Cerebral vascular adenylate cyclase: evidence for coupling to receptors for vasoactive intestinal peptide and parathyroid hormone.

abstract：:The MRC OX-2 monoclonal antibody recognises membrane glycoproteins of Mr 41,000 in rat brain and 47,000 on thymocytes. It also reacts with follicular dendritic cells in lymphoid organs, endothelium, smooth muscle, and B-lymphocytes. Indirect immunoperoxidase staining of cryostat sections showed that OX-2 antigen was p...

journal_title：Journal of neurochemistry

authors： Webb M,Barclay AN

更新日期：1984-10-01 00:00:00

abstract：:Mutations in copper/zinc superoxide dismutase (SOD1) account for 10-20% of a familial form of amyotrophic lateral sclerosis (ALS). A common feature of SOD1 mutants is abnormal aggregation of the aberrant SOD1 in neurons and glia. We now report that in ALS transgenic mouse models the constitutively expressed heat shock...

journal_title：Journal of neurochemistry

authors： Liu J,Shinobu LA,Ward CM,Young D,Cleveland DW

更新日期：2005-05-01 00:00:00

abstract：:The accumulation of choline, homocholine, and 4-hydroxybutyltrimethylammonium by rat brain synaptosomes was measured; the choline uptake mechanism transported homocholine but not hydroxybutyltrimethylammonium, which, in addition, did not block choline accumulation. In cats' superior cervical ganglia, preganglionic ner...

journal_title：Journal of neurochemistry

authors： Collier B

更新日期：1981-03-01 00:00:00

abstract：:Neuronal differentiation requires exquisitely timed cell cycle arrest for progenitors to acquire an appropriate neuronal cell fate and is achieved by communication between soluble signals, such as growth factors and extracellular matrix molecules. Here we report that the expression of TIMP-2, a matrix metalloproteinas...

journal_title：Journal of neurochemistry

authors： Jaworski DM,Pérez-Martínez L

更新日期：2006-07-01 00:00:00

abstract：:In the adult mammalian brain, neural stem cells (NSCs) reside in two neurogenic regions, the walls of the lateral ventricles, and the subgranular zone of the hippocampus, which generate new neurons for the olfactory bulb and dentate gyrus, respectively. These adult NSCs retain their self-renewal ability and capacity t...

journal_title：Journal of neurochemistry

authors： Hayashi Y,Jinnou H,Sawamoto K,Hitoshi S

更新日期：2018-12-01 00:00:00

abstract：:Neuromodulation is a fundamental process in the brain that regulates synaptic transmission, neuronal network activity and behavior. Emerging evidence demonstrates that astrocytes, a major population of glial cells in the brain, play previously unrecognized functions in neuronal modulation. Astrocytes can detect the le...

journal_title：Journal of neurochemistry

authors： Fellin T

更新日期：2009-02-01 00:00:00

abstract：:The effect of depolarizing concentrations of potassium (56 mM) on the release of [3H]taurine was examined in two types of cultured neurons from mouse brain: cerebral cortex neurons, which are largely GABAergic, and cerebellar neurons, which after treatment with kainate consist almost entirely of glutamatergic granule ...

journal_title：Journal of neurochemistry

authors： Schousboe A,Pasantes-Morales H

更新日期：1989-10-01 00:00:00

abstract：:Epidermal growth factor (EGF) is a member of a structurally related family containing heparin-binding EGF-like growth factor (HB-EGF) and transforming growth factor alpha (TGFalpha) that exerts neurotrophic activity on midbrain dopaminergic neurons. To examine neurotrophic abnormality in Parkinson's disease (PD), we m...

journal_title：Journal of neurochemistry

authors： Iwakura Y,Piao YS,Mizuno M,Takei N,Kakita A,Takahashi H,Nawa H

更新日期：2005-05-01 00:00:00

abstract：:To study the role of intracellular pH (pHi) in catecholamine secretion and the regulation of pHi in bovine chromaffin cells, the pH-sensitive fluorescent indicator [2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein] was used to monitor the on-line changes in pHi. The pHi of chromaffin cells at resting state is approxima...

journal_title：Journal of neurochemistry

authors： Kao LS,Ho MY,Cragoe EJ Jr

更新日期：1991-11-01 00:00:00

abstract：:Painful neuropathy is one of the most serious complications of diabetes and remains difficult to treat. The muscarinic acetylcholine receptor (mAChR) agonists have a profound analgesic effect on painful diabetic neuropathy. Here we determined changes in T-type and high voltage-activated Ca(2+) channels (HVACCs) and th...

journal_title：Journal of neurochemistry

authors： Cao XH,Byun HS,Chen SR,Pan HL

更新日期：2011-11-01 00:00:00

abstract：:It has been suggested that disturbances during neurodevelopment may play a crucial role in the etiology of schizophrenia (SZ). This premise is supported by brain imaging, epidemiological, and pathological studies as well as the discovery of susceptibility genes for SZ that appear to be implicated in development of the...

