Immunochemical characterization of antisera to rat neurofilament subunits.

abstract：:Properties so far studied of the 125-kDa 14C-arginylated protein from rat brain show remarkable similarities with those of the STOP (stable tubule only polypeptide) protein. On sodium dodecyl sulfate-polyacrylamide gel electrophoresis the 125-kDa 14C-arginylated protein moves to the same position as the STOP protein. ...

journal_title：Journal of neurochemistry

authors： Bongiovanni G,Barra HS,Hallak ME

更新日期：1994-12-01 00:00:00

abstract：:The role of the serotonin (5-hydroxytryptamine) autoreceptor in the regulation of the activity of tryptophan hydroxylase was investigated in rat raphe slices. The activity of tryptophan hydroxylase was estimated by measuring the accumulation of 5-hydroxytryptophan in the presence of inhibition of aromatic L-amino acid...

journal_title：Journal of neurochemistry

authors： Sawada M,Nagatsu T

更新日期：1986-03-01 00:00:00

abstract：:The normal cellular prion protein (PrP(C)) is a glycoprotein with two highly conserved potential N-linked glycosylation sites. All prion diseases, whether inherited, infectious or sporadic, are believed to share the same pathogenic mechanism that is based on the conversion of the normal cellular prion protein (PrP(C))...

journal_title：Journal of neurochemistry

authors： Goh AX,Li C,Sy MS,Wong BS

更新日期：2007-02-01 00:00:00

abstract：:Specific D2 binding in rat striatum was characterized and then the effects of chronic disruption of dopaminergic activity on antagonist and agonist binding to these sites were studied. D2 receptors were defined as those sites capable of binding [3H]spiperone in the presence of cinanserin, a 5-HT2 antagonist, but not i...

journal_title：Journal of neurochemistry

authors： MacKenzie RG,Zigmond MJ

更新日期：1984-11-01 00:00:00

abstract：:The effects of muscarinic agonists and depolarizing agents on inositol phospholipid hydrolysis in the rabbit vagus nerve were assessed by the measurement of [3H]inositol monophosphate production in nerves that had been preincubated with [3H]inositol. After 1 h of drug action, carbachol, oxotremorine, and arecoline inc...

journal_title：Journal of neurochemistry

authors： Sierro CD,Vitus J,Dunant Y

更新日期：1992-08-01 00:00:00

abstract：:It is well known that caspases are produced as proforms, which are proteolytically cleaved and activated during apoptosis or programmed cell death. We report here that caspases are activated during apoptosis by treatment with NOC18, a nitric oxide (NO) donor. Our present experiments have examined the way in which NO i...

journal_title：Journal of neurochemistry

authors： Uehara T,Kikuchi Y,Nomura Y

更新日期：1999-01-01 00:00:00

abstract：:The neurotoxin 1-methyl-4-phenylpyridinium ion (MPP+) in the brain striatum has recently been shown to bind at a putatively vesicular site labeled by [3H]tyramine ([3H]TY). Whereas in the rat and mouse striatum MPP+ antagonized TY binding competitively, in the cerebellum there was a mixed-type antagonism, which sugges...

journal_title：Journal of neurochemistry

authors： Vaccari A,Saba PL,Gessa GL,Del Zompo M

更新日期：1993-02-01 00:00:00

abstract：:Activation of extracellular signal-regulated protein kinase 1/2 (ERK1/2) are implicated in the pathophysiology of spinal cord injury (SCI). However, the specific functions of individual ERK isoforms in neurodegeneration are largely unknown. We investigated the hypothesis that ERK2 activation may contribute to patholog...

journal_title：Journal of neurochemistry

authors： Yu CG,Yezierski RP,Joshi A,Raza K,Li Y,Geddes JW

更新日期：2010-04-01 00:00:00

abstract：:Protein biosynthesis in the retina and fast axonal transport along the optic pathway were studied in rabbits in which diabetes had been experimentally induced. Retinal protein biosynthesis and axonal transport were significantly reduced in the diabetic rabbits, and the reduction was correlated to the severity of the d...

journal_title：Journal of neurochemistry

authors： Chihara E

更新日期：1981-07-01 00:00:00

abstract：:The anti-diabetic drug and peroxisome proliferator-activated receptor-gamma (PPARγ) agonist, rosiglitazone, alters astrocyte activation; however, its mechanism remains less-known. We hypothesized participation of epidermal growth factor receptor (EGFR), known to control astrocyte reactivity. We first detected that ros...

journal_title：Journal of neurochemistry

authors： Kushwaha R,Mishra J,Gupta AP,Gupta K,Vishwakarma J,Chattopadhyay N,Gayen JR,Kamthan M,Bandyopadhyay S

