Multiple C2 domains transmembrane protein 1 is expressed in CNS neurons and possibly regulates cellular vesicle retrieval and oxidative stress.

abstract：:Acetylcholine is a key neurotransmitter of the inner ear efferent system. In this study, we identify two novel nAChR subunits in the inner ear: α1 and γ, encoded by Chrna1 and Chrng, respectively. In situ hybridization shows that the messages of these two subunits are present in vestibular and cochlear hair cells duri...

journal_title：Journal of neurochemistry

authors： Scheffer D,Sage C,Plazas PV,Huang M,Wedemeyer C,Zhang DS,Chen ZY,Elgoyhen AB,Corey DP,Pingault V

更新日期：2007-12-01 00:00:00

abstract：:It has been reported that caffeine (1.5-30 mg/kg i.p.) as well as specific A1 (DPCPX, 8-cyclopentyl-1,3-dipropylxanthine) receptor antagonists fail to increase extracellular dopamine (DA) in the shell of the nucleus accumbens (NAc). However, it has also been reported that caffeine (10 and 30 mg/kg i.p.) and the A1 ant...

journal_title：Journal of neurochemistry

authors： De Luca MA,Bassareo V,Bauer A,Di Chiara G

更新日期：2007-10-01 00:00:00

abstract：:S-100 proteins are a group of three 21-kilodalton, acidic, Ca2+-binding proteins of the "E-F hand" type shown to regulate several cell activities, including microtubule (MT) assembly-disassembly. We show here that S-100 proteins interact with MTs assembled from either whole microtubule protein or purified tubulin, bot...

journal_title：Journal of neurochemistry

authors： Donato R,Giambanco I

更新日期：1989-04-01 00:00:00

abstract：:The activities of the three major catecholamine-synthesizing enzymes were determined in brain tissue pellets dissected from 500-micrometers thick horizontal sections of rat lower brainstem. The rostrocaudal distributions of the three enzymatic activities were generally not parallel, suggesting differences in the respe...

journal_title：Journal of neurochemistry

authors： Chamba G,Denoroy L,Renaud B

更新日期：1982-08-01 00:00:00

abstract：:To study the role of intracellular pH (pHi) in catecholamine secretion and the regulation of pHi in bovine chromaffin cells, the pH-sensitive fluorescent indicator [2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein] was used to monitor the on-line changes in pHi. The pHi of chromaffin cells at resting state is approxima...

journal_title：Journal of neurochemistry

authors： Kao LS,Ho MY,Cragoe EJ Jr

更新日期：1991-11-01 00:00:00

abstract：:Haptoglobin (Hp) binds hemoglobin (Hb) with high affinity and provides the primary defense against its toxicity after intravascular hemolysis. Neurons are exposed to extracellular Hb after CNS hemorrhage, and a therapeutic effect of Hp via Hb sequestration has been hypothesized. In this study, we tested the hypothesis...

journal_title：Journal of neurochemistry

authors： Chen-Roetling J,Regan RF

更新日期：2016-11-01 00:00:00

abstract：:In cerebellar granule cells, the mitogen-activated protein kinase (MAPK) or extracellular signal-regulated kinase (ERK) cascade mediates multiple functions, including proliferation, differentiation, and survival. In these cells, ERKs are activated by diverse stimuli, including cyclic adenosine monophosphate (cAMP), pi...

journal_title：Journal of neurochemistry

authors： Obara Y,Horgan AM,Stork PJ

更新日期：2007-04-01 00:00:00

abstract：:We have identified a novel mouse gene named pancortin that is expressed dominantly in the mature cerebral cortex. This gene produces four different species of proteins, Pancortin-1-4, sharing a common region in the middle of their structure with two variations at the N-terminal (A1 or A2 part) and C-terminal (C1 or C2...

journal_title：Journal of neurochemistry

authors： Nagano T,Nakamura A,Konno D,Kurata M,Yagi H,Sato M

更新日期：2000-07-01 00:00:00

abstract：:There is much evidence to suggest that G protein coupled receptors exist as oligomers but the relevance to their function is unclear. We have, therefore, examined the binding of the radiolabelled agonist [(3)H]NPA to membranes of CHO cells expressing the D(2) dopamine receptor in dissociation rate experiments. When [(...

journal_title：Journal of neurochemistry

authors： Kara E,Lin H,Strange PG

更新日期：2010-03-01 00:00:00

abstract：:Aggregate-prone mutant proteins, such as α-synuclein and huntingtin, play a prominent role in the pathogenesis of various neurodegenerative disorders; thus, it has been hypothesized that reducing the aggregate-prone proteins may be a beneficial therapeutic strategy for these neurodegenerative disorders. Here, we ident...

