Inhibition of insulin-like growth factor-1 receptor and IRS-2 signaling by ethanol in SH-SY5Y neuroblastoma cells.

abstract：:Although pharmacological stimulation of a wide variety of transmitter receptors triggers phosphoinositide (PI) turnover, little is known about the type of synaptic activity required to activate this system. To investigate this question, we have used primary cultures of embryonic cortical neurons, which develop functio...

journal_title：Journal of neurochemistry

authors： Murphy TH,Wright DD,Baraban JM

更新日期：1992-12-01 00:00:00

abstract：:Microglia are known to be a primary inflammatory cell type in the brain. However, microglial inflammatory responses are attenuated in the injured brain compared to those in cultured pure microglia. In the present study, we found that astrocytes challenged by oxygen-glucose deprivation (OGD) or H(2) O(2) released solub...

journal_title：Journal of neurochemistry

authors： Kim JH,Min KJ,Seol W,Jou I,Joe EH

更新日期：2010-12-01 00:00:00

abstract：:We previously reported that nerve terminals and glial cells lack an active uptake system capable of terminating transmitter action of substance P (SP). In the present study, we demonstrated the existence of an active uptake system for SP carboxy-terminal heptapeptide, (5-11)SP. When the slices from either rat brain or...

journal_title：Journal of neurochemistry

authors： Nakata Y,Kusaka Y,Yajima H,Segawa T

更新日期：1981-12-01 00:00:00

abstract：:This study investigated the temporal expression and cell subtype distribution of activated caspase-3 following cortical impact-induced traumatic brain injury in rats. The animals were killed and examined for protein expression of the proteolytically active subunit of caspase-3, p18, at intervals from 6 h to 14 days af...

journal_title：Journal of neurochemistry

authors： Beer R,Franz G,Srinivasan A,Hayes RL,Pike BR,Newcomb JK,Zhao X,Schmutzhard E,Poewe W,Kampfl A

更新日期：2000-09-01 00:00:00

abstract：:Since emotional stress elicits brain activation, mitochondria should be a key component of stressed brain response. However, few studies have focused on mitochondria functioning in these conditions. In this work, we aimed to determine the effects of an acute restraint stress on rat brain mitochondrial functions, with ...

journal_title：Journal of neurochemistry

authors： Batandier C,Poulet L,Hininger I,Couturier K,Fontaine E,Roussel AM,Canini F

更新日期：2014-11-01 00:00:00

abstract：:The membrane-bound or solubilized melatonin receptors were treated with protein-modifying agents under specific conditions and then assayed for 125I-melatonin binding in order to obtain information on amino acids present in the ligand binding domain. The reagents specific for sulfhydryl (N-ethylmaleimide and p-chlorom...

journal_title：Journal of neurochemistry

authors： Kosar E,Teisinger J,Vyskocil F,Vanĕcek J

更新日期：1994-08-01 00:00:00

abstract：:The metabolism of 2-fluoro-2-deoxy-D-glucose (FDG) in vivo was observed noninvasively in rat brain using 19F nuclear magnetic resonance (NMR) spectroscopy following an intravenous injection of FDG (400 mg/kg). At 3 h after infusion, four resonances with discrete chemical shifts were resolved. Chemical shift analysis o...

journal_title：Journal of neurochemistry

authors： Nakada T,Kwee IL,Conboy CB

更新日期：1986-01-01 00:00:00

abstract：:To evaluate the ability of ependymal, microglial and oligodendroglial cells to degrade leucine, the presence of 3-methylcrotonyl-CoA carboxylase (MCC) was investigated in cultures of these cells. MCC is a biotin-containing heterodimeric enzyme that is specific for the irreversible part of the leucine catabolic pathway...

journal_title：Journal of neurochemistry

authors： Murín R,Verleysdonk S,Rapp M,Hamprecht B

更新日期：2006-06-01 00:00:00

abstract：:This laboratory has previously demonstrated that the mu-selective opiate receptor agonist sufentanil can produce a naloxone-reversible increase or decrease in the stimulated formation of cyclic AMP (cAMP) in the myenteric plexus, depending on the concentration of opioid used. On the basis of these results, it was sugg...

journal_title：Journal of neurochemistry

authors： Wang L,Gintzler AR

更新日期：1995-03-01 00:00:00

abstract：:Sequence variation was found in cDNA coding for the extracellular domain of the rat gamma-aminobutyric acid type A (GABAA) receptor alpha 6 subunit. About 20% of polymerase chain reaction (PCR)-amplified alpha 6 cDNA prepared from rat cerebellar mRNA lacked nucleotides 226-255 as estimated by counting single-stranded ...

