Glucose transport in astrocytes: regulation by thyroid hormone.

abstract：:The isolation, characterization, and bioactivity in the feeding circuitry of a novel neuropeptide in the Aplysia californica central nervous system are reported. The 17-residue amidated peptide, NGGTADALYNLPDLEKIamide, has been termed cerebrin due to its primary location in the cerebral ganglion. Liquid chromatographi...

journal_title：Journal of neurochemistry

authors： Li L,Floyd PD,Rubakhin SS,Romanova EV,Jing J,Alexeeva VY,Dembrow NC,Weiss KR,Vilim FS,Sweedler JV

更新日期：2001-06-01 00:00:00

abstract：:Using optical imaging of retinal ganglion cell (RGC) calcium dynamics in living intact retinal wholemount preparations, we tested whether RGCs in an experimental rat glaucoma model were more sensitive to exogenously applied glutamate as a result of deficient glutamate clearance mechanisms. In contrast to post-natal ra...

journal_title：Journal of neurochemistry

authors： Hartwick AT,Zhang X,Chauhan BC,Baldridge WH

更新日期：2005-08-01 00:00:00

abstract：:Previous work from this laboratory has shown that in PC12 cells the phosphorylation of a specific soluble protein is decreased by nerve growth factor treatment. The protein, designated Nsp100, and its kinase have been separated and partially purified from PC12 cells. In the present work, the tissue distribution of Nsp...

journal_title：Journal of neurochemistry

authors： Hama T,Guroff G

更新日期：1985-10-01 00:00:00

abstract：:In the central nervous system, astrocytes extend endfoot processes to ensheath synapses and microvessels. However, the mechanisms underlying this astrocytic process extension remain unclear. A limitation of the use of 2D cultured astrocytes for such studies is that they display a flat, epithelioid morphology, with no ...

journal_title：Journal of neurochemistry

authors： Sato J,Horibe S,Kawauchi S,Sasaki N,Hirata KI,Rikitake Y

更新日期：2018-11-01 00:00:00

abstract：:The specific opioid receptor antagonist naloxone attenuates the behavioral and neurochemical effects of amphetamine. Furthermore, the amphetamine-induced increase in locomotor activity is attenuated by intracisternally administered naltrindole, a selective delta-opioid receptor antagonist, but not by the irreversible ...

journal_title：Journal of neurochemistry

authors： Schad CA,Justice JB Jr,Holtzman SG

更新日期：1996-12-01 00:00:00

abstract：:Transforming growth factor-beta1 (TGF-beta1) has central functions in development, tissue maintenance, and repair and has been implicated in major diseases. We discovered that TGF-beta1 contains several amphipathic helices and hydrophobic domains similar to apolipoprotein E (apoE), a protein involved in lipoprotein me...

journal_title：Journal of neurochemistry

authors： Tesseur I,Zhang H,Brecht W,Corn J,Gong JS,Yanagisawa K,Michikawa M,Weisgraber K,Huang Y,Wyss-Coray T

更新日期：2009-08-01 00:00:00

abstract：:SH-SY5Y neural cells expressing mu- and delta-opioid receptors were maintained viable in isotonic, sodium-free buffer in vitro. Intracellular sodium levels were manipulated by various methods, and ligand binding to intact cells was studied. In physiological buffer containing 118 mM sodium, [3H]Tyr-D-Ala-Gly-(Me)Phe-Gl...

journal_title：Journal of neurochemistry

authors： Yabaluri N,Medzihradsky F

更新日期：1997-03-01 00:00:00

abstract：:The kinetics of the reactions of nine opioid peptides with the neutral endopeptidase ("enkephalinase") activities of human kidney, rat kidney, and rat brain have been determined. These opioid peptides can be divided into two classes, those that are good inhibitors of Leu5-enkephalin hydrolysis (Ki less than 75 microM)...

journal_title：Journal of neurochemistry

authors： Hersh LB

更新日期：1984-08-01 00:00:00

abstract：:To better understand metabotropic/ionotropic integration in neurons we have examined the regulation of M1 muscarinic acetylcholine (mACh) receptor signalling in mature (> 14 days in vitro), synaptically-active hippocampal neurons in culture. Using a protocol where neurons are exposed to an EC(50) concentration of the ...

journal_title：Journal of neurochemistry

authors： Willets JM,Nelson CP,Nahorski SR,Challiss RA

更新日期：2007-12-01 00:00:00

abstract：:The turnover of acetylcholine (ACh) in rat brain synaptosomes and its compartmentation in the labile bound and stable bound pools were investigated. The P(2) fraction from rat brain was subjected to three sequential incubations, each terminated by centrifugation followed by determination of ACh concentrations by gas c...

