Brief, repeated exposure to substrates down-regulates dopamine transporter function in Xenopus oocytes in vitro and rat dorsal striatum in vivo.

abstract：:Alzheimer's disease (AD) is marked by the presence of neurofibrillary tangles and amyloid plaques in the brain of patients. To study plaque formation, we report on further quantitative and qualitative analysis of human and mouse amyloid beta peptides (Abeta) from brain extracts of transgenic mice overexpressing the Lo...

journal_title：Journal of neurochemistry

authors： Pype S,Moechars D,Dillen L,Mercken M

更新日期：2003-02-01 00:00:00

abstract：:Neural stem cells (NSCs) play an essential role in both the developing embryonic nervous system through to adulthood where the capacity for self-renewal may be important for normal function of the CNS, such as in learning, memory and response to injury. There has been much excitement about the possibility of transplan...

journal_title：Journal of neurochemistry

authors： Tamm C,Duckworth J,Hermanson O,Ceccatelli S

更新日期：2006-04-01 00:00:00

abstract：:The conversion of protease-sensitive prion protein (PrP-sen) to a high beta-sheet, protease-resistant and often fibrillar form (PrP-res) is a central event in transmissible spongiform encephalopathies (TSE) or prion diseases. This conversion can be induced by PrP-res itself in cell-free conversion reactions. The deter...

journal_title：Journal of neurochemistry

authors： Xiong LW,Raymond LD,Hayes SF,Raymond GJ,Caughey B

更新日期：2001-11-01 00:00:00

abstract：:Ependymins are thought to be implicated in fundamental processes involved in plasticity of the goldfish CNS. Gas-phase sequencing of purified ependymins beta and gamma revealed that they share the same N-terminal sequence. Each sequence displays microheterogeneities at several positions. Based on the protein sequences...

journal_title：Journal of neurochemistry

authors： Königstorfer A,Sterrer S,Eckerskorn C,Lottspeich F,Schmidt R,Hoffmann W

更新日期：1989-01-01 00:00:00

abstract：:Glial uptake of neurotransmitter glutamate (GLU) from the extracellular fluid was studied in vivo in rat brain by (13)C NMR and microdialysis combined with gas-chromatography/mass-spectrometry. Brain GLU C5 was (13)C enriched by intravenous [2,5-(13)C]glucose infusion, followed by [(12)C]glucose infusion to chase (13)...

journal_title：Journal of neurochemistry

authors： Kanamori K,Ross BD,Kondrat RW

更新日期：2002-11-01 00:00:00

abstract：:We have examined the metabolism of phosphate and sulfate groups modifying the P0 protein, the major protein of peripheral nervous system myelin, using an in vitro incubation system. Incorporation of [3H]leucine into the P0 peptide backbone decreased approximately 25-fold between 10 and 90 days of age, a finding reflec...

journal_title：Journal of neurochemistry

authors： Toews AD,Fischer HR,Goodrum JF,Windes S,Morell P

更新日期：1987-03-01 00:00:00

abstract：:2,4,5-Trihydroxyphenylalanine (TOPA) oxidizes in solution to form a quinone derivative that is a non-N-methyl-D-aspartate agonist and neurotoxin. Although pathways have been postulated for the formation of both TOPA and TOPA quinone from closely related catecholamines, the generation of these compounds has not been co...

journal_title：Journal of neurochemistry

authors： Newcomer TA,Palmer AM,Rosenberg PA,Aizenman E

更新日期：1993-09-01 00:00:00

abstract：:Previous research has suggested that the initial effects of cellular free radical neurotoxic insult involve large increases in intracellular Ca2+. However, the exact role of oxidative stress on the various parameters involved in these increases has not been specified. The present experiments were performed to examine ...

journal_title：Journal of neurochemistry

authors： Joseph JA,Strain JG,Jimenez ND,Fisher D

更新日期：1997-09-01 00:00:00

abstract：:GD3 synthase (Sial-T2) is a key enzyme of ganglioside synthesis that, in concert with GM2 synthase (GalNAc-T), regulates the ratio of a- and b-pathway gangliosides. In this work, we study the sub-Golgi location of an epitope-tagged version of chicken Sial-T2 transfected to CHO-K1 cells. The expressed protein was enzym...

journal_title：Journal of neurochemistry

authors： Daniotti JL,Martina JA,Giraudo CG,Zurita AR,Maccioni HJ

更新日期：2000-04-01 00:00:00

abstract：:Hyperexcitability of the hippocampus is a commonly observed phenomenon in the years preceding a diagnosis of Alzheimer's disease (AD). Our previous work suggests a dysregulation in glutamate neurotransmission may mediate this hyperexcitability, and glutamate dysregulation correlates with cognitive deficits in the rTg(...

journal_title：Journal of neurochemistry

authors： Hunsberger HC,Weitzner DS,Rudy CC,Hickman JE,Libell EM,Speer RR,Gerhardt GA,Reed MN

