Allelic variation of human serotonin transporter gene expression.

abstract：:Although the involvement of both endogenous opioid and serotonergic systems in modulation of pain and emotion was suggested, the neurochemical interaction between these systems in the brain has not previously been studied directly. Herein, the effects of the local application of serotonin (5-HT) and fluoxetine (a 5-HT...

journal_title：Journal of neurochemistry

authors： Zangen A,Nakash R,Yadid G

更新日期：1999-12-01 00:00:00

abstract：:Prolonged seizures activate members of the Bcl-2 homology domain 3-only sub-group of the Bcl-2 protein family, which are essential for initiation of apoptosis signaling. Bid is a potent pro-apoptotic Bcl-2 homology domain 3-only protein, which upon proteolytic activation translocates to mitochondria to promote activat...

journal_title：Journal of neurochemistry

authors： Engel T,Caballero-Caballero A,Schindler CK,Plesnila N,Strasser A,Prehn JH,Henshall DC

更新日期：2010-10-01 00:00:00

abstract：:The axonal outgrowth of cells of Neuro2a, a mouse neuroblastoma cell line, was suppressed on expression of the beta-galactoside alpha 1,2-fucosyltransferase (alpha 1,2-FT) gene. We recently cloned two types of rabbit alpha 1,2-FT, RFT-I and RFT-II. RFT-I exhibits comparable kinetic properties and structural homology w...

journal_title：Journal of neurochemistry

authors： Hitoshi S,Koijima N,Kusunoki S,Inokuchi J,Kanazawa I,Tsuji S

更新日期：1996-04-01 00:00:00

abstract：:Stressful treatments and immune challenges have been shown previously to elevate brain concentrations of tryptophan. The role of the autonomic nervous system in this neurochemical change was investigated using pharmacological treatments that inhibit autonomic effects. Pretreatment with the ganglionic blocker chlorison...

journal_title：Journal of neurochemistry

authors： Dunn AJ,Welch J

更新日期：1991-11-01 00:00:00

abstract：:To explore the hypothesis that alterations in cellular membrane lipids are present at the stage of pre-clinical Alzheimer's disease (AD) (i.e., cognitively normal at death, but with AD neuropathology), we performed targeted shotgun lipidomics of lipid extracts from post-mortem brains of subjects with pre-clinical AD. ...

journal_title：Journal of neurochemistry

authors： Cheng H,Wang M,Li JL,Cairns NJ,Han X

更新日期：2013-12-01 00:00:00

abstract：:For more than three decades, the venom of the black widow spider and its principal active components, latrotoxins, have been used to induce release of neurotransmitters and hormones and to study the mechanisms of exocytosis. Given the complex nature of alpha--latrotoxin (alpha-LTX) actions, this research has been cont...

journal_title：Journal of neurochemistry

authors： Silva JP,Suckling J,Ushkaryov Y

更新日期：2009-10-01 00:00:00

abstract：:In a previous study, interleukin-1beta (IL-1beta) has been shown to induce matrix metalloproteinases (MMPs) expression through mitogen-activated protein kinases and nuclear factor-kappaB pathways in rat brain astrocytes. Moreover, transactivation of growth factor receptors and phosphatidylinositol 3-kinase (PI3K)/Akt ...

journal_title：Journal of neurochemistry

authors： Wu CY,Hsieh HL,Sun CC,Tseng CP,Yang CM

更新日期：2008-05-01 00:00:00

abstract：:Gliomas are the most common primary malignant brain tumor in adults, but current treatment for glioblastoma multiforme (GBM) is insufficient. Even though glucose is the primary energetic substrate of glioma cells, they are capable of using fatty acids to generate energy. Fatty acid oxidation (FAO) in mitochondria requ...

journal_title：Journal of neurochemistry

authors： Juraszek B,Czarnecka-Herok J,Nałęcz KA

更新日期：2020-07-12 00:00:00

abstract：:We have previously shown that acrolein, a lipid peroxidation byproduct, is significantly increased following spinal cord injury in vivo, and that exposure to neuronal cells results in oxidative stress, mitochondrial dysfunction, increased membrane permeability, impaired axonal conductivity, and eventually cell death. ...

journal_title：Journal of neurochemistry

authors： Hamann K,Nehrt G,Ouyang H,Duerstock B,Shi R

更新日期：2008-02-01 00:00:00

abstract：:Variations occurring in cortical nitric oxide (NO) release were analysed with a voltametric method in rats (i) placed in control conditions, (ii) while being paradoxical sleep deprived (PSD), or (iii) recovering from a PSD. Activities of neuronal (nNOS) and inducible (iNOS) NO-synthases as well as nNOS expression were...

