Serine transhydroxymethylase activity in vertebrate retina.

abstract：:PK 11195 [1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinolinecarboxamide] is a new ligand for the "peripheral-type" benzodiazepine binding sites, chemically unrelated to benzodiazepines. It displaces with a very high potency (IC50 congruent to 10(-9) M) [3H]-RO5-4864 (a benzodiazepine which specifically labe...

journal_title：Journal of neurochemistry

authors： Benavides J,Quarteronet D,Imbault F,Malgouris C,Uzan A,Renault C,Dubroeucq MC,Gueremy C,Le Fur G

更新日期：1983-12-01 00:00:00

abstract：:This paper describes a new, sensitive assay for dopamine-beta-hydroxylase (DBH) activity in human cerebrospinal fluid (CSF), serum and brain tissues by high performance liquid chromatography (HPLC) with electrochemical detection (ED). Dopamine (DA) was used as a substrate and was incubated under optimal conditions. No...

journal_title：Journal of neurochemistry

authors： Matsui H,Kato T,Yamamoto C,Fujita K,Nagatsu T

更新日期：1981-08-01 00:00:00

abstract：:Highly purified noradrenergic, large, dense-cored vesicles were isolated from bovine sympathetic nerve endings by sucrose-D2O density gradient centrifugation. Their concentration of glycoprotein hexosamine and sialic acid was 6.6 and 3.9 mumol/100 mg lipid-free dry weight, respectively, values which are similar to tho...

journal_title：Journal of neurochemistry

authors： Margolis RU,Ledeen RW,Sbaschnig-Agler M,Byrne MC,Klein RL,Douglas BH 2nd,Margolis RK

更新日期：1987-12-01 00:00:00

abstract：:Spatial solute concentration profiles resulting from in vivo microdialysis were measured in rat caudate-putamen by quantitative autoradiography. Radiolabeled sucrose was included in the dialysate, and the tissue concentration profile measured after infusions of 14 min and 61.5 min in an acute preparation. In addition,...

journal_title：Journal of neurochemistry

authors： Dykstra KH,Hsiao JK,Morrison PF,Bungay PM,Mefford IN,Scully MM,Dedrick RL

更新日期：1992-03-01 00:00:00

abstract：:The (R) and (S) forms of 5-amino-2-hydroxyvaleric acid (2-OH-DAVA) and 5-amino-4-hydroxyvaleric acid (4-OH-DAVA) were designed as structural hybrids of the 4-aminobutyric acidB (GABAB) agonist (R)-(-)-4-amino-3-hydroxybutyric acid [(R)-(-)-3-OH-GABA] and the GABAB antagonist 5-aminovaleric acid (DAVA). (S)-(-)-2-OH-DA...

journal_title：Journal of neurochemistry

authors： Kristiansen U,Hedegaard A,Herdeis C,Lund TM,Nielsen B,Hansen JJ,Falch E,Hjeds H,Krogsgaard-Larsen P

更新日期：1992-03-01 00:00:00

abstract：:Activity-dependent plasticity in nociceptive pathways has been implicated in pathomechanisms of chronic pain syndromes. Calcitonin gene-related peptide (CGRP), which is expressed by trigeminal nociceptors, has recently been identified as a key player in the mechanism of migraine headaches. Here we show that CGRP is co...

journal_title：Journal of neurochemistry

authors： Buldyrev I,Tanner NM,Hsieh HY,Dodd EG,Nguyen LT,Balkowiec A

更新日期：2006-12-01 00:00:00

abstract：:Chondroitin sulphate proteoglycans (CSPGs) are axon growth inhibitory molecules present in the glial scar that play a part in regeneration failure after damage to the CNS and which restrict CNS plasticity. Removal of chondroitin sulphate glycosaminoglycan (GAG) chains with chondroitinase-ABC (chABC) in models of CNS i...