journal_title：Journal of neurochemistry

authors： Shen W,Henry AG,Paumier KL,Li L,Mou K,Dunlop J,Berger Z,Hirst WD

更新日期：2014-06-01 00:00:00

abstract：:We have investigated the transport characteristics of dehydroepiandrosterone sulfate (DHEAS), a neuroactive steroid, at the blood-brain barrier (BBB) in a series of functional in vivo and in vitro studies. The apparent BBB efflux rate constant of [(3)H]DHEAS evaluated by the brain efflux index method was 2.68 x 10(-2)...

journal_title：Journal of neurochemistry

authors： Asaba H,Hosoya K,Takanaga H,Ohtsuki S,Tamura E,Takizawa T,Terasaki T

更新日期：2000-11-01 00:00:00

abstract：:This study focuses on the potential involvement of carnitine palmitoyltransferase (CPT) on the phospholipid and triglyceride fatty acid turnover in neurons. This category of enzymes, which has been identified in several rat brain tissues, is well known for its role in modulating cellular fatty acid oxidation. Neuronal...

journal_title：Journal of neurochemistry

authors： Arduini A,Denisova N,Virmani A,Avrova N,Federici G,Arrigoni-Martelli E

更新日期：1994-04-01 00:00:00

abstract：:Spatial solute concentration profiles resulting from in vivo microdialysis were measured in rat caudate-putamen by quantitative autoradiography. Radiolabeled sucrose was included in the dialysate, and the tissue concentration profile measured after infusions of 14 min and 61.5 min in an acute preparation. In addition,...

journal_title：Journal of neurochemistry

authors： Dykstra KH,Hsiao JK,Morrison PF,Bungay PM,Mefford IN,Scully MM,Dedrick RL

更新日期：1992-03-01 00:00:00

abstract：:This study investigated possible D1/D2 interactions in rat and bovine striatal tissue by examining the effects of D2 antagonists on the action of dopamine at D1 dopamine receptors. In addition, the extent to which D2 antagonists may induce an agonist low-affinity state of the D1 receptor was evaluated in comparison wi...

journal_title：Journal of neurochemistry

authors： Farrell CB,Lawlor M,Dunne A,O'Boyle KM

更新日期：1995-09-01 00:00:00

abstract：:The subcellular distribution of the ectoenzyme, 5'-nucleotidase, in cerebral cortex and cerebellum of the rat was studied both biochemically and cytochemically. The fractions were characterized biochemically by marker enzymes. The localization of 5'-nucleotidase activity was also investigated cytochemically in the mye...

journal_title：Journal of neurochemistry

authors： Heymann D,Reddington M,Kreutzberg GW

更新日期：1984-10-01 00:00:00

abstract：:Synaptosomal-associated protein of 25 kDa (SNAP-25) is thought to play a key role in vesicle exocytosis and in the control of transmitter release. However, the precise mechanisms of action as well as the regulation of SNAP-25 remain unclear. Here we show by immunoprecipitation that activation of protein kinase C (PKC)...

journal_title：Journal of neurochemistry

authors： Genoud S,Pralong W,Riederer BM,Eder L,Catsicas S,Muller D

更新日期：1999-04-01 00:00:00

abstract：:The axonal outgrowth of cells of Neuro2a, a mouse neuroblastoma cell line, was suppressed on expression of the beta-galactoside alpha 1,2-fucosyltransferase (alpha 1,2-FT) gene. We recently cloned two types of rabbit alpha 1,2-FT, RFT-I and RFT-II. RFT-I exhibits comparable kinetic properties and structural homology w...

journal_title：Journal of neurochemistry

authors： Hitoshi S,Koijima N,Kusunoki S,Inokuchi J,Kanazawa I,Tsuji S

更新日期：1996-04-01 00:00:00

abstract：:Prostaglandin E1 (PGE1)-mediated transmembrane signal control systems were investigated in intact murine neuroblastoma cells (clone N1E-115). PGE1 increased intracellular levels of total inositol phosphates (IP), cyclic GMP, cyclic AMP, and calcium ([Ca2+]i). PGE1 transiently increased inositol 1,4,5-trisphosphate for...

journal_title：Journal of neurochemistry

authors： Kanba S,Sasakawa N,Nakaki T,Kanba KS,Yagi G,Kato R,Richelson E

更新日期：1991-12-01 00:00:00

abstract：:Neural stem/progenitor cells (NSPCs) are multipotent cells within the embryonic and adult brain that give rise to both neuronal and glial cell lineages. Maintenance of NSPC multipotency is promoted by low oxygen tension, although the metabolic underpinnings of this trait have not been described. In this study, we inve...

journal_title：Journal of neurochemistry

authors： Candelario KM,Shuttleworth CW,Cunningham LA

更新日期：2013-05-01 00:00:00

abstract：:In the jimpy mutant mouse, as well as in many other animals with mutations in the myelin proteolipid protein (PLP) gene, oligodendrocytes degenerate before their maturation. To analyze whether this degeneration is caused by the loss of function of PLP gene products related to oligodendrocyte maturation/survival acting...

