Antiapoptotic property of human alpha-synuclein in neuronal cell lines is associated with the inhibition of caspase-3 but not caspase-9 activity.

abstract：:The aim of the present study was to gain a deeper insight into the cell signaling pathways involved in the neuroprotection/neurorescue activity of the major green tea polyphenol (-)-epigallocatechin-3-gallate (EGCG). EGCG (1 micro m) caused an immediate (30 min) down-regulation (approximately 40%) of Bad protein level...

journal_title：Journal of neurochemistry

authors： Kalfon L,Youdim MB,Mandel SA

更新日期：2007-02-01 00:00:00

abstract：:Neuroactive steroid family includes molecules synthesized in peripheral glands (i.e., hormonal steroids) and directly in the nervous system (i.e., neurosteroids) which are key regulators of the nervous function. As already reported in clinical and experimental studies, neurodegenerative diseases affect the levels of n...

journal_title：Journal of neurochemistry

authors： Caruso D,Melis M,Fenu G,Giatti S,Romano S,Grimoldi M,Crippa D,Marrosu MG,Cavaletti G,Melcangi RC

更新日期：2014-08-01 00:00:00

abstract：:Hibernation is a seasonal phenomenon characterized by a drop in metabolic rate and body temperature. Adenosine A1 receptor agonists promote hibernation in different mammalian species, and the understanding of the mechanism inducing hibernation will inform clinical strategies to manipulate metabolic demand that are fun...

journal_title：Journal of neurochemistry

authors： Frare C,Jenkins ME,McClure KM,Drew KL

更新日期：2019-11-01 00:00:00

abstract：:Carbamylcholine stimulated phospholipase C activity in astrocytes in primary culture from the mesencephalon but not from the striatum or cerebral cortex of the mouse embryo. An alpha 1-adrenergic-mediated response was observed in all astrocyte populations. 2-Chloroadenosine potentiated the alpha 1-adrenergic response ...

journal_title：Journal of neurochemistry

authors： el-Etr M,Cordier J,Torrens Y,Glowinski J,Prémont J

更新日期：1989-03-01 00:00:00

abstract：:Insulin-like growth factor-I (IGF-I) has protective effects against beta-amyloid (Abeta)-induced neuronal cell death. Because alterations of the somatostatinergic system have been described in Alzheimer's disease, we investigated the effects of the Abeta peptide and the possible protective role of IGF-I on the somatos...

journal_title：Journal of neurochemistry

authors： Aguado-Llera D,Arilla-Ferreiro E,Campos-Barros A,Puebla-Jiménez L,Barrios V

更新日期：2005-02-01 00:00:00

abstract：:Nicotinic acetylcholine receptors (nAChRs) are present in high density in insect nervous tissue and are targeted by neonicotinoid insecticides. Improved understanding of the actions of these insecticides will assist in the development of new compounds. Here, we have used whole-cell patch-clamp recording of cholinergic...

journal_title：Journal of neurochemistry

authors： Brown LA,Ihara M,Buckingham SD,Matsuda K,Sattelle DB

更新日期：2006-10-01 00:00:00

abstract：:Kainate inhibits the exchange of D-aspartate into guinea-pig cerebrocortical synaptosomes. Kainate inhibits the Ca2+-independent efflux of endogenous glutamate in the presence of a trapping system for the released amino acid but potentiates a Ca2+-independent net efflux of endogenous and labelled glutamate and asparta...

journal_title：Journal of neurochemistry

authors： Pocock JM,Murphie HM,Nicholls DG

更新日期：1988-03-01 00:00:00

abstract：:Ketimine reductase (E.C. 1.5.1.25) was purified to apparent homogeneity from lamb forebrain by means of a rapid multi-step chromatography protocol. The purified enzyme was identified by MS/MS (mass spectrometry) as μ-crystallin. The identity was confirmed by heterologously expressing human μ-crystallin in Escherichia ...

journal_title：Journal of neurochemistry

authors： Hallen A,Cooper AJ,Jamie JF,Haynes PA,Willows RD

更新日期：2011-08-01 00:00:00

abstract：:The sulphated octapeptide of cholecystokinin (CCK-8S) was found to cause a dose-dependent increase in the basal release of aspartate, glycine, and gamma-aminobutyric acid from the striatum and the ventromedial nucleus of the hypothalamus (VMH). No effect on amino acid release was observed after electrical (VMH) or pot...

journal_title：Journal of neurochemistry

authors： Barnes S,Whistler HL,Hughes J,Woodruff GN,Hunter JC

更新日期：1991-04-01 00:00:00

abstract：:Rats were administered [3H]fucose by intracranial injection and synaptic membranes (SMs) isolated 18 h later. Oligosaccharides associated with SM glycoproteins were prepared by hydrazinolysis and analyzed by a combination of affinity chromatography on concanavalin A (Con A)-agarose, ion-exchange chromatography on DEAE...