journal_title：Journal of neurochemistry

authors： Cascella NG,Takaki M,Lin S,Sawa A

更新日期：2007-08-01 00:00:00

abstract：:Despite the increasing knowledge of Alzheimer's disease (AD) management with novel pharmacologic agents, most of them are only transiently fixing symptomatic pathology. Currently there is rapid growth in the field of neuroprotective pharmacology and increasing focus on the involvement of mitochondria in this devastati...

journal_title：Journal of neurochemistry

authors： Galindo MF,Ikuta I,Zhu X,Casadesus G,Jordán J

更新日期：2010-08-01 00:00:00

abstract：:Endogenous norepinephrine (NE) release in cerebral cortex slices taken from normal and morphine-tolerant guinea pigs was measured by HPLC. In normal slices, a linear relationship was found between electrically evoked NE release and the log of the frequency of stimulation in the range of 1-20 Hz. The efficiency of the ...

journal_title：Journal of neurochemistry

authors： Tomasini C,Guidorzi R,Bianchi C,Beani L

更新日期：1992-04-01 00:00:00

abstract：:The glutamate (Glu) terminals in rat neostriatum were removed by a unilateral frontal decortication. One to two weeks later the effects of insulin-induced hypoglycemia on the steady-state levels of amino acids [Glu, glutamine (Gln), aspartate (Asp), gamma-aminobutyric acid (GABA), taurine] and energy metabolites (gluc...

journal_title：Journal of neurochemistry

authors： Engelsen B,Westerberg E,Fonnum F,Wieloch T

更新日期：1986-11-01 00:00:00

abstract：:The modulation by adenosine analogues and endogenous adenosine of the electrically evoked release of [3H]acetylcholine ([3H]ACh) was compared in subslices of the three areas of the rat hippocampus (CA1, CA3, and dentate gyrus). The mixed A1/A2 agonist 2-chloroadenosine (CADO; 2-10 microM) inhibited, in a concentration...

journal_title：Journal of neurochemistry

authors： Cunha RA,Milusheva E,Vizi ES,Ribeiro JA,Sebastião AM

更新日期：1994-07-01 00:00:00

abstract：:Morphine is a key drug for the treatment of pain but its side effects limit its clinical application. MEL-0614, an endomorphin-1 analog, has fewer side effects than morphine in addition to its powerful analgesic effect. In this study, we measured the effect of morphine and MEL-0614 on hyperalgesia (7 days) and neuropa...

journal_title：Journal of neurochemistry

authors： Ma M,Wang Z,Wang J,Wei S,Cui J,Wang Y,Luo K,Zhao L,Liu X,Wang R

更新日期：2020-07-15 00:00:00

abstract：:Ligand binding to the cannabinoid receptor of brain membranes has been characterized using [3H]CP 55,940 and the Multiscreen Filtration System. Binding of [3H]CP 55,940 is saturable and reaches equilibrium by 45 min at room temperature. At a concentration of 10 micrograms of membrane protein/well, the KD for [3H]CP 55...

journal_title：Journal of neurochemistry

authors： Hillard CJ,Edgemond WS,Campbell WB

更新日期：1995-02-01 00:00:00

abstract：:The role of neuroactive steroids and GABA(A) receptors in the generation of spontaneous spike-and-wave discharges (SWDs) was investigated in the WAG/Rij rat model of absence epilepsy. The plasma, cerebrocortical, and thalamic concentrations of the progesterone metabolite 3alpha-hydroxy-5alpha-pregnan-20-one (3alpha,5a...

journal_title：Journal of neurochemistry

authors： Pisu MG,Mostallino MC,Dore R,Mura ML,Maciocco E,Russo E,De Sarro G,Serra M

更新日期：2008-09-01 00:00:00

abstract：:Hyperexcitability of the hippocampus is a commonly observed phenomenon in the years preceding a diagnosis of Alzheimer's disease (AD). Our previous work suggests a dysregulation in glutamate neurotransmission may mediate this hyperexcitability, and glutamate dysregulation correlates with cognitive deficits in the rTg(...

journal_title：Journal of neurochemistry

authors： Hunsberger HC,Weitzner DS,Rudy CC,Hickman JE,Libell EM,Speer RR,Gerhardt GA,Reed MN

更新日期：2015-10-01 00:00:00

abstract：:Both acidosis and oxidative stress contribute to ischemic brain injury. The present study examines interactions between acidosis and oxidative stress in murine cortical cultures. Acidosis (pH 6.2) was found to potentiate markedly neuronal death induced by H2O2 exposure. To determine if this effect was mediated by decr...

