Multiple molecular forms of acetylcholinesterase in rat vagus nerve, smooth muscle, and heart.

abstract：:Abnormal tau accumulations were observed and documented in post-mortem brains of patients affected by Alzheimer's disease (AD) long before the identification of mutations in the Microtubule-associated protein tau (MAPT) gene, encoding the tau protein, in a different neurodegenerative disease called Frontotemporal deme...

journal_title：Journal of neurochemistry

authors： Hannan SB,Dräger NM,Rasse TM,Voigt A,Jahn TR

更新日期：2016-04-01 00:00:00

abstract：:Post-traumatic immune suppression renders individuals with spinal cord injury (SCI) susceptible to infection. Normally, proper immune function is regulated by collaboration between the sympathetic nervous system (SNS) and hypothalamic-pituitary-adrenal (HPA) axis and involves the controlled release of glucocorticoids ...

journal_title：Journal of neurochemistry

authors： Lucin KM,Sanders VM,Popovich PG

更新日期：2009-09-01 00:00:00

abstract：:Angiotensin (Ang)-converting enzyme (ACE) 2 cleaves Ang-II into the vasodilator peptide Ang-(1-7), thus acting as a pivotal element in balancing the local effects of these peptides. ACE2 has been identified in various tissues and is supposed to be a modulator of cardiovascular function. Decreases in ACE2 expression an...

journal_title：Journal of neurochemistry

authors： Xia H,Lazartigues E

更新日期：2008-12-01 00:00:00

abstract：:Lysophosphatidic acid (LPA) is a potent lipid biomediator that is likely to have diverse roles in the brain. Thus, LPA-induced events in astrocytes were defined. As little as 1 nM LPA induced a rapid increase in the concentration of intracellular free calcium ([Ca2+]i) in astrocytes from neonatal rat brains. This incr...

journal_title：Journal of neurochemistry

authors： Keller JN,Steiner MR,Holtsberg FW,Mattson MP,Steiner SM

更新日期：1997-09-01 00:00:00

abstract：:Astrocytes have important roles in control of extracellular environment, de novo synthesis of neurotransmitters, and regulation of neurotransmission and blood flow. All of these functions require energy, suggesting that astrocytic metabolism should rise and fall with changes in neuronal activity and that brain imaging...

journal_title：Journal of neurochemistry

authors： Dienel GA,Schmidt KC,Cruz NF

更新日期：2007-11-01 00:00:00

abstract：:HNK-1 antibody reactive sulfoglucuronyl carbohydrate (SGC) and SSEA-1 antibody reactive Lewis X (Lex) epitope are expressed on several glycolipids, glycoproteins, and proteoglycans of the nervous system and have been implicated in cell-cell recognition, neurite outgrowth, and/or neuronal migration during development. ...

journal_title：Journal of neurochemistry

authors： Chou DK,Henion TR,Jungalwala FB

更新日期：2003-08-01 00:00:00

abstract：:Long-term ethanol exposure is known to inhibit bradykinin-stimulated phosphoinositide hydrolysis in cultures of neuroblastoma x glioma 108-15 cells. In the present study, [3H]bradykinin binding, GTP-binding protein function, and phospholipase C activity were assayed in cells grown for 4 days in 100 mM ethanol with the...

journal_title：Journal of neurochemistry

authors： Simonsson P,Rodriguez FD,Loman N,Alling C

更新日期：1991-06-01 00:00:00

abstract：:The binding of [3H]5-hydroxytryptamine (5-HT, serotonin) to cerebellar membranes was examined after preincubation of [3H]5-HT in the presence or absence of ascorbate. The tissue preparation was identical in all experiments and consisted of rat cerebellar homogenates in Tris-HCl buffer with 0.1% ascorbate. Cerebellar m...

journal_title：Journal of neurochemistry

authors： Peroutka SJ,Ison PJ,Liu DU,Barrett RW

更新日期：1986-07-01 00:00:00

abstract：:The proportion of major depressive disorder (MDD) patients around the world has increased remarkably. Although many studies of MDD have been conducted based on classic hypotheses, like alteration of the hypothalamic-pituitary-adrenal axis or monoamine neurotransmitters, the mechanisms underlying MDD remain unclear. Ai...

journal_title：Journal of neurochemistry

authors： Xu K,He Y,Chen X,Tian Y,Cheng K,Zhang L,Wang Y,Yang D,Wang H,Wu Z,Li Y,Lan T,Dong Z,Xie P

更新日期：2019-06-01 00:00:00

abstract：:This study demonstrates that in mammalian and nonmammalian species it is possible to deplete selectively and reversibly retinal glycinergic neurons of their content of glycine by exposure to sarcosine, a competitive inhibitor of glycine transporter 1 (glyt-1). This observation was used as a tool to test the hypothesis...

