Rapid down-regulation of Ret following exposure of dopaminergic neurons to neurotoxins.

abstract：:Nuclear factor (NF)-κB-mediated neuroinflammation is an important mechanism of intracerebral hemorrhage (ICH)-induced neurotoxicity. Silent information regulator 1 (SIRT1) plays a multi-protective effect in a variety of diseases by deacetylating and inhibiting NF-κB/p65. However, the role of SIRT1 in brain damage foll...

journal_title：Journal of neurochemistry

authors： Deng HJ,Zhou CH,Huang LT,Wen LB,Zhou ML,Wang CX

更新日期：2020-12-02 00:00:00

abstract：:Lumbar punctures were performed on four occasions over a 5-day period (8:30 a.m. on days 1, 3, and 5; 2:30 p.m. on day 2) on 10 normal volunteers (five of each sex; mean age, 27.7 years) to assess, with repeated sampling, the day-to-day variation of selected CSF parameters. Two subjects abstained from the lumbar punct...

journal_title：Journal of neurochemistry

authors： Ben Menachem E,Persson L,Schechter PJ,Haegele KD,Huebert N,Hardenberg J

更新日期：1989-02-01 00:00:00

abstract：:Choline acetyltransferase activity is barely detectable in a mutant pheochromocytoma PC12 cell line, A123.7, which is deficient in protein kinase A activity. Northern blot and polymerase chain reaction analyses showed that this mutant cell line has dramatically reduced levels of choline acetyltransferase mRNA, which c...

journal_title：Journal of neurochemistry

authors： Inoue H,Li YP,Wagner JA,Hersh LB

更新日期：1995-03-01 00:00:00

abstract：:35SO4-labeled fast-transported proteins of bullfrog dorsal root ganglion neurons were separated by two-dimensional gel electrophoresis, and their mobilities were compared to similar species labeled with [3H]mannose or [3H]fucose. Fluorography revealed regions of poorly resolved, high molecular weight material, likely ...

journal_title：Journal of neurochemistry

authors： Stone GC,Hammerschlag R,Bobinski JA

更新日期：1983-10-01 00:00:00

abstract：:Endoplasmic reticulum (ER) stress occurs when protein folding or maturation is disrupted. A malfunction in the ER stress response can lead to cell death and has been observed in many neurological diseases. However, how the ER stress response is regulated in neuronal cells remains largely unclear. Here, we studied an E...

journal_title：Journal of neurochemistry

authors： Eagleman DE,Zhu J,Liu DC,Seimetz J,Kalsotra A,Tsai NP

更新日期：2020-10-16 00:00:00

abstract：:Transient and time-dependent modulations of neural cell adhesion molecule (NCAM) polysialylation in the dentate gyrus of the rodent hippocampus are a feature of spatial and nonspatial forms of learning. In the hippocampal formation, polysialic acid immunoreactivity was localized to granule-like cells and their mossy f...

journal_title：Journal of neurochemistry

authors： O'Connell AW,Fox GB,Barry T,Murphy KJ,Fichera G,Foley AG,Kelly J,Regan CM

更新日期：1997-06-01 00:00:00

abstract：:This study investigates the functioning of synaptosomal ouabain-sensitive Na+ -K+ -ATPase in cold-induced edema. During vasogenic brain edema development, the enzyme affinities for Na+ and K+ are progressively decreased paralleling the increase in the tissue water content, whereas maximal velocity of the reaction is n...

journal_title：Journal of neurochemistry

authors： Averet N,Rigoulet M,Cohadon F

更新日期：1984-01-01 00:00:00

abstract：:Angiotensin-converting enzyme (ACE) activity was measured in microvessels prepared from cerebral cortices of 4-week-old spontaneously hypertensive rats (SHR). The Vmax value of the ACE activity in the cerebral microvessels of SHR was lower than that of Wistar Kyoto controls of the same age by 25% without difference in...

journal_title：Journal of neurochemistry

authors： Kobayashi H,Wada A,Izumi F,Take K,Magnoni MS

更新日期：1985-04-01 00:00:00

abstract：:Nerve growth factor (NGF) is a trophic and survival factor for cholinergic neurons, and it induces the expression of several genes that are essential for synthesis and storage of acetylcholine (ACh), specifically choline acetyltransferase, vesicular ACh transporter (VAChT), and choline transporter. We have found previ...

journal_title：Journal of neurochemistry

authors： Madziar B,Shah S,Brock M,Burke R,Lopez-Coviella I,Nickel AC,Cakal EB,Blusztajn JK,Berse B

更新日期：2008-12-01 00:00:00

abstract：:JNK/SAPK has been implicated in the pathogenesis of Alzheimer's disease, but the upstream cascade leading to JNK/SAPK activation has not been elucidated in the disease. In this study, we focused on one of the physiological activators of JNK/SAPK, JNK kinase 1 (JKK1). Although there was no significant difference in the...

