alpha-Synuclein forms a complex with transcription factor Elk-1.

abstract：:Most biological effects of tissue plasminogen activator (tPA), such as fibrinolysis, are mediated by its protease activity. Recent studies, however, have demonstrated that tPA also has several protease-independent effects such as: neuroprotection, microglial activation, and promoting LTP formation. In order to gain a ...

journal_title：Journal of neurochemistry

authors： Lee HY,Hwang IY,Im H,Koh JY,Kim YH

更新日期：2007-06-01 00:00:00

abstract：:The expression and distribution of mRNA encoding preproatrial natriuretic peptide (ppANP) in rat brain has been investigated by in situ hybridization of two 35S-labeled synthetic DNA oligonucleotides, based on a cDNA clone sequence that encodes rat ppANP. The highest relative concentrations of ppANP mRNA were detected...

journal_title：Journal of neurochemistry

authors： Gundlach AL,Knobe KE

更新日期：1992-08-01 00:00:00

abstract：:Exposure to excessive levels of light induces photoreceptor apoptosis and can be a causative factor in age-related macular degeneration (AMD). However, the cellular events that mediate this apoptotic response are poorly understood. Here, we investigated the roles of endoplasmic reticulum (ER) stress in light-induced c...

journal_title：Journal of neurochemistry

authors： Nakanishi T,Shimazawa M,Sugitani S,Kudo T,Imai S,Inokuchi Y,Tsuruma K,Hara H

更新日期：2013-04-01 00:00:00

abstract：:Rat and mouse CNS neurofilament proteins (NFPs) were characterized and compared, in terms of electrophoretic properties on polyacrylamide gels and by peptide mapping, with one another and with other co-purifying lower-molecular-weight CNS proteins, including alpha and beta tubulin. NFPs were partially purified by modi...

journal_title：Journal of neurochemistry

authors： Brown BA,Nixon RA,Strocchi P,Marotta CA

更新日期：1981-01-01 00:00:00

abstract：:Circadian clocks are internal timing systems that enable organisms to adjust their behavioral and physiological rhythms to the daily changes of their environment. These clocks generate self-sustained oscillations at the cellular, tissue, and behavioral level. The rhythm-generating mechanism is based on a gene expressi...

journal_title：Journal of neurochemistry

authors： Srikanta SB,Cermakian N

更新日期：2020-07-27 00:00:00

abstract：:Microscopic fluorescence analysis of fura-2-loaded bovine adrenal chromaffin cells demonstrates that approximately 70% of the cells responded to arachidonic acid in increasing the intracellular Ca2+ concentration. Because this increase was markedly less in the absence of external Ca2+, we examined the effect of arachi...

journal_title：Journal of neurochemistry

authors： Mochizuki-Oda N,Negishi M,Mori K,Ito S

更新日期：1993-11-01 00:00:00

abstract：:The Coffin-Lowry syndrome, a rare syndromic form of X-linked mental retardation, is caused by loss-of-function mutations in the hRSK2 (RPS6KA3) gene. To further investigate RSK2 (90-kDa ribosomal S6 kinase) implication in cognitive processes, a mrsk2_KO mouse has previously been generated as an animal model of Coffin-...

journal_title：Journal of neurochemistry

authors： Marques Pereira P,Gruss M,Braun K,Foos N,Pannetier S,Hanauer A

更新日期：2008-12-01 00:00:00

abstract：:Recent studies suggest that the chemotactic G protein-coupled receptor formyl-peptide-receptor-like-1 (FPRL1) or the scavenger receptor MARCO (macrophage receptor with collagenous structure) plays an essential role in the inflammatory response of host defense mechanisms and neurodegenerative disorders such as Alzheime...

journal_title：Journal of neurochemistry

authors： Brandenburg LO,Konrad M,Wruck CJ,Koch T,Lucius R,Pufe T

更新日期：2010-05-01 00:00:00

abstract：:Spatial solute concentration profiles resulting from in vivo microdialysis were measured in rat caudate-putamen by quantitative autoradiography. Radiolabeled sucrose was included in the dialysate, and the tissue concentration profile measured after infusions of 14 min and 61.5 min in an acute preparation. In addition,...

journal_title：Journal of neurochemistry

authors： Dykstra KH,Hsiao JK,Morrison PF,Bungay PM,Mefford IN,Scully MM,Dedrick RL

更新日期：1992-03-01 00:00:00

abstract：:Ischemic stress in the brain induces acute and massive neuronal death in the targeted area, which is followed by a second round of detrimental processes, called delayed neuronal death, in the neighboring areas. To test the hypothesis that transcriptional control plays a role in the pathophysiology of the postischemic ...

