Frataxin: a protein in search for a function.

abstract：:Previous studies have demonstrated opposing roles for adenosine A1 and A2A receptors in the modulation of extracellular levels of glutamate and dopamine in the striatum. In the present study, acute systemic administration of motor-activating doses of the A2A receptor antagonist MSX-3 significantly decreased extracellu...

journal_title：Journal of neurochemistry

authors： Quarta D,Ferré S,Solinas M,You ZB,Hockemeyer J,Popoli P,Goldberg SR

更新日期：2004-03-01 00:00:00

abstract：:Current evidence indicates that glutamate acting via the N-methyl-D-aspartate (NMDA) receptor/ion channel complex plays a major role in the neuronal degeneration associated with a variety of neurological disorders. In this report the role of glycine in NMDA neurotoxicity was examined. We demonstrate that NMDA-mediated...

journal_title：Journal of neurochemistry

authors： Patel J,Zinkand WC,Thompson C,Keith R,Salama A

更新日期：1990-03-01 00:00:00

abstract：:The effects of fatty acids, oleate and palmitate, on gamma-aminobutyric acid (GABA), aspartate, and 3,4- dihydroxyphenylethylamine (dopamine) transport and a variety of other membrane functions were studied in rat brain synaptosomes at a constant lipid-to-protein ratio. Under the conditions utilized oleate, but not pa...

journal_title：Journal of neurochemistry

authors： Troeger MB,Rafalowska U,Erecińska M

更新日期：1984-06-01 00:00:00

abstract：:Previous work from our laboratory points to plasma free tryptophan being a useful predictor of brain tryptophan concentration in many circumstances. Other work, in particular various studies on the acute effects of food intake, has emphasized the roles of plasma total tryptophan and of plasma large neutral amino acids...

journal_title：Journal of neurochemistry

authors： Sarna GS,Kantamaneni BD,Curzon G

更新日期：1985-05-01 00:00:00

abstract：:Rat glioma X mouse neuroblastoma hybrid neurotumor cells (NG108-15), synchronized by amino acid deprivation, showed a cell-cycle-dependent peak of activity of a ganglioside N-acetylgalactosaminyl transferase 14-24 h following release from the cell cycle block (S/G2 phase). Maximal expression of two typical lysosomal h...

journal_title：Journal of neurochemistry

authors： Scheideler MA,Lockney MW,Dawson G

更新日期：1984-04-01 00:00:00

abstract：:Previously, we demonstrated that systemically injected extracellular domain of neuregulin-1β1 (Nrg1β1), a nerve growth and differentiation factor, passes the blood-brain barrier and rescues dopaminergic neurons of substantia nigra in the 6-hydroxydopamine-mouse model of Parkinson's disease (PD). Here, we studied the e...

journal_title：Journal of neurochemistry

authors： Depboylu C,Rösler TW,de Andrade A,Oertel WH,Höglinger GU

更新日期：2015-05-01 00:00:00

abstract：:GTP binding regulatory protein (G protein)-coupled receptors can activate MAPK pathways via G protein-dependent and -independent mechanisms. However, the physiological outcomes correlated with the cellular signaling events are not as well characterized. In this study, we examine the involvement of G protein and beta-a...

journal_title：Journal of neurochemistry

authors： McLennan GP,Kiss A,Miyatake M,Belcheva MM,Chambers KT,Pozek JJ,Mohabbat Y,Moyer RA,Bohn LM,Coscia CJ

更新日期：2008-12-01 00:00:00

abstract：:Induction of the prodynorphin gene occurs in a tissue-specific manner following different physiological stimuli. Using electrophoretic mobility shift assays, we studied the relative activity of the five major regulatory sites in the rat prodynorphin promoter. Prodynorphin cyclic AMP-responsive element 2 (DynCRE2), Dyn...

journal_title：Journal of neurochemistry

authors： Carrión AM,Mellström B,Luckman SM,Naranjo JR

更新日期：1998-03-01 00:00:00

abstract：:Presynaptic receptors modulating the release of acetylcholine (ACh) were studied in fetal septal neurons cultured in a growth medium to which various drugs were added from day 3 in vitro (DIV 3) to DIV 14. The influence of these drugs on the function of the presynaptic muscarinic (M-) autoreceptor was determined at DI...

journal_title：Journal of neurochemistry

authors： Ehret A,Birthelmer A,Rutz S,Riegert C,Rothmaier AK,Jackisch R

更新日期：2007-08-01 00:00:00

abstract：:The content, synthesis and transport of D-aspartate (D-Asp) in the CNS of Aplysia californica is investigated using capillary electrophoresis (CE) with both laser-induced fluorescence and radionuclide detection. Millimolar concentrations of D-Asp are found in various regions of the CNS. In the cerebral ganglion, three...