journal_title：Journal of neurochemistry

authors： Pow DV

更新日期：1998-06-01 00:00:00

abstract：:rho(1) GABA(C) receptor antagonists inhibit myopia in chick but the site of this effect is not known. The sclera ultimately determines the shape and size of the globe and thus an untested possibility is that GABA agents have a scleral mechanism. Whether rho(1) GABA(C) receptors are expressed and located in chick scler...

journal_title：Journal of neurochemistry

authors： Cheng ZY,Chebib M,Schmid KL

更新日期：2011-07-01 00:00:00

abstract：:Accumulation of misfolded proteins and alterations in the ubiquitin-proteasome pathway are associated with various neurodegenerative conditions of the CNS and PNS. Aggregates containing ubiquitin and peripheral myelin protein 22 (PMP22) have been observed in the Trembler J mouse model of Charcot-Marie-Tooth disease ty...

journal_title：Journal of neurochemistry

authors： Fortun J,Li J,Go J,Fenstermaker A,Fletcher BS,Notterpek L

更新日期：2005-03-01 00:00:00

abstract：:One-week treatment with the benzodiazepine (BZ) flurazepam (FZP), results in anticonvulsant tolerance, associated with reduced GABAA receptor (GABAR) subunit protein and miniature inhibitory post-synaptic current (mIPSC) amplitude in CA1 neurons of rat hippocampus. Because protein kinase A (PKA) has been shown to modu...

journal_title：Journal of neurochemistry

authors： Lilly SM,Zeng XJ,Tietz EI

更新日期：2003-05-01 00:00:00

abstract：:Monoclonal antibodies were raised against the synaptosomal plasma membranes (SPMs) purified from the electric organ of the Torpedo. One antibody that reacts preferentially with SPMs rather than with other membrane fractions isolated from this tissue was previously found to inhibit hydrophilic and amphiphilic choline-O...

journal_title：Journal of neurochemistry

authors： Eder-Colli L,Briand PA,Pellegrinelli N,Dunant Y

更新日期：1989-11-01 00:00:00

abstract：:Huntington's disease is a progressive neurodegenerative disorder caused by a CAG trinucleotide repeat expansion in the huntingtin gene. This expansion produces a mutant form of the huntingtin protein, which contains an elongated polyglutamine stretch at its amino-terminus. Mutant huntingtin may adopt an aberrant, aggr...

journal_title：Journal of neurochemistry

authors： Roscic A,Baldo B,Crochemore C,Marcellin D,Paganetti P

更新日期：2011-10-01 00:00:00

abstract：:At 0 degrees C, when Na+ was the only cation present in the incubation medium, increasing the Na+ concentration from 3 to 10 mM enhanced the affinity of [3H]1-[2-(++di-phenylmethoxy)ethyl]-4-(3-phenyl-2-propenyl)piperaz ine [( 3H]GBR 12783) for the specific binding site present in rat striatal membranes without affect...

journal_title：Journal of neurochemistry

authors： Bonnet JJ,Benmansour S,Vaugeois JM,Costentin J

更新日期：1988-03-01 00:00:00

abstract：:We demonstrated that glutamate increased the cyclic AMP level in cultured neurons from rat spinal cord. A bath application of glutamate (300 microM) elicited a rapid increase of the cyclic AMP concentration reaching a level three times as high as the basal level in approximately 3 min, and its content then decreased t...

journal_title：Journal of neurochemistry

authors： Tsuji K,Nakamura Y,Ogata T,Shibata T,Kataoka K

更新日期：1995-10-01 00:00:00

abstract：:Environmental stress can interact with genetic predisposition to increase the risk of developing psychopathology. In this work, we tested the hypothesis that social isolation stress interacts with impaired glutathione synthesis and have cumulative effects on the neurochemical profile of the frontal cortex. A mouse mod...

journal_title：Journal of neurochemistry

authors： Corcoba A,Gruetter R,Do KQ,Duarte JMN

更新日期：2017-09-01 00:00:00

abstract：:Intracerebral administration of [3H]arachidonic acid ([3H]ArA) into 19-20-day-old rat embryos, resulted in a rapid incorporation of label into brain lipids. One hour after injection, 55.6 +/- 8.2, 18.0 +/- 3.4, and 13.7 +/- 1.3% of the total radioactivity was associated with phosphatidylcholine, phosphatidylinositol, ...

journal_title：Journal of neurochemistry

authors： Kunievsky B,Bazan NG,Yavin E

更新日期：1992-11-01 00:00:00

abstract：:Vinblastine causes alterations in the subcellular distribution of certain proteins synthesized by telencephalon slices. Proteins in various subcellular fractions were separated according to their molecular weight by sodium dodecyl sulfate-polyacrylamide gel electrophoresis, and radioactive proteins were determined by ...

