Pathogenic mutation of UBQLN2 impairs its interaction with UBXD8 and disrupts endoplasmic reticulum-associated protein degradation.

abstract：:Beta-amyloid peptides (A beta) are deposited in an aggregated fibrillar form in both diffuse and senile plaques in the brains of patients with Alzheimer's disease. The neurotoxicity of A beta in cultured neurons is dependent on its aggregation state, but the factors contributing to aggregation and fibril formation are...

journal_title：Journal of neurochemistry

authors： Du Y,Bales KR,Dodel RC,Liu X,Glinn MA,Horn JW,Little SP,Paul SM

更新日期：1998-03-01 00:00:00

abstract：:Head injury was induced in rats by a weight drop device, falling over the left hemisphere. The rats were killed at 15 min, 4 h, and 24 h after injury. Cortical slices were taken from the injured zone, from the corresponding region of the contralateral hemisphere, and from the frontal lobe of both hemispheres. These co...

journal_title：Journal of neurochemistry

authors： Shohami E,Shapira Y,Yadid G,Reisfeld N,Yedgar S

更新日期：1989-11-01 00:00:00

abstract：:(R)-[(N-propargyl-(3R) aminoindan-5-yl) ethyl methyl carbamate] (TV3326) is a novel cholinesterase and brain-selective monoamine oxidase (MAO)-A/-B inhibitor. It was developed for the treatment of dementia co-morbid with extra pyramidal disorders (parkinsonism), and depression. On chronic treatment in mice it attenuat...

journal_title：Journal of neurochemistry

authors： Sagi Y,Weinstock M,Youdim MB

更新日期：2003-07-01 00:00:00

abstract：:Proteolytic processing and phosphorylation of amyloid precursor protein (APP), and hyperphosphorylation of tau protein, have been shown to be increased in Alzheimer's disease (AD) brains, leading to increased production of beta-amyloid (Abeta) peptides and neurofibrillary tangles, respectively. These observations sugg...

journal_title：Journal of neurochemistry

authors： Butterfield DA,Abdul HM,Opii W,Newman SF,Joshi G,Ansari MA,Sultana R

更新日期：2006-09-01 00:00:00

abstract：:G-protein coupled receptors may mediate their effects on neuronal growth and differentiation through activation of extracellular signal-regulated kinases 1/2 (ERK1/2), often elicited by transactivation of growth factor receptor tyrosine kinases. This elaborate signaling process includes inducible formation and traffic...

journal_title：Journal of neurochemistry

authors： Asimaki O,Leondaritis G,Lois G,Sakellaridis N,Mangoura D

更新日期：2011-03-01 00:00:00

abstract：:The binding of the potent adenosine uptake inhibitor [3H]nitrobenzylthioinosine ([3H]NBI) to brain membrane fractions was investigated. Reversible, saturable, specific, high-affinity binding was demonstrated in both rat and human brain. The KD in both was 0.15 nM with Bmax values of 140-200 fmol/mg protein. Linear Sca...

journal_title：Journal of neurochemistry

authors： Marangos PJ,Patel J,Clark-Rosenberg R,Martino AM

更新日期：1982-07-01 00:00:00

abstract：:It is now clearly established that the brain has the capability of synthesizing various biologically active steroids including 17-hydroxypregnenolone (17OH-Delta(5)P), 17-hydroxyprogesterone (17OH-P), dehydroepiandrosterone (DHEA) and androstenedione (Delta(4)). However, the presence, distribution and activity of cyto...

journal_title：Journal of neurochemistry

authors： Do Rego JL,Tremblay Y,Luu-The V,Repetto E,Castel H,Vallarino M,Bélanger A,Pelletier G,Vaudry H

更新日期：2007-01-01 00:00:00

abstract：:Ligand binding to the cannabinoid receptor of brain membranes has been characterized using [3H]CP 55,940 and the Multiscreen Filtration System. Binding of [3H]CP 55,940 is saturable and reaches equilibrium by 45 min at room temperature. At a concentration of 10 micrograms of membrane protein/well, the KD for [3H]CP 55...

journal_title：Journal of neurochemistry

authors： Hillard CJ,Edgemond WS,Campbell WB

更新日期：1995-02-01 00:00:00

abstract：:Potassium-induced depolarization of synaptoneurosomes prepared from rat telencephalon was found to increase [3H]amino-3-hydroxy-5-methylisoxazole-4-propionate ([3H]AMPA) binding to the AMPA receptor. The effect required the presence of calcium because it was blocked by the calcium chelator EGTA but was not blocked by ...

journal_title：Journal of neurochemistry

authors： Bernard J,Massicotte G,Baudry M

更新日期：1992-01-01 00:00:00

abstract：:Most biological effects of tissue plasminogen activator (tPA), such as fibrinolysis, are mediated by its protease activity. Recent studies, however, have demonstrated that tPA also has several protease-independent effects such as: neuroprotection, microglial activation, and promoting LTP formation. In order to gain a ...

