Calcium-mediated degeneration of the axonal cytoskeleton in the Ola mouse.

abstract：:N-Copine is a novel protein with two C2 domains. Its expression is brain specific and up-regulated by neuronal activity such as kainate stimulation and tetanus stimulation evoking hippocampal CA1 long-term potentiation. We examined the localization and subcellular distribution of N-copine in mouse brain. In situ hybri...

journal_title：Journal of neurochemistry

authors： Nakayama T,Yaoi T,Kuwajima G

更新日期：1999-01-01 00:00:00

abstract：:Dp71 has an important role in the central nervous system. To better understand the function of Dp71 domains in neuronal differentiation, PC12 cells were stably transfected with a dystrophin mutant, Dp71Δ(78-79) , which lacks exons 78 and 79. Based on the percentage of cells bearing neurites and neurite length analyses...

journal_title：Journal of neurochemistry

authors： Aragón J,Romo-Yáñez J,Martínez-Herrera A,Ceja V,Rendon A,Montañez C

更新日期：2011-11-01 00:00:00

abstract：:The nerve growth factor (NGF) precursor, proNGF, is implicated in various neuropathological states. ProNGF signals apoptosis by forming a complex with the receptors p75 and sortilin, however, it can also induce neurite growth, proposed to be mediated by the receptor of mature NGF, tyrosine kinase receptor A (TrkA). Th...

journal_title：Journal of neurochemistry

authors： Kalous A,Nangle MR,Anastasia A,Hempstead BL,Keast JR

更新日期：2012-08-01 00:00:00

abstract：:Clinical and experimental data indicate that spinal cord injury (SCI) elicits pathological T-cell responses. Implicit in these data, but poorly understood, is that B lymphocytes (B cells) also contribute to the delayed pathophysiology of spinal trauma. Here, for the first time, we show that experimental spinal contusi...

journal_title：Journal of neurochemistry

authors： Ankeny DP,Lucin KM,Sanders VM,McGaughy VM,Popovich PG

更新日期：2006-11-01 00:00:00

abstract：:The rat pheochromocytoma PC12 cell line has been an invaluable model system for studying neuritogenesis. Nerve growth factor (NGF) elicits multiple aspects of neurite outgrowth in PC12 cells. It is therefore difficult to dissect and assign an individual signaling pathway to each stage of neuritogenesis. We have recent...

journal_title：Journal of neurochemistry

authors： Xiao J,Liu Y

更新日期：2003-09-01 00:00:00

abstract：:Regulator of G protein signaling (RGS) proteins are GTPase-activating proteins that modulate neurotransmitter and G protein signaling. RGS7 and its binding partners Galpha and Gbeta5 are enriched in brain, but biochemical mechanisms governing RGS7/Galpha/Gbeta5 interactions and membrane association are poorly defined....

journal_title：Journal of neurochemistry

authors： Rose JJ,Taylor JB,Shi J,Cockett MI,Jones PG,Hepler JR

更新日期：2000-11-01 00:00:00

abstract：:The expression of inducible nitric oxide synthase (NOS2) in glial cells is inhibited by neurotransmitters such as norepinephrine (NE) which elevate cAMP levels. We examined the molecular basis for this effect using a 2.2-kb fragment of the rat NOS2 promoter transfected into rat C6 glioma cells. Promoter activation (up...

journal_title：Journal of neurochemistry

authors： Gavrilyuk V,Horvath P,Weinberg G,Feinstein DL

更新日期：2001-07-01 00:00:00

abstract：:Cyclosporin A (CsA) is a clinically important immunosuppressive drug widely used to prevent graft rejection following organ or bone marrow transplantation. Although there are reports of serious neurologic alterations associated with the use of the drug, the precise mechanism of its action on the CNS still remains unkn...

journal_title：Journal of neurochemistry

authors： Mosieniak G,Figiel I,Kaminska B

更新日期：1997-03-01 00:00:00

abstract：:A diverse group of neurodegenerative diseases - including progressive supranuclear palsy (PSP), corticobasal degeneration and Alzheimer's disease among others, collectively referred to as tauopathies - are characterized by progressive, age-dependent intracellular formations of misfolded protein aggregates that play ke...

journal_title：Journal of neurochemistry

authors： Pasinetti GM,Ksiezak-Reding H,Santa-Maria I,Wang J,Ho L

更新日期：2010-09-01 00:00:00

abstract：:The effect of inhibition and down-regulation of protein kinase C (PKC) subtypes alpha, epsilon, and zeta on noradrenaline (NA) secretion from human SH-SY5Y neuroblastoma cells was investigated. The PKC inhibitor Ro 31-7549 inhibited carbachol-evoked NA release (IC(50) 0.6 microM) but not 100 mM (K+)-evoked release. In...

