Type I calmodulin-sensitive adenylyl cyclase is neural specific.

abstract：:Axonal transport of glycoconjugates was studied in the motoneurons of rat sciatic nerve following injection of [3H]glucosamine into the lumbosacral spinal cord. After varying time intervals, the sciatic nerve was exposed, and two ligatures were tied for collection of materials undergoing anterograde and retrograde tra...

journal_title：Journal of neurochemistry

authors： Aquino DA,Bisby MA,Ledeen RW

更新日期：1985-10-01 00:00:00

abstract：:The pH dependency of the binding of ligands to adenosine A2a receptors in rat striatal membranes was examined. For those agonists sensitive to adenosine deaminase a solubilised membrane preparation was used. A two- to fourfold increase in affinity was observed for CGS-21680, 5'-N-ethylcarboxamidoadenosine, adenosine, ...

journal_title：Journal of neurochemistry

authors： Askalan R,Richardson PJ

更新日期：1994-10-01 00:00:00

abstract：:The Na+ and K+ concentrations in isolated Torpedo marmorata synaptosomes were determined. Synaptosomes made according to the method of Israël et al. have high internal Na+ (290 mM) and low internal K+ (30 mM) concentrations. Modification of the homogenisation media permitted the isolation of synaptosomes which could m...

journal_title：Journal of neurochemistry

authors： Richardson PJ,Whittaker VP

更新日期：1981-04-01 00:00:00

abstract：:Recent evidence indicates that tyrosine phosphorylation may play important roles in retinal photoreceptor rod outer segments (ROS). We investigated the tyrosine phosphorylation of endogenous proteins in isolated bovine ROS. Several proteins with apparent molecular masses of 31, 39, 60, 83, 90, 97, 120, 140, and 180 kD...

journal_title：Journal of neurochemistry

authors： Bell MW,Desai N,Guo XX,Ghalayini AJ

更新日期：2000-11-01 00:00:00

abstract：:In Alzheimer's disease, the neuritic or senile amyloid plaques in hippocampus and association cortex, the diffuse plaques in brain areas such as the cerebellum and sensorimotor cortex, and the amyloid deposits in the walls of pial and parenchymal blood vessels are mainly composed of amyloid beta-peptides. In the prese...

journal_title：Journal of neurochemistry

authors： Ghersi-Egea JF,Gorevic PD,Ghiso J,Frangione B,Patlak CS,Fenstermacher JD

更新日期：1996-08-01 00:00:00

abstract：:The amyloid precursor protein (APP) is an ubiquitous receptor-like molecule involved in the pathogenesis of Alzheimer's disease (AD). APP and some of its C-terminal proteolytic fragments (CTFs) have been shown to be phosphorylated and to interact with cytosolic phosphotyrosine binding (PTB) domain containing proteins ...

journal_title：Journal of neurochemistry

authors： Venezia V,Russo C,Repetto E,Salis S,Dolcini V,Genova F,Nizzari M,Mueller U,Schettini G

更新日期：2004-09-01 00:00:00

abstract：:We report here that anti-L1 antiserum, raised against material from embryonic brain, and anti-NILE antiserum, raised against purified NILE (nerve growth factor-inducible large external) glycoprotein of PC12 cells, immunoprecipitate from PC12 cells material of the same apparent molecular weight (230 kilodaltons) by sod...

journal_title：Journal of neurochemistry

authors： Sajovic P,Kouvelas E,Trenkner E

更新日期：1986-08-01 00:00:00

abstract：:Calcium-activated neutral proteases (calpains) are regulated by specific endogenous protein inhibitors, the calpastatins, which are widely distributed in mammalian tissues. Calpastatins from different species or in various tissues from the same species exhibit considerable size heterogeneity on sodium dodecyl sulfate ...

journal_title：Journal of neurochemistry

authors： Mohan PS,Nixon RA

更新日期：1995-02-01 00:00:00

abstract：:: The amyloid cascade hypothesis of Alzheimer's disease envisages that the initial elevation of amyloid β-peptide (Aβ) levels, especially of Aβ(1-42) , is the primary trigger for the neuronal cell death specific to onset of Alzheimer's disease. There is now substantial evidence that brain amyloid levels are manipulabl...

journal_title：Journal of neurochemistry

authors： Nalivaeva NN,Beckett C,Belyaev ND,Turner AJ

更新日期：2012-01-01 00:00:00

abstract：:In cerebellar granule cells, the mitogen-activated protein kinase (MAPK) or extracellular signal-regulated kinase (ERK) cascade mediates multiple functions, including proliferation, differentiation, and survival. In these cells, ERKs are activated by diverse stimuli, including cyclic adenosine monophosphate (cAMP), pi...