更新日期：2015-10-01 00:00:00

abstract：:Oxidative stress has been shown to play a role in aging and in neurodegenerative disorders. Some of the consequences of oxidative stress are DNA base modifications, lipid peroxidation, and protein modifications such as formation of carbonyls and nitrotyrosine. These events may play a role in apoptosis, another factor ...

journal_title：Journal of neurochemistry

authors： Kaufmann JA,Bickford PC,Taglialatela G

更新日期：2001-02-01 00:00:00

abstract：:It has been established that neurosteroids can either inhibit or enhance GABA(A) receptor activity. Although GABA is the main inhibitory neurotransmitter in the mammalian retina, the effects of neurosteroids on retinal GABAergic activity have not been investigated. The aim of this work was to study the neurochemical a...

journal_title：Journal of neurochemistry

authors： Jaliffa CO,Howard S,Hoijman E,Salido E,Sarmiento MI,Arias P,Rosenstein RE

更新日期：2005-09-01 00:00:00

abstract：:Arachidonic acid (AA) plays an important role as a signaling factor in the CNS. Therefore, exposure to AA may affect cholinergic neurons in the spinal cord. To test this hypothesis, mRNA expression and activity of choline acetyltransferase (ChAT) was measured in cultured spinal cord neurons treated with increasing con...

journal_title：Journal of neurochemistry

authors： Chalimoniuk M,King-Pospisil K,Pedersen WA,Malecki A,Wylegala E,Mattson MP,Hennig B,Toborek M

更新日期：2004-08-01 00:00:00

abstract：:Previous studies from this laboratory have shown that synthesis of GT3, the precursor of c series gangliosides, occurs in proximal Golgi compartments, as has been shown for the synthesis of GM3 and GD3, the precursors of a and b series gangliosides, respectively. In this work we studied whether the synthesis of GM3, G...

journal_title：Journal of neurochemistry

authors： Rosales Fritz VM,Maxzúd MK,Maccioni HJ

更新日期：1996-10-01 00:00:00

abstract：:We report that a subtoxic dose of the succinate dehydrogenase (SDH) inhibitor malonate greatly enhances the neurotoxicity of three different excitatory amino acid agonists: N-methyl-D-aspartate (NMDA), S-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (S-AMPA), and L-glutamate. In male Sprague-Dawley rats, in...

journal_title：Journal of neurochemistry

authors： Greene JG,Greenamyre JT

更新日期：1995-05-01 00:00:00

abstract：:The protein kinase v-akt murine thymoma viral oncogene homolog (AKT) gene family comprises three human homologs that phosphorylate and inactivate glycogen synthase kinase 3beta (GSK3beta). Studies have reported the genetic association of AKT1 with schizophrenia. Additionally, decreased AKT1 protein expression and the ...

journal_title：Journal of neurochemistry

authors： Ide M,Ohnishi T,Murayama M,Matsumoto I,Yamada K,Iwayama Y,Dedova I,Toyota T,Asada T,Takashima A,Yoshikawa T

更新日期：2006-10-01 00:00:00

abstract：:The novel N-methyl-D-aspartate receptor channel ligand (+)-[3H]5-methyl-10,11-dihydro-5H-dibenzo[a,d]-cyclohepten-5, 10-imine maleate ([3H]MK-801) has been utilized to label this receptor in human brain tissue. Characteristics of [3H]MK-801 binding to well-washed membranes from 17 control subjects and 16 patients with...

journal_title：Journal of neurochemistry

authors： Procter AW,Wong EH,Stratmann GC,Lowe SL,Bowen DM

更新日期：1989-09-01 00:00:00

abstract：:In frozen-thawed repeatedly washed rat cortical synaptic membranes, Ca2+ (1-5 mM) decreased the binding of [3H]muscimol whereas it increased the binding of [3H]gamma-aminobutyric acid (GABA). However, the binding of [3H]GABA was decreased by the same extent as the binding of [3H]muscimol when the membranes were incuba...

journal_title：Journal of neurochemistry

authors： Corda MG,Guidotti A

更新日期：1983-07-01 00:00:00

abstract：:A protein that binds vesamicol has been purified from a soluble fraction of the Torpedo electric organ homogenate that does not contain synaptic vesicles. The purified vesamicol-binding protein (VBP) has a molecular mass of 470 kDa composed of 30- and 24-kDa subunits. Chemical deglycosylation yielded a single, heterog...

journal_title：Journal of neurochemistry

authors： Hicks BW,Rogers GA,Parsons SM

更新日期：1991-08-01 00:00:00

abstract：:The extension of microglial processes toward injured sites in the brain is triggered by the stimulation of the purinergic receptor P2Y(12) by extracellular ATP. We recently showed that P2Y(12) stimulation by ATP induces microglial process extension in collagen gels. In the present study, we found that a P2Y(12) agonis...

journal_title：Journal of neurochemistry

authors： Ohsawa K,Sanagi T,Nakamura Y,Suzuki E,Inoue K,Kohsaka S

更新日期：2012-04-01 00:00:00

abstract：:Intracerebroventricular injection of lipopolysaccharide (LPS) induces a marked increase in circulating interleukin (IL)-6 levels and in IL-6 mRNA expression in brain and peripheral organs. Recently, it was reported that intraperitoneal administration of alpha-adrenoceptor antagonists inhibits centrally injected LPS-in...