journal_title：Journal of neurochemistry

authors： Ying W,Han SK,Miller JW,Swanson RA

更新日期：1999-10-01 00:00:00

abstract：:Dysregulation of the central noradrenergic system is a core feature of post-traumatic stress disorder (PTSD). Here, we examined molecular changes in locus coeruleus (LC) triggered by single-prolonged stress (SPS) PTSD model at a time when behavioral symptoms are manifested, and the effect of early intervention with in...

journal_title：Journal of neurochemistry

authors： Sabban EL,Laukova M,Alaluf LG,Olsson E,Serova LI

更新日期：2015-12-01 00:00:00

abstract：:Two biochemical strategies using nick translation-type of incubation and terminal tranferase-catalyzed reaction were used to assess single-(SSB) and double-strand (DSB) breaks in DNA of permeabilized neurons isolated from young, adult, and old rat cerebral cortex. Both SSBs and DSBs accumulate with age. On prior treat...

journal_title：Journal of neurochemistry

authors： Mandavilli BS,Rao KS

更新日期：1996-10-01 00:00:00

abstract：:The histamine H1 receptor binding capacity of the amygdalas of amygdaloid kindled rats was studied. In the kindled nonstimulated amygdala, significant decreases in K(D) and B(max) values compared with those of control amygdala were found 1 week after the last kindled seizure. One month after the last kindled seizure, ...

journal_title：Journal of neurochemistry

authors： Toyota H,Ito C,Yanai K,Sato M,Watanabe T

更新日期：1999-05-01 00:00:00

abstract：:Presynaptic nicotinic acetylcholine receptors on striatal nerve terminals modulate the release of dopamine. We have compared the effects of a number of nicotinic agonists and antagonists on a perfused synaptosome preparation preloaded with [3H]dopamine. (-)-Nicotine, acetylcholine, and the nicotinic agonists cytisine ...

journal_title：Journal of neurochemistry

authors： Rapier C,Lunt GG,Wonnacott S

更新日期：1990-03-01 00:00:00

abstract：:Cytokines and catecholamines are known to constitute a significant portion of the regulatory neuroimmune networks involved in maintaining homeostasis in the central nervous system (CNS). Although we have already reported an increase in norepinephrine (NE) turnover within the locus coeruleus (LC) at 2 and 4 h after the...

journal_title：Journal of neurochemistry

authors： Kaneko YS,Mori K,Nakashima A,Sawada M,Nagatsu I,Ota A

更新日期：2005-07-01 00:00:00

abstract：:The biggest risk factor for Alzheimer's disease is the process of ageing, but the mechanisms that lead to the manifestation of the disease remain to be elucidated. Why age triggers the disease is unclear but an emerging theme is the inability for a cell to efficiently maintain many key processes such as energy product...

journal_title：Journal of neurochemistry

authors： Roberts BR,Ryan TM,Bush AI,Masters CL,Duce JA

更新日期：2012-01-01 00:00:00

abstract：:Administration of L-DOPA (50 mg/kg) elicits a significant increase in extracellular dopamine in striata of rats treated with the catecholaminergic neurotoxin 6-hydroxydopamine but not in striata of intact rats. To assess the role of dopaminergic nerve terminals in determining the effects of exogenous L-DOPA on extrace...

journal_title：Journal of neurochemistry

authors： Wachtel SR,Abercrombie ED

更新日期：1994-07-01 00:00:00

abstract：:This review examines the involvement of nitrotyrosine as a marker for peroxynitrite-mediated damage in the dopamine neuronal system. We propose that the dopamine neuronal phenotype can influence the cytotoxic signature of peroxynitrite. Dopamine and tetrahydrobiopterin are concentrated in dopamine neurons, and both ar...

journal_title：Journal of neurochemistry

authors： Kuhn DM,Sakowski SA,Sadidi M,Geddes TJ

更新日期：2004-05-01 00:00:00

abstract：:Both increased gamma-aminobutyric acid (GABA)-ergic and decreased glutamatergic neurotransmission have been suggested relative to the pathophysiology of hepatic encephalopathy. This proposed disturbance in neurotransmitter balance, however, is based mainly on brain tissue analysis. Because the approach of whole tissue...

journal_title：Journal of neurochemistry

authors： Bosman DK,Deutz NE,Maas MA,van Eijk HM,Smit JJ,de Haan JG,Chamuleau RA

更新日期：1992-08-01 00:00:00

abstract：:Docosahexaenoic acid (DHA), an n-3 fatty acid, is rapidly deposited during the period of rapid brain development. The influence of n-3 fatty acid deficiency on learning performance in adult rats over two generations was investigated. Rats were fed either an n-3 fatty acid-adequate (n-3 Adq) or -deficient (n-3 Def) die...

journal_title：Journal of neurochemistry

authors： Moriguchi T,Greiner RS,Salem N Jr

更新日期：2000-12-01 00:00:00