Neuroprotection of lubeluzole is mediated through the signal transduction pathways of nitric oxide.

abstract：:Activation of the apoptogenic sphingomyelin-dependent signaling pathway in neuronally differentiated PC12 cells with cell-permeant C2-ceramide resulted in a transient and short-lived emission of reactive oxygen species that was maximal 6 h after the beginning of treatment, followed immediately by nuclear translocation...

journal_title：Journal of neurochemistry

authors： France-Lanord V,Brugg B,Michel PP,Agid Y,Ruberg M

更新日期：1997-10-01 00:00:00

abstract：:NNC 01-0012, a second-generation benzazepine compound, pharmacologically differentiates multiple vertebrate D1 receptor subtypes (D1A, D1B, D1C, and D1D) and displays high selectivity and affinity for dopamine D1C receptors. Functionally, whereas NNC 01-0012 acts as a full or poor antagonist at D1C and D1A receptor-me...

journal_title：Journal of neurochemistry

authors： Sugamori KS,Scheideler MA,Vernier P,Niznik HB

更新日期：1998-12-01 00:00:00

abstract：:The degradation pattern and rate of [Ile5]-Angiotensin (Ang) I, II, and III were studied in neuron-enriched and glia-enriched cells in primary cultures from rat brain. Metabolites were separated by HPLC, and their identities were evaluated by comparison of their retention times with those of synthetic Ang peptide frag...

journal_title：Journal of neurochemistry

authors： Hermann K,Phillips MI,Raizada MK

更新日期：1989-03-01 00:00:00

abstract：:Unilateral frontal cortex ablations were performed in rats so that the glutamate terminals in the ipsilateral rostral neostriatum were removed. At 1 or 7 days later, intraperitoneal injections of ammonium acetate induced different changes in amino acid concentrations in the intact and deafferentated neostriatum. After...

journal_title：Journal of neurochemistry

authors： Engelsen BA,Fosse VM,Fonnum F

更新日期：1987-03-01 00:00:00

abstract：:Ten-minute incubation with 1 mM S-nitroso-L-cysteine (NO-CYS), a nitric oxide (NO) generator, induced a 3.5-fold increase in the basal dopamine (DA) efflux from rat striatal slices. Reduced hemoglobin (100 microM), a NO scavenger, blocked this response. Nomifensine (10 microM), an inhibitor of high-affinity DA transpo...

journal_title：Journal of neurochemistry

authors： Lonart G,Johnson KM

更新日期：1994-12-01 00:00:00

abstract：:Three major subtypes of glutamate receptors that are coupled to cation channels--N-methyl-D-aspartate (NMDA), kainate, and alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) receptors--are known as ionotropic receptors in the mammalian CNS. Recently, an additional subtype that is coupled to GTP binding protei...

journal_title：Journal of neurochemistry

authors： Itano Y,Murayama T,Kitamura Y,Nomura Y

更新日期：1992-09-01 00:00:00

abstract：:The glial-derived neurotrophic protein S100beta has been implicated in the development and maintenance of the nervous system. S100beta has also been postulated to play a role in mechanisms of neuropathology because of its specific localization and selective overexpression in Alzheimer's disease. However, the exact rel...

journal_title：Journal of neurochemistry

authors： Hu J,Ferreira A,Van Eldik LJ

更新日期：1997-12-01 00:00:00

abstract：:Activation of integrin receptors in neurons can promote cell survival and synaptic plasticity, but the underlying signal transduction pathway(s) is unknown. We report that integrin signaling prevents apoptosis of embryonic hippocampal neurons by a mechanism involving integrin-linked kinase (ILK) that activates Akt kin...

journal_title：Journal of neurochemistry

authors： Gary DS,Milhavet O,Camandola S,Mattson MP

更新日期：2003-02-01 00:00:00

abstract：:We compared the characteristics of secretion stimulated by EGTA-buffered Ba(2+)- and Ca(2+)-containing solutions in digitonin-permeabilized bovine adrenal chromaffin cells. Half-maximal secretion occurred at approximately 100 microM Ba2+ or 1 microM Ca2+. Ba(2+)-stimulated release was not due to release of sequestered...

journal_title：Journal of neurochemistry

authors： TerBush DR,Holz RW

更新日期：1992-02-01 00:00:00

abstract：:The rat ATP P2X4 receptor was expressed in Xenopus laevis oocytes to assess the effect of zinc and copper as possible regulators of purinergic mechanisms. ATP applied for 20 s evoked an inward cationic current with a median effective concentration (EC50) of 21.4+/-2.8 microM and a Hill coefficient (nH) of 1.5+/-0.1. C...

journal_title：Journal of neurochemistry

authors： Acuña-Castillo C,Morales B,Huidobro-Toro JP

更新日期：2000-04-01 00:00:00

abstract：:The major component of the amyloid deposition that characterizes Alzheimer's disease is the 4-kDa beta A4 protein, which is derived from a much larger amyloid protein precursor (APP). A procedure for the complete purification of APP from human brain is described. The same amino terminal sequence of APP was found in tw...

