Pharmacological and functional heterogeneity of astrocytes: regional differences in phospholipase C stimulation by neuromediators.

Abstract:

:Carbamylcholine stimulated phospholipase C activity in astrocytes in primary culture from the mesencephalon but not from the striatum or cerebral cortex of the mouse embryo. An alpha 1-adrenergic-mediated response was observed in all astrocyte populations. 2-Chloroadenosine potentiated the alpha 1-adrenergic response in mesencephalic and striatal astrocytes but not in cortical astrocytes. It also stimulated the carbamylcholine-evoked response in mesencephalic astrocytes. Through cell-cell cooperation, 2-chloroadenosine potentiated the neuronal carbamylcholine-evoked activation of phospholipase C in homotopic cocultures (neuro-glial) from the striatum but not in homotopic cocultures (neuro-glial) from the cerebral cortex or in heterotopic cocultures (cortical astrocytes-striatal neurons; striatal astrocytes-cortical neurons.

journal_name

J Neurochem

authors

el-Etr M,Cordier J,Torrens Y,Glowinski J,Prémont J

doi

10.1111/j.1471-4159.1989.tb02551.x

subject

Has Abstract

pub_date

1989-03-01 00:00:00

pages

981-4

issue

3

eissn

0022-3042

issn

1471-4159

journal_volume

52

pub_type

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