journal_title：Journal of neurochemistry

authors： Kim JB,Piao CS,Lee KW,Han PL,Ahn JI,Lee YS,Lee JK

更新日期：2004-06-01 00:00:00

abstract：:[3H]Quipazine was used to label binding sites in rat brain membranes that display characteristics of a 5-hydroxytryptamine3 (5-HT3) receptor. The radioligand binds with high affinity (KD, 1.2 +/- 0.1 nM) to a saturable population of sites (Bmax, 3.0 +/- 0.4 pmol/g of tissue) that are differentially located in the brai...

journal_title：Journal of neurochemistry

authors： Milburn CM,Peroutka SJ

更新日期：1989-06-01 00:00:00

abstract：:Epilepsy is a serious neurological condition exhibiting complex pathology and deserving of more serious attention. More than 30% of people with epilepsy are not responsive to more than 20 anti-epileptic drugs currently available, reflecting an unmet clinical need for novel therapeutic strategies. Not much is known abo...

journal_title：Journal of neurochemistry

authors： Paudel YN,Semple BD,Jones NC,Othman I,Shaikh MF

更新日期：2019-12-01 00:00:00

abstract：:In this report we demonstrate that a defective herpes simplex virus type one (HSV-1) vector can express enzymatically active tyrosine hydroxylase in cultured striatal cells that are thereby converted into L-DOPA-producing cells. A human tyrosine hydroxylase cDNA (form II) was inserted into an HSV-1 vector (pHSVth) and...

journal_title：Journal of neurochemistry

authors： Geller AI,During MJ,Oh YJ,Freese A,O'Malley K

更新日期：1995-02-01 00:00:00

abstract：:By using two structurally unrelated hydrogen sulfide (H2 S) donors 5-(4-methoxyphenyl) -3H-1, 2-dithiole-3-thione (ADT) and sodium hydrosulfide (NaHS), this study investigated if H2 S protected blood-brain barrier (BBB) integrity following middle cerebral artery occlusion (MCAO). ICR mice underwent MCAO and received H...

journal_title：Journal of neurochemistry

authors： Wang Y,Jia J,Ao G,Hu L,Liu H,Xiao Y,Du H,Alkayed NJ,Liu CF,Cheng J

更新日期：2014-06-01 00:00:00

abstract：:The beneficial or detrimental role of gap junction communication in the pathophysiology of brain injury is still controversial. We used co-cultures of hippocampal astrocytes and neurons, where we identified homocellular astrocyte-astrocyte and heterocellular astrocyte-neuron coupling by fluorescence recovery after pho...

journal_title：Journal of neurochemistry

authors： Zündorf G,Kahlert S,Reiser G

更新日期：2007-07-01 00:00:00

abstract：:Perinatal hypoxic-ischaemic encephalopathy (HIE) occurs in 1-2 in every 1000 term infants and the devastating consequences range from cerebral palsy, epilepsy and neurological deficit to death. Cellular damage post insult occurs after a delay and is mediated by a secondary neural energy failure. AMP-activated protein ...

journal_title：Journal of neurochemistry

authors： Rousset CI,Leiper FC,Kichev A,Gressens P,Carling D,Hagberg H,Thornton C

更新日期：2015-04-01 00:00:00

abstract：:: The amyloid cascade hypothesis of Alzheimer's disease envisages that the initial elevation of amyloid β-peptide (Aβ) levels, especially of Aβ(1-42) , is the primary trigger for the neuronal cell death specific to onset of Alzheimer's disease. There is now substantial evidence that brain amyloid levels are manipulabl...

journal_title：Journal of neurochemistry

authors： Nalivaeva NN,Beckett C,Belyaev ND,Turner AJ

更新日期：2012-01-01 00:00:00

abstract：:Brain edema in hepatic encephalopathy has been associated with circulating ammonia that is metabolized to glutamine. We measured alterations in blood chemistry and brain regional specific gravity and ion and amino acid contents in models of simple hyperammonemia and liver failure induced by daily administrations of am...

journal_title：Journal of neurochemistry

authors： Hilgier W,Olson JE

更新日期：1994-01-01 00:00:00

abstract：:The Na(+)-glutamate cotransporters are believed to countertransport OH- and K+. Previous evidence that the velocity of glutamate uptake can exceed the acid extrusion capacity of astrocytes raised the question of whether intracellular pH can become rate limiting for glutamate uptake. Cytoplasmic buffering capacity and ...

journal_title：Journal of neurochemistry

authors： Judd MG,Nagaraja TN,Brookes N

更新日期：1996-01-01 00:00:00

abstract：:The administration of nicotine activates tyrosine hydroxylase in the rat adrenal gland. This activation is apparently maximal 25 min after a single subcutaneous injection of nicotine at 2.3 mg/kg. Repeated injections of nicotine (seven injections once every 30 min) are associated with a persistent activation of adrena...