journal_title：Journal of neurochemistry

authors： Moir RD,Martins RN,Bush AI,Small DH,Milward EA,Rumble BA,Multhaup G,Beyreuther K,Masters CL

更新日期：1992-10-01 00:00:00

abstract：:Serotonin N-acetyltransferase, an enzyme of the pineal gland, converts serotonin to N-acetylserotonin. The activity of this enzyme is induced by norepinephrine in the evening to reach high levels during the dark phase. Delta-sleep-inducing peptide, a humoral sleep factor, also seems to affect circadian rhythms. Intrav...

journal_title：Journal of neurochemistry

authors： Graf MV,Kastin AJ,Schoenenberger GA

更新日期：1985-02-01 00:00:00

abstract：:Major depressive disorder is a severe and chronic illness with high lifetime prevalence and a high incidence of suicide as the cause of death for patients with this diagnosis. Major depressive disorder is often treated with anti-depressants. Although these drugs have been used for many years, their exact mode of actio...

journal_title：Journal of neurochemistry

authors： Gulbins E,Walter S,Becker KA,Halmer R,Liu Y,Reichel M,Edwards MJ,Müller CP,Fassbender K,Kornhuber J

更新日期：2015-07-01 00:00:00

abstract：:A new protein kinase modulated by S-100 (tentatively referred to as protein kinase X) was partially purified from pig brain extracts. The activity of protein kinase X, which was independent of Ca2+, was demonstrated when protamine (free base), but not protamine sulfate and other proteins (including histone), was used ...

journal_title：Journal of neurochemistry

authors： Qi DF,Turner RS,Kuo JF

更新日期：1984-02-01 00:00:00

abstract：:Purkinje cell degeneration (pcd) was first identified in a spontaneous mouse mutant showing cerebellar ataxia. In addition to cerebellar Purkinje cells (PCs), retinal photoreceptors, mitral cells in the olfactory bulb, and a discrete subpopulation of thalamic neurons also degenerate in the mutant brains. The gene resp...

journal_title：Journal of neurochemistry

authors： Zhou L,Hossain MI,Yamazaki M,Abe M,Natsume R,Konno K,Kageyama S,Komatsu M,Watanabe M,Sakimura K,Takebayashi H

更新日期：2018-11-01 00:00:00

abstract：:Primary astrocyte cultures from neonatal rat brains show uptake of [3H]norepinephrine ([3H]NE). This uptake has a high-affinity component with an apparent Km of approximately 3 X 10(-7) M. At 10(-7) M [3H]NE both the initial rate of uptake and steady-state content of [3H]NE is inhibited by up to 95% by omission of ext...

journal_title：Journal of neurochemistry

authors： Kimelberg HK,Pelton EW 2nd

更新日期：1983-05-01 00:00:00

abstract：:A neurochemical evaluation of beagle dogs with naturally occurring spontaneous generalized convulsive seizures was performed. Amino acid profiles of serum, cerebrospinal fluid (CSF), and biopsied cerebral cortex from epileptic dogs were compared with those from seizure-free siblings. No differences in absolute levels ...

journal_title：Journal of neurochemistry

authors： van Gelder NM,Edmonds HL Jr,Hegreberg GA,Chatburn CC,Clemmons RM,Sylvester DM

更新日期：1980-11-01 00:00:00

abstract：:Five subtypes of the muscarinic receptor have been cloned from both the rat and human genomes. Although all five genes have the coding sequences in a single exon, their structures 5' of the initiation codon are largely uncharacterized, except for the M4 receptor. In the brain, muscarinic receptors mediate motor and me...

journal_title：Journal of neurochemistry

authors： Klett CP,Bonner TI

更新日期：1999-03-01 00:00:00

abstract：:5-Hydroxytryptamine (5-HT) specifically and reversibly inhibits nicotine-induced currents and catecholamine release in bovine adrenal chromaffin cells in culture. Pharmacological analysis indicates that the inhibition is not mediated by known 5-HT receptor subtypes. The inhibition is noncompetitive over a range of nic...

journal_title：Journal of neurochemistry

authors： Vijayaraghavan S,Schmid HA,Mapp KS

更新日期：1993-07-01 00:00:00

abstract：:Transcriptional dysregulation is a hallmark of Huntington's disease (HD) and one cause of this dysregulation is enhanced activity of the REST-mSIN3a-mSIN3b-CoREST-HDAC repressor complex, which silences transcription through REST binding to the RE1/NRSE silencer. Normally, huntingtin (HTT) prevents this binding, allowi...

journal_title：Journal of neurochemistry

authors： Conforti P,Zuccato C,Gaudenzi G,Ieraci A,Camnasio S,Buckley NJ,Mutti C,Cotelli F,Contini A,Cattaneo E

