Schwannoma-derived growth factor interacts with the epidermal growth factor receptor.

abstract：:The weaver mutant mouse has a genetically determined defect in the nigrostriatal dopaminergic system. The present study was undertaken to test the hypothesis that in the weaver mutant mouse, striatal nerve terminals undergo compensatory changes in response to this deficiency. To test this hypothesis, we studied the ba...

journal_title：Journal of neurochemistry

authors： Simon JR,Yu H,Richter JA,Vasko MR,Ghetti B

更新日期：1991-11-01 00:00:00

abstract：:The metabolism of 2-fluoro-2-deoxy-D-glucose (FDG) in vivo was observed noninvasively in rat brain using 19F nuclear magnetic resonance (NMR) spectroscopy following an intravenous injection of FDG (400 mg/kg). At 3 h after infusion, four resonances with discrete chemical shifts were resolved. Chemical shift analysis o...

journal_title：Journal of neurochemistry

authors： Nakada T,Kwee IL,Conboy CB

更新日期：1986-01-01 00:00:00

abstract：:Hypothalamic norepinephrine (NE) release regulates arterial pressure by altering sympathetic nervous system activity. Because angiotensin (Ang) (1-7) decreases hypothalamic NE release and this effect may be correlated with a diminished NE synthesis, we hypothesize that Ang-(1-7) down-regulates tyrosine hydroxylase (TH...

journal_title：Journal of neurochemistry

authors： Lopez Verrilli MA,Pirola CJ,Pascual MM,Dominici FP,Turyn D,Gironacci MM

更新日期：2009-04-01 00:00:00

abstract：:Glycine and GABA are likely co-transmitters in the spinal cord. Their possible interactions in presynaptic terminals have, however, not been investigated. We studied the effects of glycine on GABA release using superfused mouse spinal cord synaptosomes. Glycine concentration dependently elicited [(3)H]GABA release whi...

journal_title：Journal of neurochemistry

authors： Raiteri L,Raiteri M,Bonanno G

更新日期：2001-03-01 00:00:00

abstract：:Presynaptic modulation of synaptic transmission is the primary function of central nicotinic acetylcholine receptors (nAChRs) in developing and adult brain. nAChR activation regulates release of various neurotransmitters, including norepinephrine (NA). Given evidence that NA may serve a critical functional role in cer...

journal_title：Journal of neurochemistry

authors： O'Leary KT,Leslie FM

更新日期：2003-03-01 00:00:00

abstract：:Substances that mimic the actions of causative gene products of familial Parkinson's disease (PD) are candidate as causative agents of idiopathic PD. 1-Benzyl-1,2,3,4-tetrahydroisoquinoline (1BnTIQ), an endogenous neurotoxin, is present at three times higher levels in CSF of PD patients than in CSF of control subjects...

journal_title：Journal of neurochemistry

authors： Kohta R,Kotake Y,Hosoya T,Hiramatsu T,Otsubo Y,Koyama H,Hirokane Y,Yokoyama Y,Ikeshoji H,Oofusa K,Suzuki M,Ohta S

更新日期：2010-09-01 00:00:00

abstract：:The RNA integrity number (RIN) is often considered to be a critical measure of the quality of postmortem human brains. However, it has been suggested that RINs do not necessarily reflect the availability of intact mRNA. Using the Agilent bioanalyzer and qRT-PCR, we explored whether RINs provide a meaningful way of ass...

journal_title：Journal of neurochemistry

authors： Sonntag KC,Tejada G,Subburaju S,Berretta S,Benes FM,Woo TU

更新日期：2016-07-01 00:00:00

abstract：:This paper describes the interaction of neurotensin with mouse neuroblastoma N1E115 cells. Neurotensin binding sites are undetectable in nondifferentiated neuroblastoma cells. They appear during cell differentiation in the presence of a low serum concentration and dimethyl sulfoxide, and reach a maximal level after 50...

journal_title：Journal of neurochemistry

authors： Poustis C,Mazella J,Kitabgi P,Vincent JP

更新日期：1984-04-01 00:00:00

abstract：:The hippocampus is a distinct brain structure that is crucial in memory storage and retrieval. To identify comprehensively proteins of hippocampal plasma membrane (PM) and detect the neuronal-specific PM proteins, we performed a proteomic analysis of rat hippocampus PM using the following three technical strategies. F...

journal_title：Journal of neurochemistry

authors： Chen P,Li X,Sun Y,Liu Z,Cao R,He Q,Wang M,Xiong J,Xie J,Wang X,Liang S

更新日期：2006-08-01 00:00:00

abstract：:The K+-stimulated efflux of endogenous taurine from primary rat cerebellar astrocyte cultures prepared from 7-9-day-old rats was studied at 16-18 days in vitro using HPLC analysis. Taurine efflux was dose-dependent at K+ concentrations between 10 mM and 80 mM, with an EC50 of approximately 50 mM. Maximum stimulation o...

