Uptake of amino acids by brain microvessels isolated from rats after portacaval anastomosis.

abstract：:Exposure to excessive levels of light induces photoreceptor apoptosis and can be a causative factor in age-related macular degeneration (AMD). However, the cellular events that mediate this apoptotic response are poorly understood. Here, we investigated the roles of endoplasmic reticulum (ER) stress in light-induced c...

journal_title：Journal of neurochemistry

authors： Nakanishi T,Shimazawa M,Sugitani S,Kudo T,Imai S,Inokuchi Y,Tsuruma K,Hara H

更新日期：2013-04-01 00:00:00

abstract：:Limited information is available on the identity of antigens targeted by antibodies present in cerebrospinal fluid (CSF) of patients with clinically isolated syndrome (CIS). The aim of this study was to identify novel antigens for CIS and investigate their prognostic potential to predict conversion to multiple scleros...

journal_title：Journal of neurochemistry

authors： Rouwette M,Somers K,Govarts C,De Deyn PP,Hupperts R,Van Wijmeersch B,De Jong BA,Verbeek MM,Van Pesch V,Sindic C,Villar LM,Álvarez-Cermeño JC,Stinissen P,Somers V

更新日期：2012-11-01 00:00:00

abstract：:Primary cultures of astrocytes from newborn rat brain showed evidence of a substrate-saturable process for glucose transport. The system shows a relatively high affinity for the substrate, with an apparent Km of approximately 1 mM. Maintenance of the cells in medium containing thyroid-hormone-free serum for 3, 6, or 9...

journal_title：Journal of neurochemistry

authors： Roeder LM,Williams IB,Tildon JT

更新日期：1985-11-01 00:00:00

abstract：:It is well established that chronic nicotine treatment produces a dose-dependent increase in high-affinity L-[3H]nicotine binding. This increase may be due to chronic desensitization of the receptor. Sophisticated kinetic analyses of high-affinity nicotine binding to rat brain have demonstrated that the association ra...

journal_title：Journal of neurochemistry

authors： Bhat RV,Marks MJ,Collins AC

更新日期：1994-02-01 00:00:00

abstract：:The effect of hypoglycaemic, hypoxic, and ischaemic conditions on high-affinity neurotransmitter transport was studied in the human astrocytoma clone D384 and the human neuroblastoma clone SH-SY5Y. Both cell lines expressed a sodium-dependent glutamate/aspartate transporter. Km values for D-[3H]aspartate uptake were 6...

journal_title：Journal of neurochemistry

authors： O'Neill CM,Ball SG,Vaughan PF

更新日期：1994-08-01 00:00:00

abstract：:We investigated the effects of 17beta-estradiol, an estrogen, on [(3)H]norepinephrine ([(3)H]NE) secretion in PC12 cells. Pretreatment with 17beta-estradiol reduced 70 mM K(+)-induced [(3)H]NE secretion in a concentration-dependent manner with a half-maximal inhibitory concentration (IC(50)) of 2 +/- 1 microM. The 70 ...

journal_title：Journal of neurochemistry

authors： Kim YJ,Hur EM,Park TJ,Kim KT

更新日期：2000-06-01 00:00:00

abstract：:Aging in rats is associated with a loss of hippocampal neurons, which may contribute to age-related cognitive deficits. Several lines of evidence suggest that stress and glucocorticoids may contribute to age-related declines in hippocampal neuronal number. Excitatory amino acids (EAAs) have been implicated in the gluc...

journal_title：Journal of neurochemistry

authors： Lowy MT,Wittenberg L,Yamamoto BK

更新日期：1995-07-01 00:00:00

abstract：:Edaravone (Eda) is a potent scavenger of hydroxyl radicals and has been demonstrated to be beneficial for patients with acute ischemic stroke. This study was set out to investigate whether Eda protect against MPP(+)-induced cytotoxicity in rat primary cultured astrocytes. The results showed that pre-treatment with Eda...

journal_title：Journal of neurochemistry

authors： Chen H,Wang S,Ding JH,Hu G

更新日期：2008-09-01 00:00:00

abstract：:The extension of microglial processes toward injured sites in the brain is triggered by the stimulation of the purinergic receptor P2Y(12) by extracellular ATP. We recently showed that P2Y(12) stimulation by ATP induces microglial process extension in collagen gels. In the present study, we found that a P2Y(12) agonis...

journal_title：Journal of neurochemistry

authors： Ohsawa K,Sanagi T,Nakamura Y,Suzuki E,Inoue K,Kohsaka S

更新日期：2012-04-01 00:00:00

abstract：:Activation of the apoptogenic sphingomyelin-dependent signaling pathway in neuronally differentiated PC12 cells with cell-permeant C2-ceramide resulted in a transient and short-lived emission of reactive oxygen species that was maximal 6 h after the beginning of treatment, followed immediately by nuclear translocation...