journal_title：Journal of neurochemistry

authors： Zhu X,Ogawa O,Wang Y,Perry G,Smith MA

更新日期：2003-04-01 00:00:00

abstract：:Substrate-induced endocytic trafficking of dopamine transporter (DAT) has been observed, but little is known about the regulation of DAT oligomerization by substrate. The present study investigates the effect on substrates on DAT oligomerization and explores a potential link with the presence of DAT at the cell surfac...

journal_title：Journal of neurochemistry

authors： Chen N,Reith ME

更新日期：2008-05-01 00:00:00

abstract：:In the central nervous system, astrocytes extend endfoot processes to ensheath synapses and microvessels. However, the mechanisms underlying this astrocytic process extension remain unclear. A limitation of the use of 2D cultured astrocytes for such studies is that they display a flat, epithelioid morphology, with no ...

journal_title：Journal of neurochemistry

authors： Sato J,Horibe S,Kawauchi S,Sasaki N,Hirata KI,Rikitake Y

更新日期：2018-11-01 00:00:00

abstract：:The activities of choline acetyltransferase (CAT) and glutamic acid decarboxylase (GAD), markers of cholinergic and GABAergic terminals, were measured in growing and adult Gunn rats, which possess an autosomal recessive gene for jaundice or kernicterus. In the olfactory tubercle, hippocampus, neostriatum, thalamus, an...

journal_title：Journal of neurochemistry

authors： Ohno T

更新日期：1981-10-01 00:00:00

abstract：:The olfactory bulb is one of the most vulnerable brain regions in age-related proteinopathies. Proteinopathic stress is mitigated by the heat shock protein (Hsp) family of chaperones. Here, we describe age-related decreases in Hsc70 in the olfactory bulb of the female rat and higher levels of Hsp70 and Hsp25 in middle...

journal_title：Journal of neurochemistry

authors： Crum TS,Gleixner AM,Posimo JM,Mason DM,Broeren MT,Heinemann SD,Wipf P,Brodsky JL,Leak RK

更新日期：2015-06-01 00:00:00

abstract：:Ischemic postconditioning is increasingly being investigated as a therapeutic approach for cerebral ischemia. However, the majority of studies are focused on the acute protection of neurons per se. Whether and how postconditioning affects multiple cells in the recovering neurovascular unit remains to be fully elucidat...

journal_title：Journal of neurochemistry

authors： Esposito E,Hayakawa K,Ahn BJ,Chan SJ,Xing C,Liang AC,Kim KW,Arai K,Lo EH

更新日期：2018-07-01 00:00:00

abstract：:Induction of the prodynorphin gene occurs in a tissue-specific manner following different physiological stimuli. Using electrophoretic mobility shift assays, we studied the relative activity of the five major regulatory sites in the rat prodynorphin promoter. Prodynorphin cyclic AMP-responsive element 2 (DynCRE2), Dyn...

journal_title：Journal of neurochemistry

authors： Carrión AM,Mellström B,Luckman SM,Naranjo JR

更新日期：1998-03-01 00:00:00

abstract：:To enable us to study expression of tyrosine hydroxylase [TH; tyrosine 3-monooxygenase; L-tyrosine tetrahydropteridine:oxygen oxidoreductase (3-hydroxylating); EC 1.14.16.2] as a measure of dopaminergic neuron function in future experiments, methods were developed to quantify TH mRNA levels in cultures of dopaminergic...

journal_title：Journal of neurochemistry

authors： Beck KD,Knusel B,Pasinetti G,Michel PP,Zawadzka H,Goldstein M,Hefti F

更新日期：1991-08-01 00:00:00

abstract：:The N-methyl-D-aspartate (NMDA) receptor complex as defined by the binding of [3H]MK-801 has been solubilized from membranes prepared from both rat and porcine brain using the anionic detergent deoxycholate (DOC). Of the detergents tested DOC extracted the most receptors (21% for rat, 34% for pig), and the soluble com...

journal_title：Journal of neurochemistry

authors： McKernan RM,Castro S,Poat JA,Wong EH

更新日期：1989-03-01 00:00:00

abstract：:The cDNA for Tyr-Loc, a G protein-coupled receptor that clearly shows homology to a number of mammalian and fruit fly receptors for biogenic amines, was cloned from the nervous system of Locusta migratoria. Functional expression of the cloned cDNA was obtained in cultured insect cells, i.e., in Spodoptera SF9 cells us...

journal_title：Journal of neurochemistry

authors： Vanden Broeck J,Vulsteke V,Huybrechts R,De Loof A

更新日期：1995-06-01 00:00:00

abstract：:Considerable evidence indicates that the amyloid-beta (Abeta) peptide, a proteolytic fragment of the amyloid precursor protein, is the pathogenic agent in Alzheimer's disease (AD). A number of proteases have been reported as capable of degrading Abeta, among them: neprilysin, insulin-degrading enzyme, endothelin-conve...

