Spatial learning activates neural cell adhesion molecule polysialylation in a corticohippocampal pathway within the medial temporal lobe.

Abstract:

:Transient and time-dependent modulations of neural cell adhesion molecule (NCAM) polysialylation in the dentate gyrus of the rodent hippocampus are a feature of spatial and nonspatial forms of learning. In the hippocampal formation, polysialic acid immunoreactivity was localized to granule-like cells and their mossy fibre axons. We now demonstrate the latter to extend to the CA3 region where apparent recurrent and Schaffer collaterals were labelled. The axons of the CA1 pyramidal cell layer were immunopositive, as was the subiculum that they innervate. Layers I and III of the entorhinal cortex stained intensely for polysialic acid; however, these were not visible in the more lateral aspect of this region and were replaced by a single band of immunopositive neurons that extended to include the perirhinal and piriform cortices. After Morris water maze training, the number of polysialylated neurons within the entorhinal cortex exhibited a two- to threefold increase at the 10-12-h posttraining time with respect to that observed immediately after training. This increase was task specific, as no change was observed in freely swimming animals or those required to locate a visible platform. These results suggest the presence of a corticohippocampal pathway involved in the eventual consolidation of memory.

journal_name

J Neurochem

authors

O'Connell AW,Fox GB,Barry T,Murphy KJ,Fichera G,Foley AG,Kelly J,Regan CM

doi

10.1046/j.1471-4159.1997.68062538.x

subject

Has Abstract

pub_date

1997-06-01 00:00:00

pages

2538-46

issue

6

eissn

0022-3042

issn

1471-4159

journal_volume

68

pub_type

杂志文章
  • The l-isomer-selective transport of aspartic acid is mediated by ASCT2 at the blood-brain barrier.

    abstract::Aspartic acid (Asp) undergoes l-isomer-selective efflux transport across the blood-brain barrier (BBB). This transport system appears to play an important role in regulating l- and d-Asp levels in the brain. The purpose of this study was to identify the responsible transporters and elucidate the mechanism for l-isomer...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章

    doi:10.1046/j.1471-4159.2003.02063.x

    authors: Tetsuka K,Takanaga H,Ohtsuki S,Hosoya K,Terasaki T

    更新日期:2003-11-01 00:00:00

  • Formation of carnosine-Cu(II) complexes prevents and reverts the inhibitory action of copper in P2X4 and P2X7 receptors.

    abstract::To further analyze the action of copper on brain synaptic mechanisms, the brain dipeptide carnosine (beta-alanyl-L-histidine) was tested in Xenopus laevis oocytes expressing the rat P2X4 or P2X7 receptors. Ten micromolar copper halved the currents evoked by ATP in both receptors; co-application of carnosine plus coppe...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章

    doi:10.1046/j.0022-3042.2001.00732.x

    authors: Coddou C,Villalobos C,González J,Acuña-Castillo C,Loeb B,Huidobro-Toro JP

    更新日期:2002-02-01 00:00:00

  • Studies on a possible functional coupling between presynaptic acetylcholinesterase and high-affinity choline uptake in the rat brain.

    abstract::The relationships between presynaptic acetylcholinesterase (AChE) and high-affinity choline uptake (HACU) were investigated using a monolayer of rat cortex synaptosomes in superfusion conditions. The following sets of experiments were performed: determination of [3H]choline ([3H]Ch) uptake during superfusion with [3H]...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章

    doi:10.1111/j.1471-4159.1986.tb13076.x

    authors: Raiteri M,Marchi M,Caviglia AM

    更新日期:1986-12-01 00:00:00

  • Modulation of [3H]muscimol binding in rat cerebellar and cerebral cortical membranes by picrotoxin, pentobarbitone, and etomidate.

    abstract::Modulation of [3H]muscimol binding by picrotoxin, pentobarbitone, and etomidate was investigated in rat cerebellar and cerebral cortical membranes. In cerebellum, at 37 degrees C in the presence of chloride ions (150 mM), picrotoxin and picrotoxinin decreased specific [3H]muscimol binding to 43 +/- 3% of control, with...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章

    doi:10.1111/j.1471-4159.1983.tb04758.x

    authors: Quast U,Brenner O

    更新日期:1983-08-01 00:00:00

  • Hypoxia increases the susceptibility to oxidant stress and the permeability of the blood-brain barrier endothelial cell monolayer.

