Abstract:
:Carbamylcholine stimulated phospholipase C activity in astrocytes in primary culture from the mesencephalon but not from the striatum or cerebral cortex of the mouse embryo. An alpha 1-adrenergic-mediated response was observed in all astrocyte populations. 2-Chloroadenosine potentiated the alpha 1-adrenergic response in mesencephalic and striatal astrocytes but not in cortical astrocytes. It also stimulated the carbamylcholine-evoked response in mesencephalic astrocytes. Through cell-cell cooperation, 2-chloroadenosine potentiated the neuronal carbamylcholine-evoked activation of phospholipase C in homotopic cocultures (neuro-glial) from the striatum but not in homotopic cocultures (neuro-glial) from the cerebral cortex or in heterotopic cocultures (cortical astrocytes-striatal neurons; striatal astrocytes-cortical neurons.
journal_name
J Neurochemjournal_title
Journal of neurochemistryauthors
el-Etr M,Cordier J,Torrens Y,Glowinski J,Prémont Jdoi
10.1111/j.1471-4159.1989.tb02551.xsubject
Has Abstractpub_date
1989-03-01 00:00:00pages
981-4issue
3eissn
0022-3042issn
1471-4159journal_volume
52pub_type
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