Localisation of the MRC OX-2 glycoprotein on the surfaces of neurones.

abstract：:Synaptotagmin-7 (Syt-7) is one of two major calcium sensors for exocytosis in adrenal chromaffin cells, the other being synaptotagmin-1 (Syt-1). Despite a broad appreciation for the importance of Syt-7, questions remain as to its localization, function in mediating discharge of dense core granule cargos, and role in t...

journal_title：Journal of neurochemistry

authors： Bendahmane M,Morales A,Kreutzberger AJB,Schenk NA,Mohan R,Bakshi S,Philippe JM,Zhang S,Kiessling V,Tamm LK,Giovannucci DR,Jenkins PM,Anantharam A

更新日期：2020-09-01 00:00:00

abstract：:Nitric oxide (NO) is a key neuromodulator of corticostriatal synaptic transmission. We have shown previously that dopamine (DA) D1/5 receptor stimulation facilitates neuronal NO synthase (nNOS) activity in the intact striatum. To study the impact of local manipulations of D1/5 and glutamatergic NMDA receptors on stria...

journal_title：Journal of neurochemistry

authors： Park DJ,West AR

更新日期：2009-12-01 00:00:00

abstract：:It is necessary for the cell-cycle machinery of neurons to be suppressed to promote differentiation and maintenance of their terminally differentiated state. Reactivation of the cell cycle in response to neurotoxic insults leads to neuronal cell death and some cell-cycle-related proteins contribute to the process. p27...

journal_title：Journal of neurochemistry

authors： Jaiswal S,Sharma P

更新日期：2017-02-01 00:00:00

abstract：:Female mice are more susceptible to apolipoprotein E (apoE4)-induced cognitive deficits than male mice. These deficits can be antagonized by stimulating androgen receptors (ARs). To determine the role of AR in the cognitive effects of apoE4, we backcrossed mutant mice with a naturally occurring defect in the AR [testi...

journal_title：Journal of neurochemistry

authors： Rizk-Jackson A,Robertson J,Raber J

更新日期：2008-04-01 00:00:00

abstract：:Although isoelectric focusing has been used to demonstrate the presence of oligoclonal IgG in the CSF, the technique has not allowed detection of oligoclonal IgG in unconcentrated CSF. A new technique is reported, by which unconcentrated CSF is separated by isoelectric focusing, and the IgG bands are then detected by ...

journal_title：Journal of neurochemistry

authors： Lasne Y,Benzerara O,Chazot G,Creyssel R

更新日期：1981-05-01 00:00:00

abstract：:Exhaustive in vitro dephosphorylation of porcine neurofilaments (NFs) by alkaline or acid phosphatase did not cause a dissociation of the 210-kD (NF-H), 160-kD (NF-M), or 70-kD (NF-L) subunits and had no effect on the reassembly of NFs from urea or guanidine solution. Electron microscopy revealed that the NFs reassemb...

journal_title：Journal of neurochemistry

authors： Georges E,Lefebvre S,Mushynski WE

更新日期：1986-08-01 00:00:00

abstract：:Rat brain benzodiazepine receptors have been solubilized by means of the zwitterionic detergent CHAPS under conditions in which the GABA stimulation of [3H]flunitrazepam binding to the benzodiazepine receptors is maintained intact. This stimulation is partially or totally abolished when using other conventional deterg...

journal_title：Journal of neurochemistry

authors： Mernoff ST,Cherwinski HM,Becker JW,de Blas AL

更新日期：1983-09-01 00:00:00

abstract：:PRMT1, a major arginine methyltransferase, plays critical roles in transcription, DNA damage response, and cell proliferation. Although we have previously discovered the crucial roles of PRMT1 for oligodendrocyte lineage progression in the central nervous system of neural stem cell-specific PRMT1 conditional knockout ...

journal_title：Journal of neurochemistry

authors： Hashimoto M,Kumabe A,Kim JD,Murata K,Sekizar S,Williams A,Lu W,Ishida J,Nakagawa T,Endo M,Minami Y,Fukamizu A

更新日期：2020-08-16 00:00:00

abstract：:Accumulation of misfolded proteins and alterations in the ubiquitin-proteasome pathway are associated with various neurodegenerative conditions of the CNS and PNS. Aggregates containing ubiquitin and peripheral myelin protein 22 (PMP22) have been observed in the Trembler J mouse model of Charcot-Marie-Tooth disease ty...

journal_title：Journal of neurochemistry

authors： Fortun J,Li J,Go J,Fenstermaker A,Fletcher BS,Notterpek L

更新日期：2005-03-01 00:00:00

abstract：:Rosiglitazone is a member of the thiazolidinedione family of synthetic peroxisome proliferator-activated receptor (PPAR) agonists. It is a selective ligand of the PPARgamma subtype and functions by regulating the transcription of insulin-responsive genes. A screen of FDA-approved compounds identified rosiglitazone as ...

