Aggregate formation and synaptic abnormality induced by DSCR1.

abstract：:Water-soluble iron, and manganese(III) complexes of corroles and porphyrins were examined with regard to their neuroprotective/neurorescue activities by using various neuronal cytotoxic models of oxidative and nitrative stress. The present study demonstrates that the metallocorroles significantly protect human neurobl...

journal_title：Journal of neurochemistry

authors： Kupershmidt L,Okun Z,Amit T,Mandel S,Saltsman I,Mahammed A,Bar-Am O,Gross Z,Youdim MB

更新日期：2010-04-01 00:00:00

abstract：:Although myelin oligodendrocyte glycoprotein is a candidate autoantigen in multiple sclerosis, its function remains unknown. In humans, mRNA expressed by the myelin oligodendrocyte glycoprotein gene is alternatively spliced resulting in at least nine unique protein isoforms. In this study, we investigated the sub-cell...

journal_title：Journal of neurochemistry

authors： Boyle LH,Traherne JA,Plotnek G,Ward R,Trowsdale J

更新日期：2007-09-01 00:00:00

abstract：:Neuromelanin (NM) is a compound which highly accumulates mainly in catecholamine neurons of the substantia nigra (SN), and is contained in organelles (NM-containing organelles) with lipid bodies and proteins. These neurons selectively degenerate in Parkinson's disease and NM can play either a protective or toxic role....

journal_title：Journal of neurochemistry

authors： Biesemeier A,Eibl O,Eswara S,Audinot JN,Wirtz T,Pezzoli G,Zucca FA,Zecca L,Schraermeyer U

更新日期：2016-07-01 00:00:00

abstract：:L-DOPA-induced dyskinesia (LID) is among the motor complications that arise in Parkinson's disease (PD) patients after a prolonged treatment with L-DOPA. To this day, transcriptome analysis has been performed in a rat model of LID [Neurobiol. Dis., 17 (2004), 219] but information regarding the proteome is still lackin...

journal_title：Journal of neurochemistry

authors： Valastro B,Dekundy A,Krogh M,Lundblad M,James P,Danysz W,Quack G,Cenci MA

更新日期：2007-08-01 00:00:00

abstract：:During CNS injury and diseases, nitric oxide (NO) is released at a high flux rate leading to formation of peroxynitrite (ONOO(*)) and other reactive nitrogenous species, which nitrate tyrosines of proteins to form 3-nitrotyrosine (3NY), leading to cell death. Previously, we have found that motor neurons exposed to low...

journal_title：Journal of neurochemistry

authors： Bishop A,Gooch R,Eguchi A,Jeffrey S,Smallwood L,Anderson J,Estevez AG

更新日期：2009-04-01 00:00:00

abstract：:N alpha-Acyl amino acid releasing enzyme (NAARE), an enzyme cleaving acetylMet-Ala at the Met-Ala bond was purified from rat brain cytosol to apparent homogeneity by salt precipitation, gel filtration, and several steps of ion exchange. Levels of NAARE exceeded acylase measured with acetylmethionine in all brain regio...

journal_title：Journal of neurochemistry

authors： Marks N,Lo ES,Stern F,Danho W

更新日期：1983-07-01 00:00:00

abstract：:Accumulations of the neuropeptides substance P (SP), somatostatin (ST), and vasoactive intestinal polypeptide (VIP) proximal to a crush in the cervical vagus nerve of the rat have been measured using sensitive radioimmunoassays. Each of the peptides was rapidly transport towards the peripheral terminals of vagal affer...

journal_title：Journal of neurochemistry

authors： Gilbert RF,Emson PC,Fahrenkrug J,Lee CM,Penman E,Wass J

更新日期：1980-01-01 00:00:00

abstract：:Chick pineal glands in organ culture showed a circadian rhythm in the rate of thymidine incorporation. Thymidine incorporation was very markedly inhibited when 3-isobutyl-l-methylxanthine (IBMX) was continuously present. When IBMX was added to cultures in control medium during the photoperiod of the second day in cult...

journal_title：Journal of neurochemistry

authors： Wainwright SD,Wainwright LK

更新日期：1991-05-01 00:00:00

abstract：:The normal cellular prion protein (PrP(C)) is a glycoprotein with two highly conserved potential N-linked glycosylation sites. All prion diseases, whether inherited, infectious or sporadic, are believed to share the same pathogenic mechanism that is based on the conversion of the normal cellular prion protein (PrP(C))...

journal_title：Journal of neurochemistry

authors： Goh AX,Li C,Sy MS,Wong BS

更新日期：2007-02-01 00:00:00

abstract：:The critical hyaluronan binding motif (HABM) in sialoprotein associated with cones and rods (SPACR) has already been determined. As sialoproteoglycan associated with cones and rods, another interphotoreceptor matrix molecule, binds to chondroitin sulfate and heparin with or without the employment of HABMs, respectivel...

