Mass fragmentographic method for the determination of trace amounts of putative amino acid neurotransmitters and related compounds from brain perfusates collected in vivo.

abstract：:The transcription factor Nurr1 is essential for the generation of midbrain dopaminergic neurons (mDA). Only a few Nurr1-regulated genes have so far been identified and it remains unclear how Nurr1 influences the development and function of dopaminergic neurons. To identify novel Nurr1 target genes we have used genome-...

journal_title：Journal of neurochemistry

authors： Volpicelli F,Caiazzo M,Greco D,Consales C,Leone L,Perrone-Capano C,Colucci D'Amato L,di Porzio U

更新日期：2007-07-01 00:00:00

abstract：:Microtubule-associated protein tau is abnormally hyperphosphorylated and aggregated in affected neurons of Alzheimer disease brain. This hyperphosphorylated tau can be dephosphorylated at some of the abnormal phosphorylated sites by purified protein phosphatase-1, 2A, and 2B in vitro. In the present study, we have dev...

journal_title：Journal of neurochemistry

authors： Gong CX,Shaikh S,Wang JZ,Zaidi T,Grundke-Iqbal I,Iqbal K

更新日期：1995-08-01 00:00:00

abstract：:The role of gamma-aminobutyric acid (GABA) modulation of septohippocampal cholinergic neurons in kindling was investigated. Hippocampal acetylcholine release was evaluated with the microdialysis technique in freely moving rats either after acute administration of isoniazid (an inhibitor of GABA synthesis) or pentylene...

journal_title：Journal of neurochemistry

authors： Serra M,Dazzi L,Cagetti E,Chessa MF,Pisu MG,Sanna A,Biggio G

更新日期：1997-01-01 00:00:00

abstract：:The alpha-synuclein (Snca) gene is expressed at higher levels in alcohol-naïve, inbred alcohol-preferring (iP) rats than in alcohol-non preferring (iNP) rats. Snca modulates dopamine transmission and the dopamineregic system, which play a role in mediating the rewarding properties of alcohol consumption. Thus, underst...

journal_title：Journal of neurochemistry

authors： Liang T,Carr LG

更新日期：2006-10-01 00:00:00

abstract：:Juvenile neuronal ceroid lipofuscinosis (Batten disease) is a neurodegenerative disorder caused by mutation in CLN3. Defective autophagy and concomitant accumulation of autofluorescence enriched with mitochondrial ATP synthase subunit c were previously discovered in Cln3 mutant knock-in mice. In this study, we show th...

journal_title：Journal of neurochemistry

authors： Chang JW,Choi H,Cotman SL,Jung YK

更新日期：2011-02-01 00:00:00

abstract：:Changes in the free fatty acid pool size and fatty acyl chain composition of mitochondrial membrane phospholipids and their relation to disruption of mitochondrial function were examined in rat brains after 30 min of cerebral ischemia (Pulsinelli-Brierley model) and 60 min of normoxic reoxygenation. During ischemia, s...

journal_title：Journal of neurochemistry

authors： Sun D,Gilboe DD

更新日期：1994-05-01 00:00:00

abstract：:The nature of postsynaptic sites involved in the uptake and metabolism of striatal 3,4-dihydroxyphenylethylamine (dopamine, DA) was investigated. The accumulation of [3H]DA (10(-7) M) into slices of rat striatum was found to be greatly dependent (greater than 99%) on the presence of sodium ion in the incubation medium...

journal_title：Journal of neurochemistry

authors： Schoepp DD,Azzaro AJ

更新日期：1985-06-01 00:00:00

abstract：:The glial glutamate transporter EAAT2 (excitatory amino acid transporter 2) is the major mediator of glutamate clearance that terminates glutamate-mediated neurotransmission. Loss of EAAT2 and associated glutamate uptake function has been reported in the brains of patients with Alzheimer's disease (AD). We previously ...

journal_title：Journal of neurochemistry

authors： Tian G,Kong Q,Lai L,Ray-Chaudhury A,Lin CL

更新日期：2010-05-01 00:00:00

abstract：:In cerebellar granule cells, the mitogen-activated protein kinase (MAPK) or extracellular signal-regulated kinase (ERK) cascade mediates multiple functions, including proliferation, differentiation, and survival. In these cells, ERKs are activated by diverse stimuli, including cyclic adenosine monophosphate (cAMP), pi...

journal_title：Journal of neurochemistry

authors： Obara Y,Horgan AM,Stork PJ

更新日期：2007-04-01 00:00:00

abstract：:The role of neuroactive steroids and GABA(A) receptors in the generation of spontaneous spike-and-wave discharges (SWDs) was investigated in the WAG/Rij rat model of absence epilepsy. The plasma, cerebrocortical, and thalamic concentrations of the progesterone metabolite 3alpha-hydroxy-5alpha-pregnan-20-one (3alpha,5a...

