Inhibition of monoamine oxidase within monoaminergic neurons in the rat brain by (E)-beta-fluoromethylene-m-tyrosine (MDL 72394).

abstract：:The p75 neurotrophin receptor (p75NTR) is a low-affinity receptor that is capable of binding neurotrophins. Two different p75NTR knockout mouse lines are available either with a deletion in Exon III (p75NTRExIII-/- ) or in Exon IV (p75NTRExIV-/- ). In p75NTRExIII knockout mice, only the full-length p75NTR is deleted, ...

journal_title：Journal of neurochemistry

authors： Busch R,Baldus M,Vogt MA,Berger SM,Bartsch D,Gass P,von Bohlen Und Halbach O

更新日期：2017-05-01 00:00:00

abstract：:cis-4-Aminocrotonic acid (CACA; 100 microM), an analogue of GABA in a folded conformation, stimulated the passive release of [3H] GABA from slices of rat cerebellum, cerebral cortex, retina, and spinal cord and of beta-[3H]alanine from slices of cerebellum and spinal cord without influencing potassium-evoked release. ...

journal_title：Journal of neurochemistry

authors： Chebib M,Johnston GA

更新日期：1997-02-01 00:00:00

abstract：:Based on our initial finding that the nitric oxide (NO) sensitive fluorochrome diaminofluorescein (DAF) was localized to mitochondria in cultured primary neurons, we investigated whether brain mitochondria produce NO through a mitochondrial NO synthase (mtNOS) enzyme. Isolated brain mitochondria were loaded with DAF a...

journal_title：Journal of neurochemistry

authors： Lacza Z,Horn TF,Snipes JA,Zhang J,Roychowdhury S,Horváth EM,Figueroa JP,Kollai M,Szabó C,Busija DW

更新日期：2004-08-01 00:00:00

abstract：:Within the cell membrane there exist various microdomains (lipid rafts) in which specific lipids and proteins are assembled and these microdomains are recovered in the detergent-resistant low-density membrane fraction (DRM). Septin is a novel GTP-binding, cytoskeletal protein having various isoforms that assemble into...

journal_title：Journal of neurochemistry

authors： Maimaitiyiming M,Kumanogoh H,Nakamura S,Nagata K,Suzaki T,Maekawa S

更新日期：2008-08-01 00:00:00

abstract：:The turnover rate of gamma-aminobutyric acid (GABA) in the rat striatum was estimated by measuring its accumulation after inhibition of GABA-transaminase (GABA-T) with gabaculine. Intrastriatal injections of 100 micrograms gabaculine induced a rapid and complete inhibition of GABA-T. GABA accumulation was linear with ...

journal_title：Journal of neurochemistry

authors： Giorgi O,Meek JL

更新日期：1984-01-01 00:00:00

abstract：:A great body of evidence points toward a functional interaction between metabotropic glutamate 5 receptors (mGluR5) and NMDA receptors (NMDAR) that enhances synaptic plasticity and cognition. However, the molecular mechanism underlying this interaction remains unclear. Here, we show that co-activation of mGluR5 and NM...

journal_title：Journal of neurochemistry

authors： Sarantis K,Tsiamaki E,Kouvaros S,Papatheodoropoulos C,Angelatou F

更新日期：2015-11-01 00:00:00

abstract：:To examine the correlation between the structure of Bcl-2 and its inhibitory function of c-Jun N-terminal kinase (JNK) and caspase activity, we established a dopaminergic neuronal cell line, MN9D overexpressing Bcl-2 (MN9D/Bcl-2) or its structural mutants. The mutants comprised a point mutation in the BH1 (G145A; MN9D...

journal_title：Journal of neurochemistry

authors： Choi WS,Yoon SY,Chang II,Choi EJ,Rhim H,Jin BK,Oh TH,Krajewski S,Reed JC,Oh YJ

更新日期：2000-04-01 00:00:00

abstract：:Postsynaptic interactions between dopamine and glutamate receptors in the nucleus accumbens are critical for acute responses to drugs of abuse and for neuroadaptations resulting from their chronic administration. We tested the hypothesis that D(1) dopamine receptor stimulation increases phosphorylation of the AMPA rec...

journal_title：Journal of neurochemistry

authors： Chao SZ,Lu W,Lee HK,Huganir RL,Wolf ME

更新日期：2002-06-01 00:00:00

abstract：:In vitro studies indicate that p42/p44MAPK phosphorylate both nuclear and cytoplasmic proteins. However, the functional targets of p42/p44MAPK activation in vivo remain unclear. To address this question, we localized activated p42/p44MAPK in hippocampus and cortex and determined their signaling effects after electroco...

journal_title：Journal of neurochemistry

authors： Bhat RV,Engber TM,Finn JP,Koury EJ,Contreras PC,Miller MS,Dionne CA,Walton KM