journal_title：Journal of neurochemistry

authors： France-Lanord V,Brugg B,Michel PP,Agid Y,Ruberg M

更新日期：1997-10-01 00:00:00

abstract：:During CNS injury and diseases, nitric oxide (NO) is released at a high flux rate leading to formation of peroxynitrite (ONOO(*)) and other reactive nitrogenous species, which nitrate tyrosines of proteins to form 3-nitrotyrosine (3NY), leading to cell death. Previously, we have found that motor neurons exposed to low...

journal_title：Journal of neurochemistry

authors： Bishop A,Gooch R,Eguchi A,Jeffrey S,Smallwood L,Anderson J,Estevez AG

更新日期：2009-04-01 00:00:00

abstract：:Glutathione-S-transferase activity in the brain of male mammals (rat and mouse) was found to be relatively lower than in that of females. In contrast, the male aves (pigeon, kite, vulture, and crow) exhibited comparatively higher activity in brain glutathione-S-transferase than the corresponding females. Postnatal dev...

journal_title：Journal of neurochemistry

authors： Das M,Dixit R,Seth PK,Mukhtar H

更新日期：1981-04-01 00:00:00

abstract：:Two semisynthetic acetyl derivatives of the alkaloid sauroine from Huperzia saururus, monoacetyl sauroine, and diacetyl sauroine (DAS) were obtained and their chemical structures were analyzed by NMR. While monoacetyl sauroine is the typical product of acetylation, DAS is an unexpected derivative related to the keto-e...

journal_title：Journal of neurochemistry

authors： Vallejo M,Loyola S,Contreras D,Ugarte G,Cifuente D,Ortega G,Cabrera JL,Zeise M,Tonn C,Carreño M,Delgado R,Morales B,Agnese M

更新日期：2014-06-01 00:00:00

abstract：:Rats were administered [3H]fucose by intracranial injection and synaptic membranes (SMs) isolated 18 h later. Oligosaccharides associated with SM glycoproteins were prepared by hydrazinolysis and analyzed by a combination of affinity chromatography on concanavalin A (Con A)-agarose, ion-exchange chromatography on DEAE...

journal_title：Journal of neurochemistry

authors： Stanojev D,Gurd JW

更新日期：1987-05-01 00:00:00

abstract：:Brain-derived neurotrophic factor (BDNF) which is primarily associated with neuronal survivability, differentiation and synaptic plasticity has been reported to mediate neurodegeneration in hypoxia through its p75 Neurotrophin receptors (p75NTR). The molecular events promoting BDNF-mediated pro-death signalling in hyp...

journal_title：Journal of neurochemistry

authors： Sharma D,Barhwal KK,Biswal SN,Srivastava AK,Bhardwaj P,Kumar A,Chaurasia OP,Hota SK

更新日期：2019-01-01 00:00:00

abstract：:Phosphatidylserine (PS), which is synthesized in mammalian tissues by the exchange between free serine and the nitrogen bases present in membrane glycerophospholipids, is strictly required for protein kinase C (PKC) activity. PKC, as other molecules involved in signal transduction, is present in lipid rafts, considere...

journal_title：Journal of neurochemistry

authors： Buratta S,Felicetti M,Mozzi R

更新日期：2007-11-01 00:00:00

abstract：:Alzheimer's disease (AD) is a neurodegenerative disease resulting in progressive cognitive decline. Amyloid plaque deposits consisting specifically of beta-amyloid peptides that have formed fibrils displaying beta-pleated sheet conformation are associated with activated microglia and astrocytes, are colocalized with C...

journal_title：Journal of neurochemistry

authors： Zhou J,Fonseca MI,Pisalyaput K,Tenner AJ

更新日期：2008-09-01 00:00:00

abstract：:Ion channels are classically understood to regulate the flux of ions across the plasma membrane in response to a variety of environmental and intracellular cues. Ion channels serve a number of functions in intracellular membranes as well. These channels may be temporarily localized to intracellular membranes as a func...

journal_title：Journal of neurochemistry

authors： Dong XP,Wang X,Xu H

更新日期：2010-04-01 00:00:00

abstract：:Homologues of the Drosophila melanogaster tweety (tty) gene are present in mammals and Caenorhabditis elegans. The encoded proteins have five predicted membrane-spanning regions and recent findings suggest that some family members may be chloride channels. Phylogenetic analysis of the tty family including novel member...

journal_title：Journal of neurochemistry

authors： Matthews CA,Shaw JE,Hooper JA,Young IG,Crouch MF,Campbell HD

更新日期：2007-02-01 00:00:00

abstract：:Some data on the concentration range of response and the concentration for half-response (EC50) of gamma-aminobutyric acid (GABA) for the GABAA receptor are reviewed and compared. An analysis of the 36Cl- flux assay demonstrates that both the EC50 and the slope of a Hill plot depend on the ion influx or efflux assay t...