journal_title：Journal of neurochemistry

authors： Lin R,Kwok JC,Crespo D,Fawcett JW

更新日期：2008-01-01 00:00:00

abstract：:Parkinson's disease (PD) motor symptoms are caused by degeneration of nigrostriatal dopaminergic (DAergic) neurons. The most common causes of hereditary PD are mutations in the PARKIN gene. The ubiquitin ligase parkin has been shown to mediate neuroprotection in cell culture and in vivo, but the molecular mechanisms a...

journal_title：Journal of neurochemistry

authors： Hasegawa T,Treis A,Patenge N,Fiesel FC,Springer W,Kahle PJ

更新日期：2008-06-01 00:00:00

abstract：:Nicotine has been shown to stimulate neurotransmitter release from brain tissue by acting on presynaptic receptors. In this study, the ability of nicotine pretreatment to produce functional desensitization was investigated in rat striatal synaptosomes in which the release of [3H]dopamine was measured with an in vitro ...

journal_title：Journal of neurochemistry

authors： Rowell PP,Hillebrand JA

更新日期：1994-08-01 00:00:00

abstract：:Sequence variation was found in cDNA coding for the extracellular domain of the rat gamma-aminobutyric acid type A (GABAA) receptor alpha 6 subunit. About 20% of polymerase chain reaction (PCR)-amplified alpha 6 cDNA prepared from rat cerebellar mRNA lacked nucleotides 226-255 as estimated by counting single-stranded ...

journal_title：Journal of neurochemistry

authors： Korpi ER,Kuner T,Kristo P,Köhler M,Herb A,Lüddens H,Seeburg PH

更新日期：1994-09-01 00:00:00

abstract：:Mechanical strain in neural tissues can lead to the up-regulation and release of multiple cytokines including interleukin 6 (IL-6). In the retina, the mechanosensitive release of ATP can autostimulate P2X7 receptors on both retinal ganglion cell neurons and optic nerve head astrocytes. Here, we asked whether the purin...

journal_title：Journal of neurochemistry

authors： Lu W,Albalawi F,Beckel JM,Lim JC,Laties AM,Mitchell CH

更新日期：2017-05-01 00:00:00

abstract：:Nicotinic acetylcholine receptors play important roles in numerous cognitive processes as well as in several debilitating central nervous system (CNS) disorders. In order to fully elucidate the diverse roles of nicotinic acetylcholine receptors in CNS function and dysfunction, a detailed knowledge of their cellular an...

journal_title：Journal of neurochemistry

authors： Moser N,Mechawar N,Jones I,Gochberg-Sarver A,Orr-Urtreger A,Plomann M,Salas R,Molles B,Marubio L,Roth U,Maskos U,Winzer-Serhan U,Bourgeois JP,Le Sourd AM,De Biasi M,Schröder H,Lindstrom J,Maelicke A,Changeux JP,Weve

更新日期：2007-07-01 00:00:00

abstract：:The molecular forms of angiotensin converting enzyme (ACE; EC 3.4.15.1) in preparations of pig brain cortical microvessels and striatal synaptosomal membranes have been identified by immunoelectrophoretic blot analysis. The cortical microvessels contained only the endothelial form of the enzyme, Mr 180,000, which comi...

journal_title：Journal of neurochemistry

authors： Williams TA,Hooper NM,Turner AJ

更新日期：1991-07-01 00:00:00

abstract：:Rho family GTPases promote the survival of certain neuronal populations. However, pro-survival and pro-death signaling pathways regulated downstream of Rho GTPases are largely unknown. Cerebellar granule neurons (CGNs) exposed to Clostridium difficile toxin B (ToxB), a monoglucosyltransferase that specifically inhibit...

journal_title：Journal of neurochemistry

authors： Loucks FA,Le SS,Zimmermann AK,Ryan KR,Barth H,Aktories K,Linseman DA

更新日期：2006-05-01 00:00:00

abstract：:The olfactory bulb is one of the most vulnerable brain regions in age-related proteinopathies. Proteinopathic stress is mitigated by the heat shock protein (Hsp) family of chaperones. Here, we describe age-related decreases in Hsc70 in the olfactory bulb of the female rat and higher levels of Hsp70 and Hsp25 in middle...

