Slow axonal transport of soluble actin with actin depolymerizing factor, cofilin, and profilin suggests actin moves in an unassembled form.

abstract：:: The amyloid cascade hypothesis of Alzheimer's disease envisages that the initial elevation of amyloid β-peptide (Aβ) levels, especially of Aβ(1-42) , is the primary trigger for the neuronal cell death specific to onset of Alzheimer's disease. There is now substantial evidence that brain amyloid levels are manipulabl...

journal_title：Journal of neurochemistry

authors： Nalivaeva NN,Beckett C,Belyaev ND,Turner AJ

更新日期：2012-01-01 00:00:00

abstract：:Dysregulated metabolism and consequent extracellular accumulation of amyloid-β (Aβ) peptides in the brain underlie the pathogenesis of Alzheimer's disease. Extracellular Aβ in the brain parenchyma is mainly secreted from the pre-synaptic terminals of neuronal cells in a synaptic activity-dependent manner. The p24 fami...

journal_title：Journal of neurochemistry

authors： Liu L,Fujino K,Nishimura M

更新日期：2015-05-01 00:00:00

abstract：:The expression of Nex1 peaks during brain development when neurite outgrowth and synaptogenesis are highly active. We previously showed that Nex1 is a critical effector of the nerve growth factor (NGF) pathway and its overexpression results in spontaneous neuritogenesis. Furthermore, the PC12-Nex1 cells exhibit accele...

journal_title：Journal of neurochemistry

authors： Uittenbogaard M,Chiaramello A

更新日期：2004-12-01 00:00:00

abstract：:Carboxymethylation and phosphorylation of protein phosphatase 2A (PP2A) catalytic C subunit are evolutionary conserved mechanisms that critically control PP2A holoenzyme assembly and substrate specificity. Down-regulation of PP2A methylation and PP2A enzymes containing the B alpha regulatory subunit occur in Alzheimer...

journal_title：Journal of neurochemistry

authors： Nunbhakdi-Craig V,Schuechner S,Sontag JM,Montgomery L,Pallas DC,Juno C,Mudrak I,Ogris E,Sontag E

更新日期：2007-05-01 00:00:00

abstract：:The cleavage-product of amyloid precursor protein (APP) constitutes the core component of plaques found in the brains of Alzheimer's disease (AD) patients. APP is ubiquitously expressed and its precise physiological functions remain unclear. This protein has been proposed to regulate synaptic function and processes un...

journal_title：Journal of neurochemistry

authors： Senechal Y,Kelly PH,Cryan JF,Natt F,Dev KK

更新日期：2007-09-01 00:00:00

abstract：:Previous studies demonstrated that 9 kb of the rat tyrosine hydroxylase (TH) 5' flanking sequence directed appropriate spatiotemporal expression of a lacZ reporter gene to catecholaminergic cells in the CNS of transgenic mice. In the present study, specificity of transgene expression was further extended to demonstrat...

journal_title：Journal of neurochemistry

authors： Min N,Joh TH,Corp ES,Baker H,Cubells JF,Son JH

更新日期：1996-07-01 00:00:00

abstract：:Rats were submitted to a series of 10 daily electroconvulsive shocks (ECS). A first group of animals was killed 1 day after the last seizure and a second group 30 days later. Tyrosine hydroxylase (TH) activity was measured using an in vitro assay in the nucleus caudatus, anterior cortex, amygdala, substantia nigra, ve...

journal_title：Journal of neurochemistry

authors： Leviel V,Fayada C,Guibert B,Chaminade M,Machek G,Mallet J,Biguet NF

更新日期：1990-03-01 00:00:00

abstract：:Mechanical strain in neural tissues can lead to the up-regulation and release of multiple cytokines including interleukin 6 (IL-6). In the retina, the mechanosensitive release of ATP can autostimulate P2X7 receptors on both retinal ganglion cell neurons and optic nerve head astrocytes. Here, we asked whether the purin...

journal_title：Journal of neurochemistry

authors： Lu W,Albalawi F,Beckel JM,Lim JC,Laties AM,Mitchell CH

更新日期：2017-05-01 00:00:00

abstract：:Abnormalities in the kynurenine pathway may play a role in Huntington's disease (HD). In this study, tryptophan depletion and loading were used to investigate changes in blood kynurenine pathway metabolites, as well as markers of inflammation and oxidative stress in HD patients and healthy controls. Results showed tha...

journal_title：Journal of neurochemistry

authors： Stoy N,Mackay GM,Forrest CM,Christofides J,Egerton M,Stone TW,Darlington LG

更新日期：2005-05-01 00:00:00

abstract：:Patients with cancer cachexia often suffer from psychiatric disorders. In the present study, we investigated the changes in monoaminergic activities in the brain in tumor-bearing mice with reference to the development of cachexia. Two clones, clone-5 (noncachectic clone) and clone-20 (cachectic clone), derived from th...