    abstract::Using a cell culture model of the blood-brain barrier (BBB), we investigated the brain capillary endothelial cell (EC) response to hypoxia. The activities of antioxidant enzymes such as glutathione peroxidase, glutathione reductase, catalase, and superoxide dismutase and the GSH level of brain capillary ECs alone or i...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章

    doi:10.1046/j.1471-4159.1995.65052138.x

    authors: Plateel M,Dehouck MP,Torpier G,Cecchelli R,Teissier E

    更新日期:1995-11-01 00:00:00

  • Regulation of axotomy-induced dopaminergic neuron death and c-Jun phosphorylation by targeted inhibition of cdc42 or mixed lineage kinase.

    abstract::Mechanical transection of the nigrostriatal dopamine pathway at the medial forebrain bundle (MFB) results in the delayed degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNpc). We have previously demonstrated that c-Jun activation is an obligate component of neuronal death in this model. Her...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章

    doi:10.1111/j.1471-4159.2005.03568.x

    authors: Crocker SJ,Hayley SP,Smith PD,Mount MP,Lamba WR,Callaghan SM,Slack RS,Park DS

    更新日期:2006-01-01 00:00:00

  • Identification of ApoE as an autocrine/paracrine factor that stimulates neural stem cell survival via MAPK/ERK signaling pathway.

    abstract::Neural stem cells (NSCs) are self-renewing multipotent cells that undergo symmetric and asymmetric cell division during development of the nervous system. The behavior of NSCs is tightly regulated by intrinsic processes such as transcriptional and post-transcriptional control, as well as the stem cell niche factors th...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章

    doi:10.1111/j.1471-4159.2011.07227.x

    authors: Gan HT,Tham M,Hariharan S,Ramasamy S,Yu YH,Ahmed S

    更新日期:2011-05-01 00:00:00

  • Wnt signaling loss accelerates the appearance of neuropathological hallmarks of Alzheimer's disease in J20-APP transgenic and wild-type mice.

    abstract::Alzheimer's disease (AD) is a neurodegenerative pathology characterized by aggregates of amyloid-β (Aβ) and phosphorylated tau protein, synaptic dysfunction, and spatial memory impairment. The Wnt signaling pathway has several key functions in the adult brain and has been associated with AD, mainly as a neuroprotectiv...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章

    doi:10.1111/jnc.14278

    authors: Tapia-Rojas C,Inestrosa NC

    更新日期:2018-02-01 00:00:00

  • Expression of calmodulin-dependent phosphodiesterase, calmodulin-dependent protein phosphatase, and other calmodulin-binding proteins in human SMS-KCNR neuroblastoma cells.

    abstract::Calmodulin (CaM)-dependent enzymes, such as CaM-dependent phosphodiesterase (CaM-PDE), CaM-dependent protein phosphatase (CN), and CaM-dependent protein kinase II (CaM kinase II), are found in high concentrations in differentiated mammalian neurons. In order to determine whether neuroblastoma cells express these CaM-d...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章

    doi:10.1111/j.1471-4159.1989.tb09191.x

    authors: Pennypacker KR,Kincaid RL,Polli JW,Billingsley ML

    更新日期:1989-05-01 00:00:00

  • AMPA receptors modulate the reorganization of F-actin in Bergmann glia cells through the activation of RhoA.

    abstract::Alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid glutamate receptors have been shown to modulate the morphology of the lamelar processes of Bergmann glia cells in the molecular layer of the cerebellum. Here we suggest that reorganization of F-actin may underlay the changes in the morphology of the lamelar proc...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章

    doi:10.1111/jnc.14658

    authors: Rosas-Hernández R,Bastián Y,Juárez Tello A,Ramírez-Saíto Á,Escobar García DM,Pozos-Guillén A,Mendez JA

    更新日期:2019-04-01 00:00:00

  • Network-based characterization of the synaptic proteome reveals that removal of epigenetic regulator Prmt8 restricts proteins associated with synaptic maturation.

