Histamine H1 receptor binding capacities in the amygdalas of the amygdaloid kindled rat.

abstract：:Several epidemiological and preclinical studies suggest that non-steroidal anti-inflammatory drugs (NSAIDs), which inhibit cyclooxygenase (COX), reduce the risk of Alzheimer's disease (AD) and can lower β-amyloid (Aβ) production and inhibit neuroinflammation. However, follow-up clinical trials, mostly using selective ...

journal_title：Journal of neurochemistry

authors： Choi SH,Aid S,Caracciolo L,Minami SS,Niikura T,Matsuoka Y,Turner RS,Mattson MP,Bosetti F

更新日期：2013-01-01 00:00:00

abstract：:Multiple sclerosis (MS) pathology is marked by the massive infiltration of myelin-specific T cells into the CNS. Hallmarks of T helper (Th) cells during active disease are pro-inflammatory Th1/Th17 cells that predominate over immunoregulatory Th2/Treg cells. Neurodegeneration, a major factor in progressive MS, is ofte...

journal_title：Journal of neurochemistry

authors： Trager N,Smith A,Wallace Iv G,Azuma M,Inoue J,Beeson C,Haque A,Banik NL

更新日期：2014-07-01 00:00:00

abstract：:Transcriptional dysregulation is a hallmark of Huntington's disease (HD) and one cause of this dysregulation is enhanced activity of the REST-mSIN3a-mSIN3b-CoREST-HDAC repressor complex, which silences transcription through REST binding to the RE1/NRSE silencer. Normally, huntingtin (HTT) prevents this binding, allowi...

journal_title：Journal of neurochemistry

authors： Conforti P,Zuccato C,Gaudenzi G,Ieraci A,Camnasio S,Buckley NJ,Mutti C,Cotelli F,Contini A,Cattaneo E

更新日期：2013-10-01 00:00:00

abstract：:Young rats (21 days old) made nutritionally iron deficient, by feeding them a semisynthetic diet containing skimmed milk for 5 weeks, had significantly lowered hemoglobin levels (5.2 +/- 4 g/100 ml). The nonheme iron content in caudate nucleus was decreased by 47%. The behavioral response of iron-deficient rats to apo...

journal_title：Journal of neurochemistry

authors： Youdim MB,Sills MA,Heydorn WE,Creed GJ,Jacobowitz DM

更新日期：1986-09-01 00:00:00

abstract：:Neuroleptics, which are potent dopamine receptor antagonists, are used to treat psychosis. In the striatum, dopamine subtype-2 (D2) receptors interact with high-affinity adenosine subtype-2 (A2a) receptors. To examine the effect of various neuroleptics on the major subtypes of striatal dopamine and adenosine receptors...

journal_title：Journal of neurochemistry

authors： Parsons B,Togasaki DM,Kassir S,Przedborski S

更新日期：1995-11-01 00:00:00

abstract：:Potassium-induced depolarization of synaptoneurosomes prepared from rat telencephalon was found to increase [3H]amino-3-hydroxy-5-methylisoxazole-4-propionate ([3H]AMPA) binding to the AMPA receptor. The effect required the presence of calcium because it was blocked by the calcium chelator EGTA but was not blocked by ...

journal_title：Journal of neurochemistry

authors： Bernard J,Massicotte G,Baudry M

更新日期：1992-01-01 00:00:00

abstract：:Membrane vesicles, showing a 21 +/- 2-fold enrichment in the activity of 5'-nucleotidase and a 11 +/- 4-fold enrichment in the activity of angiotensin-converting enzyme relative to homogenate, were prepared from the myenteric plexus-containing longitudinal muscle layer of guinea pig ileum. Incubation of the vesicles w...

journal_title：Journal of neurochemistry

authors： Nau R,Schäfer G,Deacon CF,Cole T,Agoston DV,Conlon JM

更新日期：1986-09-01 00:00:00

abstract：:Unilateral ligation of the left common carotid artery in anesthetized Mongolian gerbils resulted in a steep rise in extracellular dopamine in the ipsilateral striatum in 9 out of 19 animals. Extracellular dopamine was measured by cerebral dialysis in vivo and reached a peak of 0.19 mM at 40 min. At the same time, the ...

journal_title：Journal of neurochemistry

authors： Slivka A,Brannan TS,Weinberger J,Knott PJ,Cohen G

更新日期：1988-06-01 00:00:00

abstract：:Alzheimer's disease (AD) is a neurodegenerative disease resulting in progressive cognitive decline. Amyloid plaque deposits consisting specifically of beta-amyloid peptides that have formed fibrils displaying beta-pleated sheet conformation are associated with activated microglia and astrocytes, are colocalized with C...

journal_title：Journal of neurochemistry

authors： Zhou J,Fonseca MI,Pisalyaput K,Tenner AJ

更新日期：2008-09-01 00:00:00

abstract：:Neurodegenerative diseases, such as Parkinson's disease, Alzheimer's disease, and Huntington's disease, are considered incurable and significantly reduce the quality of life of the patients. A variety of drugs that modulate neurotransmitter levels have been used for the treatment of the neurodegenerative diseases but ...

