Abstract：
:Accumulations of the neuropeptides substance P (SP), somatostatin (ST), and vasoactive intestinal polypeptide (VIP) proximal to a crush in the cervical vagus nerve of the rat have been measured using sensitive radioimmunoassays. Each of the peptides was rapidly transport towards the peripheral terminals of vagal afferent fibres, with average rates of flow ranging from 0.8 to 2.7 mm h-1. In the rabbit vagus nerve, SP was transported with an average rate of 4 mm h-1, which is more than double the rate for this peptide in the rat. Double crush experiments in rabbit vagus nerves indicated that the rapidly transported proportion of the total content of SP in the nerve free was about 34%. From this, the rate of transport of SP in the rapidly transported pool in the rabbit vagus nerve can be calculated to be 12 mm h-1 (280 mm day-1). Since such double crush experiments were not possible in the rat, it is not clear whether the different average rates of transport of SP in the rat and the rabbit reflect real differences in the rate of rapid transport in the two species. In common with rapid axonal transport of other neurotransmitters, the transport of SP and ST in the rat vagus nerve was blocked by colchicine, a drug that disrupts microtubules.
journal_name
J Neurochemjournal_title
Journal of neurochemistryauthors
Gilbert RF,Emson PC,Fahrenkrug J,Lee CM,Penman E,Wass Jdoi
10.1111/j.1471-4159.1980.tb04627.xsubject
Has Abstractpub_date
1980-01-01 00:00:00pages
108-13issue
1eissn
0022-3042issn
1471-4159journal_volume
34pub_type
杂志文章abstract：:The two proteins reggie-1/flotillin-2 and reggie-2/flotillin-1 form microdomains at the plasma membrane and at intracellular compartments where src tyrosine kinases associate with them. Specific GPI-anchored proteins, in particular prion protein and Thy-1, co-cluster with reggie microdomains at the plasma membrane and...
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journal_title：Journal of neurochemistry
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doi：10.1111/j.1471-4159.1981.tb01659.x
更新日期：1981-02-01 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章,评审
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pub_type： 杂志文章,评审
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更新日期：2009-10-01 00:00:00
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doi：10.1111/j.1471-4159.1993.tb03617.x
更新日期：1993-09-01 00:00:00
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pub_type： 杂志文章
doi：10.1111/j.1471-4159.2008.05289.x
更新日期：2008-06-01 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章
doi：10.1046/j.1471-4159.2000.0751172.x
更新日期：2000-09-01 00:00:00
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journal_title：Journal of neurochemistry
pub_type： 杂志文章
doi：10.1111/j.1471-4159.2004.02390.x
更新日期：2004-06-01 00:00:00
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更新日期：2005-04-01 00:00:00
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journal_title：Journal of neurochemistry
pub_type： 杂志文章
doi：10.1111/j.1471-4159.1981.tb04676.x
更新日期：1981-11-01 00:00:00
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pub_type： 杂志文章
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更新日期：1996-06-01 00:00:00
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pub_type： 杂志文章
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journal_title：Journal of neurochemistry
pub_type： 杂志文章
doi：10.1111/j.1471-4159.1980.tb09022.x
更新日期：1980-12-01 00:00:00
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pub_type： 杂志文章
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更新日期：1997-07-01 00:00:00
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journal_title：Journal of neurochemistry
pub_type： 杂志文章
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更新日期：1990-03-01 00:00:00
abstract：:This laboratory has previously demonstrated that the mu-selective opiate receptor agonist sufentanil can produce a naloxone-reversible increase or decrease in the stimulated formation of cyclic AMP (cAMP) in the myenteric plexus, depending on the concentration of opioid used. On the basis of these results, it was sugg...
journal_title：Journal of neurochemistry
pub_type： 杂志文章
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更新日期：1995-03-01 00:00:00
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更新日期：2001-02-01 00:00:00
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journal_title：Journal of neurochemistry
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更新日期：2004-03-01 00:00:00
abstract：:Cysteine-string protein (Csp) is a major synaptic vesicle and secretory granule protein first discovered in Drosophila and Torpedo. Csps were subsequently identified from Xenopus, Caenorhabditis elegans, and mammalian species. It is clear from the study of a null mutant in Drosophila that Csp is required for viability...
journal_title：Journal of neurochemistry
pub_type： 杂志文章,评审
doi：10.1046/j.1471-4159.2000.0741781.x
更新日期：2000-05-01 00:00:00