journal_title：Journal of neurochemistry

authors： Stanojev D,Gurd JW

更新日期：1987-05-01 00:00:00

abstract：:Rats learning the Morris water maze exhibit hippocampal changes in synaptic morphology and physiology that manifest as altered synaptic efficacy. Learning requires structural changes in the synapse, and multiple cell adhesion molecules appear to participate. The activity of these cell adhesion molecules is, in large p...

journal_title：Journal of neurochemistry

authors： Meighan SE,Meighan PC,Choudhury P,Davis CJ,Olson ML,Zornes PA,Wright JW,Harding JW

更新日期：2006-03-01 00:00:00

abstract：:The behavior of a microdialysis probe in vivo is mathematically described. A diffusion-reaction model is developed that not only accounts for transport of substances through tissues and probe membranes but also accounts for transport across the microvasculature and metabolism. Time-dependent equations are presented bo...

journal_title：Journal of neurochemistry

authors： Morrison PF,Bungay PM,Hsiao JK,Ball BA,Mefford IN,Dedrick RL

更新日期：1991-07-01 00:00:00

abstract：:Juvenile neuronal ceroid lipofuscinosis (Batten disease) is a neurodegenerative disorder caused by mutation in CLN3. Defective autophagy and concomitant accumulation of autofluorescence enriched with mitochondrial ATP synthase subunit c were previously discovered in Cln3 mutant knock-in mice. In this study, we show th...

journal_title：Journal of neurochemistry

authors： Chang JW,Choi H,Cotman SL,Jung YK

更新日期：2011-02-01 00:00:00

abstract：:Extracellular adenosine in the brain, which modulates various physiological and pathological processes, fluctuates in a complicated manner that reflects the circadian cycle, neuronal activity, metabolism, and disease states. The dynamics of extracellular adenosine in the brain are not fully understood, largely because...

journal_title：Journal of neurochemistry

authors： Yamashiro K,Fujii Y,Maekawa S,Morita M

更新日期：2017-01-01 00:00:00

abstract：:In the adult mammalian brain, neural stem cells (NSCs) reside in two neurogenic regions, the walls of the lateral ventricles, and the subgranular zone of the hippocampus, which generate new neurons for the olfactory bulb and dentate gyrus, respectively. These adult NSCs retain their self-renewal ability and capacity t...

journal_title：Journal of neurochemistry

authors： Hayashi Y,Jinnou H,Sawamoto K,Hitoshi S

更新日期：2018-12-01 00:00:00

abstract：:Tetanus neurotoxin and botulinum neurotoxins are the causative agents of tetanus and botulism. They block the release of neurotransmitters from synaptic vesicles in susceptible animals and man and act in nanogram quantities because of their ability to specifically attack motoneurons. They developed an ingenious strate...

journal_title：Journal of neurochemistry

authors： Binz T,Rummel A

更新日期：2009-06-01 00:00:00

abstract：:The regulatory role of ascorbic acid in norepinephrine biosynthesis was studied using digitonin-permeabilized chromaffin cells. When permeabilized chromaffin cells were incubated with [3H]3,4-dihydroxyphenylethylamine ([3H]dopamine) in calcium-free medium, the amounts of radioactive dopamine and norepinephrine measure...

journal_title：Journal of neurochemistry

authors： Morita K,Levine M,Pollard HB

更新日期：1986-03-01 00:00:00

abstract：:The purpose of this study was to determine whether vasoactive intestinal peptide (VIP) might have a presynaptic modulatory effect at cholinergic terminals in the rat hippocampal formation. The exposure of rat hippocampal slices to VIP increased [3H]acetylcholine ([3H]ACh) synthesis from the precursor [3H]choline when ...

journal_title：Journal of neurochemistry

authors： Lapchak PA,Collier B

更新日期：1988-01-01 00:00:00

abstract：:Cerebral microvessels isolated from perfused, adult murine brain produce a compound with the chromatographic properties of a monohydroxyeicosatetraenoic acid when incubated with arachidonic acid or stimulated with calcium ionophore A23187. The formation of this arachidonic acid metabolite is not reduced in the presenc...

journal_title：Journal of neurochemistry

authors： Moore SA,Figard PH,Spector AA,Hart MN

更新日期：1989-08-01 00:00:00

abstract：:We applied a differential display PCR technique to isolate molecules that are area-specific in expression in the primate neocortex, and found that growth/differentiation factor 7 (GDF7), a member of the bone morphogenetic protein (BMP)/transforming growth factor (TGF) beta super-family, is preferentially expressed in ...