    abstract::The brain adapts to dynamic environmental conditions by altering its epigenetic state, thereby influencing neuronal transcriptional programs. An example of an epigenetic modification is protein methylation, catalyzed by protein arginine methyltransferases (PRMT). One member, Prmt8, is selectively expressed in the cent...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章

    doi:10.1111/jnc.13921

    authors: Lee PK,Goh WW,Sng JC

    更新日期:2017-02-01 00:00:00

  • The effect of Cyclin-dependent kinase 5 on voltage-dependent calcium channels in PC12 cells varies according to channel type and cell differentiation state.

    abstract::Cyclin-dependent kinase 5 (Cdk5) is a Ser/Thr kinase that plays an important role in the release of neurotransmitter from pre-synaptic terminals triggered by Ca(2+) influx into the pre-synaptic cytoplasm through voltage-dependent Ca(2+) channels (VDCCs). It is reported that Cdk5 regulates L-, P/Q-, or N-type VDCC, but...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章

    doi:10.1111/jnc.12746

    authors: Furusawa K,Asada A,Saito T,Hisanaga S

    更新日期:2014-08-01 00:00:00

  • Type I calmodulin-sensitive adenylyl cyclase is neural specific.

    abstract::The distribution of type I calmodulin-sensitive adenylyl cyclase in bovine and rat tissues was examined by northern blot analysis and in situ hybridization. Northern blot analysis using poly(A)(+)-selected RNA from various bovine tissues indicated that mRNA for type I adenylyl cyclase was found only in brain, retina, ...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章

    doi:10.1111/j.1471-4159.1993.tb05852.x

    authors: Xia Z,Choi EJ,Wang F,Blazynski C,Storm DR

    更新日期:1993-01-01 00:00:00

  • A beta oligomers - a decade of discovery.

    abstract::Converging lines of evidence suggest that progressive accumulation of the amyloid beta-protein (A beta) plays a central role in the genesis of Alzheimer's disease, but it was long assumed that A beta had to be assembled into extracellular amyloid fibrils to exert its cytotoxic effects. Over the past decade, data have ...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章,评审

    doi:10.1111/j.1471-4159.2006.04426.x

    authors: Walsh DM,Selkoe DJ

    更新日期:2007-06-01 00:00:00

  • Mutant presenilin 2 transgenic mouse: effect on an age-dependent increase of amyloid beta-protein 42 in the brain.

    abstract::The N141I missense mutation in presenilin (PS) 2 is tightly linked with a form of autosomal dominant familial Alzheimer's disease (AD) in the Volga German families. We have generated transgenic mouse lines overexpressing human wild-type or mutant PS2 under transcriptional control of the chicken beta-actin promoter. In...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章

    doi:10.1046/j.1471-4159.1998.71010313.x

    authors: Oyama F,Sawamura N,Kobayashi K,Morishima-Kawashima M,Kuramochi T,Ito M,Tomita T,Maruyama K,Saido TC,Iwatsubo T,Capell A,Walter J,Grünberg J,Ueyama Y,Haass C,Ihara Y

    更新日期:1998-07-01 00:00:00

  • Multiple functional domains are involved in tomosyn regulation of exocytosis.

    abstract::Tomosyn is a cytoplasmic protein that was shown to bind to Syntaxin1 and SNAP-25 through an R-SNARE domain, forming a complex that is almost identical in structure to the neuronal SNARE complex. Tomosyn inhibits exocytosis in various cell types and these effects were attributed to direct competition between tomosyn's ...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章

    doi:10.1111/j.1471-4159.2007.04791.x

    authors: Yizhar O,Lipstein N,Gladycheva SE,Matti U,Ernst SA,Rettig J,Stuenkel EL,Ashery U

    更新日期:2007-10-01 00:00:00

  • Mimicking the nicotinic receptor binding site by a single chain Fv selected by competitive panning from a synthetic phage library.

    abstract::We have developed a novel competitive method to select from a phage display library a single chain Fv which is able to mimic the alpha-bungarotoxin binding site of the muscle nicotinic receptor. The single chain Fv was selected from a large synthetic library using alpha-bungarotoxin-coated magnetic beads. Toxin-bound ...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章

    doi:10.1046/j.1471-4159.2001.00398.x

    authors: Bracci L,Pini A,Lozzi L,Lelli B,Battestin P,Spreafico A,Bernini A,Niccolai N,Neri P

