Alpha2-macroglobulin attenuates beta-amyloid peptide 1-40 fibril formation and associated neurotoxicity of cultured fetal rat cortical neurons.

abstract：:The presence of a [3H]muscimol binding site on the purified benzodiazepine receptor was demonstrated. The purified protein was apparently homogeneous as shown by sodium dodecyl sulfate polyacrylamide gel electrophoresis (stained with silver), with a molecular weight of 60,000 +/- 3000. The benzodiazepine binding sites...

journal_title：Journal of neurochemistry

authors： Martini C,Rigacci T,Lucacchini A

更新日期：1983-10-01 00:00:00

abstract：:An early biochemical change in the Parkinsonian substantia nigra (SN) is reduction in total glutathione (GSH + GSSG) levels in affected dopaminergic neurons prior to depletion in mitochondrial complex I activity, dopamine loss, and cell death. We have demonstrated using dopaminergic PC12 cell lines genetically enginee...

journal_title：Journal of neurochemistry

authors： Hsu M,Srinivas B,Kumar J,Subramanian R,Andersen J

更新日期：2005-03-01 00:00:00

abstract：:A new technology called in vivo spectrophotometry was applied to the quantitative determination of the variations in local acetylcholinesterase (AChE) activities. Repeated measurements of the enzyme activities in the same live animal allowed the study of the in vivo inhibition of AChE by amitriptyline. Interactions be...

journal_title：Journal of neurochemistry

authors： Chappey O,Testylier G,Gourmelon P,Galonnier M,Bourre JM,Fatome M,Scherrmann JM,Viret J

更新日期：1990-01-01 00:00:00

abstract：:We have identified and cataloged 54 genes that exhibit predominant expression in the striatum. Our hypothesis is that such mRNA molecules are likely to encode proteins that are preferentially associated with particular physiological processes intrinsic to striatal neurons, and therefore might contribute to the regiona...

journal_title：Journal of neurochemistry

authors： Desplats PA,Kass KE,Gilmartin T,Stanwood GD,Woodward EL,Head SR,Sutcliffe JG,Thomas EA

更新日期：2006-02-01 00:00:00

abstract：:Multiple C2 domains transmembrane protein 1 (MCTP1) contains two transmembrane regions and three C2 domains of high Ca(2+)-binding affinity. Single-nucleotide polymorphism (SNP) of human MCTP1 gene is reportedly associated with bipolar disorder, but expression and function of MCTP1 in the CNS is still largely unknown....

journal_title：Journal of neurochemistry

authors： Qiu L,Yu H,Liang F

更新日期：2015-11-01 00:00:00

abstract：:The sodium-coupled, hemicholinium-3-sensitive, high-affinity choline transporter (CHT) is responsible for transport of choline into cholinergic nerve terminals from the synaptic cleft following acetylcholine release and hydrolysis. In this study, we address regulation of CHT function by plasma membrane cholesterol. We...

journal_title：Journal of neurochemistry

authors： Cuddy LK,Winick-Ng W,Rylett RJ

更新日期：2014-03-01 00:00:00

abstract：:Microglial activation can lead to microglial apoptosis, which may serve to remove highly reactive and possibly neurotoxic microglia. However the loss of microglia may have consequences for future recovery, protection and repair. P53, a nuclear phosphoprotein transcription factor, is critical for activating the express...

journal_title：Journal of neurochemistry

authors： Davenport CM,Sevastou IG,Hooper C,Pocock JM

更新日期：2010-01-01 00:00:00

abstract：:We have recently shown that disrupting the expression and post-synaptic clustering of gephyrin in cultured hippocampal pyramidal cells, by either gephyrin RNAi (RNA interference) or over-expression of a dominant negative gephyrin-enhanced green fluorescent protein (EGFP) fusion protein, leads to decreased number of po...

journal_title：Journal of neurochemistry

authors： Yu W,De Blas AL

更新日期：2008-02-01 00:00:00

abstract：:Published evidence has linked glutamate with the pathogenesis of Alzheimer's disease (AD) and the up-regulation of a variety of chemokines, including monocyte chemotactic protein-1 (MCP-1)/chemokine ligand 2, with AD-associated pathological changes. In this study, we assessed the potential molecular basis for the role...

journal_title：Journal of neurochemistry

authors： Lee EO,Park HJ,Kang JL,Kim HS,Chong YH

更新日期：2010-03-01 00:00:00

abstract：:The suprachiasmatic nucleus houses the central circadian clock and is characterized by the timely regulated expression of clock genes. However, neurons of the cerebellar cortex also contain a circadian oscillator with circadian expression of clock genes being controlled by the suprachiasmatic nucleus. It has been sugg...