journal_title：Journal of neurochemistry

authors： Jope RS

更新日期：1981-05-01 00:00:00

abstract：:The potential anxiolytic effects of a novel positive allosteric modulator (PAM) of the metabotropic glutamate receptor subgroup 2 (mGluR₂) were investigated using a self-referencing recording technique with enzyme-based microelectrode arrays (MEAs) that reliably measures tonic and phasic changes in extracellular gluta...

journal_title：Journal of neurochemistry

authors： Hascup ER,Hascup KN,Pomerleau F,Huettl P,Hajos-Korcsok E,Kehr J,Gerhardt GA

更新日期：2012-08-01 00:00:00

abstract：:Altered aquaporin-4 (AQP4) expression has been reported in brain edema, tumors, muscular dystrophy, and neuromyelitis optica. However, the plasma membrane organization of AQP4 and its interaction with proteins such as the dystrophin-associated protein complex are not well understood. In this study, we used sucrose den...

journal_title：Journal of neurochemistry

authors： Nicchia GP,Cogotzi L,Rossi A,Basco D,Brancaccio A,Svelto M,Frigeri A

更新日期：2008-06-01 00:00:00

abstract：:beta-Amyloid peptides (Abeta40 and Abeta42) are the major constituents of amyloid plaques, which are one of the hallmarks of Alzheimer's disease (AD). The Abeta is derived from sequential cleavages of amyloid precursor protein (APP) by beta- and gamma-secretases. gamma-Secretase consists of at least four proteins wher...

journal_title：Journal of neurochemistry

authors： Lai MT,Crouthamel MC,DiMuzio J,Pietrak BL,Donoviel DB,Bernstein A,Gardell SJ,Li YM,Hazuda D

更新日期：2006-01-01 00:00:00

abstract：:Voltage-gated sodium channels (VGSC) are involved in the generation of action potentials in neurons. Brevetoxins (PbTx) are potent allosteric enhancers of VGSC function and are associated with the periodic 'red tide' blooms. Using PbTx-2 as a probe, we have characterized the effects of activation of VGSC on Ca(2+) dyn...

journal_title：Journal of neurochemistry

authors： Dravid SM,Baden DG,Murray TF

更新日期：2004-05-01 00:00:00

abstract：:OPA1, a nuclear encoded mitochondrial protein causing autosomal dominant optic atrophy, is a key player in mitochondrial fusion and cristae morphology regulation. In the present study, we have compared the OPA1 transcription and translation products of different mouse tissues. Unlike in humans, we found only two exons...

journal_title：Journal of neurochemistry

authors： Akepati VR,Müller EC,Otto A,Strauss HM,Portwich M,Alexander C

更新日期：2008-07-01 00:00:00

abstract：:The ubiquitous polyamines spermidine and spermine are known as modulators of glutamate receptors and inwardly rectifying potassium channels. They are synthesized by a set of specific enzymes in which spermidine synthase is the rate-limiting step catalysing the formation of the spermine precursor spermidine from putres...

journal_title：Journal of neurochemistry

authors： Krauss M,Langnaese K,Richter K,Brunk I,Wieske M,Ahnert-Hilger G,Veh RW,Laube G

更新日期：2006-04-01 00:00:00

abstract：:For nearly 100 years following the first description of this neurological disorder by Dr Alois Alzheimer, amyloid plaques and neurofibrillary tangles have been hypothesized to cause neuronal loss. With evidence that the extent of insoluble, deposited amyloid poorly correlated with cognitive impairment, research effort...

journal_title：Journal of neurochemistry

authors： Larson ME,Lesné SE

更新日期：2012-01-01 00:00:00

abstract：:This study examined the respective influences of cannabinoid type-1 (CB1) receptors expressed either in forebrain GABAergic neurons, in cortical glutamatergic neurons, or in astrocytes on the turnover rates of the endocannabinoids N-arachidonoylethanolamide (AEA) and 2-arachidonoylglycerol (2-AG), and the non-cannabin...

journal_title：Journal of neurochemistry

authors： Belluomo I,Matias I,Pernègre C,Marsicano G,Chaouloff F

更新日期：2015-04-01 00:00:00

abstract：:The effects of hypoxia and hypoglycaemia on the redox state in vitro have been studied. NADH and NAD+ were extracted simultaneously from superfused cerebral cortex slices and assayed by bioluminescence. The results show a nonsignificant increase in NADH and the redox ratio in "mild hypoxia," whereas "severe hypoxia" p...

journal_title：Journal of neurochemistry

authors： Garofalo O,Cox DW,Bachelard HS

更新日期：1988-07-01 00:00:00

abstract：:alpha-Synuclein has been identified as a component of Lewy bodies in Parkinson's disease and diffuse Lewy body disease, and glial cytoplasmic inclusions (GCIs) in multiple system atrophy (MSA). To explore the role of alpha-synuclein in the pathogenesis, we searched for molecules interacting with alpha-synuclein and di...