journal_title：Journal of neurochemistry

authors： Obara Y,Horgan AM,Stork PJ

更新日期：2007-04-01 00:00:00

abstract：:In contrast to brain, the sciatic nerve concentration of vitamin E in rats increased rapidly during the postnatal period (approximately fivefold between days 1 and 8), then decreased dramatically (about twofold between days 8 and 30), and further decreased slowly between days 30 and 60 and remained constant up to 2 ye...

journal_title：Journal of neurochemistry

authors： Clément M,Bourre JM

更新日期：1990-06-01 00:00:00

abstract：:Signaling pathways mediated by corticotropin-releasing factor and its receptor 1 (CRF1) play a central role in stress responses. Dysfunction of the CRF system has been associated with neuropsychiatric disorders. However, dynamic changes in the CRF system during brain development and aging are not well investigated. In...

journal_title：Journal of neurochemistry

authors： Locci A,Yan Y,Rodriguez G,Dong H

更新日期：2020-08-19 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by a selective loss of motor neurones accompanied by intense gliosis in lesioned areas of the brain and spinal cord. Glutamate-mediated excitotoxicity resulting from impaired astroglial uptake constitutes one of the current pathophysiolog...

journal_title：Journal of neurochemistry

authors： Vermeiren C,Hemptinne I,Vanhoutte N,Tilleux S,Maloteaux JM,Hermans E

更新日期：2006-02-01 00:00:00

abstract：:Leucine-rich repeat kinase 2 (LRRK2) is a large multidomain scaffolding protein with kinase and GTPase activities involved in synaptic vesicle (SV) dynamics. While its role in Parkinson's disease has been largely investigated, little is known about LRRK2 physiological role and until now few proteins have been describe...

journal_title：Journal of neurochemistry

authors： Marte A,Russo I,Rebosio C,Valente P,Belluzzi E,Pischedda F,Montani C,Lavarello C,Petretto A,Fedele E,Baldelli P,Benfenati F,Piccoli G,Greggio E,Onofri F

更新日期：2019-08-01 00:00:00

abstract：:Studies on glial cultures have demonstrated that fetal bovine serum contains a factor that induces bipotential glial precursors known as oligodendrocyte-type 2 astrocyte (O-2A) progenitors to become type 2 astroglia rather than oligodendroglia. The goal of this research project was to characterize and purify this fact...

journal_title：Journal of neurochemistry

authors： Levison SW,McCarthy KD

更新日期：1991-09-01 00:00:00

abstract：:Nitric oxide (NO) has a number of physiological and pathophysiological effects in the nervous system. One target of NO is the mitochondrion, where it inhibits respiration and ATP synthesis, which may contribute to NO-mediated neuronal injury. Our recent studies suggested that impaired mitochondrial function impairs mi...

journal_title：Journal of neurochemistry

authors： Rintoul GL,Bennett VJ,Papaconstandinou NA,Reynolds IJ

更新日期：2006-05-01 00:00:00

abstract：:Analysis of the initial rates of 45Ca2+ uptake by rat brain mitochondria in Ca2+-1,2-bis(o-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid buffers indicated that nontelencephalic mitochondria exhibited both a much less pronounced stimulatory effect of spermine and significantly more hyperbolic kinetics of Ca2+ uptake t...

journal_title：Journal of neurochemistry

authors： Jensen JR,Lynch G,Baudry M

更新日期：1989-10-01 00:00:00

abstract：:A naturally occurring point mutation (R231H) within one of the major 3gamma-binding surface (switch II region) on the a subunit of Gs (alpha(s)) has previously been found to disrupt receptor-mediated activation of Gs. The disruption caused by mutating this conserved residue may be a general phenomenon for all a subuni...

journal_title：Journal of neurochemistry

authors： Ho MK,Yung LY,Wong YH

更新日期：1999-11-01 00:00:00

abstract：:Neuropathic pain is a debilitating chronic pain condition occurring after damage in the nervous system and is refractory to the currently available treatments. Major challenges include elucidating its mechanisms and developing new medications to treat it. Nerve injury-induced pain hypersensitivity involves aberrant ex...

journal_title：Journal of neurochemistry

authors： Tsuda M,Koga K,Chen T,Zhuo M

更新日期：2017-05-01 00:00:00

abstract：:The decrease of pyruvate and ketoglutarate dehydrogenase complex activities is the main cause of energy and acetyl-CoA deficits in thiamine deficiency-evoked cholinergic encephalopathies. However, disturbances in pathways of acetyl-CoA metabolism leading to appearance of cholinergic deficits remain unknown. Therefore,...