journal_title：Journal of neurochemistry

authors： Bering T,Carstensen MB,Rath MF

更新日期：2017-09-01 00:00:00

abstract：:The isolation, characterization, and bioactivity in the feeding circuitry of a novel neuropeptide in the Aplysia californica central nervous system are reported. The 17-residue amidated peptide, NGGTADALYNLPDLEKIamide, has been termed cerebrin due to its primary location in the cerebral ganglion. Liquid chromatographi...

journal_title：Journal of neurochemistry

authors： Li L,Floyd PD,Rubakhin SS,Romanova EV,Jing J,Alexeeva VY,Dembrow NC,Weiss KR,Vilim FS,Sweedler JV

更新日期：2001-06-01 00:00:00

abstract：:The blood-brain barrier (BBB) is important physiologically. Pathologically, BBB disruption has been implicated in a wide spectrum of neurological disorders including Parkinson's disease (PD). Recent studies indicate that caffeine is protective against PD, but by poorly understood mechanisms. Using a MPTP neurotoxin mo...

journal_title：Journal of neurochemistry

authors： Chen X,Lan X,Roche I,Liu R,Geiger JD

更新日期：2008-11-01 00:00:00

abstract：:Prenatal and early postnatal periods are important for brain development and neural function. Neonatal insults such as hypoxia-ischemia (HI) causes prolonged neural and metabolic dysregulation, affecting central nervous system maturation. There is evidence that brain hypometabolism could increase the risk of adult-ons...

journal_title：Journal of neurochemistry

authors： Durán-Carabali LE,Kawa Odorcyk F,Greggio S,Teribele Venturin G,Farias Sanches E,Garcia Schu G,Soares Carvalho A,Avila Pedroso T,de Sá Couto-Pereira N,Costa da Costa J,Dalmaz C,Rigon Zimmer E,Netto CA

更新日期：2020-10-23 00:00:00

abstract：:The effects of acute treatment with p-chloramphetamine, d-fenfluramine, and reserpine on intracellular (brain tissue and whole blood) and extracellular (CSF and platelet-free plasma) compartments of 5-hydroxytryptamine (5-HT) in the brain and blood of the same rats have been examined. These treatments affected 5-HT in...

journal_title：Journal of neurochemistry

authors： Martín F,Artigas F

更新日期：1992-09-01 00:00:00

abstract：:We studied the effects of 12-O-tetradecanoylphorbol 13-acetate (TPA), a protein kinase C (PKC) activator, and calyculin A (CLA), an inhibitor of type 1 and 2A serine/threonine phosphatases, on serotonin uptake by a human placenta choriocarcinoma cell line (BeWo) and COS-7 cells expressing recombinant serotonin transpo...

journal_title：Journal of neurochemistry

authors： Sakai N,Sasaki K,Nakashita M,Honda S,Ikegaki N,Saito N

更新日期：1997-06-01 00:00:00

abstract：:Accumulations of the neuropeptides substance P (SP), somatostatin (ST), and vasoactive intestinal polypeptide (VIP) proximal to a crush in the cervical vagus nerve of the rat have been measured using sensitive radioimmunoassays. Each of the peptides was rapidly transport towards the peripheral terminals of vagal affer...

journal_title：Journal of neurochemistry

authors： Gilbert RF,Emson PC,Fahrenkrug J,Lee CM,Penman E,Wass J

更新日期：1980-01-01 00:00:00

abstract：:The efficacy of funnel-freezing of rat brain to inactivate metabolic processes and preserve in vivo tissue glucose concentration was validated by comparing the results obtained by funnel-freezing with those obtained with freeze-blowing of brain. The arterial plasma glucose level was clamped at 9 mM in halothane-anesth...

journal_title：Journal of neurochemistry

authors： Mies G,Cruz N,Sokoloff L

更新日期：1991-05-01 00:00:00

abstract：:Interleukin (IL)-2, initially discovered for its mitogenic activity on T cells, also acts on monocytes, resulting in the activation of cytokine production, superoxide production, and tumoricidal activity. Because severe brain damage was observed in IL-2-transgenic mice, this cytokine may have some influence(s) on the ...

journal_title：Journal of neurochemistry

authors： Sawada M,Suzumura A,Marunouchi T

更新日期：1995-05-01 00:00:00

abstract：:Evidence based on the ability to accumulate [3H]noradrenaline by a mechanism sensitive to desmethylimipramine suggests that there is a period of hyperinnervation of the cerebellum by noradrenergic fibres around the beginning of the second postnatal week. Different developmental profiles for specific noradrenaline upta...

journal_title：Journal of neurochemistry

authors： Waddington G,Banks P

更新日期：1981-09-01 00:00:00

abstract：:Melatonin is neuroprotective because of its antioxidative action, but it also can modify neuronal vulnerability by altering gene expression. 5-Lipoxygenase (5-LO) gene expression is suppressed by the binding of melatonin to its high-affinity nuclear receptors. Recently, we reported that in rats the melatonin deficienc...