journal_title：Journal of neurochemistry

authors： Uomoto M,Nishibori M,Nakaya N,Takeuchi Y,Iwagaki H,Tanaka N,Saeki K

更新日期：1998-01-01 00:00:00

abstract：:PEA-15 has recently been identified as a major phosphoprotein in astrocytes and an endogenous substrate for protein kinase C. This 15-kDa protein exists under three molecular forms, an unphosphorylated form, N, and two phosphorylated forms, Pa and Pb. Antisera were raised against synthetic peptides corresponding to th...

journal_title：Journal of neurochemistry

authors： Danziger N,Yokoyama M,Jay T,Cordier J,Glowinski J,Chneiweiss H

更新日期：1995-03-01 00:00:00

abstract：:Five subtypes of the muscarinic receptor have been cloned from both the rat and human genomes. Although all five genes have the coding sequences in a single exon, their structures 5' of the initiation codon are largely uncharacterized, except for the M4 receptor. In the brain, muscarinic receptors mediate motor and me...

journal_title：Journal of neurochemistry

authors： Klett CP,Bonner TI

更新日期：1999-03-01 00:00:00

abstract：:We investigated the molecular mechanism underlying the ganglioside-induced initiation of the assembly of wild and hereditary variant-type amyloid beta-proteins, including Arctic-, Dutch-, and Flemish-type amyloid beta-proteins. We monitored the assembly of amyloid beta-protein by thioflavin-T assay, western blotting a...

journal_title：Journal of neurochemistry

authors： Yamamoto N,Matsuzaki K,Yanagisawa K

更新日期：2005-11-01 00:00:00

abstract：:Electrophorus electroplax microsomes were examined for Ca2+- and Mg2+-dependent ATPase activity. In addition to the previously reported low-affinity ATPase, a high-affinity (Ca2+,Mg2+)-ATPase was found. At low ATP and Mg2+ concentrations (200 microM or less), the high-affinity (Ca2+,Mg2+)-ATPase exhibits an activity o...

journal_title：Journal of neurochemistry

authors： Amende LM,Chock SP,Albers RW

更新日期：1983-04-01 00:00:00

abstract：:Reactive oxygen species (ROS) have been suggested to act as cellular messengers that mediate signal transduction cascades in various cell types. However, little is known about their role in this capacity in the nervous system. We have begun to investigate the role of ROS, and that of nitric oxide (NO), in mediating mi...

journal_title：Journal of neurochemistry

authors： Kanterewicz BI,Knapp LT,Klann E

更新日期：1998-03-01 00:00:00

abstract：:Aggregation of conformation-abnormal peptides probably plays a key role in the pathogenesis of many neurodegenerative diseases. DSCR1 Down syndrome (DS) critical region 1, was identified from a chromosomal region (21q22.1-q22.2) for the clinical manifestations of DS when an extra-copy is present. We report that expres...

journal_title：Journal of neurochemistry

authors： Ma H,Xiong H,Liu T,Zhang L,Godzik A,Zhang Z

更新日期：2004-03-01 00:00:00

abstract：:Although brain-derived neurotrophic factor is the most abundant and widely distributed neurotrophin in the nervous system, reproducible determinations of its levels have been hampered by difficulties in raising suitable monoclonal antibodies. Following immunization of mice with recombinant fish and mammalian brain-der...

journal_title：Journal of neurochemistry

authors： Kolbeck R,Bartke I,Eberle W,Barde YA

更新日期：1999-05-01 00:00:00

abstract：:Recently, a tyrosine hydroxylase (TH)-expressing CNS-derived cell line, CAD, was obtained that is capable of undergoing reversible morphological differentiation. The isolation of the CAD line allowed us to ask whether different DNA regulatory elements direct TH transcription when cells are growing and undifferentiated...

journal_title：Journal of neurochemistry

authors： Lazaroff M,Qi Y,Chikaraishi DM

更新日期：1998-07-01 00:00:00

abstract：:beta-Methyleneaspartate, a specific inhibitor of aspartate aminotransferase (EC 2.6.1.1.), was used to investigate the role of the malate-aspartate shuttle in rat brain synaptosomes. Incubation of rat brain cytosol, "free" mitochondria, synaptosol, and synaptic mitochondria, with 2 mM beta-methyleneaspartate resulted ...

journal_title：Journal of neurochemistry

authors： Cheeseman AJ,Clark JB

更新日期：1988-05-01 00:00:00

abstract：:Cyclooxygenases (COX)-1 and -2 are key enzymes required for the conversion of arachidonic acid to eicosanoids, potent mediators of inflammation. In patients with multiple sclerosis, COX-2 derived prostaglandins (PGs) are elevated in the CSF and COX-2 is up-regulated in demyelinating plaques. However, it is not known w...