journal_title：Journal of neurochemistry

authors： Crum TS,Gleixner AM,Posimo JM,Mason DM,Broeren MT,Heinemann SD,Wipf P,Brodsky JL,Leak RK

更新日期：2015-06-01 00:00:00

abstract：:The neuromodulator adenosine can be released as such, mainly activating inhibitory A1 receptors, or formed from released ATP, preferentially activating facilitatory A2A receptors. We tested if changes in extracellular adenosine metabolism paralleled changes in A1/A2A receptor neuromodulation in the aged rat hippocampu...

journal_title：Journal of neurochemistry

authors： Cunha RA,Almeida T,Ribeiro JA

更新日期：2001-01-01 00:00:00

abstract：:Machado-Joseph disease (MJD) is an autosomal dominant neurodegenerative disorder caused by an expansion of the polyglutamine tract near the C-terminus of the MJD-1 gene product, ataxin-3. Ataxin-3 is degraded by the proteasome. However, the precise mechanism of ataxin-3 degradation remains to be elucidated. In this st...

journal_title：Journal of neurochemistry

authors： Wang H,Jia N,Fei E,Wang Z,Liu C,Zhang T,Fan J,Wu M,Chen L,Nukina N,Zhou J,Wang G

更新日期：2007-06-01 00:00:00

abstract：:Alzheimer's disease (AD) is characterized by amyloid-beta peptide (Abeta) deposition in the brain. Abeta is produced by sequential cleavage of amyloid precursor protein (APP) by beta-secretase (BACE1: beta-site APP-cleaving enzyme 1) and gamma-secretase. Previously, we demonstrated that BACE1 also cleaves beta-galacto...

journal_title：Journal of neurochemistry

authors： Nakagawa K,Kitazume S,Oka R,Maruyama K,Saido TC,Sato Y,Endo T,Hashimoto Y

更新日期：2006-02-01 00:00:00

abstract：:Reduced levels of the protein frataxin cause the neurodegenerative disease Friedreich's ataxia. Pathology is associated with disruption of iron-sulfur cluster biosynthesis, mitochondrial iron overload, and oxidative stress. Frataxin is a highly conserved iron-binding protein present in most organisms. Despite the inte...

journal_title：Journal of neurochemistry

authors： Pastore A,Puccio H

更新日期：2013-08-01 00:00:00

abstract：:Previously, we identified protein kinase FA/glycogen synthase kinase-3 (GSK-3) as a microtubule-associated protein tau kinase that can incorporate 4 mol of phosphates into 1 mol of tau protein and cause its electrophoretic mobility shift in sodium dodecyl sulfate gels, a unique property characteristic of paired helica...

journal_title：Journal of neurochemistry

authors： Yang SD,Song JS,Yu JS,Shiah SG

更新日期：1993-11-01 00:00:00

abstract：:Among bone morphogenetic proteins (BMPs), the decapentaplegic (Dpp; BMP2, BMP4) and glass bottom boat (Gbb/60A; BMP5, BMP6, BMP7) subgroups have well-described functions guiding autonomic and sensory neuronal development, fiber formation and neurophenotypic identities. Evaluation of rat superior cervical ganglia (SCG)...

journal_title：Journal of neurochemistry

authors： Pavelock KA,Girard BM,Schutz KC,Braas KM,May V

更新日期：2007-02-01 00:00:00

abstract：:We studied whether microtubule organization is important for actions of ethanol on GABAA ergic responses by testing the effects of microtubule depolymerization on ethanol enhancement of GABA action in mouse L(tk-) cells stably transfected with GABAA receptor alpha 1 beta 1 gamma 2L subunits. The microtubule-disrupting...