journal_title：Journal of neurochemistry

authors： Pisu MG,Mostallino MC,Dore R,Mura ML,Maciocco E,Russo E,De Sarro G,Serra M

更新日期：2008-09-01 00:00:00

abstract：:Beta-carbolines have been suggested to be involved in the pathogenesis of Parkinson's disease as a result of their structural similarity to the neurotoxin N -methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). The chloral-derived beta-carboline derivative 1-trichloromethyl-1,2,3,4-tetrahydro-beta-carboline (TaClo) caus...

journal_title：Journal of neurochemistry

authors： Riederer F,Luborzewski A,God R,Bringmann G,Scholz J,Feineis D,Moser A

更新日期：2002-05-01 00:00:00

abstract：:PC12D cells, a new subline of conventional PC12 cells, respond not only to nerve growth factor but also to cyclic AMP by extending their neurites. These cells are flat in shape and are similar in appearance to PC12 cells that have been treated with nerve growth factor for a few days. In both cell lines, we have charac...

journal_title：Journal of neurochemistry

authors： Katoh-Semba R,Oohira A,Sano M,Watanabe K,Kitajima S,Kashiwamata S

更新日期：1989-03-01 00:00:00

abstract：:We have investigated the effects of fetal hypophysectomy (HX) with or without thyroxine (T4)replacement on the plasma concentrations of free methionine-enkephalin (free Met-Enk), noradrenaline, and adrenaline in late gestation sheep fetus. Plasma adrenaline concentrations were significantly higher in intact fetal shee...

journal_title：Journal of neurochemistry

authors： Simonetta G,Young IR,McMillen IC

更新日期：1994-10-01 00:00:00

abstract：:A Ca2+- and calmodulin-dependent protein kinase was purified from rat brain cytosol fraction to apparent homogeneity at approximately 800-fold and with a 5% yield. The purified enzyme had a molecular weight of 640,000 as determined by gel filtration analysis on Sephacryl S-300 and a sedimentation coefficient of 15.3 S...

journal_title：Journal of neurochemistry

authors： Fukunaga K,Yamamoto H,Matsui K,Higashi K,Miyamoto E

更新日期：1982-12-01 00:00:00

abstract：:In the preceding report we demonstrated a dose-dependent increase in 32P-phosphoprotein labeling after 24-h exposure of cultured cerebellar granule neurons to methyl mercury (MeHg), a response that was not observed in glial cultures. In the present study we have examined 32P-labeled phosphoproteins by two-dimensional ...

journal_title：Journal of neurochemistry

authors： Sarafian T,Verity MA

更新日期：1990-09-01 00:00:00

abstract：:Exosomes are small extracellular vesicles released by almost all cell types in physiological and pathological conditions. The exosomal potential to unravel disease mechanisms, or to be used as a source of biomarkers, is being explored, in particularly in the field of neurodegenerative diseases. Alzheimer's disease (AD...

journal_title：Journal of neurochemistry

authors： Soares Martins T,Trindade D,Vaz M,Campelo I,Almeida M,Trigo G,da Cruz E Silva OAB,Henriques AG

更新日期：2020-07-03 00:00:00

abstract：:In order to establish whether the antioxidant and iron-chelating activities of R-apomorphine (R-APO), a D(1)-D(2) receptor agonist, may contribute to its neuroprotective property, its S-isomer, which is not a dopamine agonist, was studied. The neuroprotective property of R- and S-APO has been studied in the MPTP model...

journal_title：Journal of neurochemistry

authors： Grünblatt E,Mandel S,Maor G,Youdim MB

更新日期：2001-04-01 00:00:00

abstract：:We report here that anti-L1 antiserum, raised against material from embryonic brain, and anti-NILE antiserum, raised against purified NILE (nerve growth factor-inducible large external) glycoprotein of PC12 cells, immunoprecipitate from PC12 cells material of the same apparent molecular weight (230 kilodaltons) by sod...

journal_title：Journal of neurochemistry

authors： Sajovic P,Kouvelas E,Trenkner E

更新日期：1986-08-01 00:00:00

abstract：:The present study investigated the effects of two serotonin (5-HT) uptake inhibitors, citalopram and paroxetine, and of a non-selective noradrenaline (NA) and 5-HT uptake blocker, imipramine, on extracellular NA and dopamine (DA) in the prefrontal cortex (PfCX), parietal cortex (ParCX) and occipital cortex (OccCX). Ci...

journal_title：Journal of neurochemistry

authors： Valentini V,Cacciapaglia F,Frau R,Di Chiara G

更新日期：2005-04-01 00:00:00

abstract：:The aim of this study is to examine how sustained exposure to two 1,4-benzodiazepines (BZDs) with different action period, diazepam and brotizolam, and a 1,5-BZD, clobazam, affects L-type high voltage-gated calcium channel (HVCC) functions and its mechanisms using primary cultures of mouse cerebral cortical neurons. T...