journal_title：Journal of neurochemistry

authors： Kagawa T,Nakao J,Yamada M,Shimizu K,Hayakawa T,Mikoshiba K,Ikenaka K

更新日期：1994-05-01 00:00:00

abstract：:gamma-Aminobutyric acid (GABA) concentrations were measured in CSF specimens from two large groups of control subjects, one without neurological or psychiatric disease, and one with a variety of neurological disorders not known to involve altered GABAergic function in brain. CSF GABA was also measured in patients with...

journal_title：Journal of neurochemistry

authors： Perry TL,Hansen S,Wall RA,Gauthier SG

更新日期：1982-03-01 00:00:00

abstract：:Previous studies have demonstrated opposing roles for adenosine A1 and A2A receptors in the modulation of extracellular levels of glutamate and dopamine in the striatum. In the present study, acute systemic administration of motor-activating doses of the A2A receptor antagonist MSX-3 significantly decreased extracellu...

journal_title：Journal of neurochemistry

authors： Quarta D,Ferré S,Solinas M,You ZB,Hockemeyer J,Popoli P,Goldberg SR

更新日期：2004-03-01 00:00:00

abstract：:5-Hydroxytryptamine (5-HT) receptors contain seven putative transmembrane domains and couple via different guanine nucleotide binding proteins to specific effector enzymes. Studies with other receptors identify the second and third intracellular loops or the C-terminus of the receptor as important for selective effect...

journal_title：Journal of neurochemistry

authors： Oksenberg D,Havlik S,Peroutka SJ,Ashkenazi A

更新日期：1995-04-01 00:00:00

abstract：:We have examined the catecholamine-sensitive adenylate cyclase in the retina of the white perch (Roccus americanus). Both dopamine and the beta-adrenergic agonist isoproterenol stimulate cyclic AMP accumulation in this retina, but serotonin, an indoleamine, and phenylephrine, an alpha-adrenergic agonist, had no effect...

journal_title：Journal of neurochemistry

authors： O'Connor P,Kropf RB,Dowling JE

更新日期：1989-09-01 00:00:00

abstract：:Studies on glial cultures have demonstrated that fetal bovine serum contains a factor that induces bipotential glial precursors known as oligodendrocyte-type 2 astrocyte (O-2A) progenitors to become type 2 astroglia rather than oligodendroglia. The goal of this research project was to characterize and purify this fact...

journal_title：Journal of neurochemistry

authors： Levison SW,McCarthy KD

更新日期：1991-09-01 00:00:00

abstract：:Myelin oligodendrocyte glycoprotein (MOG) is a protein on the surface of myelin sheaths. It is a putative target of the autoimmune attack in the inflammatory and demyelinating CNS disease multiple sclerosis and its animal model, experimental autoimmune encephalomyelitis. MOG belongs to the immunoglobulin superfamily (...

journal_title：Journal of neurochemistry

authors： Hjelmström P,Penzotti JE,Henne RM,Lybrand TP

更新日期：1998-10-01 00:00:00

abstract：:Administration of L-DOPA is commonly used to treat Parkinson's disease, yet controversy continues as to whether the dopamine arising from it aggravates neuronal loss. Several authors have reported cytotoxic effects of L-DOPA and dopamine on cultured cells, but others have not. In this report using the rat pheochromocy...

journal_title：Journal of neurochemistry

authors： Clement MV,Long LH,Ramalingam J,Halliwell B

更新日期：2002-05-01 00:00:00

abstract：:Hypoxia-inducible factor prolyl 4-hydroxylases (HIF-PHDs) are important targets against oxidative stress. We hypothesized that inhibition HIF-PHD by adaptaquin reduces hypoxic-ischemic brain injury in a neonatal mouse model. The pups were treated intraperitoneally immediately with adaptaquin after hypoxia-ischemia (HI...

journal_title：Journal of neurochemistry

authors： Li K,Li T,Wang Y,Xu Y,Zhang S,Culmsee C,Wang X,Zhu C

更新日期：2019-09-01 00:00:00

abstract：:Lipid peroxidation has been postulated as a cause of neuronal damage in both aging and neurodegenerative disease. In studies of neurodegenerative disease, iron, iron plus ascorbate, or ascorbate alone has been used to stimulate lipid peroxidation. The mechanism by which ascorbate stimulates lipid peroxidation in human...

journal_title：Journal of neurochemistry

authors： Andorn AC,Britton RS,Bacon BR

更新日期：1996-08-01 00:00:00

abstract：:We report here that anti-L1 antiserum, raised against material from embryonic brain, and anti-NILE antiserum, raised against purified NILE (nerve growth factor-inducible large external) glycoprotein of PC12 cells, immunoprecipitate from PC12 cells material of the same apparent molecular weight (230 kilodaltons) by sod...

journal_title：Journal of neurochemistry

authors： Sajovic P,Kouvelas E,Trenkner E

更新日期：1986-08-01 00:00:00