    更新日期:2001-07-01 00:00:00

  • Interleukin-10 inhibits both production of cytokines and expression of cytokine receptors in microglia.

    abstract::Microglia, macrophage-like cells in the CNS, are multifunctional cells; they play an important role in removal of dead cells or their remnants by phagocytosis in the CNS degeneration and are one of important cells in the CNS cytokine network to produce and respond to a variety of cytokines. The functions of microglia ...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章

    doi:10.1046/j.1471-4159.1999.721466.x

    authors: Sawada M,Suzumura A,Hosoya H,Marunouchi T,Nagatsu T

    更新日期:1999-04-01 00:00:00

  • Kernicterus: enzymatic evidence for difference between the development of cholinergic and GABAergic innervations in the brain of the Gunn rat.

    abstract::The activities of choline acetyltransferase (CAT) and glutamic acid decarboxylase (GAD), markers of cholinergic and GABAergic terminals, were measured in growing and adult Gunn rats, which possess an autosomal recessive gene for jaundice or kernicterus. In the olfactory tubercle, hippocampus, neostriatum, thalamus, an...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章

    doi:10.1111/j.1471-4159.1981.tb04499.x

    authors: Ohno T

    更新日期:1981-10-01 00:00:00

  • The role of MAC1 in diesel exhaust particle-induced microglial activation and loss of dopaminergic neuron function.

    abstract::Increasing reports support that air pollution causes neuroinflammation and is linked to central nervous system (CNS) disease/damage. Diesel exhaust particles (DEP) are a major component of urban air pollution, which has been linked to microglial activation and Parkinson's disease-like pathology. To begin to address ho...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章

    doi:10.1111/jnc.12231

    authors: Levesque S,Taetzsch T,Lull ME,Johnson JA,McGraw C,Block ML

    更新日期:2013-06-01 00:00:00

  • Characterization of OPA1 isoforms isolated from mouse tissues.

    abstract::OPA1, a nuclear encoded mitochondrial protein causing autosomal dominant optic atrophy, is a key player in mitochondrial fusion and cristae morphology regulation. In the present study, we have compared the OPA1 transcription and translation products of different mouse tissues. Unlike in humans, we found only two exons...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章

    doi:10.1111/j.1471-4159.2008.05401.x

    authors: Akepati VR,Müller EC,Otto A,Strauss HM,Portwich M,Alexander C

    更新日期:2008-07-01 00:00:00

  • Fast HPLC estimation of gamma-aminobutyric acid in microdialysis perfusates: effect of nipecotic and 3-mercaptopropionic acids.

    abstract::A method for rapid, automated (less than 5 min), and sensitive (detection limit 50 fmol/10 microliter) determination of gamma-aminobutyric acid (GABA) is described. The method is based on precolumn derivatization with o-phthaldialdehyde/t-butylthiol reagent and separation by reverse-phase HPLC with electrochemical det...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章

    doi:10.1111/j.1471-4159.1988.tb03101.x

    authors: Kehr J,Ungerstedt U

    更新日期:1988-10-01 00:00:00

  • Stimulatory effect of ascorbic acid on norepinephrine biosynthesis in digitonin-permeabilized adrenal medullary chromaffin cells.

    abstract::The regulatory role of ascorbic acid in norepinephrine biosynthesis was studied using digitonin-permeabilized chromaffin cells. When permeabilized chromaffin cells were incubated with [3H]3,4-dihydroxyphenylethylamine ([3H]dopamine) in calcium-free medium, the amounts of radioactive dopamine and norepinephrine measure...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章

    doi:10.1111/j.1471-4159.1986.tb13060.x

    authors: Morita K,Levine M,Pollard HB

    更新日期:1986-03-01 00:00:00

  • An enzyme-linked immunoassay for nerve growth factor (NGF): a tool for studying regulatory mechanisms involved in NGF production in brain and in peripheral tissues.