journal_title：Journal of neurochemistry

authors： Miao H,Rubakhin SS,Scanlan CR,Wang L,Sweedler JV

更新日期：2006-04-01 00:00:00

abstract：:The antagonistic effects of gallamine on muscarinic receptor-linked responses were investigated in N1E-115 neuroblastoma cells. M1 muscarinic receptor-mediated phosphoinositide hydrolysis induced by carbamylcholine was antagonized by gallamine, with a Ki value of 33 microM. By comparison, gallamine was four- to fivefo...

journal_title：Journal of neurochemistry

authors： Lee NH,el-Fakahany EE

更新日期：1989-10-01 00:00:00

abstract：:Brain-derived neurotrophic factor (BDNF) activates a variety of signaling molecules to exert various functions in the nervous system, including neuronal differentiation, survival, and regulation of synaptic plasticity. Previously, we have suggested that BIT/SHPS-1 (brain immunoglobulin-like molecule with tyrosine-base...

journal_title：Journal of neurochemistry

authors： Araki T,Yamada M,Ohnishi H,Sano SI,Hatanaka H

更新日期：2000-10-01 00:00:00

abstract：:There is ample evidence that both acid (ASMase) and neutral (NSMase) sphingomyelinases play a role in cell death so inhibitors of either enzyme could have significant value as protectors against neurodegeneration. We used a fluorogenic sphingomyelinase substrate, 6-hexadecanoylamino-4-methylumbelliferyl-phosphorylchol...

journal_title：Journal of neurochemistry

authors： Testai FD,Landek MA,Goswami R,Ahmed M,Dawson G

更新日期：2004-05-01 00:00:00

abstract：:Semaphorins are a family of secreted and membrane-associated proteins involved in growth cone guidance during development. Here, we describe the interaction of Semaphorin4F (Sema4F) with the post-synaptic density protein SAP90/PSD-95. Using the yeast two-hybrid system and coprecipitation assays we were able to show an...

journal_title：Journal of neurochemistry

authors： Schultze W,Eulenburg V,Lessmann V,Herrmann L,Dittmar T,Gundelfinger ED,Heumann R,Erdmann KS

更新日期：2001-08-01 00:00:00

abstract：:Oligodendroglial cell death in the myelin proteolipid protein (PLP) mutants can be partially rescued by the environment factor(s) supplied by the wild-type cells in vivo and in vitro. It is possible that the presence of PLP or DM-20 results in secretion of a factor or factors in the CNS influencing oligodendrocyte dev...

journal_title：Journal of neurochemistry

authors： Nakao J,Yamada M,Kagawa T,Kim SU,Miyao Y,Shimizu K,Mikoshiba K,Ikenaka K

更新日期：1995-06-01 00:00:00

abstract：:Amyloid-β peptide (Aβ) concentration in CSF is potentially a diagnostic and therapeutic target for Alzheimer's disease (AD). The purpose of this study was to clarify the elimination mechanism of human Aβ(1-40) [hAβ (1-40)] from CSF. After intracerebroventricular (ICV) administration, [(125) I]hAβ(1-40) was eliminated ...

journal_title：Journal of neurochemistry

authors： Fujiyoshi M,Tachikawa M,Ohtsuki S,Ito S,Uchida Y,Akanuma S,Kamiie J,Hashimoto T,Hosoya K,Iwatsubo T,Terasaki T

更新日期：2011-08-01 00:00:00

abstract：:1-Piperideine, 5-aminopentanoic acid, and its lactam, 2-piperidone, were identified as metabolites of cadaverine in 10,000 g mouse liver supernatants to which diamine oxidase had been added. Both metabolites were also found when the cadaverine metabolite 1-piperideine was incubated with the preparation which suggested...

journal_title：Journal of neurochemistry

authors： Callery PS,Geelhaar LA

更新日期：1984-12-01 00:00:00

abstract：:The lipid compositions of 10 different brain regions from patients affected by Alzheimer's disease/senile dementia of Alzheimer's type were analyzed. The total phospholipid amount decreased somewhat in nucleus caudatus and in white matter. The cortical areas that are morphologically affected by Alzheimer's disease, i....

journal_title：Journal of neurochemistry

authors： Söderberg M,Edlund C,Alafuzoff I,Kristensson K,Dallner G

更新日期：1992-11-01 00:00:00

abstract：:The inhibition of [3H]5-hydroxytryptamine [( 3H]5-HT) binding in rat brain by 1-[2-(3-bromoacetamidophenyl)ethyl]-4-(3-trifluoromethylphenyl) piperazine (BrAcTFMPP) and that by spiperone were compared. Spiperone inhibition of [3H]5-HT binding in cortex was consistent with displacement from two sites with dissociation ...

journal_title：Journal of neurochemistry

authors： Ransom RW,Asarch KB,Shih JC

更新日期：1985-03-01 00:00:00

abstract：:Dystonia musculorum (dt) mice suffer from a severe sensory neuropathy caused by mutations in the gene encoding the cytoskeletal cross-linker protein dystonin/bullous pemphigoid antigen 1 (Bpag1). Loss of function of dystonin/Bpag1 within neurons leads to a loss in the maintenance of cytoskeletal organization and to th...