journal_title：Journal of neurochemistry

authors： Zhao J,Yoneda M,Takeyama M,Inoue Y,Kataoka T,Ohno-Jinno A,Isogai Z,Iwaki M,Zako M

更新日期：2008-11-01 00:00:00

abstract：:Rat cerebral cortex synaptosomes were exposed in superfusion to various depolarizing stimuli and the release of somatostatin-like immunoreactivity (SRIF-LI) was measured by means of a radioimmunoassay procedure. High KCl (9-50 mM) concentration dependently evoked SRIF-LI release; the evoked overflow reached a plateau ...

journal_title：Journal of neurochemistry

authors： Bonanno G,Parodi B,Cafaggi S,Raiteri M

更新日期：1991-10-01 00:00:00

abstract：:Choline acetyltransferase (ChAT), the enzyme synthesizing acetylcholine, is known to be activated by brain derived neurotrophic factor (BDNF). We found that the specific removal of the carbohydrate polysialic acid (PSA) significantly increased BDNF-induced ChAT-activity in embryonic septal neurons. Using a p75 neurotr...

journal_title：Journal of neurochemistry

authors： Burgess A,Aubert I

更新日期：2006-11-01 00:00:00

abstract：:In situ phosphorylation of the presynaptic protein kinase C substrate B-50 was investigated in rat hippocampal slices incubated with the convulsant drug 4-aminopyridine (4-AP). Phosphorylation of B-50 was significantly enhanced 1 min after the addition of 4-AP (100 microM). This increase by 4-AP was concentration depe...

journal_title：Journal of neurochemistry

authors： Heemskerk FM,Schrama LH,Gianotti C,Spierenburg H,Versteeg DH,De Graan PN,Gispen WH

更新日期：1990-03-01 00:00:00

abstract：:Glutathione-S-transferase activity in the brain of male mammals (rat and mouse) was found to be relatively lower than in that of females. In contrast, the male aves (pigeon, kite, vulture, and crow) exhibited comparatively higher activity in brain glutathione-S-transferase than the corresponding females. Postnatal dev...

journal_title：Journal of neurochemistry

authors： Das M,Dixit R,Seth PK,Mukhtar H

更新日期：1981-04-01 00:00:00

abstract：:Animals trained in a passive avoidance task exhibit a transient time-dependent increase in hippocampal neural cell adhesion molecule (NCAM) polysialylation at 12-24 h following the initial learning trial. Using immunocytochemical techniques with a monoclonal antibody that specifically recognises NCAM-polysialic acid h...

journal_title：Journal of neurochemistry

authors： Fox GB,O'Connell AW,Murphy KJ,Regan CM

更新日期：1995-12-01 00:00:00

abstract：:Extracts of rat tissues were subjected to ultracentrifugation on linear density gradients of sucrose (5-20%) and fractions of these gradients were analyzed for acetylcholinesterase (AChE) activity. Most of the AChE activity in extracts of vagus nerve was found to sediment at 10S. However, 16S AChE, previously thought ...

journal_title：Journal of neurochemistry

authors： Skau KA,Brimijoin S

更新日期：1980-11-01 00:00:00

abstract：:Previous in vitro studies have shown that group III metabotropic glutamate receptors (mGluRs) regulate synaptic glutamate release. The present study used microdialysis to characterize this regulation in vivo in rat nucleus accumbens. Reverse dialysis of the group III mGluR agonist l-(+)-2-amino-4-phosphonobutyric acid...

journal_title：Journal of neurochemistry

authors： Xi ZX,Shen H,Baker DA,Kalivas PW

更新日期：2003-12-01 00:00:00

abstract：:Accumulating evidence indicates that increased intracellular Na(+) concentration ([Na(+) ]i ) in astroglial cells is associated with the development of brain edema under ischemic conditions, but the underlying mechanisms are still elusive. Here, we report that in primary cultured rat cortical astrocytes, elevations of...

journal_title：Journal of neurochemistry

authors： Minieri L,Pivonkova H,Harantova L,Anderova M,Ferroni S

更新日期：2015-02-01 00:00:00

abstract：:The suitability of isolated central nerve myelin preparations for probe labelling studies was assessed and the accessibility of galactosyl ceramides in myelin to galactose oxidase and sodium periodate was determined. Isolated myelin preparations present a uniform external membrane surface to added probes because lamel...

journal_title：Journal of neurochemistry

authors： Linington C,Rumsby MG

更新日期：1980-10-01 00:00:00

abstract：:Circulating antibody to the bovine white matter proteolipid apoprotein was detected in rabbits 1 month ater a single injection of the water-soluble form of the apoprotein. By double immunodiffusion, the antiserum reacted specifically with the delipidated proteolipid apoprotein and the crude proteolipid fraction contai...