journal_title：Journal of neurochemistry

authors： Uz T,Longone P,Manev H

更新日期：1997-11-01 00:00:00

abstract：:The expression of Nex1 peaks during brain development when neurite outgrowth and synaptogenesis are highly active. We previously showed that Nex1 is a critical effector of the nerve growth factor (NGF) pathway and its overexpression results in spontaneous neuritogenesis. Furthermore, the PC12-Nex1 cells exhibit accele...

journal_title：Journal of neurochemistry

authors： Uittenbogaard M,Chiaramello A

更新日期：2004-12-01 00:00:00

abstract：:The effects of the protein kinase inhibitor H-7 on early and delayed responses to nerve growth factor (NGF) were investigated in PC12 cells. H-7 reduced the NGF-induced expression of c-Fos in a dose-dependent manner without affecting the time course of c-Fos appearance. Conversely, H-7 potentiated delayed NGF effects,...

journal_title：Journal of neurochemistry

authors： Kahle P,Mangold M,Kuwahara T,Schubenel R,Hertel C

更新日期：1994-02-01 00:00:00

abstract：:Mitochondrial dysfunction and oxidative stress are known to occur following acute seizure activity but their contribution during epileptogenesis is largely unknown. The goal of this study was to determine the extent of mitochondrial oxidative stress, changes to redox status, and mitochondrial DNA (mtDNA) damage during...

journal_title：Journal of neurochemistry

authors： Waldbaum S,Liang LP,Patel M

更新日期：2010-12-01 00:00:00

abstract：:To better understand metabotropic/ionotropic integration in neurons we have examined the regulation of M1 muscarinic acetylcholine (mACh) receptor signalling in mature (> 14 days in vitro), synaptically-active hippocampal neurons in culture. Using a protocol where neurons are exposed to an EC(50) concentration of the ...

journal_title：Journal of neurochemistry

authors： Willets JM,Nelson CP,Nahorski SR,Challiss RA

更新日期：2007-12-01 00:00:00

abstract：:Changes in the activity of Na+,K+-ATPase and in the water, Na+, and K+ levels in the parietal cortex, hippocampus, and thalamus were investigated in rats 1, 3, 6, and 24 h following systemic kainic acid injection. An increase in Na+,K+-ATPase activity was observed in all three regions 3 h after the treatment, with a s...

journal_title：Journal of neurochemistry

authors： Sztriha L,Joó F,Dux L,Böti Z

更新日期：1987-07-01 00:00:00

abstract：:Glutamate receptor (GluR) δ1 is widely expressed in the developing forebrain, whereas GluRδ2 is selectively expressed in cerebellar Purkinje cells. Recently, we found that trans-synaptic interaction of postsynaptic GluRδ2 and pre-synaptic neurexins (NRXNs) through cerebellin precursor protein (Cbln) 1 mediates excitat...

journal_title：Journal of neurochemistry

authors： Yasumura M,Yoshida T,Lee SJ,Uemura T,Joo JY,Mishina M

更新日期：2012-06-01 00:00:00

abstract：:Acidosis is a universal response of tissue to ischemia. In the brain, severe acidosis has been linked to worsening of cerebral infarction. However, milder acidosis can have protective effects. As part of our investigations of the therapeutic window in our neuronal tissue culture model of ischemia, we investigated the ...

journal_title：Journal of neurochemistry

authors： Vornov JJ,Thomas AG,Jo D

更新日期：1996-12-01 00:00:00

abstract：:The cholesterol esterifying enzyme which incorporates exogenous free [1-14C]oleate into cholesteryl ester is present in rat sciatic endoneurium. Cholesterol esterification is optimal at pH 4.8. Exogenous ATP, CoA, and oleyl-CoA do not greatly affect its activity. Various detergents and bile salts are inhibitory. Enzym...

journal_title：Journal of neurochemistry

authors： Yao JK,Dyck PJ

更新日期：1981-07-01 00:00:00

abstract：:In the last 40 years, especially with the application of new neurochemical and molecular biological techniques, there has been explosive progress in understanding how certain ligands and drugs are transported across the blood-brain barrier and choroid plexus out of brain and CSF. In the CNS, there are several separate...

journal_title：Journal of neurochemistry

authors： Spector R

更新日期：2010-01-01 00:00:00

abstract：:The effects of glutamatergic excitotoxins on intracellular Cl- were investigated in the CA1 pyramidal cell layer of the hippocampal slice. Hippocampal slices from rats (14-19 days old) were loaded with 6-methoxy-N-ethylquinolinium chloride (MEQ), a Cl(-)-sensitive fluorescent probe with a fluorescence intensity that c...

journal_title：Journal of neurochemistry

authors： Inglefield JR,Schwartz-Bloom RD

更新日期：1998-10-01 00:00:00