journal_title：Journal of neurochemistry

authors： Iwata A,Miura S,Kanazawa I,Sawada M,Nukina N

更新日期：2001-04-01 00:00:00

abstract：:This study evaluated the developmental gene and protein expression of proton-coupled oligopeptide transporters (POTs: peptide transporter, PepT1 and PepT2; peptide-histidine transporter, PhT1 and PhT2) in different regions of rodent brain, and the age-dependent uptake of a POT substrate, glycylsarcosine (GlySar), in b...

journal_title：Journal of neurochemistry

authors： Hu Y,Xie Y,Keep RF,Smith DE

更新日期：2014-06-01 00:00:00

abstract：:Alzheimer's amyloid beta-protein (Abeta) has been reported to potentiate glutamate toxicity in neurons, but very little is known about interaction between Abeta and glutamate in astrocytes. Therefore, in the present study, we investigated the effects of Abeta and glutamate on morphology of astrocytes. Cultured rat cor...

journal_title：Journal of neurochemistry

authors： Abe K,Saito H

更新日期：2000-01-01 00:00:00

abstract：:Developmental profiles were determined for the activities of eight enzymes involved in fatty acid beta-oxidation in rat brain. The enzymes studied were the palmitoyl-CoA, octanoyl-CoA, butyryl-CoA, glutaryl-CoA, and 3-hydroxyacyl-CoA dehydrogenases, the enoyl-CoA hydratase (crotonase), and the C4- and C10-thiolases. W...

journal_title：Journal of neurochemistry

authors： Reichmann H,Maltese WA,DeVivo DC

更新日期：1988-08-01 00:00:00

abstract：:Rat cerebral cortex synaptosomes were exposed in superfusion to various depolarizing stimuli and the release of somatostatin-like immunoreactivity (SRIF-LI) was measured by means of a radioimmunoassay procedure. High KCl (9-50 mM) concentration dependently evoked SRIF-LI release; the evoked overflow reached a plateau ...

journal_title：Journal of neurochemistry

authors： Bonanno G,Parodi B,Cafaggi S,Raiteri M

更新日期：1991-10-01 00:00:00

abstract：:Declining levels of estrogen in women result in increases in gonadotropins such as luteinizing hormone (LH) through loss of feedback inhibition. LH, like estrogen, is modulated by hormone replacement therapy. However, the role of post-menopausal gonadotropin increases on cognition has not been evaluated. Here, we demo...

journal_title：Journal of neurochemistry

authors： Bryan KJ,Mudd JC,Richardson SL,Chang J,Lee HG,Zhu X,Smith MA,Casadesus G

更新日期：2010-02-01 00:00:00

abstract：:From immunizations of mice with a glutathione S-transferase fusion protein containing residues 724-781 of the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor subunit GluR1-flop, two monoclonal antibodies (mAbs) were developed that differed widely in their ranges of specificity. In immunocytochemical ...

journal_title：Journal of neurochemistry

authors： Tönnes J,Stierli B,Cerletti C,Behrmann JT,Molnár E,Streit P

更新日期：1999-11-01 00:00:00

abstract：:The effect of Gi/o protein-coupled receptors on adenylyl cyclase type 2 (AC2) has been studied in Sf9 insect cells. Stimulation of cells expressing AC2 with the phorbol ester 12-O-tetradecanoyl phorbol-13-acetate (TPA) led to a twofold stimulation of cAMP synthesis that could be blocked with the protein kinase C inhib...

journal_title：Journal of neurochemistry

authors： Näsman J,Kukkonen JP,Holmqvist T,Akerman KE

更新日期：2002-12-01 00:00:00

abstract：:p-glycoprotein (p-gp) is an ATP-binding cassette transporter and its overexpression is responsible for the acquisition of the multidrug resistance phenotype in human tumors. p-gp is localized at the blood-brain barrier and is involved in brain cytoprotection. Our previous work used immunoprecipitation to show that cav...

journal_title：Journal of neurochemistry

authors： Barakat S,Demeule M,Pilorget A,Régina A,Gingras D,Baggetto LG,Béliveau R

更新日期：2007-04-01 00:00:00

abstract：:The release of preaccumulated gamma-amino[3H]butyric acid ([3H]GABA) from putative GABAergic amacrine cells was studied in neuronal monolayer cultures made from embryonic chick retina. Release was specifically stimulated by excitatory amino acid agonists. N-Methyl-D-aspartate (NMDA; EC50, 19.1 +/- 5.0 microM), kainic ...

journal_title：Journal of neurochemistry

authors： Hofmann HD,Möckel V

更新日期：1991-03-01 00:00:00

abstract：:Androgens affect cognitive processes in both humans and animals. The effects of androgens may be limited to certain cognitive domains, specifically spatial memory, but this hypothesis remains elusive. Here, we tested castrated and sham-operated mice in various behavioral tasks to ask whether androgens affect multiple ...

journal_title：Journal of neurochemistry

authors： Benice TS,Raber J

更新日期：2009-08-01 00:00:00