journal_title：Journal of neurochemistry

authors： Whatley VJ,Brozowski SJ,Hadingham KL,Whiting PJ,Harris RA

更新日期：1996-03-01 00:00:00

abstract：:Melatonin and 5-methoxytryptamine inhibited forskolin-stimulated cyclic AMP formation in cultured neural cells prepared from embryonic chick retina. Both methoxyindoles exhibited similar potency and efficacy, with EC50 values of 0.8 nM for melatonin and 7.2 nM for 5-methoxytryptamine. Inhibition of cyclic AMP formatio...

journal_title：Journal of neurochemistry

authors： Iuvone PM,Gan J,Alonso-Gómez AL

更新日期：1995-04-01 00:00:00

abstract：:Cell and tissue concentrations of NO2- and NO3- are important indicators of nitric oxide synthase activity and crucial in the regulation of many metabolic functions, as well as in nonenzymatic nitric oxide release. We adapted the capillary electrophoresis technique to quantify NO2- and NO3- levels in single identified...

journal_title：Journal of neurochemistry

authors： Cruz L,Moroz LL,Gillette R,Sweedler JV

更新日期：1997-07-01 00:00:00

abstract：:Amyotrophic lateral sclerosis is a neurodegenerative fatal disease. The only drug recognized to increase the survival time is riluzole(RLZ). In animal models, minocycline (MNC) delayed the onset of the disease and increased the survival time (in combination with RLZ). The objective of our work was to study the interac...

journal_title：Journal of neurochemistry

authors： Milane A,Fernandez C,Vautier S,Bensimon G,Meininger V,Farinotti R

更新日期：2007-10-01 00:00:00

abstract：:Choline acetyltransferase (ChAT), the enzyme synthesizing acetylcholine, is known to be activated by brain derived neurotrophic factor (BDNF). We found that the specific removal of the carbohydrate polysialic acid (PSA) significantly increased BDNF-induced ChAT-activity in embryonic septal neurons. Using a p75 neurotr...

journal_title：Journal of neurochemistry

authors： Burgess A,Aubert I

更新日期：2006-11-01 00:00:00

abstract：UNLABELLED:J. Neurochem. (2012) 121, 597-606. ABSTRACT:In cultured rat neocortical interneurons, we have studied the effect of long-term application of NMDA or AMPA on the surface density of the NMDA (GluN) receptor subunits GluN1 and GluN2B. Stimulation of Ca(2+) -permeable AMPA (GluA) receptors located on the intern...

journal_title：Journal of neurochemistry

authors： Meyer DK,Lindemeyer AK,Wilmes T,Sobottka H,Nörenberg W

更新日期：2012-05-01 00:00:00

abstract：:Ammonium (NH(4) (+) ) is required to maintain pathways involved in shuttling metabolic precursors between astrocytes and neurones. Under hyperammonaemic conditions, increases in the cellular influx of NH(4) (+) , and accompanying changes in ion concentrations, may contribute to disruptions in metabolism and neurotrans...

journal_title：Journal of neurochemistry

authors： Kelly T,Rose CR

更新日期：2010-12-01 00:00:00

abstract：:Stimulation of glutamate binding by the dipeptide L-phenylalanyl-L-glutamate (Phe-Glu) was inhibited by the peptidase inhibitor bestatin, suggesting that the stimulation was caused by glutamate liberated from the dipeptide and not by the dipeptide itself. It further suggests that this form of glutamate binding should ...

journal_title：Journal of neurochemistry

authors： Kessler M,Petersen G,Vu HM,Baudry M,Lynch G

更新日期：1987-04-01 00:00:00

abstract：:Ependymins are thought to be implicated in fundamental processes involved in plasticity of the goldfish CNS. Gas-phase sequencing of purified ependymins beta and gamma revealed that they share the same N-terminal sequence. Each sequence displays microheterogeneities at several positions. Based on the protein sequences...

journal_title：Journal of neurochemistry

authors： Königstorfer A,Sterrer S,Eckerskorn C,Lottspeich F,Schmidt R,Hoffmann W

更新日期：1989-01-01 00:00:00