journal_title：Journal of neurochemistry

authors： Jankowska-Kulawy A,Bielarczyk H,Pawełczyk T,Wróblewska M,Szutowicz A

更新日期：2010-10-01 00:00:00

abstract：:Seven monoclonal antibodies (MAbs) directed to tetrasialoganglioside (GQ1b) were established, purified GQ1b being used for immunization and hybridoma screening. All of the MAbs reacted strongly with GQ1b, although they also reacted with other gangliosides, with different specificities and reactivities. Some MAbs (1H10...

journal_title：Journal of neurochemistry

authors： Yamamoto H,Tsuji S,Nagai Y

更新日期：1990-02-01 00:00:00

abstract：:In the early postnatal period, energy metabolism in the suckling rodent brain relies to a large extent on metabolic pathways alternate to glucose such as the utilization of ketone bodies (KBs). However, how KBs affect neuronal excitability is not known. Using recordings of single NMDA and GABA-activated channels in ne...

journal_title：Journal of neurochemistry

authors： Rheims S,Holmgren CD,Chazal G,Mulder J,Harkany T,Zilberter T,Zilberter Y

更新日期：2009-08-01 00:00:00

abstract：:Previous work has demonstrated that there is a selective increase in extracellular taurine in the brain during acute water intoxication. One aim of the present study was to investigate whether plasma taurine contributes to this increase. To this end, the concentrations of taurine, other amino acids, and ethanolamine (...

journal_title：Journal of neurochemistry

authors： Lehmann A,Carlström C,Nagelhus EA,Ottersen OP

更新日期：1991-02-01 00:00:00

abstract：:The neuromodulator adenosine can be released as such, mainly activating inhibitory A1 receptors, or formed from released ATP, preferentially activating facilitatory A2A receptors. We tested if changes in extracellular adenosine metabolism paralleled changes in A1/A2A receptor neuromodulation in the aged rat hippocampu...

journal_title：Journal of neurochemistry

authors： Cunha RA,Almeida T,Ribeiro JA

更新日期：2001-01-01 00:00:00

abstract：:Proteolytic fragmentation of [3H]diisopropylfluorophosphate-labelled catalytic subunits of different molecular forms of acetylcholinesterase demonstrates that all forms extracted from the electric organ from Torpedo marmorata are true acetylcholinesterases. This is supported by immunochemical results showing that the ...

journal_title：Journal of neurochemistry

authors： Stieger S,Brodbeck U,Witzemann V

更新日期：1987-08-01 00:00:00

abstract：:Organotypic rat hippocampal slice cultures were used to study the role of excitatory amino acid transporters (EAATs) in kainate-induced cell death. Expression of the neuronal (EAAT3) or glial (EAAT2) transporters was inhibited with antisense phosphothioate oligonucleotides, and cytotoxicity was assessed with propidium...

journal_title：Journal of neurochemistry

authors： Simantov R,Liu W,Broutman G,Baudry M

更新日期：1999-11-01 00:00:00

abstract：:We have previously reported that insulin/insulin-like growth factor (IGF)-I induced the alpha 1 isoform of Na+,K(+)-ATPase in cultured astrocytes. In this study the effects of insulin/IGF-I on Na+,K(+)-ATPase activity and cell proliferation were examined in astrocytes cultured under the various conditions, to test the...

journal_title：Journal of neurochemistry

authors： Matsuda T,Murata Y,Tanaka K,Hosoi R,Hayashi M,Tamada K,Takuma K,Baba A

更新日期：1996-02-01 00:00:00

abstract：:In vitro, the transport into and release of [3H]deoxycytidine from the isolated choroid plexus, the anatomical locus of the blood-cerebrospinal fluid barrier, were studied separately. By use of the ability of nitrobenzylthioinosine (NBTI) to inhibit deoxycytidine efflux from choroid plexus, the transport of 1 microM [...

journal_title：Journal of neurochemistry

authors： Spector R,Huntoon S

更新日期：1983-05-01 00:00:00

abstract：:Two monoclonal antibodies that recognize Alzheimer's neurofibrillary tangles (ANTs), AD10 and AB18, have been characterized by immunoblotting against human and calf spinal cord neurofilament (NF) and calf brain microtubule preparations. Both antibodies bind to the 200-kilodalton (kd) (NF-H) and 160-kd (NF-M) but not t...

journal_title：Journal of neurochemistry

authors： Ksiezak-Reding H,Yen SH

更新日期：1987-02-01 00:00:00

abstract：:Chronic cocaine use in humans and animal models is known to lead to pronounced alterations in glutamatergic function in brain regions associated with reinforcement. Previous studies have examined ionotropic glutamate receptor (iGluR) subunit protein level changes following acute and chronic experimenter-administered c...

journal_title：Journal of neurochemistry

authors： Tang W,Wesley M,Freeman WM,Liang B,Hemby SE

更新日期：2004-05-01 00:00:00