Effect of cholecystokinin octapeptide on endogenous amino acid release from the rat ventromedial nucleus of the hypothalamus and striatum.

Abstract:

:The sulphated octapeptide of cholecystokinin (CCK-8S) was found to cause a dose-dependent increase in the basal release of aspartate, glycine, and gamma-aminobutyric acid from the striatum and the ventromedial nucleus of the hypothalamus (VMH). No effect on amino acid release was observed after electrical (VMH) or potassium (striatum) stimulation. Experiments performed using the CCKB-selective antagonist L-365,260 and the CCKA-selective antagonist L-364,718 suggested that this action of CCK-8S was mediated via the CCKB receptor. The ability of CCK-8S to evoke amino acid release was not dependent on the presence of extracellular calcium, though the effect was abolished by tetrodotoxin. Inhibition of protein kinase activity by staurosporine prevented the excitatory effects of CCK-8S on amino acid release.

journal_name

J Neurochem

authors

Barnes S,Whistler HL,Hughes J,Woodruff GN,Hunter JC

doi

10.1111/j.1471-4159.1991.tb11439.x

subject

Has Abstract

pub_date

1991-04-01 00:00:00

pages

1409-16

issue

4

eissn

0022-3042

issn

1471-4159

journal_volume

56

pub_type

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