journal_title：Journal of neurochemistry

authors： Clément P,Sarda N,Cespuglio R,Gharib A

更新日期：2004-08-01 00:00:00

abstract：:Here, we explore the mechanism of action of isoxylitone (ISOX), a molecule discovered in the plant Delphinium denudatum, which has been shown to have anticonvulsant properties. Patch-clamp electrophysiology assayed the activity of ISOX on voltage-gated sodium channels (VGSCs) in both cultured neurons and brain slices ...

journal_title：Journal of neurochemistry

authors： Ashraf MN,Gavrilovici C,Shah SU,Shaheen F,Choudhary MI,Rahman AU,Fahnestock M,Simjee SU,Poulter MO

更新日期：2013-09-01 00:00:00

abstract：:Hyperexcitability of the hippocampus is a commonly observed phenomenon in the years preceding a diagnosis of Alzheimer's disease (AD). Our previous work suggests a dysregulation in glutamate neurotransmission may mediate this hyperexcitability, and glutamate dysregulation correlates with cognitive deficits in the rTg(...

journal_title：Journal of neurochemistry

authors： Hunsberger HC,Weitzner DS,Rudy CC,Hickman JE,Libell EM,Speer RR,Gerhardt GA,Reed MN

更新日期：2015-10-01 00:00:00

abstract：:We examined the modulation of nitric oxide production in vivo by measuring levels of nitrite (NO2-) and nitrate (NO3-) in the dialysate of the cerebellum in conscious rats, by using an in vivo brain microdialysis technique. The levels of both NO2- and NO3- were decreased by the intraperitoneal injection of NG-nitro-L-...

journal_title：Journal of neurochemistry

authors： Yamada K,Nabeshima T

更新日期：1997-03-01 00:00:00

abstract：:Substantial amounts of phospholipase A2 activity were detected in bovine brain cytosol. The major phospholipase A2 activity was present in the precipitate at 40% saturation with solid ammonium sulfate. After the desaltate of the precipitate was loaded onto an Ultrogel AcA 54 gel filtration column, almost all the activ...

journal_title：Journal of neurochemistry

authors： Hirashima Y,Farooqui AA,Mills JS,Horrocks LA

更新日期：1992-08-01 00:00:00

abstract：:The choline analogue ethylcholine mustard aziridinium (AF64A) is a potent and irreversible inhibitor of choline uptake in brain synaptosomes and is used as a neurotoxin to produce animal models of cholinergic hypofunction. However, previous studies have shown that intraocular administration of AF64A in rats not only r...

journal_title：Journal of neurochemistry

authors： Gómez C,Martín C,Galea E,Estrada C

更新日期：1993-04-01 00:00:00

abstract：:Rat brain benzodiazepine receptors have been solubilized by means of the zwitterionic detergent CHAPS under conditions in which the GABA stimulation of [3H]flunitrazepam binding to the benzodiazepine receptors is maintained intact. This stimulation is partially or totally abolished when using other conventional deterg...

journal_title：Journal of neurochemistry

authors： Mernoff ST,Cherwinski HM,Becker JW,de Blas AL

更新日期：1983-09-01 00:00:00

abstract：:The capacity of D1 and D2 agonists and antagonists to regulate the in vivo release and metabolism of dopamine (DA) in mesolimbic and nigrostriatal DA neurons of the mouse was determined using gas chromatographic and mass fragmentographic (GC-MF) analysis. DA release was inferred from levels of 3-methoxytyramine (3-MT)...

journal_title：Journal of neurochemistry

authors： Boyar WC,Altar CA

更新日期：1987-03-01 00:00:00

abstract：:Extracts of skeletal muscle contain chromatographically distinct molecules that enhance the cholinergic development of cultured embryonic rat spinal cord neurons. We have recently purified a 20-22 kilodalton anionic polypeptide choline acetyltransferase (ChAT) development factor (CDF) from rat skeletal muscle extracts...

journal_title：Journal of neurochemistry

authors： McManaman J,Crawford F,Clark R,Richker J,Fuller F

更新日期：1989-12-01 00:00:00

abstract：:The presence of serine transhydroxymethylase (STHM; EC 2.1.2.1) in crude homogenates of rat, guinea pig and goat retina has been demonstrated. There was a variation in the levels of retinal STHM activity in the three species. Substantial STHM activity was found in all the three retinal preparations in the absence of p...

journal_title：Journal of neurochemistry

authors： Dasgupta P,Narayanaswami A

更新日期：1982-09-01 00:00:00

abstract：:The effects of a potent adenosine deaminase inhibitor, deoxycoformycin, on purine and amino acid neuro-transmitter release from the ischemic rat cerebral cortex were studied with the cortical cup technique. Cerebral ischemia (20 min) was elicited by four-vessel occlusion. Purine and amino acid releases were compared f...