journal_title：Journal of neurochemistry

authors： Yamin R,Bagchi S,Hildebrant R,Scaloni A,Widom RL,Abraham CR

更新日期：2007-01-01 00:00:00

abstract：:Antibodies raised against the synthetic peptide NH2-QKSDDDYEDYASNKTC-COOH (gamma 2 1-15 Cys), which corresponds to the N-terminal amino acid sequence with a C-terminal cysteine of the human gamma 2 subunit of the gamma-aminobutyric acidA (GABAA) receptor, were used to study the quantitative immunoprecipitation of agon...

journal_title：Journal of neurochemistry

authors： Duggan MJ,Pollard S,Stephenson FA

更新日期：1992-01-01 00:00:00

abstract：:The myelin transcription factor 1 (Myt1) gene family is comprised of three zinc finger genes [Myt1, Myt1L (Myt1-Like) and NZF3] of the structurally unique CCHHC class that are expressed predominantly in the developing CNS. To understand the mechanism by which this family regulates neural differentiation, we searched f...

journal_title：Journal of neurochemistry

authors： Romm E,Nielsen JA,Kim JG,Hudson LD

更新日期：2005-06-01 00:00:00

abstract：:The lipids of gastrocnemius muscle from normal and dystrophic (dy) mice of the Bar Harbor, 129Re strain were studied. Animals were fed diets containing either 3.1% or 1.1% of total calories as linoleic acid. Lipid analyses were also done on muscle from a new mouse mutant, A2G-adr, which has abnormal muscle function, c...

journal_title：Journal of neurochemistry

authors： Rebello T,Watts DC

更新日期：1985-07-01 00:00:00

abstract：:Measurements were made of the amino acid content of a cellular clone (K55) derived from mouse cerebellar cultures transformed in vitro by simian virus-40 (Alliot and Pessac, 1981) and that appears to be astroglial. Both the total amount of amino acids as well as the percentage of glycine in K55 cells were higher than ...

journal_title：Journal of neurochemistry

authors： Cambier D,Alliot F,Pessac B

更新日期：1983-05-01 00:00:00

abstract：:The effect of cerebral hypoxia-ischemia (HI) on levels and tyrosine phosphorylation of the NMDA receptor was examined in 7- (P7) and 21 (P21)-day-old rats. Unilateral HI was administered by ligation of the right common carotid artery and exposure to an atmosphere of 8% O2/92% N2 for 2 (P7) or 1.5 (P21) h. This duratio...

journal_title：Journal of neurochemistry

authors： Gurd JW,Bissoon N,Beesley PW,Nakazawa T,Yamamoto T,Vannucci SJ

更新日期：2002-08-01 00:00:00

abstract：:While it has been reported that familial Alzheimer's disease (FAD)-linked mutants of amyloid precursor protein (APP) and presenilin (PS)2 induce neuronal cytotoxicity in a manner sensitive to antioxidant and pertussis toxin (PTX), little of the mechanism for PS1-mediated neuronal cell death has been characterized. We ...

journal_title：Journal of neurochemistry

authors： Hashimoto Y,Ito Y,Arakawa E,Kita Y,Terashita K,Niikura T,Nishimoto I

更新日期：2002-02-01 00:00:00

abstract：:Major depressive disorder is a common form of mental illness. Many brain regions are implicated in the pathophysiology and symptomatology of depression. Among key brain areas is the striatum that controls reward and mood and is involved in the development of core depression-like behavior in animal models of depression...

journal_title：Journal of neurochemistry

authors： Mao LM,Wang JQ

更新日期：2018-05-01 00:00:00

abstract：:The irreversible inhibition of the monoamine oxidase (MAO) activity within monoaminergic neurons in the rat brain 24 h after single or repeated administration of (E)-beta-fluoromethylene-m-tyrosine (FMMT, MDL 72394) was examined. The enzyme activity was determined by incubating synaptosome-rich homogenates of hypothal...

journal_title：Journal of neurochemistry

authors： Fagervall I,Ross SB

更新日期：1989-02-01 00:00:00

abstract：:Epilepsy is a serious neurological condition exhibiting complex pathology and deserving of more serious attention. More than 30% of people with epilepsy are not responsive to more than 20 anti-epileptic drugs currently available, reflecting an unmet clinical need for novel therapeutic strategies. Not much is known abo...

journal_title：Journal of neurochemistry

authors： Paudel YN,Semple BD,Jones NC,Othman I,Shaikh MF

更新日期：2019-12-01 00:00:00

abstract：:Melatonin is neuroprotective because of its antioxidative action, but it also can modify neuronal vulnerability by altering gene expression. 5-Lipoxygenase (5-LO) gene expression is suppressed by the binding of melatonin to its high-affinity nuclear receptors. Recently, we reported that in rats the melatonin deficienc...

journal_title：Journal of neurochemistry

authors： Uz T,Longone P,Manev H

更新日期：1997-11-01 00:00:00