更新日期：1998-02-01 00:00:00

abstract：:The microtubule-based motor protein kinesin is thought to drive anterograde organelle transport in axons, but nothing is known about how its force-generating activity or organelle-binding properties are regulated. Studies in other motility systems suggest that protein phosphorylation is a reasonable candidate for this...

journal_title：Journal of neurochemistry

authors： Hollenbeck PJ

更新日期：1993-06-01 00:00:00

abstract：:Major depressive disorder is a severe and chronic illness with high lifetime prevalence and a high incidence of suicide as the cause of death for patients with this diagnosis. Major depressive disorder is often treated with anti-depressants. Although these drugs have been used for many years, their exact mode of actio...

journal_title：Journal of neurochemistry

authors： Gulbins E,Walter S,Becker KA,Halmer R,Liu Y,Reichel M,Edwards MJ,Müller CP,Fassbender K,Kornhuber J

更新日期：2015-07-01 00:00:00

abstract：:Choline acetyltransferase activity is barely detectable in a mutant pheochromocytoma PC12 cell line, A123.7, which is deficient in protein kinase A activity. Northern blot and polymerase chain reaction analyses showed that this mutant cell line has dramatically reduced levels of choline acetyltransferase mRNA, which c...

journal_title：Journal of neurochemistry

authors： Inoue H,Li YP,Wagner JA,Hersh LB

更新日期：1995-03-01 00:00:00

abstract：:G protein-coupled receptors are important regulators of cellular signaling processes. Within the large family of rhodopsin-like receptors, those binding to biogenic amines form a discrete subgroup. Activation of biogenic amine receptors leads to transient changes of intracellular Ca²⁺-([Ca²⁺](i)) or 3',5'-cyclic adeno...

journal_title：Journal of neurochemistry

authors： Balfanz S,Jordan N,Langenstück T,Breuer J,Bergmeier V,Baumann A

更新日期：2014-04-01 00:00:00

abstract：:The aim of the present study was to gain a deeper insight into the cell signaling pathways involved in the neuroprotection/neurorescue activity of the major green tea polyphenol (-)-epigallocatechin-3-gallate (EGCG). EGCG (1 micro m) caused an immediate (30 min) down-regulation (approximately 40%) of Bad protein level...

journal_title：Journal of neurochemistry

authors： Kalfon L,Youdim MB,Mandel SA

更新日期：2007-02-01 00:00:00

abstract：:The study of aging is critical for a better understanding of many age-related diseases. The free radical theory of aging, one of the prominent aging hypotheses, holds that during aging, increasing reactive oxygen species in mitochondria causes mutations in the mitochondrial DNA and damages mitochondrial components, re...

journal_title：Journal of neurochemistry

authors： Manczak M,Jung Y,Park BS,Partovi D,Reddy PH

更新日期：2005-02-01 00:00:00

abstract：:The roles of the intracellular calcium pool involved in regulating the Ca2+ profile and the neuronal survival rate during development were studied by using thapsigargin (TG), a specific inhibitor of endoplasmic reticulum (ER) Ca2+-ATPase in cultured cerebellar granule neurons. Measuring the neuronal [Ca2+]i directly i...

journal_title：Journal of neurochemistry

authors： Yao CJ,Lin CW,Lin-Shiau SY

更新日期：1999-08-01 00:00:00

abstract：:Angiopoietin-1, an angiogenic factor, stabilizes brain microvessels through Tie-2 receptor tyrosine kinase. In traumatic brain injury, blood-brain barrier (BBB) disruption is an aggravating factor that induces brain edema and neuroinflammation. We previously showed that BQ788, an endothelin ETB receptor antagonist, pr...

journal_title：Journal of neurochemistry

authors： Michinaga S,Tanabe A,Nakaya R,Fukutome C,Inoue A,Iwane A,Minato Y,Tujiuchi Y,Miyake D,Mizuguchi H,Koyama Y

更新日期：2020-08-01 00:00:00

abstract：:We have previously shown that in cell extracts from rat striatum, cyclic AMP response element (CRE) binding protein (CREB), rather than AP-1 proteins, preferentially interacts with the CRE-2 element of the proenkephalin second messenger-inducible enhancer, even under conditions in which AP-1 proteins are highly induce...

journal_title：Journal of neurochemistry

authors： Konradi C,Cole RL,Green D,Senatus P,Leveque JC,Pollack AE,Grossbard SJ,Hyman SE

更新日期：1995-09-01 00:00:00

abstract：:Although the involvement of both endogenous opioid and serotonergic systems in modulation of pain and emotion was suggested, the neurochemical interaction between these systems in the brain has not previously been studied directly. Herein, the effects of the local application of serotonin (5-HT) and fluoxetine (a 5-HT...

journal_title：Journal of neurochemistry

authors： Zangen A,Nakash R,Yadid G

更新日期：1999-12-01 00:00:00

abstract：:A rapid and simple chromatographic procedure using HPLC with electrochemical detection is described for simultaneous determination of the substrates from precursor amino acids to metabolites related to synthesis and metabolism of three monoamine neurotransmitters--norepinephrine (NE), dopamine (DA), and 5-hydroxytrypt...