journal_title：Journal of neurochemistry

authors： Philibert RA,Rogers KL,Allen AJ,Dutton GR

更新日期：1988-07-01 00:00:00

abstract：:Post-ischemic inflammation is an essential step in the progression of ischemic stroke. This review focuses on the function of infiltrating immune cells, macrophages, and T cells, in ischemic brain injury. The brain is a sterile organ; however, the activation of Toll-like receptor (TLR) 2 and TLR4 is pivotal in the beg...

journal_title：Journal of neurochemistry

authors： Shichita T,Ago T,Kamouchi M,Kitazono T,Yoshimura A,Ooboshi H

更新日期：2012-11-01 00:00:00

abstract：:Five muscarinic receptor genes (m1-m5) that encode distinct muscarinic receptor subtypes have been cloned. Because of their structural homology and pharmacological similarity, ligand binding probes currently available do not clearly distinguish among the subtypes. To obtain a clear distribution within the CNS of molec...

journal_title：Journal of neurochemistry

authors： Wei J,Walton EA,Milici A,Buccafusco JJ

更新日期：1994-09-01 00:00:00

abstract：:The aim of this study is to examine how sustained exposure to two 1,4-benzodiazepines (BZDs) with different action period, diazepam and brotizolam, and a 1,5-BZD, clobazam, affects L-type high voltage-gated calcium channel (HVCC) functions and its mechanisms using primary cultures of mouse cerebral cortical neurons. T...

journal_title：Journal of neurochemistry

authors： Katsura M,Shibasaki M,Kurokawa K,Tsujimura A,Ohkuma S

更新日期：2007-12-01 00:00:00

abstract：:This study attempts to determine if projections ascending from the guinea pig cochlear nucleus (CN) could be glutamatergic and/or aspartatergic. Multiple radio frequency lesions were made to ablate the right CN. The ablation was verified histologically. To identify the principal targets of CN efferents, silver impregn...

journal_title：Journal of neurochemistry

authors： Suneja SK,Benson CG,Gross J,Potashner SJ

更新日期：1995-01-01 00:00:00

abstract：:As an initial step to study the function of the gene encoding the human neuropeptide FF (NPFF), we cloned a 4.7-kb sequence from the promoter region. Primer extension and 5'-rapid amplification of cDNA ends revealed multiple transcription initiation sites. Northern blot analysis of the mRNA expression revealed a speci...

journal_title：Journal of neurochemistry

authors： Nystedt JM,Brandt AM,Mandelin J,Vilim FS,Ziff EB,Panula P

更新日期：2002-09-01 00:00:00

abstract：:Hippocampus mossy fibre terminals activate CA3 pyramidal neurons via two distinct mechanisms, both quantal and glutamatergic: (i) rapid excitatory transmission in response to afferent action potentials and (ii) delayed and prolonged release following nicotinic receptor activation. These processes were analysed here us...

journal_title：Journal of neurochemistry

authors： Bancila V,Cordeiro JM,Bloc A,Dunant Y

更新日期：2009-07-01 00:00:00

abstract：:The expression of Nex1 peaks during brain development when neurite outgrowth and synaptogenesis are highly active. We previously showed that Nex1 is a critical effector of the nerve growth factor (NGF) pathway and its overexpression results in spontaneous neuritogenesis. Furthermore, the PC12-Nex1 cells exhibit accele...

journal_title：Journal of neurochemistry

authors： Uittenbogaard M,Chiaramello A

更新日期：2004-12-01 00:00:00

abstract：:The protein B-50 is dephosphorylated in rat cortical synaptic plasma membranes (SPM) by protein phosphatase type 1 and 2A (PP-1 and PP-2A)-like activities. The present studies further demonstrate that B-50 is dephosphorylated not only by a spontaneously active PP-1-like enzyme, but also by a latent form after pretreat...

journal_title：Journal of neurochemistry

authors： Han YF,Wang W,Schlender KK,Ganjeizadeh M,Dokas LA

更新日期：1992-07-01 00:00:00

abstract：:The dopamine transporter is a plasma membrane protein that controls extracellular concentrations of the neurotransmitter dopamine. The physiological importance of the DAT provides the impetus for studies aimed at understanding the molecular mechanisms underlying regulation of the DAT gene. In this study, we identified...

journal_title：Journal of neurochemistry

authors： Wang J,Bannon MJ

更新日期：2005-04-01 00:00:00

abstract：:The regional and developmental expression of NMDA receptors containing the NR2D subunit was analyzed on the level of the subunit mRNA and protein in rat brain. RNase protection experiments indicated that among two proposed splice variants of the NR2D subunit, only the NR2D-2 subunit is expressed. The regional distribu...