journal_title：Journal of neurochemistry

authors： Doonan F,Wallace DM,O'Driscoll C,Cotter TG

更新日期：2009-04-01 00:00:00

abstract：:The present experiments show that N-[3H]-methylcarbamylcholine ([3H]MCC) binds specifically and with high affinity to rat hippocampus, frontal cortex, and striatum. The highest maximal density of binding sites was apparent in frontal cortex and the lowest in hippocampus. [3H]MCC binding was potently inhibited by nicot...

journal_title：Journal of neurochemistry

authors： Araujo DM,Lapchak PA,Collier B,Quirion R

更新日期：1988-07-01 00:00:00

abstract：:Regulation of prostaglandin (PG) E2 receptors was investigated in a 3-[(3-cholamidopropyl)dimethylammonio]-1-propanesulfonate-solubilized fraction from the synaptic membrane of porcine temporal cortex. The fraction was preincubated with exogenous protein kinases, and then the binding of PGE2 was measured. PGE2 binding...

journal_title：Journal of neurochemistry

authors： Morii H,Tanemura M,Watanabe Y

更新日期：1991-10-01 00:00:00

abstract：:Neuropeptide Y (NPY) is an important regulator of energy balance in mammals through its orexigenic, antithermogenic, and insulin secretagogue actions. We investigated the regulation of endogenous NPY release from rat hypothalamic slices by NPY receptor ligands and calcium channel antagonists. High-potassium stimulatio...

journal_title：Journal of neurochemistry

authors： King PJ,Widdowson PS,Doods HN,Williams G

更新日期：1999-08-01 00:00:00

abstract：:The current study used an ethanol antagonist, increased atmospheric pressure, to test the hypothesis that ethanol acts on multiple sites in glycine receptors (GlyRs). The effects of 12 times normal atmospheric pressure of helium-oxygen gas (pressure) on ethanol-induced potentiation of GlyR function in Xenopus oocytes ...

journal_title：Journal of neurochemistry

authors： Davies DL,Crawford DK,Trudell JR,Mihic SJ,Alkana RL

更新日期：2004-06-01 00:00:00

abstract：:The Na(+)-glutamate cotransporters are believed to countertransport OH- and K+. Previous evidence that the velocity of glutamate uptake can exceed the acid extrusion capacity of astrocytes raised the question of whether intracellular pH can become rate limiting for glutamate uptake. Cytoplasmic buffering capacity and ...

journal_title：Journal of neurochemistry

authors： Judd MG,Nagaraja TN,Brookes N

更新日期：1996-01-01 00:00:00

abstract：:Adult rat cerebral cortex slices when incubated in media in increasing K+ concentrations, from 3 to 20 mM ("physiological" conditions), exhibited an increase of Ki+ and a decrease of Nai+ and Cli-. This phenomenon appeared at 30 days postnatally, which is fairly late during development. Over 20 mM-K+ ("pathological" c...

journal_title：Journal of neurochemistry

authors： Grisar T,Franck G

更新日期：1981-05-01 00:00:00

abstract：:Epinephrine (Epi) mediates various physiological effects via alpha2A-adrenergic receptors (alpha2A-ARs). Studies in mice with a point mutation in the gene for alpha2A-AR have shown that these receptors are responsible for the centrally mediated depressor effects of alpha2-AR agonists. These studies underscore the impo...

journal_title：Journal of neurochemistry

authors： Reutter MA,Richards EM,Sumners C

更新日期：1998-01-01 00:00:00

abstract：:We have used biologically active derivatives of beta-nerve growth factor (NGF), modified by biotinylation via carboxyl groups, to target the specific binding of liposomes to cultured rat and human tumor cells bearing NGF receptors. Liposomes, to be used for targeting, were prepared by conjugating streptavidin to phosp...

journal_title：Journal of neurochemistry

authors： Rosenberg MB,Breakefield XO,Hawrot E

更新日期：1987-03-01 00:00:00

abstract：:A decline in the calcium-dependent release of neurotransmitters appears to underlie the decreased neuronal function that accompanies reduced oxygen tensions (hypoxia). To determine if alterations in calcium uptake are primary to these changes, synaptosomal calcium uptake was measured in the presence of 100%, 2.5%, or ...