journal_title：Journal of neurochemistry

authors： Watakabe A,Fujita H,Hayashi M,Yamamori T

更新日期：2001-03-01 00:00:00

abstract：:For more than three decades, the venom of the black widow spider and its principal active components, latrotoxins, have been used to induce release of neurotransmitters and hormones and to study the mechanisms of exocytosis. Given the complex nature of alpha--latrotoxin (alpha-LTX) actions, this research has been cont...

journal_title：Journal of neurochemistry

authors： Silva JP,Suckling J,Ushkaryov Y

更新日期：2009-10-01 00:00:00

abstract：:The ubiquitous polyamines spermidine and spermine are known as modulators of glutamate receptors and inwardly rectifying potassium channels. They are synthesized by a set of specific enzymes in which spermidine synthase is the rate-limiting step catalysing the formation of the spermine precursor spermidine from putres...

journal_title：Journal of neurochemistry

authors： Krauss M,Langnaese K,Richter K,Brunk I,Wieske M,Ahnert-Hilger G,Veh RW,Laube G

更新日期：2006-04-01 00:00:00

abstract：:A protein that binds vesamicol has been purified from a soluble fraction of the Torpedo electric organ homogenate that does not contain synaptic vesicles. The purified vesamicol-binding protein (VBP) has a molecular mass of 470 kDa composed of 30- and 24-kDa subunits. Chemical deglycosylation yielded a single, heterog...

journal_title：Journal of neurochemistry

authors： Hicks BW,Rogers GA,Parsons SM

更新日期：1991-08-01 00:00:00

abstract：:The transcription factor Nurr1 is essential for the generation of midbrain dopaminergic neurons (mDA). Only a few Nurr1-regulated genes have so far been identified and it remains unclear how Nurr1 influences the development and function of dopaminergic neurons. To identify novel Nurr1 target genes we have used genome-...

journal_title：Journal of neurochemistry

authors： Volpicelli F,Caiazzo M,Greco D,Consales C,Leone L,Perrone-Capano C,Colucci D'Amato L,di Porzio U

更新日期：2007-07-01 00:00:00

abstract：:Metipranolol is a β-adrenergic receptor antagonist that is given orally for the treatment of hypertension and also applied topically to the cornea for treating glaucoma. It also inhibits nitrosative stress which has previously been shown to be the cause of cone photoreceptor death in retinitis pigmentosa. In this stud...

journal_title：Journal of neurochemistry

authors： Kanan Y,Khan M,Lorenc VE,Long D,Chadha R,Sciamanna J,Green K,Campochiaro PA

更新日期：2019-01-01 00:00:00

abstract：:A decline in the calcium-dependent release of neurotransmitters appears to underlie the decreased neuronal function that accompanies reduced oxygen tensions (hypoxia). To determine if alterations in calcium uptake are primary to these changes, synaptosomal calcium uptake was measured in the presence of 100%, 2.5%, or ...

journal_title：Journal of neurochemistry

authors： Peterson C,Gibson GE

更新日期：1984-01-01 00:00:00

abstract：:Immunoaffinity chromatography with a monoclonal antibody produced against bovine tau protein was used to purify tau proteins from human brain. Fifty grams of brain tissue yielded approximately 2 mg of pure tau proteins. The affinity-purified human tau was used to produce a high-titered rabbit anti-human tau serum. The...

journal_title：Journal of neurochemistry

authors： Mercken M,Vandermeeren M,Lübke U,Six J,Boons J,Vanmechelen E,Van de Voorde A,Gheuens J

更新日期：1992-02-01 00:00:00

abstract：:It is now clearly established that the brain has the capability of synthesizing various biologically active steroids including 17-hydroxypregnenolone (17OH-Delta(5)P), 17-hydroxyprogesterone (17OH-P), dehydroepiandrosterone (DHEA) and androstenedione (Delta(4)). However, the presence, distribution and activity of cyto...

journal_title：Journal of neurochemistry

authors： Do Rego JL,Tremblay Y,Luu-The V,Repetto E,Castel H,Vallarino M,Bélanger A,Pelletier G,Vaudry H

更新日期：2007-01-01 00:00:00

abstract：:Molecular mechanisms underlying tauopathy remain undetermined. In the current study, single cell gene expression profiling was coupled with custom-designed cDNA array analysis to evaluate tau expression and other cytoskeletal elements within individual neuronal populations in patients with no cognitive impairment (NCI...

journal_title：Journal of neurochemistry

authors： Ginsberg SD,Che S,Counts SE,Mufson EJ

更新日期：2006-03-01 00:00:00

abstract：:Stimulated dopamine overflow has been measured with in vivo voltammetry in the caudate-putamen and nucleus accumbens. Overflow was induced by electrical stimulation of the medial forebrain bundle with 120 1-ms, 300-microA, biphasic pulses at frequencies between 10 and 60 Hz. Overflow was measured with a Nafion-coated,...

journal_title：Journal of neurochemistry

authors： May LJ,Wightman RM

更新日期：1989-09-01 00:00:00