更新日期：2019-06-01 00:00:00

abstract：:Neuropeptide Y (NPY) is an important regulator of energy balance in mammals through its orexigenic, antithermogenic, and insulin secretagogue actions. We investigated the regulation of endogenous NPY release from rat hypothalamic slices by NPY receptor ligands and calcium channel antagonists. High-potassium stimulatio...

journal_title：Journal of neurochemistry

authors： King PJ,Widdowson PS,Doods HN,Williams G

更新日期：1999-08-01 00:00:00

abstract：:The RGS proteins are a recently discovered family of G protein regulators that have been shown to act as GTPase-activating proteins (GAPs) on the G(alpha i) and G(alpha q) subfamilies of the heterotrimeric G proteins. Here, we demonstrate that RGS7 is a potent GAP in vitro on G(alpha i1), and G(alpha o) heterotrimeric...

journal_title：Journal of neurochemistry

authors： Shuey DJ,Betty M,Jones PG,Khawaja XZ,Cockett MI

更新日期：1998-05-01 00:00:00

abstract：:Purines are a class of small organic molecules that are essential for all cells. They play critical roles in neuronal differentiation and function. Their importance is highlighted by several inherited disorders of purine metabolism, such as Lesch-Nyhan disease, which is caused by a deficiency of the purine salvage enz...

journal_title：Journal of neurochemistry

authors： Göttle M,Burhenne H,Sutcliffe D,Jinnah HA

更新日期：2013-12-01 00:00:00

abstract：:Recombinant baculoviral vectors efficiently transduce several types of cells in the brain. To characterize host responses to virus challenge, thus verifying the suitability of using baculovirus for the development of gene therapy strategies in the central nervous system, we used cDNA microarray technology to examine i...

journal_title：Journal of neurochemistry

authors： Boulaire J,Zhao Y,Wang S

更新日期：2009-06-01 00:00:00

abstract：:Therapy of malignant glioma relies on treatment with the O6 -methylating agent temozolomide (TMZ) concomitant with ionizing radiation followed by adjuvant TMZ. For the treatment of recurrences, DNA chloroethylating drugs are also used. The main killing lesion induced by these drugs is O6 -alkylguanine. Since this dama...

journal_title：Journal of neurochemistry

authors： Aasland D,Reich TR,Tomicic MT,Switzeny OJ,Kaina B,Christmann M

更新日期：2018-01-01 00:00:00

abstract：:Exogenous phospholipases have been used extensively as tools to study the role of membrane lipids in receptor mechanisms. We used in vitro quantitative autoradiography to evaluate the effect of phospholipase A2 (PLA2) on N-methyl-D-aspartate (NMDA) and non-NMDA glutamate receptors in rat brain. PLA2 pretreatment induc...

journal_title：Journal of neurochemistry

authors： Catania MV,Hollingsworth Z,Penney JB,Young AB

更新日期：1993-01-01 00:00:00

abstract：:Monoamine action in the dorsal striatum and nucleus accumbens plays essential roles in striatal physiology. Although research often focuses on dopamine and its receptors, norepinephrine (NE) and adrenergic receptors are also crucial in regulating striatal function. While noradrenergic neurotransmission has been identi...

journal_title：Journal of neurochemistry

authors： Meitzen J,Luoma JI,Stern CM,Mermelstein PG

更新日期：2011-03-01 00:00:00

abstract：:The monoamines dopamine, norepinephrine, epinephrine, and serotonin and their major metabolites 3,4-dihydroxyphenylacetic acid, homovanillic acid, 3-methoxy-4-hydroxyphenylethylene glycol, and 5-hydroxyindoleacetic acid were measured in the CNS of the rat during development from fetal day 18 to young adult. The catech...

journal_title：Journal of neurochemistry

authors： Herregodts P,Velkeniers B,Ebinger G,Michotte Y,Vanhaelst L,Hooghe-Peters E

更新日期：1990-09-01 00:00:00

abstract：:The transcription factor cAMP response element binding protein (CREB), a member of the basic region leucine zipper (bZIP) family of proteins, is the major cAMP response element (CRE) binding. Other bZIP proteins, including CREB2, activating transcription factor 2 (ATF2), or CAAT/enhancer binding protein (C/EBP) have b...

journal_title：Journal of neurochemistry

authors： Thiel G,Al Sarraj J,Vinson C,Stefano L,Bach K

更新日期：2005-01-01 00:00:00

abstract：:The effect of L-phenylalanine on the transport of tyrosine was studied using membrane vesicles from rat brain synaptosomes. Phenylalanine, which is accumulated in phenylketonuria, competitively inhibits tyrosine uptake at concentrations similar to those found in phenylketonuric patients, with a Ki of the same order of...