journal_title：Journal of neurochemistry

authors： Murai S,Saito H,Masuda Y,Itoh T

更新日期：1988-02-01 00:00:00

abstract：:Microdialysis probes were inserted bilaterally into the striatum of 7-day-old rat pups (n = 30) to examine extracellular fluid levels of dopamine, its metabolites 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA), and the serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA). The dialysis samples w...

journal_title：Journal of neurochemistry

authors： Gordon K,Statman D,Johnston MV,Robinson TE,Becker JB,Silverstein FS

更新日期：1990-02-01 00:00:00

abstract：:In heterologous expression systems, dopamine transporter (DAT) cell-surface localization is reduced after relatively prolonged exposure to d-amphetamine (AMPH) or dopamine (DA), suggesting a role for substrate-mediated regulation of transporter function. Here, we investigated whether brief, repeated periods of substra...

journal_title：Journal of neurochemistry

authors： Gulley JM,Doolen S,Zahniser NR

更新日期：2002-10-01 00:00:00

abstract：:Chondroitin sulphate proteoglycans (CSPGs) are axon growth inhibitory molecules present in the glial scar that play a part in regeneration failure after damage to the CNS and which restrict CNS plasticity. Removal of chondroitin sulphate glycosaminoglycan (GAG) chains with chondroitinase-ABC (chABC) in models of CNS i...

journal_title：Journal of neurochemistry

authors： Lin R,Kwok JC,Crespo D,Fawcett JW

更新日期：2008-01-01 00:00:00

abstract：:The possibilities of interference by glycerophosphoryl ethanolamine (GPE) in the estimation of taurine levels in cerebral cortex, midbrain, cerebellum, medullapons, and spinal cord of developing human fetal brain regions were eliminated by hydrolyzing tissue extracts with 6 M HCl. Cysteic acid thus produced was separa...

journal_title：Journal of neurochemistry

authors： Datta SC

更新日期：1988-04-01 00:00:00

abstract：:Our interest in investigating the presynaptic modulation of acetylcholine release led to the development of a synaptosomal preparation from the guinea pig ileum myenteric plexus-longitudinal muscle. A crude synaptosomal fraction (P2) was obtained by homogenization and differential centrifugation. The preparation exhib...

journal_title：Journal of neurochemistry

authors： Briggs CA,Cooper JR

更新日期：1981-03-01 00:00:00

abstract：:To further analyze the action of copper on brain synaptic mechanisms, the brain dipeptide carnosine (beta-alanyl-L-histidine) was tested in Xenopus laevis oocytes expressing the rat P2X4 or P2X7 receptors. Ten micromolar copper halved the currents evoked by ATP in both receptors; co-application of carnosine plus coppe...

journal_title：Journal of neurochemistry

authors： Coddou C,Villalobos C,González J,Acuña-Castillo C,Loeb B,Huidobro-Toro JP

更新日期：2002-02-01 00:00:00

abstract：:Dopamine neurons have been suggested to use glutamate as a cotransmitter. To identify the basis of such a phenotype, we have examined the expression of the three recently identified vesicular glutamate transporters (VGLUT1-3) in postnatal rat dopamine neurons in culture. We found that the majority of isolated dopamine...

journal_title：Journal of neurochemistry

authors： Dal Bo G,St-Gelais F,Danik M,Williams S,Cotton M,Trudeau LE

更新日期：2004-03-01 00:00:00

abstract：:Intact neurofilaments (NF) purified from mammalian brain and spinal cord promote the assembly of microtubules in solutions of pure phosphocellulose (PC)-purified tubulin. This assembly is temperature-dependent and is inhibited by mitotic spindle inhibitors. The ability of NF to induce microtubule formation is 20% of t...

journal_title：Journal of neurochemistry

authors： Leterrier JF,Wong J,Liem RK,Shelanski ML

更新日期：1984-11-01 00:00:00

abstract：:Epidermal growth factor (EGF) is a member of a structurally related family containing heparin-binding EGF-like growth factor (HB-EGF) and transforming growth factor alpha (TGFalpha) that exerts neurotrophic activity on midbrain dopaminergic neurons. To examine neurotrophic abnormality in Parkinson's disease (PD), we m...

journal_title：Journal of neurochemistry

authors： Iwakura Y,Piao YS,Mizuno M,Takei N,Kakita A,Takahashi H,Nawa H

更新日期：2005-05-01 00:00:00

abstract：:p-glycoprotein (p-gp) is an ATP-binding cassette transporter and its overexpression is responsible for the acquisition of the multidrug resistance phenotype in human tumors. p-gp is localized at the blood-brain barrier and is involved in brain cytoprotection. Our previous work used immunoprecipitation to show that cav...

journal_title：Journal of neurochemistry

authors： Barakat S,Demeule M,Pilorget A,Régina A,Gingras D,Baggetto LG,Béliveau R

更新日期：2007-04-01 00:00:00