journal_title：Journal of neurochemistry

authors： Korpi ER,Kuner T,Kristo P,Köhler M,Herb A,Lüddens H,Seeburg PH

更新日期：1994-09-01 00:00:00

abstract：:Diabetic retinopathy (DR) is one of the common complications associated with diabetes mellitus and the leading cause of blindness worldwide. Recent research has demonstrated that DR is not only a microvascular disease but may be a result of neurodegenerative processes. Moreover, glucose-induced neuron and glial cell d...

journal_title：Journal of neurochemistry

authors： Zorrilla-Zubilete MA,Yeste A,Quintana FJ,Toiber D,Mostoslavsky R,Silberman DM

更新日期：2018-01-01 00:00:00

abstract：:The immediate acyl chain donor for fatty acid esterification of proteolipid protein (PLP) was identified in an in vitro system. Rat brain total membranes, after removal of crude nuclear and mitochondrial fractions, were incubated with radioactive acyl donors, extracted with chloroform/methanol, and analyzed by sodium ...

journal_title：Journal of neurochemistry

authors： Bizzozero OA,Lees MB

更新日期：1986-02-01 00:00:00

abstract：:The critical hyaluronan binding motif (HABM) in sialoprotein associated with cones and rods (SPACR) has already been determined. As sialoproteoglycan associated with cones and rods, another interphotoreceptor matrix molecule, binds to chondroitin sulfate and heparin with or without the employment of HABMs, respectivel...

journal_title：Journal of neurochemistry

authors： Zhao J,Yoneda M,Takeyama M,Inoue Y,Kataoka T,Ohno-Jinno A,Isogai Z,Iwaki M,Zako M

更新日期：2008-11-01 00:00:00

abstract：:Experimental evidence suggests that magnesium plays a role in the pathophysiological sequelae of brain injury. The present study examined the variation of blood ionized and total magnesium, as well as potassium, sodium, and ionized calcium, after experimental fluid percussion brain injury in rats. Blood ionized magnes...

journal_title：Journal of neurochemistry

authors： Bareyre FM,Saatman KE,Helfaer MA,Sinson G,Weisser JD,Brown AL,McIntosh TK

更新日期：1999-07-01 00:00:00

abstract：:Peroxynitrite, the product of the radical-radical reaction between nitric oxide and superoxide anion, is a potent oxidant involved in tissue damage in neurodegenerative disorders. We investigated the modifications induced by peroxynitrite in tyrosine residues of proteins from synaptosomes. Peroxynitrite treatment (> o...

journal_title：Journal of neurochemistry

authors： Di Stasi AM,Mallozzi C,Macchia G,Petrucci TC,Minetti M

更新日期：1999-08-01 00:00:00

abstract：:2,4,5-Trihydroxyphenylalanine (TOPA) oxidizes in solution to form a quinone derivative that is a non-N-methyl-D-aspartate agonist and neurotoxin. Although pathways have been postulated for the formation of both TOPA and TOPA quinone from closely related catecholamines, the generation of these compounds has not been co...

journal_title：Journal of neurochemistry

authors： Newcomer TA,Palmer AM,Rosenberg PA,Aizenman E

更新日期：1993-09-01 00:00:00

abstract：:Choline acetyltransferase activity is barely detectable in a mutant pheochromocytoma PC12 cell line, A123.7, which is deficient in protein kinase A activity. Northern blot and polymerase chain reaction analyses showed that this mutant cell line has dramatically reduced levels of choline acetyltransferase mRNA, which c...

journal_title：Journal of neurochemistry

authors： Inoue H,Li YP,Wagner JA,Hersh LB

更新日期：1995-03-01 00:00:00

abstract：:Selective serotonin reuptake inhibitors (SSRIs) were designed to treat depression by increasing serotonin levels throughout the brain via inhibition of clearance from the extracellular space. Although increases in serotonin levels are observed after acute SSRI exposure, 3-6 weeks of continuous use is required for reli...

journal_title：Journal of neurochemistry

authors： Dankoski EC,Carroll S,Wightman RM

更新日期：2016-03-01 00:00:00

abstract：:Brain gangliosides from four vertebrate classes (fish, amphibia, aves, and mammalia) were studied by patterns generated with the use of two-dimensional thin-layer chromatography. In an effort to retain possible alkalilabile gangliosides, samples were not base-hydrolyzed. Resultant chromatograms revealed complex patter...

journal_title：Journal of neurochemistry

authors： Hunter GD,Wiegant VM,Dunn AJ

更新日期：1981-10-01 00:00:00

abstract：:The in vitro and in vivo performance of three different semipermeable microdialysis membranes was compared: a proprietary polycarbonate-ether membrane made by Carnegie Medecin; cuprophan, a regenerated cellulose membrane; and polyacrylonitrile. When microdialysis probes were tested in a stirred in vitro solution, larg...