journal_title：Journal of neurochemistry

authors： De Repentigny Y,Deschênes-Furry J,Jasmin BJ,Kothary R

更新日期：2003-08-01 00:00:00

abstract：:Although transient receptor potential (TRP) channels expressed in the spinal substantia gelatinosa play a role in modulating nociceptive transmission, their properties have not been fully examined yet. In order to address this issue, the effects of 1,8-cineole and its stereoisomer 1,4-cineole on excitatory transmissio...

journal_title：Journal of neurochemistry

authors： Jiang CY,Wang C,Xu NX,Fujita T,Murata Y,Kumamoto E

更新日期：2016-02-01 00:00:00

abstract：:The zinc-finger transcription factor Yin Yang 1 (YY1) is a multifunctional protein that plays a critical role in embryonic development. Although it has been shown to play a role in eye development, its expression in the retina was not previously described. Here, we investigated YY1 expression in chicken tissues and we...

journal_title：Journal of neurochemistry

authors： Bernard M,Voisin P

更新日期：2008-05-01 00:00:00

abstract：:The effects of gamma-aminobutyric acid (GABA) on the extracellular levels of taurine and on excitability in the dentate gyrus were studied in anesthetized rats by the dialytrode technique. The dentate gyrus was perfused by means of a dialytrode with Krebs-Ringer-bicarbonate or GABA solutions. Amino acid contents in pe...

journal_title：Journal of neurochemistry

authors： Lerma J,Herranz AS,Herreras O,Muñoz D,Solís JM,del Río RM,Delgado JM

更新日期：1985-03-01 00:00:00

abstract：:A new protein kinase modulated by S-100 (tentatively referred to as protein kinase X) was partially purified from pig brain extracts. The activity of protein kinase X, which was independent of Ca2+, was demonstrated when protamine (free base), but not protamine sulfate and other proteins (including histone), was used ...

journal_title：Journal of neurochemistry

authors： Qi DF,Turner RS,Kuo JF

更新日期：1984-02-01 00:00:00

abstract：:Dysregulation of the central noradrenergic system is a core feature of post-traumatic stress disorder (PTSD). Here, we examined molecular changes in locus coeruleus (LC) triggered by single-prolonged stress (SPS) PTSD model at a time when behavioral symptoms are manifested, and the effect of early intervention with in...

journal_title：Journal of neurochemistry

authors： Sabban EL,Laukova M,Alaluf LG,Olsson E,Serova LI

更新日期：2015-12-01 00:00:00

abstract：:We have examined cyclic GMP concentrations, guanylate cyclase activities, and cyclic GMP phosphodiesterase (PDE) activities in developing retinas of congenic mice with different allelic combinations at the retinal degeneration (rd) and retinal degeneration slow (rds) loci. Although guanylate cyclase activities were fo...

journal_title：Journal of neurochemistry

authors： Fletcher RT,Sanyal S,Krishna G,Aguirre G,Chader GJ

更新日期：1986-04-01 00:00:00

abstract：:The distribution of type I calmodulin-sensitive adenylyl cyclase in bovine and rat tissues was examined by northern blot analysis and in situ hybridization. Northern blot analysis using poly(A)(+)-selected RNA from various bovine tissues indicated that mRNA for type I adenylyl cyclase was found only in brain, retina, ...

journal_title：Journal of neurochemistry

authors： Xia Z,Choi EJ,Wang F,Blazynski C,Storm DR

更新日期：1993-01-01 00:00:00

abstract：:2,4,5-Trihydroxyphenylalanine (TOPA) oxidizes in solution to form a quinone derivative that is a non-N-methyl-D-aspartate agonist and neurotoxin. Although pathways have been postulated for the formation of both TOPA and TOPA quinone from closely related catecholamines, the generation of these compounds has not been co...

journal_title：Journal of neurochemistry

authors： Newcomer TA,Palmer AM,Rosenberg PA,Aizenman E

更新日期：1993-09-01 00:00:00

abstract：:The neuromodulator adenosine can be released as such, mainly activating inhibitory A1 receptors, or formed from released ATP, preferentially activating facilitatory A2A receptors. We tested if changes in extracellular adenosine metabolism paralleled changes in A1/A2A receptor neuromodulation in the aged rat hippocampu...

journal_title：Journal of neurochemistry

authors： Cunha RA,Almeida T,Ribeiro JA

更新日期：2001-01-01 00:00:00

abstract：:Phospholipase C gamma 1 (PLC-gamma 1) is involved at an early step in signal transduction of many hormones and growth factors and catalyzes the hydrolysis of phosphatidylinositol (PI) 4,5-bisphosphate to diacylglycerol and inositol trisphosphate, two potent intracellular second messenger molecules. The transformation ...

journal_title：Journal of neurochemistry

authors： Widmer HR,Kaplan DR,Rabin SJ,Beck KD,Hefti F,Knüsel B

更新日期：1993-06-01 00:00:00