journal_title：Journal of neurochemistry

authors： Lee HY,Hwang IY,Im H,Koh JY,Kim YH

更新日期：2007-06-01 00:00:00

abstract：:Phosphatidylserine (PS), which is synthesized in mammalian tissues by the exchange between free serine and the nitrogen bases present in membrane glycerophospholipids, is strictly required for protein kinase C (PKC) activity. PKC, as other molecules involved in signal transduction, is present in lipid rafts, considere...

journal_title：Journal of neurochemistry

authors： Buratta S,Felicetti M,Mozzi R

更新日期：2007-11-01 00:00:00

abstract：:Aminoguanidine inhibits the development of retinopathy in diabetic animals, but the mechanism remains unclear. Inasmuch as aminoguanidine is a relatively selective inhibitor of the inducible isoform of nitric oxide synthase (iNOS), we have investigated the effects of hyperglycemia on the retinal nitric oxide (NO) path...

journal_title：Journal of neurochemistry

authors： Du Y,Smith MA,Miller CM,Kern TS

更新日期：2002-03-01 00:00:00

abstract：:These studies were undertaken to test the hypothesis that alterations in phosphatidylinositol metabolism can modulate neurotransmitter release in the central nervous system. The effects of 1,2-diacylglycerols (DAGs) on dopamine release in the rat central nervous system were determined by measuring dopamine release fro...

journal_title：Journal of neurochemistry

authors： Davis ME,Patrick RL

更新日期：1990-02-01 00:00:00

abstract：:Local cerebral glucose utilization (LCGU) was measured, using the quantitative autoradiographic [14C]2-deoxy-D-glucose method, in 56 brain regions of 3-month-old, awake Fischer-344 rats, after intraperitoneal administration of sulpiride (SULP) 100 mg/kg. SULP, an "atypical" neuroleptic, is a selective antagonist of D2...

journal_title：Journal of neurochemistry

authors： Pizzolato G,Soncrant TT,Larson DM,Rapoport SI

更新日期：1987-08-01 00:00:00

abstract：:To enable us to study expression of tyrosine hydroxylase [TH; tyrosine 3-monooxygenase; L-tyrosine tetrahydropteridine:oxygen oxidoreductase (3-hydroxylating); EC 1.14.16.2] as a measure of dopaminergic neuron function in future experiments, methods were developed to quantify TH mRNA levels in cultures of dopaminergic...

journal_title：Journal of neurochemistry

authors： Beck KD,Knusel B,Pasinetti G,Michel PP,Zawadzka H,Goldstein M,Hefti F

更新日期：1991-08-01 00:00:00

abstract：:Coordinate secretion of two prohormone/proneuropeptide processing enzymes [pro-opiomelanocortin converting enzyme (PCE) and an aminopeptidase B-like enzyme (APBE)] and alpha-melanotropin (alpha-MSH) from bovine intermediate lobe pituitary cells was studied. Stimulation of secretion with 8-bromo-cyclic AMP produced sig...

journal_title：Journal of neurochemistry

authors： Castro MG,Birch NP,Loh YP

更新日期：1989-05-01 00:00:00

abstract：:Incorporation of [1-14C]palmitic acid into neutral lipids and phospholipids of rat cerebral cortex was examined in vitro in normal Krebs--Ringer bicarbonate buffer containing 3% (wt/vol) albumin and 0.75 mM palmitic acid. Under standard assay conditions, radioactivity in the triacylglycerol fraction increased rapidly ...

journal_title：Journal of neurochemistry

authors： Mizobuchi M,Morisaki N,Matsuoka N,Saito Y,Kumagai A

更新日期：1982-05-01 00:00:00

abstract：:Abnormalities of alpha-synuclein (alpha-Syn) are mechanistically linked to Parkinson's disease (PD) and other alpha-synucleinopathies. To gain additional insights into the relationships between alpha-Syn expression and cell death, we examined the effects of expressing human alpha-Syn (Hualpha-Syn) variants on the cell...

journal_title：Journal of neurochemistry

authors： Li W,Lee MK

更新日期：2005-06-01 00:00:00

abstract：:Previous studies have shown that activation of the cyclic AMP (cAMP) pathway down-regulates CREB expression in CATH.a cells, an effect that appears to be mediated via inhibition of CREB gene transcription. In the current study, we compared this effect in CATH.a cells with regulation of CREB expression in another cell ...

journal_title：Journal of neurochemistry

authors： Coven E,Ni Y,Widnell KL,Chen J,Walker WH,Habener JF,Nestler EJ

更新日期：1998-11-01 00:00:00

abstract：:The histamine H1 receptor binding capacity of the amygdalas of amygdaloid kindled rats was studied. In the kindled nonstimulated amygdala, significant decreases in K(D) and B(max) values compared with those of control amygdala were found 1 week after the last kindled seizure. One month after the last kindled seizure, ...