journal_title：Journal of neurochemistry

authors： Peterson C,Gibson GE

更新日期：1984-01-01 00:00:00

abstract：:Choline acetyltransferase (ChAT), the enzyme synthesizing acetylcholine, is known to be activated by brain derived neurotrophic factor (BDNF). We found that the specific removal of the carbohydrate polysialic acid (PSA) significantly increased BDNF-induced ChAT-activity in embryonic septal neurons. Using a p75 neurotr...

journal_title：Journal of neurochemistry

authors： Burgess A,Aubert I

更新日期：2006-11-01 00:00:00

abstract：:The Review highlighted in this Editorial followed a CAEN Return Home Grant. ...

journal_title：Journal of neurochemistry

authors： William Rebeck G,Pak DTS

更新日期：2017-10-01 00:00:00

abstract：:Isolated rat CNS mitochondria and cultured cortical astrocytes were examined for behavior indicative of a mitochondrial permeability transition (mPT). Exposure of isolated CNS mitochondria to elevated calcium or phosphate or both produced loss of absorbance indicative of mitochondrial swelling. The absorbance decrease...

journal_title：Journal of neurochemistry

authors： Kristal BS,Dubinsky JM

更新日期：1997-08-01 00:00:00

abstract：:Most physiological processes in mammals are synchronized to the daily light:dark cycle by a circadian clock located in the hypothalamic suprachiasmatic nucleus. Signal transduction of light-induced phase advances of the clock is mediated through a neuronal nitric oxide synthase-guanilyl cyclase pathway. We have employ...

journal_title：Journal of neurochemistry

authors： Baidanoff FM,Plano SA,Doctorovich F,Suárez SA,Golombek DA,Chiesa JJ

更新日期：2014-04-01 00:00:00

abstract：:: The amyloid cascade hypothesis of Alzheimer's disease envisages that the initial elevation of amyloid β-peptide (Aβ) levels, especially of Aβ(1-42) , is the primary trigger for the neuronal cell death specific to onset of Alzheimer's disease. There is now substantial evidence that brain amyloid levels are manipulabl...

journal_title：Journal of neurochemistry

authors： Nalivaeva NN,Beckett C,Belyaev ND,Turner AJ

更新日期：2012-01-01 00:00:00

abstract：:Leptin is well known as a hormone important in the central control of appetitive behaviors via receptor-mediated actions in the hypothalamus, where leptin adjusts food intake to maintain homeostasis with the body's energy stores. Recent evidence has shown that leptin and its receptors are widespread in the CNS and may...

journal_title：Journal of neurochemistry

authors： Signore AP,Zhang F,Weng Z,Gao Y,Chen J

更新日期：2008-09-01 00:00:00

abstract：:Microvessels were isolated from canine cerebral cortex, and the composition of the endothelial cell membrane was investigated. Endothelial cell membranes were separated from the surrounding basement membrane, solubilized, and subjected to sodium dodecyl sulfate-polyacrylamide gel electrophoresis in 12% gels. Staining ...

journal_title：Journal of neurochemistry

authors： Lidinsky WA,Drewes LR

更新日期：1983-11-01 00:00:00

abstract：:After a brief period of global ischemia, the hippocampal CA1 region is more susceptible to irreversible damage than the paramedian neocortex. To test whether primary differences in bioenergetic parameters may be present between these regions, respiration rates and respiratory control activities were measured. In synap...

journal_title：Journal of neurochemistry

authors： Davey GP,Canevari L,Clark JB

更新日期：1997-12-01 00:00:00

abstract：:A continuous enzyme-linked fluorometric assay was used for determining the characteristics for glutamate exocytosis from guinea-pig cerebrocortical synaptosomes. Ca2+-dependent release can be induced not only by K+, but also by the Na+ channel activator veratridine and the Ca2+ ionophore ionomycin. K+-induced release ...

journal_title：Journal of neurochemistry

authors： Sanchez-Prieto J,Sihra TS,Nicholls DG

更新日期：1987-07-01 00:00:00

abstract：:2'-Deoxycoformycin (DCF), a potent inhibitor of adenosine deaminase (ADA), is increasingly used as a tool to investigate adenosine metabolism and neuromodulation. To advance further the usefulness of DCF for studies of purines in the CNS, we determined the inhibitory potency of this compound against ADA and adenylate ...

journal_title：Journal of neurochemistry

authors： Padua R,Geiger JD,Dambock S,Nagy JI

更新日期：1990-04-01 00:00:00

abstract：:Circadian clocks are internal timing systems that enable organisms to adjust their behavioral and physiological rhythms to the daily changes of their environment. These clocks generate self-sustained oscillations at the cellular, tissue, and behavioral level. The rhythm-generating mechanism is based on a gene expressi...

journal_title：Journal of neurochemistry

authors： Srikanta SB,Cermakian N

更新日期：2020-07-27 00:00:00