journal_title：Journal of neurochemistry

authors： White FP

更新日期：1980-07-01 00:00:00

abstract：:U-78518F, a 21-aminosteroid from the novel family of lipid peroxidation inhibitors (lazaroids), increased survival of dopamine (DA) neurons in mesencephalic cell cultures incubated with the neurotoxin 1-methyl-4-phenylpyridinium (MPP+). Protection against DA neuron death occurred with increasing concentrations of U-78...

journal_title：Journal of neurochemistry

authors： Sanchez-Ramos JR,Song S,Mash DC,Weiner WJ

更新日期：1992-01-01 00:00:00

abstract：:Apoptotic cell death has been proposed to play a role in the neuronal loss observed following traumatic injury in the CNS and PNS. The present study uses an in vitro tissue culture model to investigate whether free fatty acids (FFAs), at concentrations comparable to those found following traumatic brain injury, trigge...

journal_title：Journal of neurochemistry

authors： Ulloth JE,Casiano CA,De Leon M

更新日期：2003-02-01 00:00:00

abstract：:Glutamate is the major excitatory transmitter in the vertebrate brain and its extracellular levels are tightly regulated to prevent excitotoxic effects. The Na(+)-dependent glutamate/aspartate transporter GLAST/EAAT1 is regulated in the short and in the long term by glutamate. A receptors-independent change in its mem...

journal_title：Journal of neurochemistry

authors： Rosas S,Vargas MA,López-Bayghen E,Ortega A

更新日期：2007-05-01 00:00:00

abstract：:Calcitonin gene-related peptide-like immunoreactivity (CGRP-LI) was measured in selected regions of the cervical, thoracic, and lumbar spinal cord of untreated rabbits and, following intrathecal injection of the serotonergic neurotoxin 5,7-dihydroxytryptamine (5,7-DHT), in the thoracolumbar cord in rats using a sheep ...

journal_title：Journal of neurochemistry

authors： Fone KC

更新日期：1992-10-01 00:00:00

abstract：:The blood-brain barrier (BBB) and blood-spinal cord barrier (BSCB) are highly specialized structures that limit molecule entry from the blood and maintain homeostasis within the central nervous system (CNS). BBB and BSCB breakdown are associated with multiple neurodegenerative diseases. Given the key role of neuroprot...

journal_title：Journal of neurochemistry

authors： Kumar V,Lee JD,Coulson EJ,Woodruff TM

更新日期：2020-07-06 00:00:00

abstract：:We have assessed the expression, molecular identification and functional role of Na+ channels (Na(v)) in carotid bodies (CB) obtained from normoxic and chronically hypoxic adult rats. Veratridine evoked release of catecholamines (CA) from an in vitro preparation of intact CBs obtained from normoxic animals, the respon...

journal_title：Journal of neurochemistry

authors： Caceres AI,Obeso A,Gonzalez C,Rocher A

更新日期：2007-07-01 00:00:00

abstract：:beta-Adrenergic receptor subtypes, beta 1 and beta 2, were studied during pre- and postnatal development in the rat brain. [125I]Iodocyanopindolol (6-300 pmol/L) binding assays in the presence of 5-hydroxytryptamine (0.6-6 mumol/L) were used to measure exclusively beta-adrenergic receptors. In forebrain tissue, satura...

journal_title：Journal of neurochemistry

authors： Erdtsieck-Ernste BH,Feenstra MG,Boer GJ

更新日期：1991-09-01 00:00:00

abstract：:The C57BL/Ola (Ola) mouse is a mutant substrain in which transected axons undergo very slow Wallerian degeneration. Because axonal degradation during Wallerian degeneration is calcium dependent, we tested whether Ola axons are susceptible to calcium-mediated axonal degeneration by comparing neurofilament degradation b...

journal_title：Journal of neurochemistry

authors： Glass JD,Schryer BL,Griffin JW

更新日期：1994-06-01 00:00:00

abstract：:Exposure to excessive levels of light induces photoreceptor apoptosis and can be a causative factor in age-related macular degeneration (AMD). However, the cellular events that mediate this apoptotic response are poorly understood. Here, we investigated the roles of endoplasmic reticulum (ER) stress in light-induced c...

journal_title：Journal of neurochemistry

authors： Nakanishi T,Shimazawa M,Sugitani S,Kudo T,Imai S,Inokuchi Y,Tsuruma K,Hara H

更新日期：2013-04-01 00:00:00

abstract：:Parkinson's disease is a neurodegenerative movement disorder. The histopathology of Parkinson's disease comprises proteinaceous inclusions known as Lewy bodies, which contains aggregated α-synuclein. Cathepsin D (CD) is a lysosomal protease previously demonstrated to cleave α-synuclein and decrease its toxicity in bot...

journal_title：Journal of neurochemistry

authors： Crabtree D,Dodson M,Ouyang X,Boyer-Guittaut M,Liang Q,Ballestas ME,Fineberg N,Zhang J

更新日期：2014-03-01 00:00:00