journal_title：Journal of neurochemistry

authors： Song DK,Im YB,Jung JS,Suh HW,Huh SO,Park SW,Wie MB,Kim YH

更新日期：1999-04-01 00:00:00

abstract：:Inhibition of the GABA transporter subtype GAT1 by the clinically available anti-epileptic drug tiagabine has proven to be an effective strategy for the treatment of some patients with partial seizures. In 2005, the investigational drug EF1502 was described as possessing activity at both GAT1 and BGT-1. When combined ...

journal_title：Journal of neurochemistry

authors： Madsen KK,Clausen RP,Larsson OM,Krogsgaard-Larsen P,Schousboe A,White HS

更新日期：2009-05-01 00:00:00

abstract：:The role of the serotonin (5-hydroxytryptamine) autoreceptor in the regulation of the activity of tryptophan hydroxylase was investigated in rat raphe slices. The activity of tryptophan hydroxylase was estimated by measuring the accumulation of 5-hydroxytryptophan in the presence of inhibition of aromatic L-amino acid...

journal_title：Journal of neurochemistry

authors： Sawada M,Nagatsu T

更新日期：1986-03-01 00:00:00

abstract：:In the jimpy mutant mouse, as well as in many other animals with mutations in the myelin proteolipid protein (PLP) gene, oligodendrocytes degenerate before their maturation. To analyze whether this degeneration is caused by the loss of function of PLP gene products related to oligodendrocyte maturation/survival acting...

journal_title：Journal of neurochemistry

authors： Kagawa T,Nakao J,Yamada M,Shimizu K,Hayakawa T,Mikoshiba K,Ikenaka K

更新日期：1994-05-01 00:00:00

abstract：:Malignant gliomas are common and aggressive brain tumours associated with significant morbidity and mortality. We showed in this report that substratum adherence and migration by human U87MG glioma cells in culture were significantly attenuated by the extracellular domains of Nogo-A (Nogo-66) and the myelin-associated...

journal_title：Journal of neurochemistry

authors： Liao H,Duka T,Teng FY,Sun L,Bu WY,Ahmed S,Tang BL,Xiao ZC

更新日期：2004-09-01 00:00:00

abstract：:Here, we examined whether amyloid-beta (Abeta) protein participates in cell death and retinal function using three types of transgenic (Tg) mice in vivo [human mutant amyloid precursor protein (APP) Tg (Tg 2576) mice, mutant presenilin-1 (PS-1) knock-in mice, and APP/PS-1 double Tg mice]. ELISA revealed that the insol...

journal_title：Journal of neurochemistry

authors： Shimazawa M,Inokuchi Y,Okuno T,Nakajima Y,Sakaguchi G,Kato A,Oku H,Sugiyama T,Kudo T,Ikeda T,Takeda M,Hara H

更新日期：2008-10-01 00:00:00

abstract：:The effects of fatty acids, oleate and palmitate, on gamma-aminobutyric acid (GABA), aspartate, and 3,4- dihydroxyphenylethylamine (dopamine) transport and a variety of other membrane functions were studied in rat brain synaptosomes at a constant lipid-to-protein ratio. Under the conditions utilized oleate, but not pa...

journal_title：Journal of neurochemistry

authors： Troeger MB,Rafalowska U,Erecińska M

更新日期：1984-06-01 00:00:00

abstract：:For nearly 100 years following the first description of this neurological disorder by Dr Alois Alzheimer, amyloid plaques and neurofibrillary tangles have been hypothesized to cause neuronal loss. With evidence that the extent of insoluble, deposited amyloid poorly correlated with cognitive impairment, research effort...

journal_title：Journal of neurochemistry

authors： Larson ME,Lesné SE

更新日期：2012-01-01 00:00:00

abstract：:beta-Amyloid peptides (Abeta40 and Abeta42) are the major constituents of amyloid plaques, which are one of the hallmarks of Alzheimer's disease (AD). The Abeta is derived from sequential cleavages of amyloid precursor protein (APP) by beta- and gamma-secretases. gamma-Secretase consists of at least four proteins wher...

journal_title：Journal of neurochemistry

authors： Lai MT,Crouthamel MC,DiMuzio J,Pietrak BL,Donoviel DB,Bernstein A,Gardell SJ,Li YM,Hazuda D

更新日期：2006-01-01 00:00:00

abstract：:Tau, a microtubule binding protein, is not only a major component of neurofibrillary tangles in Alzheimer's disease, but also a causative gene for hereditary frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17). We show here that an FTDP-17 tau mutation (V337M) in SH-SY5Y cells reduces microtubul...

journal_title：Journal of neurochemistry

authors： Furukawa K,Wang Y,Yao PJ,Fu W,Mattson MP,Itoyama Y,Onodera H,D'Souza I,Poorkaj PH,Bird TD,Schellenberg GD

更新日期：2003-10-01 00:00:00