journal_title：Journal of neurochemistry

authors： Aragón MC,Giménez C,Valdivieso F

更新日期：1982-10-01 00:00:00

abstract：:Some data on the concentration range of response and the concentration for half-response (EC50) of gamma-aminobutyric acid (GABA) for the GABAA receptor are reviewed and compared. An analysis of the 36Cl- flux assay demonstrates that both the EC50 and the slope of a Hill plot depend on the ion influx or efflux assay t...

journal_title：Journal of neurochemistry

authors： Kardos J,Cash DJ

更新日期：1990-10-01 00:00:00

abstract：:This study examines the proteolysis of the carboxy terminal domain of the full-length (alpha 1(212)) and truncated (alpha 1(190)) forms of the rabbit skeletal muscle L-type calcium channel alpha 1 subunit by calpain I and calpain II. Although both forms of the alpha 1 subunit show little sensitivity to proteolysis by ...

journal_title：Journal of neurochemistry

authors： De Jongh KS,Colvin AA,Wang KK,Catterall WA

更新日期：1994-10-01 00:00:00

abstract：:A glycoprotein ATPase in cholinergic synaptic vesicles of Torpedo electric organ was solubilized with octa-ethylene glycol dodecyl ether detergent. Study of potential stabilizing factors identified crude brain phosphatidylserine, glycerol, dithiothreitol, and protease inhibitors as of value in maintaining activity. Th...

journal_title：Journal of neurochemistry

authors： Yamagata SK,Noremberg K,Parsons SM

更新日期：1989-11-01 00:00:00

abstract：:Two monoclonal antibodies that recognize Alzheimer's neurofibrillary tangles (ANTs), AD10 and AB18, have been characterized by immunoblotting against human and calf spinal cord neurofilament (NF) and calf brain microtubule preparations. Both antibodies bind to the 200-kilodalton (kd) (NF-H) and 160-kd (NF-M) but not t...

journal_title：Journal of neurochemistry

authors： Ksiezak-Reding H,Yen SH

更新日期：1987-02-01 00:00:00

abstract：:Methylone, 3,4-methylenedioxypyrovalerone (MDPV), and mephedrone are psychoactive ingredients of 'bath salts' and their abuse represents a growing public health care concern. These drugs are cathinone derivatives and are classified chemically as β-ketoamphetamines. Because of their close structural similarity to the a...

journal_title：Journal of neurochemistry

authors： Anneken JH,Angoa-Pérez M,Kuhn DM

更新日期：2015-04-01 00:00:00

abstract：:The presence of the biologically uncommon D-aspartic acid (D-aspartate) in human brain white matter has been previously reported. The earlier study has now been expanded to include D/L-aspartate ratios from 67 normal brains. The data show that the D-aspartate content increases rapidly from 1 year to approximately 35 y...

journal_title：Journal of neurochemistry

authors： Man EH,Fisher GH,Payan IL,Cadilla-Perezrios R,Garcia NM,Chemburkar R,Arends G,Frey WH 2nd

更新日期：1987-02-01 00:00:00

abstract：:Head injury was induced in rats by a weight drop device, falling over the left hemisphere. The rats were killed at 15 min, 4 h, and 24 h after injury. Cortical slices were taken from the injured zone, from the corresponding region of the contralateral hemisphere, and from the frontal lobe of both hemispheres. These co...

journal_title：Journal of neurochemistry

authors： Shohami E,Shapira Y,Yadid G,Reisfeld N,Yedgar S

更新日期：1989-11-01 00:00:00

abstract：:A continuous enzyme-linked fluorometric assay was used for determining the characteristics for glutamate exocytosis from guinea-pig cerebrocortical synaptosomes. Ca2+-dependent release can be induced not only by K+, but also by the Na+ channel activator veratridine and the Ca2+ ionophore ionomycin. K+-induced release ...

journal_title：Journal of neurochemistry

authors： Sanchez-Prieto J,Sihra TS,Nicholls DG

更新日期：1987-07-01 00:00:00

abstract：:Spinal cord injury (SCI) elicits a neuroinflammatory reaction dominated by microglia and monocyte-derived macrophages (MDM). Because MDM do not infiltrate the spinal cord until days after injury, it may be possible to control whether they differentiate into neuroprotective or neurotoxic effector cells. However, doing ...

journal_title：Journal of neurochemistry

authors： Longbrake EE,Lai W,Ankeny DP,Popovich PG

更新日期：2007-08-01 00:00:00

abstract：:The angiotensin II competitive antagonist [125I]-Sar1, Ile8-angiotensin II was not transported from the vascular space to the cerebroventricular space in either intact or nephrectomized rats. In addition [125I]Sar1, Ile8-angiotensin II lacked the capacity to move in the opposite direction over a 20-min collection peri...

journal_title：Journal of neurochemistry

authors： Harding JW,Sullivan MJ,Hanesworth JM,Cushing LL,Wright JW

更新日期：1988-02-01 00:00:00