journal_title：Journal of neurochemistry

authors： Kardos J,Cash DJ

更新日期：1990-10-01 00:00:00

abstract：:We have examined cyclic GMP concentrations, guanylate cyclase activities, and cyclic GMP phosphodiesterase (PDE) activities in developing retinas of congenic mice with different allelic combinations at the retinal degeneration (rd) and retinal degeneration slow (rds) loci. Although guanylate cyclase activities were fo...

journal_title：Journal of neurochemistry

authors： Fletcher RT,Sanyal S,Krishna G,Aguirre G,Chader GJ

更新日期：1986-04-01 00:00:00

abstract：:The effect of lead ions on the release of acetylcholine (ACh) was investigated in intact and digitonin-permeabilized rat cerebrocortical synaptosomes that had been prelabeled with [3H]choline. Release of ACh was inferred from the release of total 3H label or by determination of [3H]ACh. Application of 1 microM Pb2+ to...

journal_title：Journal of neurochemistry

authors： Shao Z,Suszkiw JB

更新日期：1991-02-01 00:00:00

abstract：:The adenylate cyclase activity of rat hippocampal plasma membranes can be stimulated by vasoactive intestinal polypeptide (VIP). Low concentrations (10(-9) to 19(-7) M) of 5'-guanylyl-imido diphosphate (GppNHp) evoke a transient inhibition of the enzyme, which is followed by stimulation with increasing GppNHp concentr...

journal_title：Journal of neurochemistry

authors： Girardot JM,Kempf J,Cooper DM

更新日期：1983-09-01 00:00:00

abstract：:In vivo microdialysis in C57BL/6J (B6) mouse was used to test the hypothesis that activating adenosine A(2A) receptors in the pontine reticular formation (PRF) increases acetylcholine (ACh) release and rapid eye movement (REM) sleep. Eight concentrations of the adenosine A(2A) receptor agonist 2-p-(2-carboxyethyl)phen...

journal_title：Journal of neurochemistry

authors： Coleman CG,Baghdoyan HA,Lydic R

更新日期：2006-03-01 00:00:00

abstract：:One-week treatment with the benzodiazepine (BZ) flurazepam (FZP), results in anticonvulsant tolerance, associated with reduced GABAA receptor (GABAR) subunit protein and miniature inhibitory post-synaptic current (mIPSC) amplitude in CA1 neurons of rat hippocampus. Because protein kinase A (PKA) has been shown to modu...

journal_title：Journal of neurochemistry

authors： Lilly SM,Zeng XJ,Tietz EI

更新日期：2003-05-01 00:00:00

abstract：:The developing central nervous system is a primary target of ethanol toxicity. The teratogenic effect of ethanol may result from its action on prostaglandins. Prostaglandins are generated through the release of arachidonic acid (AA) by the action of cytosolic phospholipase A(2) (cPLA(2)) on membrane-bound phospholipid...

journal_title：Journal of neurochemistry

authors： Luo J,Lindström CL,Donahue A,Miller MW

更新日期：2001-03-01 00:00:00

abstract：:Aggregation of conformation-abnormal peptides probably plays a key role in the pathogenesis of many neurodegenerative diseases. DSCR1 Down syndrome (DS) critical region 1, was identified from a chromosomal region (21q22.1-q22.2) for the clinical manifestations of DS when an extra-copy is present. We report that expres...

journal_title：Journal of neurochemistry

authors： Ma H,Xiong H,Liu T,Zhang L,Godzik A,Zhang Z

更新日期：2004-03-01 00:00:00

abstract：:The effect of compounds that activate sodium channels on the number of muscarinic acetylcholine receptors in neuroblastoma NIE 115 cells has been investigated. The cells were used in electrically unexcitable ("control" cells) and excitable ("differentiated" cells) states. Although receptor assays using a single concen...

journal_title：Journal of neurochemistry

authors： Milligan G,Strange PG

更新日期：1984-07-01 00:00:00

abstract：:Although isoelectric focusing has been used to demonstrate the presence of oligoclonal IgG in the CSF, the technique has not allowed detection of oligoclonal IgG in unconcentrated CSF. A new technique is reported, by which unconcentrated CSF is separated by isoelectric focusing, and the IgG bands are then detected by ...

journal_title：Journal of neurochemistry

authors： Lasne Y,Benzerara O,Chazot G,Creyssel R

更新日期：1981-05-01 00:00:00

abstract：:Overactivation of glutamate receptors mediates neuronal death in several acute and chronic neurodegenerative diseases. The intracellular processes underlying this form of death, however, remain poorly understood. Depending on the severity of insult, N-methyl-D-aspartate (NMDA) receptor activation induces either apopto...

journal_title：Journal of neurochemistry

authors： Tenneti L,D'Emilia DM,Troy CM,Lipton SA

更新日期：1998-09-01 00:00:00