journal_title：Journal of neurochemistry

authors： Toyota H,Ito C,Yanai K,Sato M,Watanabe T

更新日期：1999-05-01 00:00:00

abstract：:Vinblastine causes alterations in the subcellular distribution of certain proteins synthesized by telencephalon slices. Proteins in various subcellular fractions were separated according to their molecular weight by sodium dodecyl sulfate-polyacrylamide gel electrophoresis, and radioactive proteins were determined by ...

journal_title：Journal of neurochemistry

authors： White FP

更新日期：1980-07-01 00:00:00

abstract：:Brain edema in hepatic encephalopathy has been associated with circulating ammonia that is metabolized to glutamine. We measured alterations in blood chemistry and brain regional specific gravity and ion and amino acid contents in models of simple hyperammonemia and liver failure induced by daily administrations of am...

journal_title：Journal of neurochemistry

authors： Hilgier W,Olson JE

更新日期：1994-01-01 00:00:00

abstract：:Recently, in the course of our search for the prostacyclin receptor in the brain, we found a novel subtype, designated as IP2, which was finely discriminated by use of the specific ligand (15R)-16-m-tolyl-17,18,19,20-tetranorisocarbacyclin (15R-TIC) and specifically localized in the rostral part of the brain. In the p...

journal_title：Journal of neurochemistry

authors： Watanabe Y,Matsumura K,Takechi H,Kato K,Morii H,Björkman M,Långström B,Noyori R,Suzuki M,Watanabe Y

更新日期：1999-06-01 00:00:00

abstract：:Using a whole-cell binding procedure with long incubations at low temperature and subsequent acid stripping, we have characterized an atypical endothelin (ET) receptor in primary rat cortical astrocyte cultures. We found the following: (a) no competition for 125I-ET-1 binding by the ET(A) antagonists BQ-123 and LU 135...

journal_title：Journal of neurochemistry

authors： Jensen N,Hasselblatt M,Sirén AL,Schilling L,Schmidt M,Ehrenreich H

更新日期：1998-02-01 00:00:00

abstract：:Mitogen-activated protein (MAP) kinases have been implicated in multiple responses to extracellular stimuli. In this study we show that MAP kinase activity is enhanced after a KCl pulse. This activation correlates with an increased tyrosine phosphorylation of a 42-kDa protein as determined by antiphosphotyrosine immun...

journal_title：Journal of neurochemistry

authors： Baron C,Benes C,Van Tan H,Fagard R,Roisin MP

更新日期：1996-03-01 00:00:00

abstract：:The Review highlighted in this Editorial followed a CAEN Return Home Grant. ...

journal_title：Journal of neurochemistry

authors： William Rebeck G,Pak DTS

更新日期：2017-10-01 00:00:00

abstract：:The function of membrane phospholipids (PL) in the regulation of gamma-aminobutyric acid (GABA) transport and GABA carrier binding has been investigated in organized cultures of rat cerebral cortex. The cellular lipid composition has been changed by growing the cells in a delipidated nutrient solution or by short-term...

journal_title：Journal of neurochemistry

authors： Giesing M,Gerken U,Kastrup H

更新日期：1985-03-01 00:00:00

abstract：:Prolonged stress affects homeostasis in various organs and induces stress-associated disorders. We examined the cellular changes of pituitary gland under the continuous stress condition using a rat model in which rats were kept in a cage filled with water to a height of 1.5 cm for up to 5 days. Among the pituitary hor...

journal_title：Journal of neurochemistry

authors： Ogawa T,Shishioh-Ikejima N,Konishi H,Makino T,Sei H,Kiryu-Seo S,Tanaka M,Watanabe Y,Kiyama H

更新日期：2009-06-01 00:00:00

abstract：:Marked accumulation of arachidonic acid (AA) and intracellular Ca2+ and Na+ overloads are seen during brain ischemia. In this study, we show that, in neurons, AA induces cytosolic Na+ ([Na+](cyt)) and Ca2+ ([Ca2+](cyt)) overload via a non-selective cation conductance (NSCC), resulting in mitochondrial [Na+](m) and [Ca...

journal_title：Journal of neurochemistry

authors： Fang KM,Chang WL,Wang SM,Su MJ,Wu ML

更新日期：2008-03-01 00:00:00

abstract：:Oxidative stress has been shown to play a role in aging and in neurodegenerative disorders. Some of the consequences of oxidative stress are DNA base modifications, lipid peroxidation, and protein modifications such as formation of carbonyls and nitrotyrosine. These events may play a role in apoptosis, another factor ...

journal_title：Journal of neurochemistry

authors： Kaufmann JA,Bickford PC,Taglialatela G

更新日期：2001-02-01 00:00:00