Glutamate receptor δ1 induces preferentially inhibitory presynaptic differentiation of cortical neurons by interacting with neurexins through cerebellin precursor protein subtypes.

abstract：:The ubiquitous second messenger cyclic GMP (cGMP) is synthesized by soluble guanylate cyclases in response to nitric oxide (NO) and degraded by phosphodiesterases (PDE). We studied the homeostasis of cGMP in living thalamic neurons by using the genetically encoded fluorescence resonance energy transfer sensor Cygnet, ...

journal_title：Journal of neurochemistry

authors： Hepp R,Tricoire L,Hu E,Gervasi N,Paupardin-Tritsch D,Lambolez B,Vincent P

更新日期：2007-09-01 00:00:00

abstract：:Dystonia musculorum (dt) mice suffer from a severe sensory neuropathy caused by mutations in the gene encoding the cytoskeletal cross-linker protein dystonin/bullous pemphigoid antigen 1 (Bpag1). Loss of function of dystonin/Bpag1 within neurons leads to a loss in the maintenance of cytoskeletal organization and to th...

journal_title：Journal of neurochemistry

authors： De Repentigny Y,Deschênes-Furry J,Jasmin BJ,Kothary R

更新日期：2003-08-01 00:00:00

abstract：:Repeated intermittent treatment with amphetamine (AMPH) induces both neurite outgrowth and enhanced AMPH-stimulated dopamine (DA) release in PC12 cells. We investigated the role of protein kinases in the induction of these AMPH-mediated events by using inhibitors of protein kinase C (PKC), mitogen activated protein ki...

journal_title：Journal of neurochemistry

authors： Park YH,Kantor L,Guptaroy B,Zhang M,Wang KK,Gnegy ME

更新日期：2003-12-01 00:00:00

abstract：:Inhalation of either 0.5% or 1.0% halothane in air caused a slight decrease in the cAMP concentration in rat cerebral cortex and cerebellum. During recovery, concentrations returned to normal in 3 h, or less. In contrast, cGMP decreased sixfold in cerebellum, but increased twofold in cortex. Recovery time for cerebell...

journal_title：Journal of neurochemistry

authors： Divakaran P,Rigor BM,Wiggins RC

更新日期：1980-08-01 00:00:00

abstract：:Expression of rat brain gamma-aminobutyric acid type A (GABA(A)) receptors in Xenopus laevis oocytes can be achieved by injection of the oocytes with synaptosomes. This approach has now been applied to evaluate changes in the function of nigral GABA(A) receptors after degeneration of the striatonigral GABAergic pathwa...

journal_title：Journal of neurochemistry

authors： Sanna E,Motzo C,Usala M,Pau D,Cagetti E,Biggio G

更新日期：1998-06-01 00:00:00

abstract：:A new neuronal cell line was generated by transfection of rat olfactory epithelium with immortalizing recombinant oncogene E1A of adenovirus-2. The resulting 13.S.1.24 line of transformed cells expressed an antigenic phenotype of olfactory neuronal progenitors. Addition of dopamine to 13.S.1.24 cultures induced reduct...

journal_title：Journal of neurochemistry

authors： Coronas V,Féron F,Hen R,Sicard G,Jourdan F,Moyse E

更新日期：1997-11-01 00:00:00

abstract：:Presynaptic receptors modulating the release of acetylcholine (ACh) were studied in fetal septal neurons cultured in a growth medium to which various drugs were added from day 3 in vitro (DIV 3) to DIV 14. The influence of these drugs on the function of the presynaptic muscarinic (M-) autoreceptor was determined at DI...

journal_title：Journal of neurochemistry

authors： Ehret A,Birthelmer A,Rutz S,Riegert C,Rothmaier AK,Jackisch R

更新日期：2007-08-01 00:00:00

abstract：:The present study investigated the effects of two serotonin (5-HT) uptake inhibitors, citalopram and paroxetine, and of a non-selective noradrenaline (NA) and 5-HT uptake blocker, imipramine, on extracellular NA and dopamine (DA) in the prefrontal cortex (PfCX), parietal cortex (ParCX) and occipital cortex (OccCX). Ci...

journal_title：Journal of neurochemistry

authors： Valentini V,Cacciapaglia F,Frau R,Di Chiara G

更新日期：2005-04-01 00:00:00

abstract：:The effect of inhibition and down-regulation of protein kinase C (PKC) subtypes alpha, epsilon, and zeta on noradrenaline (NA) secretion from human SH-SY5Y neuroblastoma cells was investigated. The PKC inhibitor Ro 31-7549 inhibited carbachol-evoked NA release (IC(50) 0.6 microM) but not 100 mM (K+)-evoked release. In...

journal_title：Journal of neurochemistry

authors： Turner NA,Walker JH,Ball SG,Vaughan PF

更新日期：1996-06-01 00:00:00

abstract：:Free radicals have been implicated in the etiology of many neurodegenerative conditions. Yet, because these species are highly reactive and thus short-lived it has been difficult to test these hypotheses. We adapted a method in which hydroxyl radicals are trapped by salicylate in vivo, resulting in the stable and quan...

