Muscarinic toxins: tools for the study of the pharmacological and functional properties of muscarinic receptors.

Abstract:

:Muscarinic receptors mediate metabotropic actions of acetylcholine in the CNS and PNS and autocrine functions of acetylcholine in non-neuronal systems. Because of the lack of highly selective muscarinic ligands, the precise location, functional role, and roles in various diseases of the five muscarinic receptor subtypes remain unclear. Muscarinic toxins isolated from the venom of Dendroaspis snakes have a natural high affinity and selectivity, associated with roles as competitive antagonists, allosteric modulators, and potential agonists. These toxins may therefore be invaluable tools for studying muscarinic receptors. We review data on the structural and pharmacological characterization of the muscarinic toxins, focusing on recent structure-function studies on toxin-receptor interactions. We discuss the potential benefits of using these toxins for investigating muscarinic function in vivo.

journal_name

J Neurochem

authors

Servent D,Fruchart-Gaillard C

doi

10.1111/j.1471-4159.2009.06092.x

subject

Has Abstract

pub_date

2009-06-01 00:00:00

pages

1193-202

issue

5

eissn

0022-3042

issn

1471-4159

pii

JNC6092

journal_volume

109

pub_type

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