journal_title：Journal of neurochemistry

authors： Palumbo S,Toscano CD,Parente L,Weigert R,Bosetti F

更新日期：2012-05-01 00:00:00

abstract：:This study examines the proteolysis of the carboxy terminal domain of the full-length (alpha 1(212)) and truncated (alpha 1(190)) forms of the rabbit skeletal muscle L-type calcium channel alpha 1 subunit by calpain I and calpain II. Although both forms of the alpha 1 subunit show little sensitivity to proteolysis by ...

journal_title：Journal of neurochemistry

authors： De Jongh KS,Colvin AA,Wang KK,Catterall WA

更新日期：1994-10-01 00:00:00

abstract：:The aim of the present study was to explore the possible role of kappa/dynorphin system in the development of tolerance to nicotine antinociception in mice. First, we observed that kappa-opioid receptor (KOP-r) participates in the acute spinal antinociception produced by nicotine (3 and 5 mg/kg, s.c.) since the pre-tr...

journal_title：Journal of neurochemistry

authors： Galeote L,Maldonado R,Berrendero F

更新日期：2008-05-01 00:00:00

abstract：:gamma-Aminobutyric acid (GABA) and glutamic acid decarboxylase (GAD) activities were measured in the ovary and the Fallopian tube of rats and compared with brain values. GABA levels in the Fallopian tube were about twice as high as in the brain, while in the ovary they represented only about 5% of the amino acid conte...

journal_title：Journal of neurochemistry

authors： Apud JA,Tappaz ML,Celotti F,Negri-Cesi P,Masotto C,Racagni G

更新日期：1984-07-01 00:00:00

abstract：:Major depressive disorder is a severe and chronic illness with high lifetime prevalence and a high incidence of suicide as the cause of death for patients with this diagnosis. Major depressive disorder is often treated with anti-depressants. Although these drugs have been used for many years, their exact mode of actio...

journal_title：Journal of neurochemistry

authors： Gulbins E,Walter S,Becker KA,Halmer R,Liu Y,Reichel M,Edwards MJ,Müller CP,Fassbender K,Kornhuber J

更新日期：2015-07-01 00:00:00

abstract：:Uptake and release of alanine were measured in lumbar sympathetic chains excised from embryos of white leghorn chickens, 14-15 days old, and incubated in a modified Eagle's minimum essential medium. In the presence of [U-14C]glucose, glucose carbon accumulated in alanine in the medium at a rate that increased when unl...

journal_title：Journal of neurochemistry

authors： Larrabee MG

更新日期：1984-09-01 00:00:00

abstract：:In this study, we examined the molecular and functional characterization of choline uptake into cultured rat cortical astrocytes. Choline uptake into astrocytes showed little dependence on extracellular Na+. Na+-independent choline uptake was saturable and mediated by a single transport system, with an apparent Michae...

journal_title：Journal of neurochemistry

authors： Inazu M,Takeda H,Matsumiya T

更新日期：2005-09-01 00:00:00

abstract：:Neuronal survival after ischemic injury is determined through the induction of several biological pathways. We examined whether lubeluzole, an agent efficacious in both clinical and experimental models of cerebral ischemia, modulated the signal transduction mechanisms of nitric oxide (NO), a downstream mediator of ano...

journal_title：Journal of neurochemistry

authors： Maiese K,TenBroeke M,Kue I

更新日期：1997-02-01 00:00:00

abstract：:The origin of afferent somatostatin-containing fibers terminating in medial and ventral parts of the striatum has been investigated by performing various neurochemical and surgical lesions in the rat. Lesions of the anterior hypothalamus, amygdala, and the hippocampal commissure as well as lesions with 6-hydroxydopami...

journal_title：Journal of neurochemistry

authors： Widmann R,Mensdorff-Pouilly N,Pfaller K,Sperk G

更新日期：1987-06-01 00:00:00

abstract：:Calmodulin regulated spectrin-associated protein 1 (CAMSAP1) is a vertebrate microtubule-binding protein, and a representative of a family of cytoskeletal proteins that arose with animals. We reported previously that the central region of the protein, which contains no recognized functional domain, inhibited neurite o...

journal_title：Journal of neurochemistry

authors： King MD,Phillips GW,Bignone PA,Hayes NV,Pinder JC,Baines AJ

更新日期：2014-02-01 00:00:00

abstract：:Calcium influx into SH-SY5Y human neuroblastoma cells after ionophore treatment or transient permeabilization in calcium-containing medium increased ALZ-50 immunoreactivity markedly. This increase was prevented by inhibitors active against calpain or against protein kinase C (PKC), suggesting that both of these enzyme...

journal_title：Journal of neurochemistry

authors： Shea TB,Spencer MJ,Beermann ML,Cressman CM,Nixon RA

更新日期：1996-04-01 00:00:00