journal_title：Journal of neurochemistry

authors： Giovanni A,Liang LP,Hastings TG,Zigmond MJ

更新日期：1995-04-01 00:00:00

abstract：:Phospholipase C gamma 1 (PLC-gamma 1) is involved at an early step in signal transduction of many hormones and growth factors and catalyzes the hydrolysis of phosphatidylinositol (PI) 4,5-bisphosphate to diacylglycerol and inositol trisphosphate, two potent intracellular second messenger molecules. The transformation ...

journal_title：Journal of neurochemistry

authors： Widmer HR,Kaplan DR,Rabin SJ,Beck KD,Hefti F,Knüsel B

更新日期：1993-06-01 00:00:00

abstract：:beta-Amyloid peptides (Abeta40 and Abeta42) are the major constituents of amyloid plaques, which are one of the hallmarks of Alzheimer's disease (AD). The Abeta is derived from sequential cleavages of amyloid precursor protein (APP) by beta- and gamma-secretases. gamma-Secretase consists of at least four proteins wher...

journal_title：Journal of neurochemistry

authors： Lai MT,Crouthamel MC,DiMuzio J,Pietrak BL,Donoviel DB,Bernstein A,Gardell SJ,Li YM,Hazuda D

更新日期：2006-01-01 00:00:00

abstract：:We sought to investigate whether dexamethasone produces a coordinated, time-dependent effect on all enzymes in the catecholamine biosynthetic pathway in PC12 cells. The levels of mRNAs of tyrosine hydroxylase (TH), aromatic L-amino acid decarboxylase (AADC), and dopamine beta-hydroxylase (DBH) were examined at 0, 6, 1...

journal_title：Journal of neurochemistry

authors： Kim KT,Park DH,Joh TH

更新日期：1993-03-01 00:00:00

abstract：:Calsenilin/DREAM/KChIP3 was identified as a calcium-binding protein that interacts with presenilins, serves as a transcription repressor, and binds to the A-type potassium channel. In this study, we hypothesized that calsenilin might be involved in the neurodegeneration of Alzheimer's disease and examined calsenilin e...

journal_title：Journal of neurochemistry

authors： Jo DG,Lee JY,Hong YM,Song S,Mook-Jung I,Koh JY,Jung YK

更新日期：2004-02-01 00:00:00

abstract：:Dopamine neurons have been suggested to use glutamate as a cotransmitter. To identify the basis of such a phenotype, we have examined the expression of the three recently identified vesicular glutamate transporters (VGLUT1-3) in postnatal rat dopamine neurons in culture. We found that the majority of isolated dopamine...

journal_title：Journal of neurochemistry

authors： Dal Bo G,St-Gelais F,Danik M,Williams S,Cotton M,Trudeau LE

更新日期：2004-03-01 00:00:00

abstract：:RIC-3 enhances the functional expression of certain nicotinic acetylcholine receptors (nAChRs) in vertebrates and invertebrates and increases the availability of functional receptors in cultured cells and Xenopus laevis oocytes. Maximal activity of RIC-3 may be cell-type dependent, so neither mammalian nor invertebrat...

journal_title：Journal of neurochemistry

authors： Bennett HM,Lees K,Harper KM,Jones AK,Sattelle DB,Wonnacott S,Wolstenholme AJ

更新日期：2012-12-01 00:00:00

abstract：:Glia maturation factor-beta, a protein found in the brains of all vertebrates thus far examined, appears to play a role in the differentiation, maintenance, and regeneration of the nervous system. Using oligonucleotide probes based on the sequences of three tryptic peptides derived from bovine glia maturation factor-b...

journal_title：Journal of neurochemistry

authors： Kaplan R,Zaheer A,Jaye M,Lim R

更新日期：1991-08-01 00:00:00

abstract：:Neuronal death due to excessive activation of N-methyl-d-aspartate (NMDA) receptors is a hallmark of neurodegenerative diseases. The polyamines: putrescine, spermine, and spermidine, bind to specific sites on the NMDA receptor and promote its activation, but their role in NMDA-induced neuronal death is ill defined. In...

journal_title：Journal of neurochemistry

authors： Pernet V,Bourgeois P,Di Polo A

更新日期：2007-11-01 00:00:00

abstract：:P-glycoprotein (P-gp), an adenosine triphosphate (ATP)-binding cassette transporter which acts as a drug efflux pump, is highly expressed at the blood-brain barrier (BBB) where it plays an important role in brain protection. Recently, P-gp has been reported to be located in the caveolae of multidrug-resistant cells. I...

journal_title：Journal of neurochemistry

authors： Jodoin J,Demeule M,Fenart L,Cecchelli R,Farmer S,Linton KJ,Higgins CF,Béliveau R

更新日期：2003-11-01 00:00:00

abstract：:A previous report has described the presence of t-[35S]-butylbicyclophosphorothionate binding sites and GABA-gated Cl- flux in the human neuroblastoma IMR-32 cell line. We now report the further characterisation of this binding site and, even more important, the identification of the GABAA receptor alpha 3 sub-unit ex...