journal_title：Journal of neurochemistry

authors： Wenzel A,Villa M,Mohler H,Benke D

更新日期：1996-03-01 00:00:00

abstract：:Cavernous angiomas are vascular malformations that cause neurodegeneration and symptoms including epileptiform seizures, headache, and motor deficits. Following neurosurgical removal of the angiomas, patients mostly recover well and become seizure-free. This study reports on the levels of certain amino acids in angiom...

journal_title：Journal of neurochemistry

authors： von Essen C,Rydenhag B,Nyström B,Mozzi R,van Gelder N,Hamberger A

更新日期：1996-07-01 00:00:00

abstract：:The effect of ethanol on insulin-like growth factor-1 (IGF-I)-mediated signal transduction and functional activation in neuronal cells was examined. In human SH-SY5Y neuroblastoma cells, ethanol inhibited tyrosine autophosphorylation of the IGF-I receptor. This corresponded to the inhibition of IGF-I-induced phosphory...

journal_title：Journal of neurochemistry

authors： Seiler AE,Ross BN,Rubin R

更新日期：2001-01-01 00:00:00

abstract：:Expression of rat brain gamma-aminobutyric acid type A (GABA(A)) receptors in Xenopus laevis oocytes can be achieved by injection of the oocytes with synaptosomes. This approach has now been applied to evaluate changes in the function of nigral GABA(A) receptors after degeneration of the striatonigral GABAergic pathwa...

journal_title：Journal of neurochemistry

authors： Sanna E,Motzo C,Usala M,Pau D,Cagetti E,Biggio G

更新日期：1998-06-01 00:00:00

abstract：:The effect of the neuropeptide substance P on the binding of the cholinergic ligands to the nicotinic acetylcholine receptor of Torpedo electroplaque membranes was examined at a physiological concentration of NaCl (150 mM). Substance P had no effect on the initial rate of 125I-alpha-bungarotoxin binding at concentrati...

journal_title：Journal of neurochemistry

authors： Min CK,Weiland GA

更新日期：1993-06-01 00:00:00

abstract：:Before this study, the human norepinephrine transporter (hNET) was the only member of the biogenic amine neurotransmitter transporter family that had not been demonstrated to be a functional homo-oligomer. Here, using two forms of the transporter, I155C and hNET-myc, with distinct antigenicity and inhibitor sensitivit...

journal_title：Journal of neurochemistry

authors： Kocabas AM,Rudnick G,Kilic F

更新日期：2003-06-01 00:00:00

abstract：:The effects of heat stress on protein synthesis and fast axonal transport were examined in an in vitro bullfrog primary afferent neuron preparation. The magnitude of effect was determined for individual [35S]methionine-labelled protein species separated via two-dimensional gel electrophoresis. Elevation of temperature...

journal_title：Journal of neurochemistry

authors： Stone GC,Dougher MM

更新日期：1988-09-01 00:00:00

abstract：:For nearly 100 years following the first description of this neurological disorder by Dr Alois Alzheimer, amyloid plaques and neurofibrillary tangles have been hypothesized to cause neuronal loss. With evidence that the extent of insoluble, deposited amyloid poorly correlated with cognitive impairment, research effort...

journal_title：Journal of neurochemistry

authors： Larson ME,Lesné SE

更新日期：2012-01-01 00:00:00

abstract：:Choline acetyltransferase (ChAT) catalyzes the reaction between choline and acetylcoenzyme A (AcCoA) to form acetylcholine (ACh) in nerve terminals. ACh metabolism has implications in numerous aspects of physiology and varied disease states, such as Alzheimer's disease. Therefore a specific, sensitive, and reliable me...

journal_title：Journal of neurochemistry

authors： Bailey JA,Lahiri DK

更新日期：2012-08-01 00:00:00

abstract：:Although isoelectric focusing has been used to demonstrate the presence of oligoclonal IgG in the CSF, the technique has not allowed detection of oligoclonal IgG in unconcentrated CSF. A new technique is reported, by which unconcentrated CSF is separated by isoelectric focusing, and the IgG bands are then detected by ...

journal_title：Journal of neurochemistry

authors： Lasne Y,Benzerara O,Chazot G,Creyssel R

更新日期：1981-05-01 00:00:00

abstract：:A clone of murine neuroblastoma (N1E-115) was shown to have functional receptors for the nonapeptide bradykinin. These receptors mediated a large, rapid (about 1 min to peak) and calcium-dependent increase in cyclic GMP. The median effective concentration (EC50) averaged 1.4 nM. In addition, this event was inhibited b...

journal_title：Journal of neurochemistry

authors： Snider RM,Richelson E

更新日期：1984-12-01 00:00:00