journal_title：Journal of neurochemistry

authors： Phillis JW,Walter GA,Simpson RE

更新日期：1991-02-01 00:00:00

abstract：:Cholinergic signaling plays an important role in regulating the growth and regeneration of axons in the nervous system. The α7 nicotinic receptor (α7) can drive synaptic development and plasticity in the hippocampus. Here, we show that activation of α7 significantly reduces axon growth in hippocampal neurons by coupli...

journal_title：Journal of neurochemistry

authors： Nordman JC,Phillips WS,Kodama N,Clark SG,Del Negro CA,Kabbani N

更新日期：2014-05-01 00:00:00

abstract：:As the leading genetic cause for infantile death, Spinal Muscular Atrophy (SMA) has been extensively studied since its first description in the early 1890s. Though today much is known about the cause of the disease, a cure or effective treatment is not currently available. Recently the short chain fatty acid valproic ...

journal_title：Journal of neurochemistry

authors： Lunke S,El-Osta A

更新日期：2009-06-01 00:00:00

abstract：:Leptinotoxin-h (LPTx), a neurotoxin (otherwise designated beta-leptinotarsin-h) known to stimulate the release of neurotransmitters from synapses, was purified from the hemolymph of the potato beetle, Leptinotarsa haldemani, by a simplification of the procedure originally developed by Crosland et al. [Biochemistry 23,...

journal_title：Journal of neurochemistry

authors： Madeddu L,Pozzan T,Robello M,Rolandi R,Hsiao TH,Meldolesi J

更新日期：1985-12-01 00:00:00

abstract：:In complex tissues where multiple subtypes of nicotinic acetylcholine receptors (nAChRs) are expressed, immunohistochemistry has been the most popular tool for investigation of nAChR subunit distribution. However, recent studies with nAChR subunit knockout mice demonstrated that a large panel of antibodies is unsuitab...

journal_title：Journal of neurochemistry

authors： Shelukhina IV,Kryukova EV,Lips KS,Tsetlin VI,Kummer W

更新日期：2009-05-01 00:00:00

abstract：:Expression of the Ca(2+)-dependent phospholipids binding protein annexin A2 (ANX2) in the brain is thought to be largely associated with brain pathological conditions such as tumor, inflammation, and neurodegeneration. The recent findings that ANX2 heterotetramer is involved in learning and neuronal activities necessi...

journal_title：Journal of neurochemistry

authors： Zhao WQ,Lu B

更新日期：2007-03-01 00:00:00

abstract：:Angiotensin II (Ang II) interacts with the neuronal AT1 receptor subtype and initiates a cascade of signaling events involving activation of Ras-Raf-1-MAP kinase. Raf-1-dependent activation of mitogen-activated protein kinase (MAPK) is the key in the chronic norepinephrine neuromodulatory actions of Ang II and is asso...

journal_title：Journal of neurochemistry

authors： Lu D,Yang H,Raizada MK

更新日期：1998-01-01 00:00:00

abstract：:A rapid and simple chromatographic procedure using HPLC with electrochemical detection is described for simultaneous determination of the substrates from precursor amino acids to metabolites related to synthesis and metabolism of three monoamine neurotransmitters--norepinephrine (NE), dopamine (DA), and 5-hydroxytrypt...

journal_title：Journal of neurochemistry

authors： Murai S,Saito H,Masuda Y,Itoh T

更新日期：1988-02-01 00:00:00

abstract：:We previously reported that nerve terminals and glial cells lack an active uptake system capable of terminating transmitter action of substance P (SP). In the present study, we demonstrated the existence of an active uptake system for SP carboxy-terminal heptapeptide, (5-11)SP. When the slices from either rat brain or...

journal_title：Journal of neurochemistry

authors： Nakata Y,Kusaka Y,Yajima H,Segawa T

更新日期：1981-12-01 00:00:00

abstract：:Advances in lipidomics technology have facilitated the precise detection, identification and profiling of lipid species within tissues. Mass spectrometry allows for identification of lipids as a function of the total number of carbons and double bonds in their acyl chains. Such detailed descriptions of lipid compositi...

journal_title：Journal of neurochemistry

authors： Rappley I,Myers DS,Milne SB,Ivanova PT,Lavoie MJ,Brown HA,Selkoe DJ

更新日期：2009-10-01 00:00:00

abstract：:Astrocytes remove glutamate from the synaptic cleft via specific transporters, and impaired glutamate reuptake may promote excitotoxic neuronal injury. In a model of viral encephalomyelitis caused by neuroadapted Sindbis virus (NSV), mice develop acute paralysis and spinal motor neuron degeneration inhibited by the AM...

journal_title：Journal of neurochemistry

authors： Prow NA,Irani DN

更新日期：2008-05-01 00:00:00