Abstract:
:Malignant gliomas are common and aggressive brain tumours associated with significant morbidity and mortality. We showed in this report that substratum adherence and migration by human U87MG glioma cells in culture were significantly attenuated by the extracellular domains of Nogo-A (Nogo-66) and the myelin-associated glycoprotein (MAG). U87MG cells contained significant amounts of endogenous Nogo-66 receptor (NgR), and treatment of the cells with phosphatidylinositol-specific phospholipase C (PI-PLC) or NgR antibodies resulted in an increase in their ability to adhere to, or migrate through, Nogo-66- and MAG-coated substrates. Nogo-66 and MAG may therefore modulate glioma growth and migration by acting through the NgR, a phenomenon that has potential therapeutic implications.
journal_name
J Neurochemjournal_title
Journal of neurochemistryauthors
Liao H,Duka T,Teng FY,Sun L,Bu WY,Ahmed S,Tang BL,Xiao ZCdoi
10.1111/j.1471-4159.2004.02573.xkeywords:
subject
Has Abstractpub_date
2004-09-01 00:00:00pages
1156-62issue
5eissn
0022-3042issn
1471-4159pii
JNC2573journal_volume
90pub_type
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