journal_title：Journal of neurochemistry

authors： Turner NA,Walker JH,Ball SG,Vaughan PF

更新日期：1996-06-01 00:00:00

abstract：:Proteasomal dysfunction has been recently implicated in the pathogenesis of several neurodegenerative diseases, including Parkinson's disease and diffuse Lewy body disease. We have developed an in vitro model of proteasomal dysfunction by applying pharmacological inhibitors of the proteasome, lactacystin or ZIE[O-tBu]...

journal_title：Journal of neurochemistry

authors： Rideout HJ,Larsen KE,Sulzer D,Stefanis L

更新日期：2001-08-01 00:00:00

abstract：:Primary cultures of astrocytes from newborn rat brain showed evidence of a substrate-saturable process for glucose transport. The system shows a relatively high affinity for the substrate, with an apparent Km of approximately 1 mM. Maintenance of the cells in medium containing thyroid-hormone-free serum for 3, 6, or 9...

journal_title：Journal of neurochemistry

authors： Roeder LM,Williams IB,Tildon JT

更新日期：1985-11-01 00:00:00

abstract：:Protein aggregation into amyloid fibrils is a key feature of a multitude of neurodegenerative diseases such as Alzheimer's, Parkinson's, and Prion disease. To detect amyloid fibrils, fluorophores with high sensitivity and better efficiency coupled with the low toxicity are in high demand even to date. In this pursuit,...

journal_title：Journal of neurochemistry

authors： Pravin N,Kumar R,Tripathi S,Kumar P,Mohite GM,Navalkar A,Panigrahi R,Singh N,Gadhe LG,Manchanda S,Shimozawa M,Nilsson P,Johansson J,Kumar A,Maji SK,Shanmugam M

更新日期：2020-08-04 00:00:00

abstract：:G protein-coupled receptors are important regulators of cellular signaling processes. Within the large family of rhodopsin-like receptors, those binding to biogenic amines form a discrete subgroup. Activation of biogenic amine receptors leads to transient changes of intracellular Ca²⁺-([Ca²⁺](i)) or 3',5'-cyclic adeno...

journal_title：Journal of neurochemistry

authors： Balfanz S,Jordan N,Langenstück T,Breuer J,Bergmeier V,Baumann A

更新日期：2014-04-01 00:00:00

abstract：:Chick pineal glands in organ culture showed a circadian rhythm in the rate of thymidine incorporation. Thymidine incorporation was very markedly inhibited when 3-isobutyl-l-methylxanthine (IBMX) was continuously present. When IBMX was added to cultures in control medium during the photoperiod of the second day in cult...

journal_title：Journal of neurochemistry

authors： Wainwright SD,Wainwright LK

更新日期：1991-05-01 00:00:00

abstract：:For a long time, prolyl endopeptidase (PEP) was believed to inactivate neuropeptides in the extracellular space. However, reports on the intracellular activity of PEP suggest additional, as yet unidentified, physiological functions for this enzyme. Here, we demonstrate using biochemical methods of subcellular fraction...

journal_title：Journal of neurochemistry

authors： Schulz I,Zeitschel U,Rudolph T,Ruiz-Carrillo D,Rahfeld JU,Gerhartz B,Bigl V,Demuth HU,Rossner S

更新日期：2005-08-01 00:00:00

abstract：:We applied a differential display PCR technique to isolate molecules that are area-specific in expression in the primate neocortex, and found that growth/differentiation factor 7 (GDF7), a member of the bone morphogenetic protein (BMP)/transforming growth factor (TGF) beta super-family, is preferentially expressed in ...

journal_title：Journal of neurochemistry

authors： Watakabe A,Fujita H,Hayashi M,Yamamori T

更新日期：2001-03-01 00:00:00

abstract：:In PC12 cells, preincubated with [3H]inositol, nerve growth factor (NGF) stimulated an approximately 100% increase in the levels of [3H]inositol 1,3,4-trisphosphate ([3H]-Ins(1,3,4)P3], [3H]inositol 1,4,5-trisphosphate ([3H]Ins(1,4,5)P3], and [3H]inositol 1,3,4,5-tetrakisphosphate ([3H]Ins(1,3,4,5)P4] as early as 5-15...

journal_title：Journal of neurochemistry

authors： Contreras ML

更新日期：1993-09-01 00:00:00

abstract：:Studies on glial cultures have demonstrated that fetal bovine serum contains a factor that induces bipotential glial precursors known as oligodendrocyte-type 2 astrocyte (O-2A) progenitors to become type 2 astroglia rather than oligodendroglia. The goal of this research project was to characterize and purify this fact...

journal_title：Journal of neurochemistry

authors： Levison SW,McCarthy KD

更新日期：1991-09-01 00:00:00

abstract：:We have demonstrated by indirect immunofluorescence the cellular localization of a monoclonal antibody (mAb 224-58), produced after immunization of a mouse with human central nervous system (CNS) myelin. Serologically, mAb 224-58 was found to be specific for 3'-sulfomonogalactosylglycolipids, namely 3'-sulfogalactosyl...