journal_title：Journal of neurochemistry

authors： Fossom LH,Sterling C,Tank AW

更新日期：1991-12-01 00:00:00

abstract：:The blood-brain barrier (BBB) and blood-spinal cord barrier (BSCB) are highly specialized structures that limit molecule entry from the blood and maintain homeostasis within the central nervous system (CNS). BBB and BSCB breakdown are associated with multiple neurodegenerative diseases. Given the key role of neuroprot...

journal_title：Journal of neurochemistry

authors： Kumar V,Lee JD,Coulson EJ,Woodruff TM

更新日期：2020-07-06 00:00:00

abstract：:De novo heterozygous mutations in the STX1B gene, encoding syntaxin 1B, cause a familial, fever-associated epilepsy syndrome. Syntaxin 1B is an essential component of the pre-synaptic neurotransmitter release machinery as a soluble N-ethylmaleimide-sensitive factor attachment protein receptor protein that regulates th...

journal_title：Journal of neurochemistry

authors： Mishima T,Fujiwara T,Kofuji T,Saito A,Terao Y,Akagawa K

更新日期：2020-08-28 00:00:00

abstract：:Neurofilament (NF) proteins are distributed in a diminishing proximodistal gradient along rat sciatic nerve when compared with total noncollagen or other proteins in nerve. About a twofold decline of NF proteins can be detected by quantitating nerve proteins that have been separated by gel electrophoresis. A similar d...

journal_title：Journal of neurochemistry

authors： Schlaepfer WW,Bruce J

更新日期：1990-08-01 00:00:00

abstract：:We report on the expression of ionotropic glutamate receptor subunits in primary neuronal cultures from rat cortex, hippocampus and cerebellum and of metabotropic glutamate (mGlu) receptor subtypes in these neuronal cultures as well as in cortical astroglial cultures. We found that the NMDA receptor (NR) subunits NR1,...

journal_title：Journal of neurochemistry

authors： Janssens N,Lesage AS

更新日期：2001-06-01 00:00:00

abstract：:Fast-performance liquid chromatography was used to purify assembly-competent tubulin from porcine brain microtubule protein prepared by two cycles of assembly-disassembly. Microtubule protein (1-100 mg at 1.5-2.5 mg/ml) in buffer consisting of 0.1 M 2-(N-morpholino)ethanesulfonic acid, 0.5 mM MgCl2, 1 mM EGTA, 0.3 M K...

journal_title：Journal of neurochemistry

authors： Roychowdhury S,Gaskin F

更新日期：1986-05-01 00:00:00

abstract：:The circadian rhythm of methionine S-adenosyltransferase, which catalyzes the formation of S-adenosylmethionine, a cosubstrate for melatonin in the pineal gland, follows the pattern of hydroxyindole-O-methyltransferase. Around the middle of the dark period, methionine S-adenosyltransferase and hydroxyindole-O-methyltr...

journal_title：Journal of neurochemistry

authors： Guchhait RB,Monjan AA

更新日期：1981-06-01 00:00:00

abstract：:Spinocerebellar ataxia type 3 (SCA3) is an autosomal dominantly inherited neurodegenerative disorder for which no curative therapy is available. The cause of this disease is the expansion of a CAG repeat in the so-called ATXN3 gene leading to an expanded polyglutamine stretch in the ataxin-3 protein. Although the func...

journal_title：Journal of neurochemistry

authors： Schmidt J,Schmidt T,Golla M,Lehmann L,Weber JJ,Hübener-Schmid J,Riess O

更新日期：2016-07-01 00:00:00

abstract：:Melatonin is neuroprotective because of its antioxidative action, but it also can modify neuronal vulnerability by altering gene expression. 5-Lipoxygenase (5-LO) gene expression is suppressed by the binding of melatonin to its high-affinity nuclear receptors. Recently, we reported that in rats the melatonin deficienc...

journal_title：Journal of neurochemistry

authors： Uz T,Longone P,Manev H

更新日期：1997-11-01 00:00:00

abstract：:Chromogranin A and two other proteins (A1 and A2) of the soluble proteins of bovine chromaffin granules were isolated by extraction from polyacrylamide gels after electrophoresis. The carbohydrate content of these proteins was 5%, with galactose, N-acetylgalactosamine, and sialic acid as the main sugars. Membranes of ...

journal_title：Journal of neurochemistry

authors： Fischer-Colbrie R,Schachinger M,Zangerle R,Winkler H

更新日期：1982-03-01 00:00:00

abstract：:The angiotensin II competitive antagonist [125I]-Sar1, Ile8-angiotensin II was not transported from the vascular space to the cerebroventricular space in either intact or nephrectomized rats. In addition [125I]Sar1, Ile8-angiotensin II lacked the capacity to move in the opposite direction over a 20-min collection peri...

journal_title：Journal of neurochemistry

authors： Harding JW,Sullivan MJ,Hanesworth JM,Cushing LL,Wright JW

更新日期：1988-02-01 00:00:00