kim YH

更新日期：1999-04-01 00:00:00

abstract：:Treatment with phorbol esters such as 12-O-tetradecanoylphorbol acetate (TPA) rapidly enhances [3H]norepinephrine secretion from digitonin-permeabilized adrenal chromaffin cells. When TPA treatment was prolonged for several hours, a second distinct enhancing effect was observed. This later enhancement was most promine...

journal_title：Journal of neurochemistry

authors： Bittner MA,Holz RW

更新日期：1990-01-01 00:00:00

abstract：:Tissue plasminogen activator (tPA) administration beyond 4.5 h of stroke symptoms is beneficial for patients but has an increased risk of cerebral hemorrhage. Thus, increasing the therapeutic window of tPA is important for stroke recovery. We previously showed that prothymosin alpha (ProTα) or its mimetic hexapeptide ...

journal_title：Journal of neurochemistry

authors： Halder SK,Matsunaga H,Ueda H

更新日期：2020-06-01 00:00:00

abstract：:To assess the importance of the cysteine residues Cys347 and Cys351 in the carboxylic tail in the human D1 dopamine receptor, seven mutant receptors were constructed by PCR. The pharmacological and functional properties of the wild-type and mutant receptors were assessed following transient expression in COS-7 cells. ...

journal_title：Journal of neurochemistry

authors： Jensen AA,Pedersen UB,Kiemer A,Din N,Andersen PH

更新日期：1995-09-01 00:00:00

abstract：:Intraperitoneal injection of the cyclic imine 1-piperideine in mice resulted in measurable quantities of 5-aminopentanoic acid in brain. 5-Aminopentanoic acid is a methylene homologue of gamma-aminobutyric acid (GABA) that is a weak GABA agonist. 5-Aminopentanoic acid formed in the periphery was ruled out as the sourc...

journal_title：Journal of neurochemistry

authors： Callery PS,Geelhaar LA

更新日期：1985-09-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a severe neurodegenerative disorder characterized pathologically by motor neuron degeneration and associated with aggregation of RNA-binding proteins. TATA-binding protein-associated factor 15 (TAF15) accumulates as cytoplasmic aggregates in neuronal cells, and clearance of these...

journal_title：Journal of neurochemistry

authors： Choi HJ,Joo Cha S,Do HA,Kim HJ,Lee JW,Kim K

更新日期：2020-09-11 00:00:00

abstract：:In the present study we have applied a brain microdialysis technique to investigate the effects of ouabain infusion on the release of dopamine, acetylcholine, and amino acids from striatal neurons in freely moving rats. Ouabain caused an increase in the dialysate levels of dopamine; its metabolite 3,4-dihydroxyphenyla...

journal_title：Journal of neurochemistry

authors： Westerink BH,Damsma G,de Vries JB

更新日期：1989-03-01 00:00:00

abstract：:Synaptic scaffolding molecule (S-SCAM) is a synaptic protein that consists of PDZ domains, a guanylate kinase domain, and WW domains. It interacts with N-methyl-d-aspartate receptor subunits, neuroligin, and beta-catenin. Here, we identified Axin as a novel binding partner of S-SCAM. Axin was co-immunoprecipitated wit...

journal_title：Journal of neurochemistry

authors： Hirabayashi S,Nishimura W,Iida J,Kansaku A,Kishida S,Kikuchi A,Tanaka N,Hata Y

更新日期：2004-07-01 00:00:00

abstract：:Amyloid-β peptide (Aβ) concentration in CSF is potentially a diagnostic and therapeutic target for Alzheimer's disease (AD). The purpose of this study was to clarify the elimination mechanism of human Aβ(1-40) [hAβ (1-40)] from CSF. After intracerebroventricular (ICV) administration, [(125) I]hAβ(1-40) was eliminated ...

journal_title：Journal of neurochemistry

authors： Fujiyoshi M,Tachikawa M,Ohtsuki S,Ito S,Uchida Y,Akanuma S,Kamiie J,Hashimoto T,Hosoya K,Iwatsubo T,Terasaki T

更新日期：2011-08-01 00:00:00

abstract：:Three fractions (one soluble and two membrane-bound) of choline acetyltransferase (ChAT) isolated from a nerve ending fraction of mouse forebrain, which have previously been reported to differ in several biochemical and physical aspects, were also found to differ in their rates of postnatal development. At 2 days of a...

journal_title：Journal of neurochemistry

authors： Benishin CG,Carroll PT

更新日期：1984-09-01 00:00:00

abstract：:Somatodendritic voltage-dependent K(+) currents (Kv4.2) channels mediate transient A-type K(+) currents and play critical roles in controlling neuronal excitability. Accumulating evidence has indicated that Kv4.2 channels are key regulatory components of the signaling pathways that lead to synaptic plasticity. In cont...

journal_title：Journal of neurochemistry

authors： Lei Z,Deng P,Xu ZC

更新日期：2008-07-01 00:00:00