更新日期：2013-10-01 00:00:00

abstract：:The question of developmental relationships amongst myelin-related membranes in subfractions of myelinating mouse brain (15 days) was investigated by a time-staggered double isotope protocol using [3H]leucine and [14C]leucine. Preliminary results are interpreted and discussed in the context of a mathematical conceptua...

journal_title：Journal of neurochemistry

authors： Pereyra PM,Braun PE,Greenfield S,Hogan EL

更新日期：1983-10-01 00:00:00

abstract：:It is well-known that the extracellular concentration of calcium affects neuronal excitability and synaptic transmission. Less is known about the physiological concentration of extracellular calcium in the brain. In electrophysiological brain slice experiments, the artificial cerebrospinal fluid traditionally contains...

journal_title：Journal of neurochemistry

authors： Forsberg M,Seth H,Björefeldt A,Lyckenvik T,Andersson M,Wasling P,Zetterberg H,Hanse E

更新日期：2019-05-01 00:00:00

abstract：:The metabolism of L-tryptophan to the neuroactive kynurenine pathway metabolites, L-kynurenine, kynurenate and quinolinate, and the effects of two inhibitors of quinolinate synthesis (6-chlorotryptophan and 4-chloro-3-hydroxyanthranilate) were investigated by mass spectrometric assays in cultured cells and in vivo. Ce...

journal_title：Journal of neurochemistry

authors： Naritsin DB,Saito K,Markey SP,Chen CY,Heyes MP

更新日期：1995-11-01 00:00:00

abstract：:Our previous observations have shown that neuroactive steroid levels in the brain are affected by acute experimental autoimmune encephalomyelitis (EAE) with sex and regional specificity (Giatti et al. 2010). To better understand the effect of EAE on neuroactive steroids, we have here assessed the levels of pregnenolon...

journal_title：Journal of neurochemistry

authors： Caruso D,D'Intino G,Giatti S,Maschi O,Pesaresi M,Calabrese D,Garcia-Segura LM,Calza L,Melcangi RC

更新日期：2010-08-01 00:00:00

abstract：:Neuronal nicotinic acetylcholine receptors labelled with tritiated agonists are reduced in the cerebral cortex in Alzheimer's disease (AD), but to date it has not been demonstrated which nicotinic receptor subunits contribute to this deficit. In the present study, autopsy tissue from the temporal cortex of 14 AD cases...

journal_title：Journal of neurochemistry

authors： Martin-Ruiz CM,Court JA,Molnar E,Lee M,Gotti C,Mamalaki A,Tsouloufis T,Tzartos S,Ballard C,Perry RH,Perry EK

更新日期：1999-10-01 00:00:00

abstract：:The spontaneously hypertensive rat (SHR) is widely used as a model of attention-deficit/hyperactivity disorder (ADHD). Deficits in central nicotinic receptors (nAChRs) have been previously observed in SHRs, which is interesting since epidemiological studies have identified an association between smoking and ADHD sympt...

journal_title：Journal of neurochemistry

authors： Wigestrand MB,Mineur YS,Heath CJ,Fonnum F,Picciotto MR,Walaas SI

更新日期：2011-10-01 00:00:00

abstract：:Rats fasted overnight were allowed to consume single meals containing 0, 18, or 40% protein or continued to fast; after 2 h, brains and sera were taken and assayed for various amino acids. In general, serum levels of most amino acids were reduced by the 0% protein meal and elevated by the high-protein meal when compar...

journal_title：Journal of neurochemistry

authors： Glaeser BS,Maher TJ,Wurtman RJ

更新日期：1983-10-01 00:00:00

abstract：:Taurine is the abundant sulfur-containing beta-amino acid in brain where it exerts a neuroprotective effect. Although it is known that the blood-brain barrier (BBB) mediates taurine transport, the regulation of taurine transport have not been clarified yet. A conditionally immortalized rat brain capillary endothelial ...

journal_title：Journal of neurochemistry

authors： Kang YS,Ohtsuki S,Takanaga H,Tomi M,Hosoya K,Terasaki T

更新日期：2002-12-01 00:00:00

abstract：:(R)-[3H]Tomoxetine is a radioligand that binds to the norepinephrine (NE) uptake site with high affinity but also binds to a second, lower-affinity site. The goal of the present study was to identify the nature of this low-affinity site by comparing the binding properties of (R)-[3H]tomoxetine with those of (R/S)-[3H]...

journal_title：Journal of neurochemistry

authors： Gehlert DR,Schober DA,Gackenheimer SL

更新日期：1995-06-01 00:00:00

abstract：:During development, neurons extend axons toward their appropriate synaptic targets to establish functional neuronal connections. The growth cone, a highly motile structure at the tip of the axon, is capable of recognizing extracellular guidance cues and translating them into directed axon outgrowth through modulation ...

journal_title：Journal of neurochemistry

authors： Duquette PM,Lamarche-Vane N

更新日期：2020-02-01 00:00:00