journal_title：Journal of neurochemistry

authors： Guerci A,Monge M,Baron-Van Evercooren A,Lubetzki C,Dancea S,Boutry JM,Goujet-Zalc C,Zalc B

更新日期：1986-02-01 00:00:00

abstract：:Nitric oxide (NO) is a key neuromodulator of corticostriatal synaptic transmission. We have shown previously that dopamine (DA) D1/5 receptor stimulation facilitates neuronal NO synthase (nNOS) activity in the intact striatum. To study the impact of local manipulations of D1/5 and glutamatergic NMDA receptors on stria...

journal_title：Journal of neurochemistry

authors： Park DJ,West AR

更新日期：2009-12-01 00:00:00

abstract：:The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor activated by dioxin and polyaromatic hydrocarbons. Recent studies have revealed that AhR activity in central neurons depends on the NMDA receptor. In this study, we investigated how the neuronal activity influence AhR-mediated dioxin-respon...

journal_title：Journal of neurochemistry

authors： Lin CH,Juan SH,Wang CY,Sun YY,Chou CM,Chang SF,Hu SY,Lee WS,Lee YH

更新日期：2008-03-01 00:00:00

abstract：:During development, dynamic changes in the axonal growth cone and dendrite are necessary for exploratory movements underlying initial axo-dendritic contact and ultimately the formation of a functional synapse. In the adult central nervous system, an impressive degree of plasticity is retained through morphological and...

journal_title：Journal of neurochemistry

authors： Gordon-Weeks PR,Fournier AE

更新日期：2014-04-01 00:00:00

abstract：:Progressive supranuclear palsy (PSP) is a neurodegenerative movement disorder of unknown etiology. We hypothesized that mitochondrial DNA (mtDNA) aberration could occur in this disease and contribute to its pathogenesis. To address this we created transmitochondrial cytoplasmic hybrid (cybrid) cell lines expressing mi...

journal_title：Journal of neurochemistry

authors： Swerdlow RH,Golbe LI,Parks JK,Cassarino DS,Binder DR,Grawey AE,Litvan I,Bennett JP Jr,Wooten GF,Parker WD

更新日期：2000-10-01 00:00:00

abstract：:Rat retina tissue contains relatively high amounts of GD3 in relation to ganglio-series gangliosides even in the adult stages. This was attributed in part to an activity ratio between the enzyme that converts GM3 to GD3 [sialytransferase II (ST-II)] and the enzyme that converts GM3 to GM2 [N-acetylgalactosaminyltransf...

journal_title：Journal of neurochemistry

authors： Martina JA,Daniotti JL,Maccioni HJ

更新日期：1995-03-01 00:00:00

abstract：:The relationships between presynaptic acetylcholinesterase (AChE) and high-affinity choline uptake (HACU) were investigated using a monolayer of rat cortex synaptosomes in superfusion conditions. The following sets of experiments were performed: determination of [3H]choline ([3H]Ch) uptake during superfusion with [3H]...

journal_title：Journal of neurochemistry

authors： Raiteri M,Marchi M,Caviglia AM

更新日期：1986-12-01 00:00:00

abstract：:Peroxynitrite, the product of the radical-radical reaction between nitric oxide and superoxide anion, is a potent oxidant involved in tissue damage in neurodegenerative disorders. We investigated the modifications induced by peroxynitrite in tyrosine residues of proteins from synaptosomes. Peroxynitrite treatment (> o...

journal_title：Journal of neurochemistry

authors： Di Stasi AM,Mallozzi C,Macchia G,Petrucci TC,Minetti M

更新日期：1999-08-01 00:00:00

abstract：:A rapid and simple chromatographic procedure using HPLC with electrochemical detection is described for simultaneous determination of the substrates from precursor amino acids to metabolites related to synthesis and metabolism of three monoamine neurotransmitters--norepinephrine (NE), dopamine (DA), and 5-hydroxytrypt...

journal_title：Journal of neurochemistry

authors： Murai S,Saito H,Masuda Y,Itoh T

更新日期：1988-02-01 00:00:00

abstract：:Gliosis is commonly observed in the CNS following tissue damage, and it also occurs in aging and in many neurodegenerative diseases. Glial fibrillary acidic protein (GFAP) accumulation is a prominent feature of astrocytic gliosis. An inhibition or delay in GFAP synthesis could mitigate scar formation and thus reduce t...

journal_title：Journal of neurochemistry

authors： Li XM,Qi J,Juorio AV,Boulton AA

更新日期：1993-10-01 00:00:00

abstract：:Rat glioma X mouse neuroblastoma hybrid neurotumor cells (NG108-15), synchronized by amino acid deprivation, showed a cell-cycle-dependent peak of activity of a ganglioside N-acetylgalactosaminyl transferase 14-24 h following release from the cell cycle block (S/G2 phase). Maximal expression of two typical lysosomal h...

journal_title：Journal of neurochemistry

authors： Scheideler MA,Lockney MW,Dawson G

更新日期：1984-04-01 00:00:00