journal_title：Journal of neurochemistry

authors： Noble PJ,Anderson SM,De Souza RJ,Cross AJ,Stephenson FA

更新日期：1993-08-01 00:00:00

abstract：:The present study demonstrates that [3H]imipramine binds to both high- and low-affinity imipramine binding components on membranes prepared from rat cerebral cortex. Scatchard and computer analyses of saturation experiments using a wide range of [3H]imipramine concentrations (0.5 nM-50 nM) revealed the presence of two...

journal_title：Journal of neurochemistry

authors： Conway PG,Brunswick DJ

更新日期：1985-07-01 00:00:00

abstract：:Although isoelectric focusing has been used to demonstrate the presence of oligoclonal IgG in the CSF, the technique has not allowed detection of oligoclonal IgG in unconcentrated CSF. A new technique is reported, by which unconcentrated CSF is separated by isoelectric focusing, and the IgG bands are then detected by ...

journal_title：Journal of neurochemistry

authors： Lasne Y,Benzerara O,Chazot G,Creyssel R

更新日期：1981-05-01 00:00:00

abstract：:Challenge of protease-activated receptors induces cytosolic Ca(2+) concentration ([Ca(2+) ](c)) increase, mitogen-activated protein kinase activation and reactive oxygen species (ROS) formation with a bandwidth of responses in individual cells. We detected in this study in situ the thrombin-induced [Ca(2+) ](c) rise a...

journal_title：Journal of neurochemistry

authors： Zündorf G,Reiser G

更新日期：2011-12-01 00:00:00

abstract：:Mutations in the tau gene cause frontotemporal dementia and parkinsonism linked to chromosome-17 (FTDP-17). Functionally, about half of the known mutations increase the alternative mRNA splicing of exon 10 of the tau gene, resulting in the overproduction of tau isoforms with four microtubule-binding repeats. The other...

journal_title：Journal of neurochemistry

authors： Yoshida H,Crowther RA,Goedert M

更新日期：2002-02-01 00:00:00

abstract：:For more than three decades, the venom of the black widow spider and its principal active components, latrotoxins, have been used to induce release of neurotransmitters and hormones and to study the mechanisms of exocytosis. Given the complex nature of alpha--latrotoxin (alpha-LTX) actions, this research has been cont...

journal_title：Journal of neurochemistry

authors： Silva JP,Suckling J,Ushkaryov Y

更新日期：2009-10-01 00:00:00

abstract：:In PC12 cells, preincubated with [3H]inositol, nerve growth factor (NGF) stimulated an approximately 100% increase in the levels of [3H]inositol 1,3,4-trisphosphate ([3H]-Ins(1,3,4)P3], [3H]inositol 1,4,5-trisphosphate ([3H]Ins(1,4,5)P3], and [3H]inositol 1,3,4,5-tetrakisphosphate ([3H]Ins(1,3,4,5)P4] as early as 5-15...

journal_title：Journal of neurochemistry

authors： Contreras ML

更新日期：1993-09-01 00:00:00

abstract：:We have studied the responsiveness of vascular adenylate cyclase to vasoactive intestinal peptide (VIP) and parathyroid hormone (PTH) using preparations of cerebral microvessels and arteries. Cerebral microvessels obtained from rats, guinea-pigs, cattle, and pigs all responded potently to bovine (b) PTH-(1-34), wherea...

journal_title：Journal of neurochemistry

authors： Huang M,Rorstad OP

更新日期：1984-09-01 00:00:00

abstract：:Beta-carbolines have been suggested to be involved in the pathogenesis of Parkinson's disease as a result of their structural similarity to the neurotoxin N -methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). The chloral-derived beta-carboline derivative 1-trichloromethyl-1,2,3,4-tetrahydro-beta-carboline (TaClo) caus...

journal_title：Journal of neurochemistry

authors： Riederer F,Luborzewski A,God R,Bringmann G,Scholz J,Feineis D,Moser A

更新日期：2002-05-01 00:00:00

abstract：:There is ample evidence that both acid (ASMase) and neutral (NSMase) sphingomyelinases play a role in cell death so inhibitors of either enzyme could have significant value as protectors against neurodegeneration. We used a fluorogenic sphingomyelinase substrate, 6-hexadecanoylamino-4-methylumbelliferyl-phosphorylchol...

journal_title：Journal of neurochemistry

authors： Testai FD,Landek MA,Goswami R,Ahmed M,Dawson G

更新日期：2004-05-01 00:00:00

abstract：:Although brain-derived neurotrophic factor is the most abundant and widely distributed neurotrophin in the nervous system, reproducible determinations of its levels have been hampered by difficulties in raising suitable monoclonal antibodies. Following immunization of mice with recombinant fish and mammalian brain-der...

journal_title：Journal of neurochemistry

authors： Kolbeck R,Bartke I,Eberle W,Barde YA

更新日期：1999-05-01 00:00:00