    abstract::A sensitive enzyme-linked immunosorbent assay (ELISA) for nerve growth factor (NGF) has been developed. The sensitivity of this assay (0.1 pg/well) permits the quantification of endogenous immunoreactive NGF in the peripheral nervous system and the CNS. Studies on the regulatory mechanisms involved in NGF production i...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章

    doi:10.1111/j.1471-4159.1987.tb05736.x

    authors: Weskamp G,Otten U

    更新日期:1987-06-01 00:00:00

  • Glutamate neurotoxicity in rat cerebellar granule cells: a major role for xanthine oxidase in oxygen radical formation.

    abstract::To gain insight into the mechanism through which the neurotransmitter glutamate causally participates in several neurological diseases, in vitro cultured cerebellar granule cells were exposed to glutamate and oxygen radical production was investigated. To this aim, a novel procedure was developed to detect oxygen radi...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章

    doi:10.1046/j.1471-4159.1997.68052038.x

    authors: Atlante A,Gagliardi S,Minervini GM,Ciotti MT,Marra E,Calissano P

    更新日期:1997-05-01 00:00:00

  • Identification of an ectokinase activity in cerebellar granule primary neuronal cultures.

    abstract::Primary neuronal cultures from 8-day-old rat cerebellum were incubated in the presence of exogenously added 16 nM [gamma-32P]ATP. Phosphorylation of a 45-kDa endogenous protein was detected within 1 min and increased linearly for approximately 20 min. Unlike what was seen with [gamma-32P]ATP, in the presence of [32P]o...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章

    doi:10.1046/j.1471-4159.1994.63062028.x

    authors: Volonté C,Merlo D,Ciotti MT,Calissano P

    更新日期:1994-12-01 00:00:00

  • Effect of presynaptic P2 receptor stimulation on transmitter release.

    abstract::Because ATP is degraded to adenosine, its effect could be mediated by both P1 and P2 receptors. Hence, the actions of an ATP analogue, resistant to enzymatic breakdown (alpha, beta-methylene ATP), were studied on the resting and electrically evoked release of radioactivity from longitudinal muscle strips of guinea pig...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章

    doi:10.1111/j.1471-4159.1991.tb02039.x

    authors: Sperlagh B,Vizi ES

    更新日期:1991-05-01 00:00:00

  • Kainate receptor-mediated depression of glutamatergic transmission involving protein kinase A in the lateral amygdala.

    abstract::Kainate receptors (KARs) have been described as modulators of synaptic transmission at different synapses. However, this role of KARs has not been well characterized in the amygdala. We have explored the effect of kainate receptor activation at the synapse established between fibers originating at medial geniculate nu...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章

    doi:10.1111/j.1471-4159.2012.07665.x

    authors: Negrete-Díaz JV,Duque-Feria P,Andrade-Talavera Y,Carrión M,Flores G,Rodríguez-Moreno A

    更新日期:2012-04-01 00:00:00

  • Antisense strategy unravels a dopamine receptor distinct from the D2 subtype, uncoupled with adenylyl cyclase, inhibiting prolactin release from rat pituitary cells.

    abstract::The antisense strategy was used to unravel the functional contribution of the mRNAs encoding dopamine (DA) receptors to the multiple transduction mechanisms operated by DA in rat pituitary cells. An antisense oligonucleotide was designed to recognize seven nucleotides upstream and 11 nucleotides downstream from the in...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章

    doi:10.1046/j.1471-4159.1994.62041260.x

    authors: Valerio A,Alberici A,Tinti C,Spano P,Memo M

    更新日期:1994-04-01 00:00:00

  • Enzymes of fatty acid beta-oxidation in developing brain.

    abstract::Developmental profiles were determined for the activities of eight enzymes involved in fatty acid beta-oxidation in rat brain. The enzymes studied were the palmitoyl-CoA, octanoyl-CoA, butyryl-CoA, glutaryl-CoA, and 3-hydroxyacyl-CoA dehydrogenases, the enoyl-CoA hydratase (crotonase), and the C4- and C10-thiolases. W...

    journal_title:Journal of neurochemistry

    pub_type: 杂志文章

    doi:10.1111/j.1471-4159.1988.tb01044.x

    authors: Reichmann H,Maltese WA,DeVivo DC

    更新日期:1988-08-01 00:00:00