journal_title：Journal of neurochemistry

authors： Hsiao JK,Ball BA,Morrison PF,Mefford IN,Bungay PM

更新日期：1990-04-01 00:00:00

abstract：:The ubiquitous second messenger cyclic GMP (cGMP) is synthesized by soluble guanylate cyclases in response to nitric oxide (NO) and degraded by phosphodiesterases (PDE). We studied the homeostasis of cGMP in living thalamic neurons by using the genetically encoded fluorescence resonance energy transfer sensor Cygnet, ...

journal_title：Journal of neurochemistry

authors： Hepp R,Tricoire L,Hu E,Gervasi N,Paupardin-Tritsch D,Lambolez B,Vincent P

更新日期：2007-09-01 00:00:00

abstract：:Neurosecretory terminals (neurosecretosomes, NSS) were isolated from rat neurohypophyses. High [K+]o or veratridine stimulated secretion of vasopressin and oxytocin by up to approximately 100-fold. Stimulated secretion was dependent on calcium and temperature, and could be elicited from NSS maintained in culture for 4...

journal_title：Journal of neurochemistry

authors： Payza K,Russell JT

更新日期：1991-08-01 00:00:00

abstract：:Transgenic Huntington's disease (HD) mice, expressing exon 1 of the HD gene with an expanded CAG repeat, are totally resistant to striatal lesion induced by excessive NMDA receptor activation. We now show that striatal lesions induced by the mitochondrial toxin malonate are reduced by 70-80% in transgenic HD mice comp...

journal_title：Journal of neurochemistry

authors： Hansson O,Castilho RF,Korhonen L,Lindholm D,Bates GP,Brundin P

更新日期：2001-08-01 00:00:00

abstract：:Interleukin-1 (IL-1) is a proinflammatory cytokine released by many cell types that acts in both an autocrine and/or paracrine fashion. While IL-1 is best described as an important mediator of the peripheral immune response during infection and inflammation, increasing evidence implicates IL-1 signaling in the pathoge...

journal_title：Journal of neurochemistry

authors： Fogal B,Hewett SJ

更新日期：2008-07-01 00:00:00

abstract：:The protein tyrosine kinase Src is known to regulate NMDA receptors in native neurons. While NR2A, NR2B and NR2D are known to be phosphorylated on tyrosine residues, the exact sites have remained unidentified. Immunoprecipitation of NMDA receptor subunits followed by western blotting was used to analyze the state of t...

journal_title：Journal of neurochemistry

authors： Yang M,Leonard JP

更新日期：2001-04-01 00:00:00

abstract：:Vesicular glutamate transporter (VGLUT) is responsible for the vesicular storage of l-glutamate, and plays an essential role in glutamate-mediated intercellular signal transmission in the CNS and in some neuroendocrine cells. Intestinal L cells are the glucose-responsive neuroendocrine cells responsible for the secret...

journal_title：Journal of neurochemistry

authors： Uehara S,Jung SK,Morimoto R,Arioka S,Miyaji T,Juge N,Hiasa M,Shimizu K,Ishimura A,Otsuka M,Yamamoto A,Maechler P,Moriyama Y

更新日期：2006-01-01 00:00:00

abstract：:The extension of microglial processes toward injured sites in the brain is triggered by the stimulation of the purinergic receptor P2Y(12) by extracellular ATP. We recently showed that P2Y(12) stimulation by ATP induces microglial process extension in collagen gels. In the present study, we found that a P2Y(12) agonis...

journal_title：Journal of neurochemistry

authors： Ohsawa K,Sanagi T,Nakamura Y,Suzuki E,Inoue K,Kohsaka S

更新日期：2012-04-01 00:00:00

abstract：:The decrease in receptor-stimulated cyclic AMP production after chronic ethanol exposure was suggested previously to be secondary to an ethanol-induced increase in extracellular adenosine. The present study was undertaken to ascertain whether a similar mechanism was responsible for the ethanol-induced desensitization ...

journal_title：Journal of neurochemistry

authors： Rabin RA,Fiorella D,Van Wylen DG

更新日期：1993-03-01 00:00:00

abstract：:Myelination of peripheral nerves by Schwann cells depends upon a gene regulatory network controlled by early growth response Egr2/Krox20, which is specifically required for Schwann cells to initiate and maintain myelination. To elucidate the mechanism by which Egr2 regulates gene expression during myelination, we have...

journal_title：Journal of neurochemistry

authors： Jang SW,Srinivasan R,Jones EA,Sun G,Keles S,Krueger C,Chang LW,Nagarajan R,Svaren J

更新日期：2010-12-01 00:00:00

abstract：:The effect of a unilateral perinatal hypoxic-ischemic brain injury on dopamine D1 and D2 receptors and uptake sites was investigated in rats by using in vitro quantitative binding autoradiography, 2-3 weeks after the insult. We observed significant decreases in the Bmax and KD for [3H]SCH 23390-labeled D1 and in the B...

journal_title：Journal of neurochemistry

authors： Przedborski S,Kostic V,Jackson-Lewis V,Cadet JL,Burke RE

更新日期：1991-12-01 00:00:00