journal_title：Journal of neurochemistry

authors： Huang M,Rathore SS,Lindau M

更新日期：2019-10-01 00:00:00

abstract：:The glutamate receptor 2 (GluR2) subunit determines many of the functional properties of the alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate subtype of glutamate receptor. The roles of untranslated regions (UTRs) in mRNA stability, transport, or translation are increasingly recognized. The 3' end of the GluR2 tra...

journal_title：Journal of neurochemistry

authors： Irier HA,Shaw R,Lau A,Feng Y,Dingledine R

更新日期：2009-04-01 00:00:00

abstract：:In heterologous expression systems, dopamine transporter (DAT) cell-surface localization is reduced after relatively prolonged exposure to d-amphetamine (AMPH) or dopamine (DA), suggesting a role for substrate-mediated regulation of transporter function. Here, we investigated whether brief, repeated periods of substra...

journal_title：Journal of neurochemistry

authors： Gulley JM,Doolen S,Zahniser NR

更新日期：2002-10-01 00:00:00

abstract：:Rat brain benzodiazepine receptors have been solubilized by means of the zwitterionic detergent CHAPS under conditions in which the GABA stimulation of [3H]flunitrazepam binding to the benzodiazepine receptors is maintained intact. This stimulation is partially or totally abolished when using other conventional deterg...

journal_title：Journal of neurochemistry

authors： Mernoff ST,Cherwinski HM,Becker JW,de Blas AL

更新日期：1983-09-01 00:00:00

abstract：:Huntington's disease (HD) is an autosomal-dominant neurodegenerative disorder caused by a poly-glutamine expansion in huntingtin, the protein encoded by the HD gene. PolyQ-expanded huntingtin is toxic to neurons, especially the medium spiny neurons of the striatum. At the same time, wild-type huntingtin has important ...

journal_title：Journal of neurochemistry

authors： Zhang Y,Engelman J,Friedlander RM

更新日期：2009-01-01 00:00:00

abstract：:beta-Amyloid peptides (Abeta40 and Abeta42) are the major constituents of amyloid plaques, which are one of the hallmarks of Alzheimer's disease (AD). The Abeta is derived from sequential cleavages of amyloid precursor protein (APP) by beta- and gamma-secretases. gamma-Secretase consists of at least four proteins wher...

journal_title：Journal of neurochemistry

authors： Lai MT,Crouthamel MC,DiMuzio J,Pietrak BL,Donoviel DB,Bernstein A,Gardell SJ,Li YM,Hazuda D

更新日期：2006-01-01 00:00:00

abstract：:Gangliosides administered exogenously are well-known effectors of differentiation in many neuroblastoma lines and primary neuronal cultures. Previous studies suggested the phosphoinositide signaling mechanism could be a contributing factor. We have found that treatment of Neuro-2A cells with bovine brain ganglioside m...

journal_title：Journal of neurochemistry

authors： Vaswani KK,Wu GS,Ledeen RW

更新日期：1990-08-01 00:00:00

abstract：:The function of membrane phospholipids (PL) in the regulation of gamma-aminobutyric acid (GABA) transport and GABA carrier binding has been investigated in organized cultures of rat cerebral cortex. The cellular lipid composition has been changed by growing the cells in a delipidated nutrient solution or by short-term...

journal_title：Journal of neurochemistry

authors： Giesing M,Gerken U,Kastrup H

更新日期：1985-03-01 00:00:00

abstract：:The transcription factor Nurr1 is essential for the generation of midbrain dopaminergic neurons (mDA). Only a few Nurr1-regulated genes have so far been identified and it remains unclear how Nurr1 influences the development and function of dopaminergic neurons. To identify novel Nurr1 target genes we have used genome-...

journal_title：Journal of neurochemistry

authors： Volpicelli F,Caiazzo M,Greco D,Consales C,Leone L,Perrone-Capano C,Colucci D'Amato L,di Porzio U

更新日期：2007-07-01 00:00:00

abstract：:We examined the effects of chronic ethanol exposure on the levels of N-methyl-D-aspartate receptor subunit 1 (NMDAR1) protein, an essential component of N-methyl-D-aspartate glutamate receptors, in rat brain. By immunoblotting procedures using a specific antibody for the NMDAR1 subunit, we found that ethanol dramatica...

journal_title：Journal of neurochemistry

authors： Trevisan L,Fitzgerald LW,Brose N,Gasic GP,Heinemann SF,Duman RS,Nestler EJ

更新日期：1994-04-01 00:00:00

abstract：:A study was made of the actions of the excitant neurotoxin, kainic acid, on the uptake and the release of D-[2,3-3H]aspartate (D-ASP) in slices of guinea pig cerebral neocortex and striatum. The slices took up D-ASP, reaching concentrations of the amino acid in the tissue which were 14-23 times that in the medium. Sub...