journal_title：Journal of neurochemistry

authors： Macklin WB,Schwarting GA,Lees MB,Cohen SR

更新日期：1981-01-01 00:00:00

abstract：:Our previous studies have implicated perlecan, a specific heparan sulfate proteoglycan, in the pathogenesis of fibrillar beta-amyloid protein (A beta) accumulation and persistence in Alzheimer's disease (AD) brain. In the present investigation, we determined if perlecan mRNA was present in rodent and human brain tissu...

journal_title：Journal of neurochemistry

authors： Maresh GA,Erezyilmaz D,Murry CE,Nochlin D,Snow AD

更新日期：1996-09-01 00:00:00

abstract：:The uptake of amino acids by microvessels isolated from brains of rats was studied. Previous studies have demonstrated alterations in blood-brain amino acid transport after portacaval shunt in rats. In order to elucidate whether such changes in the blood-brain barrier were located in the microvessels, brain microvesse...

journal_title：Journal of neurochemistry

authors： Cardelli-Cangiano P,Cangiano C,James JH,Jeppsson B,Brenner W,Fischer JE

更新日期：1981-02-01 00:00:00

abstract：:Carbamylcholine stimulated phospholipase C activity in astrocytes in primary culture from the mesencephalon but not from the striatum or cerebral cortex of the mouse embryo. An alpha 1-adrenergic-mediated response was observed in all astrocyte populations. 2-Chloroadenosine potentiated the alpha 1-adrenergic response ...

journal_title：Journal of neurochemistry

authors： el-Etr M,Cordier J,Torrens Y,Glowinski J,Prémont J

更新日期：1989-03-01 00:00:00

abstract：:Axonal growth cone motility requires precise regulation of adhesion to navigate the complex environment of the nervous system and reach its target. Myristoylated alanine-rich C kinase substrate (MARCKS) protein is enriched in the developing brain and plays an important, phosphorylation-dependent role in the modulation...

journal_title：Journal of neurochemistry

authors： Sosa LJ,Malter JS,Hu J,Bustos Plonka F,Oksdath M,Nieto Guil AF,Quiroga S,Pfenninger KH

更新日期：2016-06-01 00:00:00

abstract：:Acidosis is a universal response of tissue to ischemia. In the brain, severe acidosis has been linked to worsening of cerebral infarction. However, milder acidosis can have protective effects. As part of our investigations of the therapeutic window in our neuronal tissue culture model of ischemia, we investigated the ...

journal_title：Journal of neurochemistry

authors： Vornov JJ,Thomas AG,Jo D

更新日期：1996-12-01 00:00:00

abstract：:Amylin forms large beta-pleated neurotoxic oligomers but shows only 38% sequence similarity to A beta. As patterns of gene expression during neuronal apoptosis appear stimulus and cell type specific, we compared the pattern of amylin-induced gene expression in rat cortical neurons with that shown previously to be indu...

journal_title：Journal of neurochemistry

authors： Tucker HM,Rydel RE,Wright S,Estus S

更新日期：1998-08-01 00:00:00

abstract：:Each of the known classes of mammalian glycosaminoglycans, with the exception of keratan sulphate, was found in cerebral cortex samples from patients with Alzheimer-type dementia and age-matched controls. These molecules were quantitated, after electrophoresis and staining with Alcian Blue dye, by scanning densitometr...

journal_title：Journal of neurochemistry

authors： Jenkins HG,Bachelard HS

更新日期：1988-11-01 00:00:00

abstract：:The motor signs of Parkinson's disease have been partly attributed to an overinhibition of the external globus pallidus (GP) that results from hyperactivity of striatopallidal GABA/enkephalinergic neurons. The goals of this study were to measure basal levels of extracellular fluid GABA in the GP of normal cats, 1-meth...

journal_title：Journal of neurochemistry

authors： Schroeder JA,Schneider JS

更新日期：2002-08-01 00:00:00

abstract：:Sequence data from key fragments of the P2 protein established the order of cyanogen bromide (CNBr) peptides in the structure of the protein and the primary structure for approximately one-half of the molecule. Data were obtained from the three tryptic peptides of blocked NH2-terminal CNBr peptide (CN3), the large CNB...

journal_title：Journal of neurochemistry

authors： Weise MJ,Hsieh DL,Levit S,Brostoff SW

更新日期：1980-08-01 00:00:00

abstract：:An acid-hydrolyzable conjugate of 3,4-dihydroxyphenylethylamine (dopamine, DA) was detected in superfusates from slices from rat striatum. The concentrations of endogenous free and conjugated DA, and of the acid metabolites (3,4-dihydroxyphenylacetic acid [DOPAC] and homovanillic acid [HVA]) in superfusates were measu...

journal_title：Journal of neurochemistry

authors： Tyce GM,Rorie DK

更新日期：1982-11-01 00:00:00