journal_title：Journal of neurochemistry

authors： Katsura M,Shibasaki M,Kurokawa K,Tsujimura A,Ohkuma S

更新日期：2007-12-01 00:00:00

abstract：:alpha-Synuclein has been identified as a component of Lewy bodies in Parkinson's disease and diffuse Lewy body disease, and glial cytoplasmic inclusions (GCIs) in multiple system atrophy (MSA). To explore the role of alpha-synuclein in the pathogenesis, we searched for molecules interacting with alpha-synuclein and di...

journal_title：Journal of neurochemistry

authors： Iwata A,Miura S,Kanazawa I,Sawada M,Nukina N

更新日期：2001-04-01 00:00:00

abstract：:The metabolism of 2-fluoro-2-deoxy-D-glucose (FDG) in vivo was observed noninvasively in rat brain using 19F nuclear magnetic resonance (NMR) spectroscopy following an intravenous injection of FDG (400 mg/kg). At 3 h after infusion, four resonances with discrete chemical shifts were resolved. Chemical shift analysis o...

journal_title：Journal of neurochemistry

authors： Nakada T,Kwee IL,Conboy CB

更新日期：1986-01-01 00:00:00

abstract：:Neurodegenerative diseases, such as Parkinson's disease, Alzheimer's disease, and Huntington's disease, are considered incurable and significantly reduce the quality of life of the patients. A variety of drugs that modulate neurotransmitter levels have been used for the treatment of the neurodegenerative diseases but ...

journal_title：Journal of neurochemistry

authors： Huang M,Rathore SS,Lindau M

更新日期：2019-10-01 00:00:00

abstract：:Leucine and beta-(+/-)-2-aminobicyclo[2.2.1]heptane-2-carboxylic acid (BCH) stimulated, in a dose-dependent manner, reductive amination of 2-oxoglutarate in rat brain synaptosomes treated with Triton X-100. The concentration dependence curves were sigmoid, with 10-15-fold stimulations at 15 mM leucine (or BCH); oxidat...

journal_title：Journal of neurochemistry

authors： Erecińska M,Nelson D

更新日期：1990-04-01 00:00:00

abstract：:Acetyltransferase enzymatic activity was detected and measured in homogenates obtained from intact nerve fibers and their saparate cellular components, in the tropical squid Sepioteuthis sepioidea. The levels of acetylcholine synthesis were determined in pooled samples of whole stellar nerve, intact giant nerve fiber,...

journal_title：Journal of neurochemistry

authors： Heumann R,Villegas J,Herzfeld DW

更新日期：1981-02-01 00:00:00

abstract：:Expression of the neurotrophin-3 (NT-3) receptor (TrkC) and the effects of NT-3 on signal transduction were investigated in highly enriched populations of embryonic rat hippocampal pyramidal neurons grown in bilaminar cultures. PCR analysis revealed that the predominant trkC isoform is K1, which lacks an insert in the...

journal_title：Journal of neurochemistry

authors： Marsh HN,Palfrey HC

更新日期：1996-09-01 00:00:00

abstract：:Dysregulated metabolism and consequent extracellular accumulation of amyloid-β (Aβ) peptides in the brain underlie the pathogenesis of Alzheimer's disease. Extracellular Aβ in the brain parenchyma is mainly secreted from the pre-synaptic terminals of neuronal cells in a synaptic activity-dependent manner. The p24 fami...

journal_title：Journal of neurochemistry

authors： Liu L,Fujino K,Nishimura M

更新日期：2015-05-01 00:00:00

abstract：:Overexpression of gp120, the major coat protein of the HIV-1 virus, in central glial cells, or treatment of neurons with gp120 in culture, produces apoptotic neuronal death. Here we demonstrate that CEP-1347 (KT7515), an inhibitor of mixed lineage kinase 3 (MLK3), an upstream activator of JNK, inhibits gp120IIIB-induc...

journal_title：Journal of neurochemistry

authors： Bodner A,Maroney AC,Finn JP,Ghadge G,Roos R,Miller RJ

更新日期：2002-09-01 00:00:00

abstract：:The I1-imidazoline receptor (I1R) is a proposed target for drug action relevant to blood pressure and glucose control. The imidazoline receptor antisera-selected (IRAS) gene, also known as Nischarin, has several characteristics of an I1R. To test the contribution of IRAS to I1R binding capacity and cell-signaling func...

journal_title：Journal of neurochemistry

authors： Sun Z,Chang CH,Ernsberger P

更新日期：2007-04-01 00:00:00

abstract：:Astrogliosis occurs after brain ischemia, and excessive astrogliosis can devastate the neuronal recovery. Previous reports show that galectin-1 (Gal-1) regulates proliferation of several cell types and plays an important role after nervous system injuries. Here, we found that expression of Gal-1 was remarkably up-regu...

journal_title：Journal of neurochemistry

authors： Qu WS,Wang YH,Ma JF,Tian DS,Zhang Q,Pan DJ,Yu ZY,Xie MJ,Wang JP,Wang W

更新日期：2011-01-01 00:00:00