journal_title：Journal of neurochemistry

authors： Potashner SJ,Gerard D

更新日期：1983-06-01 00:00:00

abstract：:The microtubule-based motor protein kinesin is thought to drive anterograde organelle transport in axons, but nothing is known about how its force-generating activity or organelle-binding properties are regulated. Studies in other motility systems suggest that protein phosphorylation is a reasonable candidate for this...

journal_title：Journal of neurochemistry

authors： Hollenbeck PJ

更新日期：1993-06-01 00:00:00

abstract：:Glutamate or a related excitatory amino acid is thought to be the major excitatory neurotransmitter of hippocampal afferents, intrinsic neurons, and efferents. We have used an autoradiographic technique to investigate the status of excitatory amino acid receptors in the hippocampal formation of patients dying with dem...

journal_title：Journal of neurochemistry

authors： Greenamyre JT,Penney JB,D'Amato CJ,Young AB

更新日期：1987-02-01 00:00:00

abstract：:We have investigated the transport characteristics of dehydroepiandrosterone sulfate (DHEAS), a neuroactive steroid, at the blood-brain barrier (BBB) in a series of functional in vivo and in vitro studies. The apparent BBB efflux rate constant of [(3)H]DHEAS evaluated by the brain efflux index method was 2.68 x 10(-2)...

journal_title：Journal of neurochemistry

authors： Asaba H,Hosoya K,Takanaga H,Ohtsuki S,Tamura E,Takizawa T,Terasaki T

更新日期：2000-11-01 00:00:00

abstract：:Activation of integrin receptors in neurons can promote cell survival and synaptic plasticity, but the underlying signal transduction pathway(s) is unknown. We report that integrin signaling prevents apoptosis of embryonic hippocampal neurons by a mechanism involving integrin-linked kinase (ILK) that activates Akt kin...

journal_title：Journal of neurochemistry

authors： Gary DS,Milhavet O,Camandola S,Mattson MP

更新日期：2003-02-01 00:00:00

abstract：:Purified tribulin, an endogenous monoamine oxidase (MAO) inhibitor, has been identified by direct probe insertion mass spectrometry as the indole-2,3-dione, isatin. A gas chromatographic-mass spectrometric assay for isatin has been developed and used to measure its relatively high concentrations in unpurified human ur...

journal_title：Journal of neurochemistry

authors： Glover V,Halket JM,Watkins PJ,Clow A,Goodwin BL,Sandler M

更新日期：1988-08-01 00:00:00

abstract：:Alzheimer's disease is characterized neuropathologically by the presence of neuritic and amyloid plaques, vascular amyloid, and neurofibrillary tangles in specific brain areas. The main constituent of amyloid deposits is amyloid beta protein, a 40-42 amino acid proteolytic product of the amyloid beta-precursor protein...

journal_title：Journal of neurochemistry

authors： Conn KJ,Pietropaolo M,Ju ST,Abraham CR

更新日期：1996-05-01 00:00:00

abstract：:The contents of cystathionine and taurine, as well as cystathionine beta-synthase activity in various regions of the brains of normal and DL-propargylglycine-treated rats, were measured. The content of cystathionine in each region of brain increased gradually from 0.5 mg to 20 mg/200 g body weight in relation to the d...

journal_title：Journal of neurochemistry

authors： Kodama H,Ikeda H,Awata S,Nakayama K

更新日期：1985-04-01 00:00:00

abstract：:White matter infarct induces demyelination and brain dysfunction. We previously reported that transplantation of brain microvascular endothelial cells improved the behavioral outcome and promoted remyelination by increasing the number of oligodendrocyte precursor cells in the rat model of white matter infarct. In this...

journal_title：Journal of neurochemistry

authors： Xu B,Kurachi M,Shimauchi-Ohtaki H,Yoshimoto Y,Ishizaki Y

更新日期：2020-06-01 00:00:00

abstract：:In situ phosphorylation of the presynaptic protein kinase C substrate B-50 was investigated in rat hippocampal slices incubated with the convulsant drug 4-aminopyridine (4-AP). Phosphorylation of B-50 was significantly enhanced 1 min after the addition of 4-AP (100 microM). This increase by 4-AP was concentration depe...

journal_title：Journal of neurochemistry

authors： Heemskerk FM,Schrama LH,Gianotti C,Spierenburg H,Versteeg DH,De Graan PN,Gispen WH

更新日期：1990-03-01 00:00:00

abstract：:The turnover rate of gamma-aminobutyric acid (GABA) in the rat striatum was estimated by measuring its accumulation after inhibition of GABA-transaminase (GABA-T) with gabaculine. Intrastriatal injections of 100 micrograms gabaculine induced a rapid and complete inhibition of GABA-T. GABA accumulation was linear with ...

journal_title：Journal of neurochemistry

authors： Giorgi O,Meek JL

更新日期：1984-01-01 00:00:00